83-87-4

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Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.

E Giraud et al.

Antimicrobial agents and chemotherapy, 43(9), 2131-2137 (1999-09-03)

The occurrence of mutations in the genes coding for gyrase (gyrA and gyrB) and topoisomerase IV (parE and parC) of Salmonella typhimurium experimental mutants selected in vitro and in vivo and of 138 nalidixic acid-resistant Salmonella field isolates was investigated.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin.

J-B Delhorme et al.

The British journal of surgery, 105(6), 668-676 (2018-02-08)

The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic

Molecular epidemiological survey on quinolone resistance genotype and phenotype of Escherichia coli in septicemic broilers in Hebei, China.

Rong Xie et al.

Poultry science, 93(2), 335-339 (2014-02-27)

In this study, the quinolone-resistant determining region (QRDR) of gyrA of Escherichia coli and plasmid-mediated quinolone resistance (PMQR) genes, qnr(qnrA, qnrB, and qnrS), and aac(6 ')-Ib-cr were detected, sequenced, and analyzed. In addition, antimicrobial susceptibility tests (using the Kirby-Bauer disc diffusion

Arsenic concentration variability, health risk assessment, and source identification using multivariate analysis in selected villages of public water system, Lahore, Pakistan.

Jawairia Sultana et al.

Environmental monitoring and assessment, 186(2), 1241-1251 (2013-11-08)

This paper reports high levels and variability in arsenic (As) levels at locations identified as one of the highest As-contaminated locations in Pakistan. Groundwater pollution related to arsenic has been reported since many years in the areas lying in outskirts

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.

Issan Yee San Tam et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 12(5), 1647-1653 (2006-03-15)

This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. Mutational profile of exons 18 to 21

Amino acid limitation and flow to the duodenum at four stages of lactation. 2. Extent of lysine limitation.

C G Schwab et al.

Journal of dairy science, 75(12), 3503-3518 (1992-12-01)

Four multiparous Holstein cows with ruminal and duodenal cannulas were assigned to 4 x 4 Latin squares at peak (wk 4), early (wk 14 to 16), mid (wk 21 to 23), and late (wk 29 to 31) lactation to determine

Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters.

Jason L Hornick et al.

The American journal of surgical pathology, 27(9), 1183-1196 (2003-09-10)

Myoepitheliomas and mixed tumors were only recently recognized to occur primarily in soft tissue, and only small case numbers have been described. To characterize these tumors further and to evaluate prognostic parameters, 101 myoepithelial tumors of soft tissue were retrieved

Comparison of bismuth-containing quadruple and concomitant therapies as a first-line treatment option for Helicobacter pylori.

Abdurrahman Kadayifci et al.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 23(1), 8-13 (2012-04-17)

Helicobacter pylori eradication rates with standard triple regimens are worsening, and alternative treatments are urgently needed in some populations. The present study aimed to compare the efficacy of bismuth-based quadruple and concomitant regimens. Consecutive Helicobacter pylori-positive patients with non-ulcer dyspepsia

Enantioselective intramolecular [2 + 2]-photocycloaddition reactions of 4-substituted quinolones catalyzed by a chiral sensitizer with a hydrogen-bonding motif.

Christiane Müller et al.

Journal of the American Chemical Society, 133(41), 16689-16697 (2011-10-01)

Six 2-quinolones, which bear a terminal alkene linked by a three- or four-membered tether to carbon atom C4 of the quinolone, were synthesized and subjected to an intramolecular [2 + 2]-photocycloaddition. The reaction delivered the respective products in high yields

Understanding the complexity of wastewater: The combined impacts of carbohydrates and sulphate on the performance of bioelectrochemical systems.

Fei Zhao et al.

Water research, 176, 115737-115737 (2020-04-03)

Bioelectrochemical systems (BES) have long been viewed as a promising wastewater treatment technology. However, in reality, the performance of bioelectrochemical systems fed with real (and therefore complex) wastewaters is often disappointing. We have sought to investigate the combined impacts of

Chemical modification of spinach plastocyanin using 4-chloro-3,5-dinitrobenzoic acid: characterization of four singly-modified forms.

