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J Bonelli et al.
International journal of clinical pharmacology, therapy, and toxicology, 26(6), 297-299 (1988-06-01)
The pharmacokinetic data of methylepoxyproscillaridin (3'-methyl-4'-5'-epoxyproscillaridin) (P35) after 1 mg i.v. or oral administration in two different galenic preparations (hard and soft gelatin capsules) in randomized succession were studied in 9 healthy volunteers, showing a bioavailability of 88 +/- 10.5%
Eli Muchtar et al.
Leukemia research, 38(12), 1401-1406 (2014-07-26)
Total therapy 3 is an intensified protocol for multiple myeloma (MM). The "real life" outcomes of this protocol were seldom reported. Data was obtained for 81 patients (newly diagnosed, n=49; progressive MM, n=32), most of which had high-risk parameters. Overall
K J Tinckam et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(2), 417-426 (2015-01-24)
Donor-specific HLA antibodies (DSA) have an adverse effect on short-term and long-term lung transplant outcomes. We implemented a perioperative strategy to treat DSA-positive recipients, leading to equivalent rejection and graft survival outcomes. Pretransplant DSA were identified to HLA-A, B, C
F I V Errera et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 39(7), 883-888 (2006-07-25)
Diabetes mellitus (DM) is a highly prevalent complex genetic disorder. There has been a worldwide effort in the identification of susceptibility genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good
Josef Finsterer et al.
International journal of cardiology, 130(2), 174-179 (2007-12-07)
This retrospective study aimed to find out how often CK is elevated in left-ventricular hypertrabeculation/noncompaction (LVHT), how often CK-elevation is due to neuromuscular disorders (NMDs), other cardiac disease, or causes other than cardiac or NMD, and how often CK-elevation is
Dieter Saur et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(6), 1662-1667 (2004-02-06)
Infantile hypertrophic pyloric stenosis (IHPS), characterized by enlarged pyloric musculature and gastric-outlet obstruction, is associated with altered expression of neuronal nitric oxide synthase (nNOS). Here we have studied molecular mechanisms by which nNOS gene expression is altered in pyloric tissues
A Titia Lely et al.
Journal of hypertension, 28(12), 2414-2421 (2010-09-11)
Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype
Iwona Lugowska et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(11), 8277-8285 (2015-05-24)
The identification of prognostic factors in cutaneous melanoma allows choosing the most effective treatment, especially in group of patients with locoregional disease. Markers related to carcinogenesis and angiogenesis in particular have effect on the course of the disease. The aim
P A van Diemen et al.
Journal of cardiovascular computed tomography, 14(1), 60-67 (2019-07-16)
Scan quality can have a significant effect on the diagnostic performance of non-invasive imaging techniques. However, the extent of its influence has scarcely been investigated in a head-to-head manner. Two-hundred and eight patients underwent CCTA, SPECT, and PET prior to
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block
Gilbert W Moeckel et al.
The Journal of biological chemistry, 278(21), 19352-19357 (2003-03-15)
The mechanism by which COX2 inhibition decreases renal cell survival is poorly understood. In the present study we examined the effect of COX2 activity on organic osmolyte accumulation in renal medulla and in cultured mouse renal medullary interstitial cells (MMICs)
P F Piguet et al.
International journal of experimental pathology, 78(1), 43-48 (1997-02-01)
In order to evaluate the role and mode of action of TNF in bleomycin-induced lung fibrosis, mice deficient for TNF and LT alpha (delta TNF/LT alpha) were examined at 2 months of age and after 3 weekly i.v. injections of
Herbert L Bonkovsky et al.
The American journal of medicine, 127(12), 1233-1241 (2014-07-13)
Recent descriptions of the clinical and laboratory features of subjects with acute porphyrias in the US are lacking. Our aim was to describe clinical, biochemical, and genetic features of 108 subjects. Between September 2010 and December 2012, 108 subjects with
Laurence M M Crombag et al.
The European respiratory journal, 53(2) (2018-12-24)
Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging
Louise A Jopling et al.
The Journal of biological chemistry, 277(9), 6864-6873 (2001-11-29)
Th2 lymphocytes play a central role in the control and maintenance of allergic inflammation. The chemokine receptor CCR4 is preferentially expressed on the surface of Th2 lymphocytes polarised in vitro. However, CCR4 is found on the surface of a significant
Louise A Jopling et al.
The Journal of biological chemistry, 277(9), 6864-6873 (2001-11-29)
Th2 lymphocytes play a central role in the control and maintenance of allergic inflammation. The chemokine receptor CCR4 is preferentially expressed on the surface of Th2 lymphocytes polarised in vitro. However, CCR4 is found on the surface of a significant
Marta Brunetti et al.
