81-64-1

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Molecular cloning and characterization of Siamese crocodile (Crocodylus siamensis) copper, zinc superoxide dismutase (CSI-Cu,Zn-SOD) gene.

Penporn Sujiwattanarat et al.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 191, 187-195 (2015-11-03)

Superoxide dismutase (SOD, EC 1.15.1.1) is an antioxidant enzyme found in all living cells. It regulates oxidative stress by breaking down superoxide radicals to oxygen and hydrogen peroxide. A gene coding for Cu,Zn-SOD was cloned and characterized from Siamese crocodile

[Study on activation of AKT/mTOR pathway in anaplastic large cell lymphoma].

Jin-Fan Li et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 29(10), 649-653 (2009-01-30)

To study the expression of anaplastic lymphoma kinase (ALK) and the phosphorylation status of AKT, mammalian target of rapamycin (mTOR), 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70S6K) and their interrelationships and clinical pathological significance in anaplastic large

Usefulness of B-type Natriuretic Peptides to Predict Cardiovascular Events in Women (from the Women's Health Study).

Brendan M Everett et al.

The American journal of cardiology, 116(4), 532-537 (2015-06-18)

Natriuretic peptides are positively associated with incident cardiovascular disease (CVD), but data in women, particularly with regard to improvements in risk prediction, are sparse. We measured the N-terminal prohormone form of B-type natriuretic peptide (NT-proBNP) in 480 cases of incident

WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.

Christoph Wissmann et al.

The Journal of pathology, 201(2), 204-212 (2003-10-01)

To detect novel Wnt-pathway genes involved in tumourigenesis, this study analysed the RNA expression levels of 40 genes of the Wnt pathway by chip hybridization of microdissected matched pairs of 54 primary prostate carcinomas. Eleven genes showed greater than two-fold

Successive epoxy and carbodiimide cross-linking of dermal sheep collagen.

R Zeeman et al.

Biomaterials, 20(10), 921-931 (1999-06-03)

Cross-linking of dermal sheep collagen (N-DSC, T(S) = 46 degrees C, number of amine groups = 31 (n/1000)) with 1,4-butanediol diglycidyl ether (BDDGE) at pH 9.0 resulted in a material (BD90) with a high T(S)(69 degrees C), a decreased number

Identification of the mouse and rat orthologs of the gene mutated in Usher syndrome type IIA and the cellular source of USH2A mRNA in retina, a target tissue of the disease.

Dali Huang et al.

Genomics, 80(2), 195-203 (2002-08-06)

Usher syndrome type IIA (MIM: 27601) is an autosomal recessive disorder characterized by moderate to severe congenital deafness and progressive retinitis pigmentosa. We recently identified the human Usher syndrome type IIA gene (USH2A) on chromosome 1q41, which encodes a protein

Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.

Abbas Agaimy et al.

The American journal of surgical pathology, 34(11), 1663-1671 (2010-10-22)

Colorectal fibroblastic polyp and intramucosal perineurioma are 2 synonyms for a recently described benign mucosal lesion with a predilection for the rectosigmoid colon. These lesions are characterized by aggregates of bland spindled cells separating and distorting mucosal crypts. The latter

Successful outpatient graded administration of trimethoprim-sulfamethoxazole in patients without HIV and with a history of sulfonamide adverse drug reaction.

Regan C Pyle et al.

The journal of allergy and clinical immunology. In practice, 2(1), 52-58 (2014-02-26)

The outcomes of trimethoprim-sulfamethoxazole (TMP-SMX) desensitization have been widely reported in the HIV literature but less so in the non-HIV literature. To evaluate the safety and efficacy of graded administration of TMP-SMX in patients without HIV and with a history

Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes.

Kazutaka Sakamoto et al.

BMC musculoskeletal disorders, 12(1), 82-82 (2011-04-29)

Osteonecrosis of the femoral head is a common complication of high-dose glucocorticoid treatment. Intravascular thrombosis is thought to be associated with the ischemic state of the femoral head. Plasminogen activator inhibitor-1 (PAI-1) is an adipokine, which are physiologically active substances

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.

Diamant Thaçi et al.

Lancet (London, England), 387(10013), 40-52 (2015-10-12)

Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with dupilumab, a fully-human monoclonal antibody that blocks both pathways. We aimed to assess the efficacy and safety

Downstaging of hepatocellular cancer before liver transplant: long-term outcome compared to tumors within Milan criteria.

Francis Y Yao et al.