E L Gross et al.

Biochimica et biophysica acta, 1016(1), 107-114 (1990-03-15)

Chemical modification of plastocyanin was carried out using 4-chloro-3,5-dinitrobenzoic acid, which has the effect of replacing positive charges on amino groups with negatively charged carboxyl groups. Four singly-modified forms were obtained which were separated using anion exchange FPLC. The four

Association of XRCC1 gene polymorphisms with the susceptibility and chromosomal aberration of testicular germ cell tumors.

Norihiko Tsuchiya et al.

International journal of oncology, 28(5), 1217-1223 (2006-04-06)

It is known that many genomic and genetic alterations caused by aging or environmental factors are responsible for cancer development and progression. XRCC1 is involved in the repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating

Nutritional requirements of human malignant (leukemic) cell lines: implications for adjuvant therapy.

D P Beebe et al.

Cancer research, 47(9), 2380-2384 (1987-05-01)

Metabolic requirements of malignant cell lines derived from patients with chronic myelogenous and acute lymphoblastic leukemias were compared to those of proliferating normal cells (mitogen-stimulated human lymphocytes) and circulating blasts from acute myeloblastic and acute lymphoblastic leukemias. Requirements were judged

NS1 Recombinant Proteins Are Efficiently Produced in Pichia pastoris and Have Great Potential for Use in Diagnostic Kits for Dengue Virus Infections.

Mariana Fonseca Xisto et al.

Diagnostics (Basel, Switzerland), 10(6) (2020-06-11)

Dengue is one of the major diseases causing global public health concerns. Despite technological advances in vaccine production against all its serotypes, it is estimated that the dengue virus is responsible for approximately 390 million infections per year. Laboratory diagnosis

Phenotypic and Genetic Diversity of Aeromonas Species Isolated from Fresh Water Lakes in Malaysia.

Wei Ching Khor et al.

PloS one, 10(12), e0145933-e0145933 (2015-12-29)

Gram-negative bacilli of the genus Aeromonas are primarily inhabitants of the aquatic environment. Humans acquire this organism from a wide range of food and water sources as well as during aquatic recreational activities. In the present study, the diversity and

Correlation of interleukin-6, serum lactate, and C-reactive protein to inflammation, complication, and outcome during the surgical course of patients with acute abdomen.

Praveen Ravishankaran et al.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 31(9), 685-690 (2011-09-20)

In the present scenario, doctors have to rely on radiological methods for diagnosis of acute abdomen in addition to their clinical skill. The use of serum markers for assessing the outcome of such patients is still debatable. Our aim was

Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum.

Dale F Sharrad et al.

The Journal of comparative neurology, 521(11), 2523-2537 (2013-01-09)

Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies and neurites composed mainly of the presynaptic protein α-synuclein. Frequently, Lewy bodies and neurites are identified in the gut of Parkinson's disease patients and may underlie associated gastrointestinal dysfunctions. We

Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine.

A S R Araujo et al.

Molecular and cellular biochemistry, 303(1-2), 89-95 (2007-04-21)

Thyroxine can cause cardiac hypertrophy by activating growth factors, such as IGF-I (insulin-like growth factor-I). Since oxidative stress is enhanced in the hyperthyroidism, it would control protein expression involved in this hypertrophy. Male Wistar rats were divided into four groups:

Gene dosage analysis identifies large deletions of the FECH gene in 10% of families with erythropoietic protoporphyria.

Sharon D Whatley et al.

The Journal of investigative dermatology, 127(12), 2790-2794 (2007-06-29)

Erythropoietic protoporphyria (EPP) is an inherited cutaneous porphyria characterized by partial deficiency of ferrochelatase (FECH), accumulation of protoporphyrin IX in erythrocytes, skin, and liver, and acute photosensitivity. Genetic counseling in EPP requires identification of FECH mutations, but current sequencing-based procedures

Purification and characterization of the prohormone convertase PC1(PC3).

