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Hans Hilpert et al.
Journal of medicinal chemistry, 56(23), 9789-9801 (2013-11-15)
Starting from the weakly active dual CatS/K inhibitor 5, structure-based design supported by X-ray analysis led to the discovery of the potent and selective (>50,000-fold vs CatK) cyclopentane derivative 22 by exploiting specific ligand-receptor interactions in the S2 pocket of
Masashi Muroi et al.
The Journal of biological chemistry, 281(9), 5484-5491 (2006-01-13)
A cell surface receptor complex consisting of CD14, Toll-like receptor (TLR4), and MD-2 recognizes lipid A, the active moiety of lipopolysaccharide (LPS). Escherichia coli-type lipid A, a typical lipid A molecule, potently activates both human and mouse macrophage cells, whereas
Younis Baqi et al.
Journal of medicinal chemistry, 54(3), 817-830 (2011-01-07)
Evaluation and optimization of anthraquinone derivatives related to Reactive Blue 2 at P2X2 receptors yielded the first potent and selective P2X2 receptor antagonists. The compounds were tested for inhibition of ATP (10 μM) mediated currents in Xenopus oocytes expressing the
Alberto Deganello et al.
Oral oncology, 93, 29-38 (2019-05-22)
When amenable to radical excision, cancer involving the maxilla is typically treated with maxillectomy followed by adjuvant therapy. Posterior tumor extension beyond the maxillary box leads to the invasion of complex areas, where achieving clear margins may be challenging. Patients
Marta Olive-Gadea et al.
Stroke, 51(10), 3133-3137 (2020-08-28)
Reliable recognition of large vessel occlusion (LVO) on noncontrast computed tomography (NCCT) may accelerate identification of endovascular treatment candidates. We aim to validate a machine learning algorithm (MethinksLVO) to identify LVO on NCCT. Patients with suspected acute stroke who underwent
Jaroslav Meluzín et al.
Heart and vessels, 24(3), 157-163 (2009-05-26)
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for
Cynthia Alcántara et al.
Bioresource technology, 191, 173-186 (2015-05-20)
Algal-bacterial symbiosis, implemented in an innovative anoxic-aerobic photobioreactor configuration with biomass recycling, supported an efficient removal of total organic carbon (86-90%), inorganic carbon (57-98%) and total nitrogen (68-79%) during synthetic wastewater treatment at a hydraulic and sludge retention times of
W Asher Wolf et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 13(3), 452-458 (2014-08-03)
Eosinophilic esophagitis (EoE) is commonly treated with swallowed (topical) corticosteroids (tCS). However, few factors have been described that predict outcomes of steroid therapy. We aimed to identify factors associated with nonresponse to tCS and report outcomes of second-line treatment for
S Laivoranta-Nyman et al.
Clinical and experimental rheumatology, 24(6), 636-642 (2007-01-09)
To study the associations of tumor necrosis factor (TNF) a, b and c microsatellite markers with 1) the clinical disease activity and 2) the induction of remissions in patients with early rheumatoid arthritis (RA) treated with two treatment strategies. In
P Kranke et al.
British journal of anaesthesia, 111(6), 938-945 (2013-07-23)
Postoperative nausea and vomiting (PONV) remain significant clinical problems for patients, especially nausea. The D2-antagonist droperidol was popular for prophylaxis until safety concerns limited its use. In early testing, APD421 (amisulpride for i.v. injection), a D2/D3-antagonist, has shown promising antiemetic
Miguel Ángel Sánchez-Madrigal et al.
Journal of food science and technology, 52(5), 2701-2710 (2015-04-22)
The stability of antioxidants in extruded and nixtamalized blue maize flours with calcium hydroxide [Ca(OH)2] and calcium lactate [C6H10O6Ca] were evaluated. Extruded blue maize flours batches were obtained by mixing blue maize flours separately with different Ca(OH)2 (0.1, 0.2 and
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.
Mathis K Stokke et al.
Cardiovascular research, 86(1), 63-71 (2009-12-19)
To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(flox/flox) (FF) control mice.
H Nielsen et al.
The Journal of pharmacology and experimental therapeutics, 260(2), 637-643 (1992-02-01)
Human s.c. resistance arteries (internal diameters 158-353 microns) were mounted in a microvascular myograph, and experiments were designed to examine the calcium pools utilized by selective stimulation of alpha-1 and alpha-2 adrenoceptors. In a concentration-dependent manner, phenylephrine and B-HT 933
Eric T Everett et al.
European journal of oral sciences, 119 Suppl 1, 8-12 (2012-01-25)
Genetic factors underlie the susceptibility and the resistance to dental fluorosis (DF). The A/J (DF susceptible) and 129P3/J (DF resistant) mouse strains have previously been used to detect quantitative trait loci (QTLs) associated with DF on chromosome (Chr) 2 and
F Vult von Steyern et al.
Neuroscience, 136(1), 87-93 (2005-10-06)
Motor neurons to the slowly contracting extensor soleus muscle in behaving rats begin to fire tonically in the 2nd week after birth. In the adult, tonic firing becomes predominant and appears to arise from plateau potentials under monoaminergic control. In
Marcel Dautzenberg et al.
