78314

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Comprehensive methodology for Staphylococcus aureus lipidomics by liquid chromatography and quadrupole time-of-flight mass spectrometry.

Weronika Hewelt-Belka et al.

Journal of chromatography. A, 1362, 62-74 (2014-08-28)

Staphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a

Development and validation of an ultrafiltration-UPLC-MS/MS method for rapid quantification of unbound docetaxel in human plasma.

Ping Du et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 28-35 (2014-07-27)

Docetaxel lipid microsphere (DT-LM) is a novel formulation of docetaxel without Tween-80. A sensitive, robust and reproducible ultrafiltration (UF) followed by UPLC-MS/MS method was developed and validated for the quantification of unbound docetaxel in human plasma using paclitaxel as IS.

Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity.

Tara Man Kadayat et al.

Bioorganic & medicinal chemistry, 23(1), 160-173 (2014-12-08)

For the development of potential anticancer agents, we designed and synthesized 30 new 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives containing aryl moiety such as furyl, thienyl, pyridyl, and phenyl at 2- and 4-position of 5H-indeno[1,2-b]pyridine. They were evaluated for topoisomerase I and II inhibitory

Haematocrit corrected analysis of creatinine in dried blood spots through potassium measurement.

Jeroen C G den Burger et al.

Analytical and bioanalytical chemistry, 407(2), 621-627 (2014-11-07)

We developed a method for the analysis of creatinine in dried blood spot (DBS) samples to facilitate monitoring of renal function in combination with TDM of immunosuppressive drugs for transplant patients outside the hospital. An 8-mm disc of the DBS

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis.

Sabrina D Lamour et al.

PLoS neglected tropical diseases, 9(10), e0004200-e0004200 (2015-10-28)

Human African trypanosomiasis (HAT) remains a major neglected tropical disease in Sub-Saharan Africa. As clinical symptoms are usually non-specific, new diagnostic and prognostic markers are urgently needed to enhance the number of identified cases and optimise treatment. This is particularly

Acid-catalyzed hydrothermal severity on the fractionation of agricultural residues for xylose-rich hydrolyzates.

Ji Ye Lee et al.

Bioresource technology, 132, 84-90 (2013-02-12)

The objective of this work was to investigate the feasibility of acid-catalyzed hydrothermal fractionation for maximum solubilization of the hemicellulosic portion of three agricultural residues. The fractionation conditions converted into combined severity factor (CS) in the range of 1.2-2.9. The

Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.

Ramesh Boinpally et al.

Clinical therapeutics, 36(11), 1638-1649 (2014-09-23)

Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major depressive disorder in adults. Vilazodone seems to be metabolized primarily by the cytochrome P-450 (CYP) 3A4 isozyme and non-CYP-mediated pathways; concomitant use of drugs

Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.

Gordon C C Yang et al.

Journal of hazardous materials, 277, 53-61 (2014-04-08)

This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to remove the contaminants. To this

Determination of selected water-soluble vitamins using hydrophilic chromatography: a comparison of photodiode array, fluorescence, and coulometric detection, and validation in a breakfast cereal matrix.

Swen Langer et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 73-81 (2014-05-06)

Water-soluble vitamins are an important class of compounds that require quantification from food sources to monitor nutritional value. In this study we have analysed six water-soluble B vitamins ([thiamine (B1), riboflavin (B2), nicotinic acid (B3, NAc), nicotinamide (B3, NAm), pyridoxal

An Automated Method for the Determination of Trimebutine and N-Mono-Desmethyl Trimebutine by On-Line Turbulent Flow Coupled with Liquid Chromatography-Tandem Mass Spectrometry in Human Plasma: Application to a Fatal Poisoning Case with Toxicokinetic Study.

Islam Amine Larabi et al.

Journal of analytical toxicology, 39(9), 720-725 (2015-09-06)

A liquid chromatography-MS-MS turbulent flow on-line extraction method was developed for the determination of trimebutine (TMB) and its main active metabolite N-mono-desmethyltrimebutine (nortrimebutine or nor-TMB) in human plasma. After protein precipitation and internal standard (IS, haloperidol-d4) addition, 50 µL of

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug.