Y Zhou et al.

The Journal of biological chemistry, 268(8), 5615-5623 (1993-03-15)

The prohormone convertases PC1 (also known as PC3) and PC2 have been implicated in the biosynthesis of several polypeptide hormones and neuropeptides. In order to understand the regulation and the cell biology of prohormone cleavage, we have purified recombinant mouse

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.

A J Ouellette et al.

Infection and immunity, 62(11), 5040-5047 (1994-11-01)

Cryptdins are antimicrobial peptides of the defensin family that are produced by intestinal Paneth cells. mRNAs encoding 17 cryptdin isoforms have been characterized from a cDNA library generated from a single jejunal crypt. Six cryptdin cDNAs correspond to known peptides

Point-of-care C-reactive protein testing to facilitate implementation of isoniazid preventive therapy for people living with HIV.

Christina Yoon et al.

Journal of acquired immune deficiency syndromes (1999), 65(5), 551-556 (2013-12-19)

Symptom-based tuberculosis screening identifies less than one-third of eligible HIV-infected patients as candidates for isoniazid preventive therapy (IPT). We evaluated whether testing for C-reactive protein (CRP) improves patient selection for IPT. We measured CRP levels (normal <10 mg/L) using a

Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4).

Amy Ho Yan Kwok et al.

General and comparative endocrinology, 157(2), 99-106 (2008-05-20)

Prostaglandin E(2) (PGE(2)) is an important chemical mediator responsible for regulation of many vital physiological processes. Four receptor subtypes have been identified to mediate its biological actions. Among these subtypes, prostaglandin E receptor subtypes 2 and 4 (EP(2) and EP(4))

Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial.

Masashi Mizokami et al.

The Lancet. Infectious diseases, 15(6), 645-653 (2015-04-13)

Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and are more likely to have been previously treated for hepatitis C. We aimed to assess the efficacy and

Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies.

Helen Moinova et al.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 21(4), 594-600 (2012-02-09)

We have previously established aberrant DNA methylation of vimentin exon-1 (VIM methylation) as a common epigenetic event in colon cancer and as a biomarker for detecting colon neoplasia. We now examine vimentin methylation in neoplasia of the upper gastrointestinal tract.

Conservation of Bmp2 post-transcriptional regulatory mechanisms.

David T Fritz et al.

The Journal of biological chemistry, 279(47), 48950-48958 (2004-09-11)

Bone morphogenetic protein (BMP) orthologs from diverse species like flies and humans are functionally interchangeable and play key roles in fundamental processes such as dorso-ventral axis formation in metazoans. Because both transcriptional and post-transcriptional mechanisms play central roles in modulating

Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization.

K S Prabhu et al.

The Biochemical journal, 360(Pt 2), 345-354 (2001-11-22)

A 25 kDa subunit of glutathione S-transferase (GST) from sheep liver microsomes (microsomal GSTA1-1) with a significant selenium-independent glutathione peroxidase activity has been isolated and characterized. Several analytical criteria, including EDTA stripping, protease protection assay and extraction with alkaline Na(2)CO(3)

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.

N Koyanagi et al.

Cancer research, 54(7), 1702-1706 (1994-04-01)

The search for compounds active against solid tumors has led us to the discovery of a novel sulfonamide, E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4- methoxybenzenesulfonamide), which inhibits tubulin polymerization. When administered orally, E7010 showed good antitumor activity against various rodent tumors and human tumor

Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.

Tran Thuy Chau et al.

Antimicrobial agents and chemotherapy, 51(12), 4315-4323 (2007-10-03)

This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 and characterizes the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains. For

Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger.

Denise Baratti-Mayer et al.

The Lancet. Global health, 1(2), e87-e96 (2014-08-12)

Noma is a poorly studied disease that leads to severe facial tissue destruction in children in developing countries, but the cause remains unknown. We aimed to identify the epidemiological and microbiological risk factors associated with noma disease. We did a

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