Hepatology (Baltimore, Md.), 61(6), 1968-1977 (2015-02-19)

We report on the long-term intention-to-treat (ITT) outcome of 118 patients with hepatocellular carcinoma (HCC) undergoing downstaging to within Milan/United Network for Organ Sharing T2 criteria before liver transplantation (LT) since 2002 and compare the results with 488 patients listed

DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.

J M Oppert et al.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 18(8), 526-531 (1994-08-01)

The objective of this study was to identify DNA sequence variation in the UCP gene and to investigate its relationship with some obesity phenotypes. Two studies were carried out: (1) association study in unrelated subjects, and (2) sib-pair linkage analysis

In-tube solid-phase microextraction with a hybrid monolithic column for the preconcentration of ultra-trace metals prior to simultaneous determination by ICP-MS.

Jia-Jun Fei et al.

Mikrochimica acta, 187(6), 356-356 (2020-05-30)

The preparation of an amino-functionalized hybrid monolithic column (TEOS-co-AEAPTES) via one-pot co-condensation of tetraethoxysilane (TEOS) and N-(β-aminoethyl)-γ-aminopropyltriethoxysilane (AEAPTES) in a capillary is descibed. It was used as solid-phase microextraction (SPME) matrix followed by inductively coupled plasma-mass spectrometry (ICP-MS) for determination

E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor.

Yoshihiro Ohishi et al.

Human pathology, 43(6), 808-817 (2011-11-15)

We recently have demonstrated nuclear localization of E-cadherin in ovarian adult granulosa cell tumors (Histopathology 2011;58:423). The purpose of the present study is to investigate the diagnostic utility of E-cadherin nuclear staining for the differential diagnosis between ovarian adult granulosa

Nanofluidic digital PCR for KRAS mutation detection and quantification in gastrointestinal cancer.

Daniel Azuara et al.

Clinical chemistry, 58(9), 1332-1341 (2012-06-30)

Concomitant quantification of multiple mutant KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) alleles may provide information in addition to that provided by standard mutation-detection procedures. We assessed the feasibility of a nanofluidic digital PCR array platform to detect and

Sequencing of eleven introns in genomic DNA encoding rat glucagon receptor and multiple alternative splicing of its mRNA.

B Maget et al.

FEBS letters, 351(2), 271-275 (1994-09-05)

We used the PCR (polymerase chain reaction) to amplify fragments of glucagon receptor DNA from genomic DNA. Sequencing of the subcloned fragments demonstrated that genomic DNA encoding the glucagon receptor spans over 12 exons interrupted by 11 introns. The introns

Label-Free Quantitative Proteomics Identifies Novel Plasma Biomarkers for Distinguishing Pulmonary Tuberculosis and Latent Infection.

Huishan Sun et al.

Frontiers in microbiology, 9, 1267-1267 (2018-06-29)

The lack of effective differential diagnostic methods for active tuberculosis (TB) and latent infection (LTBI) is still an obstacle for TB control. Furthermore, the molecular mechanism behind the progression from LTBI to active TB has been not elucidated. Therefore, we

Effects of altering the dose and timing of triptorelin when given as an intravaginal gel for advancing and synchronizing ovulation in weaned sows.

R V Knox et al.

Theriogenology, 82(3), 379-386 (2014-06-04)

Previous studies have shown that triptorelin gel (TG) given intravaginally in gel form is effective for advancing the time of ovulation in weaned sows. Three experiments were performed to determine the effects of altering the dose and timing of administration

Methylenediphosphonotetrathioate: synthesis, characterization, and chemical properties.

Aviran Amir et al.

Inorganic chemistry, 52(6), 3133-3140 (2013-03-05)

Metal chelators are potential therapeutic agents for treating diseases such as Wilson's and Alzheimer's where the pathology involves an excess of metal-ions (Cu(II) and Zn(II)/Cu(II)/Fe(II/III), respectively). In addition to the high affinity of the metal-ion to the chelators, metal selectivity

Long-term survival after surgery for acute coronary syndromes in relation to perioperative troponin T release and angina class - a prospective study in 200 patients.

S Bjessmo et al.

The Thoracic and cardiovascular surgeon, 57(3), 148-152 (2009-03-31)

Patients with acute coronary syndrome have an increased risk of cardiac death or myocardial infarction after urgent coronary artery bypass surgery (CABG). Symptoms and signs of ongoing ischemia, such as elevated cardiac troponin T and angina at rest at the

Effects of glycemic control upon serum lipids and lipid transfers to HDL in patients with type 2 diabetes mellitus: novel findings in unesterified cholesterol status.