Sifei Han et al.

Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)

Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)

Quantification of 5,7-dimethoxyflavone in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application to a pharmacokinetic study.

Di Bei et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 11-17 (2014-12-23)

5,7-Dimethoxyflavone (5,7-DMF), a natural flavonoid abundant in many plants, has been reported to have many beneficial pharmacological effects, including strong chemopreventive and chemosensitizing properties, anti-oxidant, cardiovascular protectant, and anti-inflammatory activities. However, to date 5,7-DMF was evaluated mainly in vitro and

Simultaneous determination of remimazolam and its carboxylic acid metabolite in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry.

Ying Zhou et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 78-83 (2014-12-09)

A robust and validated method based on ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) has been developed for the simultaneous determination of remimazolam, which is a new chemical entity, and its major carboxylic acid metabolite (M1) in human

Direct injection human plasma analysis for the quantification of antihypertensive drugs for therapeutic drug monitoring using hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry.

Stefanos Meimaroglou et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1004, 1-9 (2015-10-04)

The concept of personalized medicine is related to the development of new sensitive, precise and accurate analytical methods for therapeutic drug monitoring. In this article a rapid, sensitive and specific method was developed for the quantification of aliskiren, losartan, valsartan

Effect of dissolved oxygen concentration on iron efficiency: Removal of three chloroacetic acids.

Shun Tang et al.

Water research, 73, 342-352 (2015-02-24)

The monochloroacetic, dichloroacetic and trichloroacetic acid (MCAA, DCAA and TCAA) removed by metallic iron under controlled dissolved oxygen conditions (0, 0.75, 1.52, 2.59, 3.47 or 7.09 mg/L DO) was investigated in well-mixed batch systems. The removal of CAAs increased first

The use of enzyme-coupled magnetic nanoparticles for studying the spectra of unusual substrates of mushroom tyrosinase by direct surface-assisted laser desorption/ionisation and high-resolution electrospray ionisation quadrupole-quadrupole-time-of-flight mass spectrometry.

Aleksander Salwiński et al.

Rapid communications in mass spectrometry : RCM, 28(18), 1957-1963 (2014-08-19)

Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate. This shows the potential for the application of EMPs as a non-organic matrix for monitoring

Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor, perifosine, in a non-human primate model.

Diane E Cole et al.

Cancer chemotherapy and pharmacology, 75(5), 923-928 (2015-03-06)

Central nervous system tumors are histologically and biologically heterogeneous. Standard treatment for malignant tumors includes surgery, radiation and chemotherapy, yet surgical resection is not always an option and chemotherapeutic agents have limited benefit. Recent investigations have focused on molecularly targeted

Profiling of regioisomeric triacylglycerols in edible oils by supercritical fluid chromatography/tandem mass spectrometry.

Jae Won Lee et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 193-199 (2014-02-21)

In this study, supercritical fluid chromatography (SFC) coupled with triple quadrupole mass spectrometry was applied to the profiling of several regioisomeric triacylglycerols (TAGs). SFC conditions (column, flow rate, modifier) were optimized for the effective separation of TAGs. In the column

Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans.

Prem K Gupta et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(4), 534-552 (2015-01-23)

The disposition and metabolism of hydrastine was investigated in 11 healthy subjects following an oral dose of 2.7 g of goldenseal supplement containing 78 mg of hydrastine. Serial blood samples were collected for 48 hours, and urine was collected for

Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes.

Michael Lever et al.

Cardiovascular drugs and therapy, 28(5), 459-468 (2014-07-26)

Betaine deficiency is a probable cardiovascular risk factor and a cause of elevated homocysteine. Urinary betaine excretion is increased by fibrate treatment, and is also often elevated in diabetes. Does fibrate further increase betaine excretion in diabetes, and does it

Hydrophilic interaction liquid chromatography for the separation of acidic agricultural compounds.

Peilin Yang et al.

