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C F Massaro et al.
Fitoterapia, 95, 247-257 (2014-04-08)
Propolis of Australian stingless bees (Tetragonula carbonaria, Meliponini) originating from Corymbia torelliana (Myrtaceae) fruit resins was tested for its antimicrobial activities as well as its flavonoid contents. This study aimed at the isolation, structural elucidation and antibacterial testing of flavanones
Steven A Grover et al.
The lancet. Diabetes & endocrinology, 3(2), 114-122 (2014-12-09)
Despite the increased risk of cardiovascular disease and type 2 diabetes associated with excess bodyweight, development of a clinically meaningful metric for health professionals remains a challenge. We estimated the years of life lost and the life-years lost from diabetes
Younghye Kim et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 33(5), 517-523 (2014-08-02)
Abnormal expression of the spindle assembly checkpoint proteins causes tumor cell aneuploidy, which has been reported in various malignancies. The expression of mitotic arrest deficient 2 (MAD2) and cell-division cycle 20 homolog (CDC20), the key spindle assembly checkpoint proteins, has
Charles J Glueck et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 14(3), 286-294 (2007-12-28)
We prospectively assessed associations of thrombophilia- hypofibrinolysis with central retinal vein occlusion (CRVO) (40 patients) and central retinal artery occlusion (CRAO) (9 patients). We used polymerase chain reaction measures for thrombophilia (factor V Leiden, prothrombin, C677T MTHFR, platelet glycoprotein PlA1/A2)
Koji Tanaka et al.
International journal of stroke : official journal of the International Stroke Society, 9(8), 1045-1051 (2014-03-14)
Atrial fibrillation impairs left atrial appendage function and the thrombus formation in the left atrial appendage is a major cause of cardioembolic stroke. To evaluate the association between the volume of the left atrial appendage measured by real-time three-dimensional transesophageal
D Boerboom et al.
Biology of reproduction, 64(1), 206-215 (2001-01-03)
The preovulatory LH rise is the physiological trigger of follicular luteinization, a process during which the synthesis of progesterone is markedly increased. To study the control of follicular progesterone biosynthesis in mares, the objectives of this study were to clone
Kun Qian et al.
Public health nutrition, 23(14), 2485-2493 (2020-06-11)
To determine which set of BMI cut-offs is the most appropriate to define child and adolescent obesity in urban China. A cross-sectional study was carried out between 1 November and 31 December in 2017. Community Healthcare Center in Minhang District
K Kingo et al.
The British journal of dermatology, 156(4), 646-652 (2007-02-01)
Interleukin (IL) 19, IL-20 and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and in inflammation. The genes encoding IL-19, IL-20 and IL-24 are located within a
Hong-chun Zhao et al.
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 41(12), 945-949 (2007-03-10)
To study the expression of S phase kinase associated protein 2 (Skp2), phosphatase and tensin homolog deleted on chromosome ten (PTEN) in human laryngeal carcinoma and precancerous lesions, to explore their relations and clinical significance. Formalin-fixed and paraffin-embedded tissues from
Andre Pascal Kengne et al.
The lancet. Diabetes & endocrinology, 2(1), 19-29 (2014-03-14)
The comparative performance of existing models for prediction of type 2 diabetes across populations has not been investigated. We validated existing non-laboratory-based models and assessed variability in predictive performance in European populations. We selected non-invasive prediction models for incident diabetes
Norman G Egger et al.
Digestive diseases and sciences, 47(2), 419-426 (2002-02-22)
The coexistence of factors considered to contribute to development of porphyria cutanea tarda was studied in 39 consecutive patients. Highly prevalent factors were alcohol intake in 79%, smoking in 86%, hepatitis C virus infection in 74%, estrogen use in 73%
Sandra S Wise et al.
Toxicology and applied pharmacology, 279(2), 113-118 (2014-06-22)
Sea turtles are a charismatic and ancient ocean species and can serve as key indicators for ocean ecosystems, including coral reefs and sea grass beds as well as coastal beaches. Genotoxicity studies in the species are absent, limiting our understanding
Shekman L Wong et al.
The Journal of clinical endocrinology and metabolism, 89(6), 2672-2677 (2004-06-08)
Leptin is an adipocyte-secreted hormone that regulates energy homeostasis and neuroendocrine function. Replacement therapy with recombinant methionyl human leptin (r-metHuLeptin) improves obesity, insulin resistance, hyperlipidemia, and neuroendocrine dysfunction associated with low-leptin states. We administered three doses of r-metHuLeptin (0.1, 0.3
Hector H Garcia et al.
The Lancet. Infectious diseases, 14(8), 687-695 (2014-07-08)
Neurocysticercosis causes a substantial burden of seizure disorders worldwide. Treatment with either praziquantel or albendazole has suboptimum efficacy. We aimed to establish whether combination of these drugs would increase cysticidal efficacy and whether complete cyst resolution results in fewer seizures.
Heiko Kock et al.