Virchows Archiv : an international journal of pathology, 474(2), 177-185 (2018-11-24)
Dipeptidyl peptidase 9 (DPP9) was recently identified as fusion gene in ovarian high-grade serous carcinoma (HGSC). The aim of this study was to analyze the expression and clinical relevance of DPP8 and DPP9 in ovarian carcinoma, with focus on HGSC.
Hyesun Kim et al.
Ophthalmic surgery, lasers & imaging retina, 46(4), 423-427 (2015-05-15)
To evaluate punctate hyperfluorescent spots on indocyanine green angiography (ICGA) in eyes with polypoidal choroidal vasculopathy (PCV). Retrospective observation case series of 88 eyes of 81 patients (63 men and 18 women) analyzing fundus photography, fluorescein angiography, ICGA, and spectral-domain
Sandra Erbs et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(10), 1814-1819 (2003-08-09)
Background- Polymorphisms in the promoter (T-786C) and exon 7 (G894T) of the endothelial nitric oxide synthase (eNOS) gene were shown to be associated with reduced vascular NO production or increased proteolytic cleavage of eNOS. Therefore, we aimed to determine the
Grzegorz Helbig et al.
Medical oncology (Northwood, London, England), 29(4), 2379-2384 (2012-03-03)
The prevalence of JAK2V617F tyrosine kinase mutation differs between various variants of myelofibrosis with the higher detection rate for patients with post-polycythemia vera myelofibrosis (post-PV MF; 91%) if compared to primary myelofibrosis (PMF; 45%) and post-essential thrombocythemia myelofibrosis (post-ET MF;
Tianzhu Qin et al.
Journal of contaminant hydrology, 230, 103598-103598 (2020-01-04)
This study presents a pore-scale investigation of two-phase flow dynamics during nanofluid flooding in subsurface formations containing non-aqueous phase liquids (NAPLs) such as crude oils. The goal was to gain fundamental understanding of the dominant displacement mechanisms of NAPL at
Thomas S Uldrick et al.
Blood, 124(24), 3544-3552 (2014-10-22)
Kaposi sarcoma (KS) herpesvirus-associated multicentric Castleman disease (KSHV-MCD) is a lymphoproliferative disorder, most commonly seen in HIV-infected patients, that has a high mortality if untreated. Concurrent KS is common. Although rituximab has reported activity in KSHV-MCD, its use is often
B Filipe et al.
Clinical genetics, 76(3), 242-255 (2009-10-02)
Patients presenting familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) or multiple colorectal adenomas (MCRAs) phenotype are clinically difficult to distinguish. We aimed to genetically characterize 107 clinically well-characterized patients with FAP-like phenotype, and stratified according to the recent
Charles U Nottingham et al.
International urology and nephrology, 52(4), 639-644 (2019-12-22)
To compare perioperative and post-operative outcomes for holmium laser enucleation of the prostate (HoLEP) between cases performed with a 550 µm or 1000 µm fiber. We retrospectively reviewed the most recent 50 patients undergoing HoLEP with a 550 µm fiber and the most
J Hall et al.
The Journal of biological chemistry, 262(23), 11046-11051 (1987-08-15)
In order to define the interaction domain on Rhodospirillum rubrum cytochrome c2 for the photosynthetic reaction center, positively charged lysine amino groups on cytochrome c2 were modified to form negatively charged carboxydinitrophenyl lysines. The reaction mixture was separated into six
Shinobu Ohnuma et al.
Surgery, 145(1), 57-68 (2008-12-17)
Alternative splicing is a molecular mechanism by which different combinations of exons can be alternatively spliced to produce different mRNA isoforms. Recently, several databases have been published to predict the alternative splicing of mRNA; cancer-specific alternative splicing has also been
S M Zaki et al.
Folia morphologica, 77(2), 234-245 (2017-10-25)
Cisplatin-induced peripheral nerve neurotoxicity (CIPN) is the main obstacle in cisplatin treatment. The aim of this study was to compare the modulatory effects of N-acetylcysteine (NAC) and progesterone on CIPN, because there are scarce literature data on the protective effect
Min Ho Lee et al.
International journal of clinical pharmacology and therapeutics, 50(11), 778-786 (2012-09-05)
To investigate the hepatoprotective effect, safety and tolerability of oral preparation comprising dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) plus garlic oil (GO) in chronic hepatitis patients. In this double-blind, placebo-controlled clinical trial conducted for 6 weeks with 1-week follow-up, a total of 88
A A A Jacobs et al.
Animal : an international journal of animal bioscience, 7(9), 1508-1516 (2013-04-20)
Stearoyl-CoA desaturase (SCD) in the bovine mammary gland introduces a cis-double bond at the Δ9 position in a wide range of fatty acids (FA). Several long-chain polyunsaturated fatty acids (PUFA) inhibit expression of SCD, but information on the effect of
Scott J C Pallett et al.
The Lancet. Respiratory medicine, 8(9), 885-894 (2020-07-28)
Health-care workers constitute a high-risk population for acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the
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