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Forest H Andrews et al.
Bioorganic chemistry, 43, 26-36 (2012-01-17)
Thiamin diphosphate (ThDP) is the biologically active form of vitamin B(1), and ThDP-dependent enzymes are found in all forms of life. The catalytic mechanism of this family requires the formation of a common intermediate, the 2α-carbanion-enamine, regardless of whether the
Ferruccio Santini et al.
Thyroid : official journal of the American Thyroid Association, 18(10), 1065-1069 (2008-09-26)
Many natural substances and drugs have long been known to cause goiter or thyroid dysfunction. More recently, several environmental pollutants, such as pesticides and industrial compounds, have been investigated for their thyroid-disrupting activity and related adverse effects on human health.
Marie Meyer-Monath et al.
Analytical and bioanalytical chemistry, 406(30), 7785-7797 (2014-11-10)
Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method was developed to identify and quantify some pesticides and their
Zhi-de Zhou et al.
International journal of biological macromolecules, 47(1), 21-26 (2010-04-20)
Saccharomyces cerevisiae alcohol dehydrogenase (SCAD) was effectively immobilized on hybrid alginate-chitosan beads which are hardened with glutaraldehyde. Immobilization conditions and characterization of the immobilized enzyme were investigated. Orthogonal test design and intuitive analysis method were employed to evaluate the effects
M J Prieto-Castelló et al.
Toxicology letters, 192(1), 34-39 (2010-02-02)
The CYP2E1 has been identified as the main cytochrome P450 isoform involved in human styrene metabolism. CYP2E1 presents polymorphism in humans and the different genotypes may, at least partly, be related to the different levels of individual expression of enzyme
Gerhard Triebig et al.
International archives of occupational and environmental health, 82(4), 463-480 (2008-09-03)
Associations between occupational styrene exposure and impairment of hearing function were investigated, guided by three questions: are there hearing losses concerning high frequency and standard audiometric test? Are there dose-response relationships and measurable thresholds of effects? Are there signs of
Aalo K Gupta et al.
Inorganic chemistry, 49(7), 3531-3539 (2010-03-12)
To further understand copper-promoted oxidation reactions, the Cu(I) complexes LCuX (L = N,N'-di-tert-butyl-N,N'-dimethylethylenediamine; X = benzoylformate (BF) or p-nitro-benzoylformate) were synthesized, fully characterized by X-ray crystallography and spectroscopy in solution, and their reactivity with O(2) at -80 degrees C examined.
[Simultaneous determination of urinary hippuric acid and o-, m-, p-methylhippuric acids with liquid chromatography].
C Lacroix et al.
Journal of chromatography, 382, 275-279 (1986-10-31)
Caleb J Allpress et al.
Journal of the American Chemical Society, 135(2), 659-668 (2012-12-12)
Mononuclear Fe(II) complexes ([(6-Ph(2)TPA)Fe(PhC(O)C(R)C(O)Ph)]X (3-X: R = OH, X = ClO(4) or OTf; 4: R = H, X = ClO(4))) supported by the 6-Ph(2)TPA chelate ligand (6-Ph(2)TPA = N,N-bis((6-phenyl-2-pyridyl)methyl)-N-(2-pyridylmethyl)amine) and containing a β-diketonate ligand bound via a six-membered chelate ring
Frédéric Cosnier et al.
Journal of analytical toxicology, 36(5), 312-318 (2012-04-12)
A convenient and reliable gas chromatographic method was developed for the simultaneous determination of six aromatic acid metabolites of styrene and styrene-oxide in rat urine; i.e., benzoic (BA), phenylacetic (PAA), mandelic (MA), phenylglyoxylic (PGA), hippuric (HA) and phenylaceturic (PAUA) acids.
Sébastien Gagné
Rapid communications in mass spectrometry : RCM, 26(7), 845-852 (2012-03-01)
Ultra-performance liquid chromatography coupled with tandem mass spectrometry was used for the biological monitoring of workers occupationally exposed to solvents. The method was developed using a triple quadrupole to investigate the relevant urinary metabolites of styrene, namely mandelic acid and
Sirilak Wongvijitsuk et al.
International journal of hygiene and environmental health, 214(2), 127-137 (2010-10-30)
The present study aimed to evaluate the effects of styrene exposure at levels below the recommended standards of the Threshold Limit Value (TLV-TWA(8)) of 20 ppm (ACGIH, 2004) in reinforced-fiberglass plastics workers. Study subjects comprised 50 exposed workers and 40
Giovanna Tranfo et al.
La Medicina del lavoro, 103(5), 402-412 (2012-10-20)
Styrene is used in manufacturing fiberglass reinforced plastics: and occupational exposure was related to neurotoxicology and genotoxicity. The sum of the metabolites mandelic and phenylglyoxylic acids is the ACGIH biomarker for occupational exposure with a BEI of 400 mg/g of
Zhiyong Yang et al.
The Journal of organic chemistry, 77(16), 7086-7091 (2012-07-28)
Nontransition metal-catalyzed synthesis of 2-aryl benzothiazoles was achieved through K(2)S(2)O(8)-mediated oxidative condensation of benzothiazoles with aryl aldehydes. The same transformation can also be effected when the aryl aldehydes were replaced with phenylglyoxylic acids.