O G Laverdy et al.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(4), 232-239 (2015-02-07)

Investigate the relations of glycemic levels with plasma lipids and in vitro lipid transfers to HDL in patients with type 2 diabetes mellitus. 143 patients with type 2 diabetes not taking anti-lipidemic drugs were separated into 2 groups: group A

Adjunctive zonisamide therapy in the long-term treatment of children with partial epilepsy: results of an open-label extension study of a phase III, randomized, double-blind, placebo-controlled trial.

Renzo Guerrini et al.

Epilepsia, 55(4), 568-578 (2014-03-14)

To investigate the safety/tolerability and efficacy of long-term adjunctive zonisamide and its impact on growth and development in children (6-18 years) with partial epilepsy. Open-label extension of a phase III, placebo-controlled trial. Started with double-blind transition period (2-11 weeks), during which patients

Association of polymorphic MHC microsatellites with GVHD, survival, and leukemia relapse in unrelated hematopoietic stem cell transplant donor/recipient pairs matched at five HLA loci.

S Li et al.

Tissue antigens, 63(4), 362-368 (2004-03-11)

In order to determine whether matching/mismatching for microsatellite polymorphism provides useful information on acute graft-vs-host disease (GVHD), survival, and leukemia relapse in hematopoietic stem cell (HSC) transplantation, we genotyped for polymorphisms at 13 microsatellite loci within the major histocompatibility complex

Treatment, Outcomes, and Adherence to Medication Regimens Among Dual Medicare-Medicaid-Eligible Adults With Myocardial Infarction.

Jacob A Doll et al.

JAMA cardiology, 1(7), 787-794 (2016-10-21)

Patients with dual Medicare-Medicaid eligibility have a higher burden of chronic disease conditions and increased health care utilization compared with patients with Medicare coverage alone, but the treatment patterns and outcomes of dual-eligible patients with myocardial infarction (MI) are unknown.

Association between the TNF-2 allele and a better survival in cardiogenic shock.

Olivier Appoloni et al.

Chest, 125(6), 2232-2237 (2004-06-11)

Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of heart failure. We explored a possible association between TNF-alpha, interleukin (IL)-6, IL-10, transforming growth factor (TGF)-beta, and interferon (IFN)-gamma cytokine polymorphisms, their in vivo production, and mortality from cardiogenic

Insects as alternative feed for ruminants: comparison of protein evaluation methods.

Pablo G Toral et al.

Journal of animal science and biotechnology, 13(1), 21-21 (2022-02-12)

The high dependence of intensive ruminant production on soybean meal and the environmental impact of this crop encourage the search for alternative protein-rich feeds. The use of insects seems promising, but the extent of their ruminal protein degradation is largely

A comparison of progestin-based protocols to synchronize estrus in postpartum beef cows.

J E Stegner et al.

Journal of animal science, 82(4), 1016-1021 (2004-04-15)

Two progestin-based protocols for estrus synchronization in postpartum beef cows were compared following treatment administration on the basis of estrous response, interval to and synchrony of estrus, and pregnancy. Cows were assigned to one of the two treatment protocols by

Purification and characterization of class mu glutathione S-transferase isozymes from rabbit hepatic tissue.

T Primiano et al.

Archives of biochemistry and biophysics, 301(2), 404-410 (1993-03-01)

Class mu glutathione S-transferases (GSTs) are important in the detoxication of epoxides generated by oxidative metabolism. Phenobarbital, 3-methylcholanthrene, and pyridine have failed to enhance the expression of class mu GST isozymes in rabbit hepatic tissue (T. Primiano, S. G. Kim

ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.

Fang Wang et al.

Gastroenterology, 159(1), 289-305 (2020-03-17)

We investigated whether ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1) is involved in development of hepatocellular carcinoma (HCC). We analyzed clinical and gene expression data from The Cancer Genome Atlas. Albumin-Cre (HepWT) mice and mice with hepatocyte-specific disruption of Abl1

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data.

Angelo Di Leo et al.

The Lancet. Oncology, 12(12), 1134-1142 (2011-09-16)

Prediction of response to anthracycline-based therapy for breast cancer is challenging. We aimed to assess the value of HER2 and TOP2A as predictive markers of response to anthracycline-based adjuvant therapy in patients with early breast cancer. We did a meta-analysis

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