The Annals of occupational hygiene, 59(6), 788-796 (2015-03-27)
A field study was carried out in order to derive a factor for the conversion of historic worker exposure data on airborne beryllium (Be) obtained by sampling according to the 37-mm closed faced filter cassette (CFC) 'total' particulate method into
W G Chung et al.
Japanese journal of pharmacology, 84(2), 213-220 (2000-12-29)
Rat and human liver microsomes oxidized ranitidine to its N-oxide (66-76%) and S-oxide (13-18%) and desmethylranitidine (12-16%). N- and S-oxidations of ranitidine were inhibited by metimazole [flavin-containing monooxygenase (FMO) inhibitor] to 96-97% and 71-85%, respectively, and desmethylation of ranitidine was
H Gelderblom et al.
European journal of cancer (Oxford, England : 1990), 50(2), 388-396 (2013-11-13)
Brostallicin is a DNA minor groove binder that has shown activity in patients with soft tissue sarcoma (STS) failing first-line therapy. The present study assessed the safety and efficacy of first-line brostallicin in patients with advanced or metastatic STS >60
A S Perry et al.
British journal of cancer, 96(10), 1587-1594 (2007-04-25)
Promoter hypermethylation is central in deregulating gene expression in cancer. Identification of novel methylation targets in specific cancers provides a basis for their use as biomarkers of disease occurrence and progression. We developed an in silico strategy to globally identify
Yoshio Tomizawa et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(19 Pt 1), 6816-6822 (2005-10-06)
It has been reported that the mutations of epidermal growth factor receptor (EGFR) are detected in lung cancers. Studies of EGFR mutations in large numbers of patients' tumors with clinical data including response to EGFR tyrosine kinase directed therapy are
Yi-Long Wu et al.
The Lancet. Oncology, 14(8), 777-786 (2013-06-21)
The results of FASTACT, a randomised, placebo-controlled, phase 2 study, showed that intercalated chemotherapy and erlotinib significantly prolonged progression-free survival (PFS) in patients with advanced non-small-cell lung cancer. We undertook FASTACT-2, a phase 3 study in a similar patient population.
Hans F A Vasen et al.
Gastroenterology, 140(3), 850-856 (2010-12-07)
Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline mutations in p16-Leiden have a lifetime risk of 15% to 20% of developing pancreatic cancer. We assessed the feasibility of detecting pancreatic cancer
Gretchen A Stevens et al.
The Lancet. Global health, 3(9), e528-e536 (2015-08-16)
Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6-59 months. We aimed to estimate trends in the prevalence of vitamin A deficiency between 1991 and 2013 and its mortality
Javier Zarranz-Ventura et al.
American journal of ophthalmology, 158(6), 1136-1145 (2014-09-15)
To identify clinical outcomes and treatment patterns of intravitreal dexamethasone implant (Ozurdex; Allergan, Inc) in noninfectious uveitis in the clinical setting. Multicenter retrospective cohort study. Eighty-two eyes (63 patients) receiving 142 implant injections over 35 months were included. Treatment indication
Christiane L Haase et al.
PLoS genetics, 8(11), e1003063-e1003063 (2012-12-05)
Rare genetic variants, identified by in-detail resequencing of loci, may contribute to complex traits. We used the apolipoprotein A-I gene (APOA1), a major high-density lipoprotein (HDL) gene, and population-based resequencing to determine the spectrum of genetic variants, the phenotypic characteristics
Alice T Shaw et al.
The Lancet. Oncology, 18(12), 1590-1599 (2017-10-28)
Most patients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops, commonly within the CNS. This study aimed to analyse the safety, efficacy
Sunil Kumar et al.
Journal of gastroenterology and hepatology, 27(12), 1825-1830 (2012-09-20)
Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms. A total of 150 IBS
Gary Middleton et al.
The Lancet. Oncology, 15(8), 829-840 (2014-06-24)
We aimed to assess the efficacy and safety of sequential or simultaneous telomerase vaccination (GV1001) in combination with chemotherapy in patients with locally advanced or metastatic pancreatic cancer. TeloVac was a three-group, open-label, randomised phase 3 trial. We recruited patients
Matthew T Seymour et al.
The Lancet. Oncology, 14(8), 749-759 (2013-06-04)
Therapeutic antibodies targeting EGFR have activity in advanced colorectal cancer, but results from clinical trials are inconsistent and the population in which most benefit is derived is uncertain. Our aim was to assess the addition of panitumumab to irinotecan in
Mathilde Touvier et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 20(5), 1003-1016 (2011-03-08)
Our objective was to conduct a systematic review and meta-analysis of prospective studies on colorectal cancer (CRC) and vitamin D intake and 25-hydroxyvitamin D status, as part of the World Cancer Research Fund Continuous Update Project. We also aimed at
T A Brick et al.
Journal of dairy science, 95(4), 1894-1905 (2012-03-31)
The objectives of this study were to assess the responses to treatments (clinical cure and cow survival 14 d posttherapy) of cows with clinical endometritis (CE) that received intrauterine infusion of a hypertonic solution of 50% dextrose (DEX) or subcutaneous
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