Journal of separation science, 38(13), 2253-2259 (2015-04-25)

Organic acids with very low pKa require extremely low pH conditions to achieve adequate retention in reversed-phase liquid chromatography, but an extremely low pH mobile phase can cause instrument reliability problems and limit the choice of columns. Hydrophilic interaction chromatography

Proteomic LC-MS analysis of Arabidopsis cytosolic ribosomes: Identification of ribosomal protein paralogs and re-annotation of the ribosomal protein genes.

Maureen Hummel et al.

Journal of proteomics, 128, 436-449 (2015-08-02)

Arabidopsis thaliana cytosolic ribosomes are large complexes containing eighty-one distinct ribosomal proteins (r-proteins), four ribosomal RNAs (rRNA) and a plethora of associated (non-ribosomal) proteins. In plants, r-proteins of cytosolic ribosomes are each encoded by two to seven different expressed and

Chemical shift powder spectra enhanced by multiple-contact cross-polarization under slow magic-angle spinning.

Jésus Raya et al.

Journal of magnetic resonance (San Diego, Calif. : 1997), 227, 93-102 (2013-01-15)

A simple multiple-contact cross-polarization (CP) scheme is applied to a powder sample of ferrocene and β-calcium formate under static and magic-angle spinning (MAS) conditions. The method is described analytically through the density matrix formalism. We show that multiple equilibrations-re-equilibrations with

UPLC-MS/MS method for determination of bepotastine in human plasma.

Yun Kyoung Choi et al.

Journal of chromatographic science, 52(8), 886-893 (2013-09-12)

A sensitive and rapid method for quantitation of bepotastine in human plasma has been established using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS). Valsartan was used as an internal standard. Bepotastine and internal standard in plasma sample were

Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays.

Stefanie H Grimm et al.

Analytical and bioanalytical chemistry, 407(2), 471-485 (2014-12-03)

We herein present the first LC-MS/MS quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for dopamine, DAT; norepinephrine, NET; serotonin, SERT), and its application to MS Binding Assays. For HPLC, an R18 column with

Noscapine recirculates enterohepatically and induces self-clearance.

Rao Mukkavilli et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 90-99 (2015-06-01)

Noscapine (Nos), an antitussive benzylisoquinoline opium alkaloid, is a non-toxic tubulin-binding agent currently in Phase II clinical trials for cancer chemotherapy. While preclinical studies have established its tumor-inhibitory properties in various cancers, poor absorptivity and rapid first-pass metabolism producing several

Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma.

Aljona Saleh et al.

Journal of pharmaceutical and biomedical analysis, 104, 1-11 (2014-12-03)

MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pharmacokinetic studies on mice. A bioanalytical

Salting-out-assisted liquid-liquid extraction with acetonitrile for the determination of trimetazidine in rat plasma using liquid chromatography-mass spectrometry.

Xin Xiong et al.

Biomedical chromatography : BMC, 29(2), 268-274 (2014-06-24)

A high-throughout bioanalytical method based on salting-out-assisted liquid/liquid extraction (SALLE) method with acetonitrile and mass spectrometry-compatible salts followed by LC-MS/MS analysis of trimetazidine in rat plasma is presented. It required only 50 μL of plasma and allows the use of minimal

Study of retention and peak shape in hydrophilic interaction chromatography over a wide pH range.

David V McCalley

Journal of chromatography. A, 1411, 41-49 (2015-08-16)

Retention factor and column efficiency measurements were made for 14 test compounds comprising acids, bases and neutrals on two pairs of amide and bare silica HILIC columns, each pair obtained from a different manufacturer. The columns were tested with up

Influence of the antimicrobial compound allyl isothiocyanate against the Aspergillus parasiticus growth and its aflatoxins production in pizza crust.

Juan M Quiles et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 222-228 (2015-07-07)

Aflatoxins (AFs) are secondary metabolites produced by different species of Aspergillus, such as Aspergillus ﬂavus and Aspergillus parasiticus, which possess mutagenic, teratogenic and carcinogenic activities in humans. In this study, active packaging devices containing allyl isothiocyanate (AITC) or oriental mustard

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