The Journal of physiology, 589(Pt 19), 4731-4744 (2011-08-10)
Nitric oxide (NO) blunts the myogenic response (MR) in renal blood flow (RBF) autoregulation. We sought to clarify the roles of NO synthase (NOS) isoforms, i.e. neuronal NOS (nNOS) from macula densa, endothelial NOS (eNOS) from the endothelium, and inducible
Way Seah Lee et al.
Journal of paediatrics and child health, 43(9), 636-639 (2007-08-11)
We conducted a prospective study to determine the role of alpha1-antitrypsin (alpha1AT) deficiency in the pathogenesis of neonatal cholestasis and other childhood liver diseases in a multi-ethnic Southeast Asian population. Prospective patients with neonatal cholestasis (group 1), other liver diseases
Z H Ye et al.
Chemosphere, 52(9), 1571-1579 (2003-07-18)
Wetland microcosms were used to evaluate the ability of constructed wetlands to remove extremely high concentrations of selenocyanate (SeCN-), arsenic (As), and boron (B) from wastewater generated by a coal gasification plant in Indiana. The wetland microcosms significantly reduced the
Alla Khodorova et al.
Canadian journal of physiology and pharmacology, 88(6), 668-675 (2010-07-16)
A profound tachyphylaxis of the acute nocifensive flinching (pain) response to subcutaneous injection of endothelin-1 (ET-1) into the hind paw footpad is shown by the reduced response to a second injection. Flinching from the second injection was 20% +/- 5%
Jin-Ping Lai et al.
Hepatology (Baltimore, Md.), 47(4), 1211-1222 (2008-03-06)
It has been shown that the heparin-degrading endosulfatase, sulfatase 1 (SULF1), functions as a liver tumor suppressor, but the role of the related sulfatase, sulfatase 2 (SULF2), in liver carcinogenesis remains to be elucidated. We investigated the effect of SULF2
C M Nutting et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 20(7), 1275-1279 (2009-02-28)
Treatment options for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) are limited with response rates to cytotoxic chemotherapy of approximately 30% and median survival of 6 months. In a multicentre phase II study, 32 patients with recurrent
J Gao et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 22(11), 669-672 (2002-01-05)
Angiotensin-converting enzyme (ACE) plays a key role in the metabolism of angiotensin II (AT II) and inactivation of bradykinins and tachykinins, which are potent bronchial constrictors and mediators of inflammation asthma, and ACE is heavily expressed in the lungs. An
Shang-Chiung Chen et al.
The Journal of urology, 181(1), 336-342 (2008-11-18)
The potent effects of PAI-1 on tumorigenesis and angiogenesis in various experimental models are complex, complicated and at times contradictory. We determined the therapeutic potential of PAI-1 for inhibiting bladder tumor invasion under conditions that closely mimic the clinical setting.
J P Payan et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(12), 1470-1478 (1999-11-26)
The excretion and metabolism of neurotoxic 1,2-diethylbenzene (1, 2-DEB) was studied in male Sprague-Dawley rats after i.v. (1 mg/kg) or oral (1 or 100 mg/kg) administration of 1,2-diethyl[U-(14)C]benzene ([(14)C]1,2-DEB). Whatever the treatment, radioactivity was mainly excreted in urine (65-76% of
A Welz et al.
Journal of cardiac surgery, 7(2), 163-169 (1992-06-01)
A canine femoral artery model was used for evaluation of a dialdehyde starch preserved bovine internal mammary artery (BIMA) (3 and 4 mm internal diameter) in comparison to a polytetrafluoroethylene (PTFE) graft. The study comprised three groups for a 2-hour
M Haap et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 113(5), 275-281 (2005-06-01)
Insulin resistance is associated with both type 2 diabetes (T2 D) and polycystic ovary syndrome (PCOS). There is an association of T2 D with several polymorphisms in candidate genes related to insulin resistance. However, there is limited information about the
Takeshi Nakamura et al.
Oncology reports, 14(3), 617-623 (2005-08-04)
Angiogenesis is an essential step in tumor growth and metastasis, but rather than being controlled by means of a simple mechanism, the control of tumor angiogenesis may be mediated by several angiogenic factors. We investigated the expression of basic fibroblast
M W Ritzel et al.
The Journal of biological chemistry, 276(4), 2914-2927 (2000-10-18)
The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Both have homologs in other mammalian species and belong to a gene family (CNT) that also
Niall F Davis et al.
Pancreas, 43(5), 750-754 (2014-04-11)
This study aimed to identify the preoperative, perioperative, and postoperative factors affecting 10-year pancreas allograft survival after simultaneous pancreas and kidney (SPK) transplantation. Analysis was performed on a prospectively maintained database of 56 SPK transplants consecutively performed between January 1992
Mira Rosenblat et al.
Atherosclerosis, 226(1), 110-117 (2012-11-13)
To assess the anti-atherogenic effects on macrophage cholesterol biosynthesis rate, and on cellular oxidative stress by the combination of simvastatin with a potent polyphenolic antioxidant (punicalagin), or with a phytosterol (β-sitosterol), or with pomegranate juice (POM, that contains both of
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