Yu-Cai He et al.
Bioresource technology, 115, 88-95 (2011-10-29)
Benzoylformic acid was synthesized from the hydrolysis of benzoyl cyanide by a newly isolated Rhodococcus sp. CCZU10-1. In this study, an aqueous-toluene biphasic system was developed for highly efficient production of benzoylformic acid from the hydrolysis of benzoyl cyanide. In
S Fustinoni et al.
Toxicology letters, 192(1), 40-44 (2010-02-02)
The aim of this work is to compare several short-term biomarkers of styrene exposure, namely urinary styrene (StyU), mercapturic acids (M1+M2), mandelic acid (MA), phenylglyoxylic acid (PGA), phenylglycine (PHG), and 4-vinylphenol conjugates (VP), for use as biomarkers of exposure in
Tianyi Jiang et al.
Microbial cell factories, 11, 151-151 (2012-11-28)
NAD-independent L-lactate dehydrogenase (L-iLDH) from Pseudomonas stutzeri SDM can potentially be used for the kinetic resolution of small aliphatic 2-hydroxycarboxylic acids. However, this enzyme showed rather low activity towards aromatic 2-hydroxycarboxylic acids. Val-108 of L-iLDH was changed to Ala by
Oindrila Das et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 18(3), 401-410 (2013-02-19)
Two biomimetic iron(II) benzoylformate complexes, [LFe(II)(BF)(2)] (2) and [LFe(II)(NO(3))(BF)] (3) (L is 2,9-dimethyl-1,10-phenanthroline and BF is monoanionic benzoylformate), have been synthesized from an iron(II)-dichloro complex [LFe(II)Cl(2)] (1). All the iron(II) complexes have been structurally and spectroscopically characterized. The iron(II) center
Ruy J Cruz et al.
The Journal of surgical research, 165(1), 151-157 (2009-12-05)
Ethyl pyruvate (EP) has been shown to ameliorate hepatic, renal, and intestinal mucosal injury and down-regulate expression of several pro-inflammatory mediators in a wide variety of preclinical models of critical illnesses, such as sepsis, burn injury, acute pancreatitis, stroke, and
Tetsuro Sato et al.
Neurotoxicology, 30(1), 97-102 (2008-12-09)
We aimed to investigate whether styrene can affect the vibration perception threshold (VPT) and to examine the dose-effect relationship at current and past styrene exposure levels. VPT was examined using a Vibrometer (TM-31A) for 67 subjects exposed to styrene in
Gisella Terre'Blanche et al.
Neurotoxicity research, 20(1), 97-101 (2010-10-12)
Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in man and animals, and styrene share a common metabolic pathway yielding
Andreas Seeber et al.
International archives of occupational and environmental health, 82(6), 757-770 (2009-03-31)
Associations between occupational styrene exposures and impairment of visual functions were investigated with a view to answering three questions: (1) are the published findings for colour vision deficiencies and impaired contrast sensitivity to reproduce in a new study approach, (2)
Ming Zhang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 115(1), 295-303 (2010-02-17)
Ethylbenzene is an important industrial chemical that has recently been classified as a possible human carcinogen (International Agency of Research on Cancer class 2B), but the available data do not support the genotoxic mechanism of ethylbenzene-induced tumors in kidney. We
Jesus M Aizpurua et al.
The Journal of organic chemistry, 74(17), 6691-6702 (2009-08-01)
Mechanistic details of the Mg(2+) ion-activated enantioselective reduction of methyl benzoylformate have been investigated at a B3LYP/6-31G* theory level, using peptide NADH models 1 rigidified with a beta-lactam ring. Computation of the reaction pathway revealed important structural differences between the
Yuan-Yang Wu et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 38(3), 229-234 (2009-06-09)
To establish a GC/MS method for analysis of cotinine (COT), phenylglyoxylic acid (PA) and mandelic acid (MA) in human urine. Human urine samples were extracted by CCl(3) and derivatized with MSTFA after dried completely. The contents of COT, PA and
Carla Costa et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 735-746 (2012-07-14)
Styrene is a widely used chemical in the manufacture of synthetic rubber, resins, polyesters, and plastics. The highest levels of human exposure to styrene occur during the production of reinforced plastic products. The objective of this study was to examine
Yan-Rang Wang et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 27(11), 655-659 (2010-02-09)
To investigate the influence of ethylbenzene on the levels of mandelic acid (MA) and phenylglyoxylic acid (PGA) in urine, the ultrastructure and the expressions of mitochondrial apoptotic-related genes in the rat nephridial tissues. Four groups of 10 males of Sprague-Dawley
T Sakai et al.
Sangyo igaku. Japanese journal of industrial health, 31(1), 9-16 (1989-01-01)
For the biological monitoring of exposure to solvent composed of toluene, xylene, and ethylbenzene used in a printing factory with gravure machines, we developed a HPLC method for the simultaneous determination of urinary metabolites of this solvent, i.e. hippuric acid
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