840503P

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CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.

Annemieke de Jong et al.

Nature immunology, 15(2), 177-185 (2013-12-24)

T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we

Specific role of phosphatidylglycerol and functional overlaps with other thylakoid lipids in Arabidopsis chloroplast biogenesis.

Koichi Kobayashi et al.

Plant cell reports, 34(4), 631-642 (2014-12-06)

With phosphate deficiency, the role of phosphatidylglycerol is compensated by increased glycolipid content in thylakoid membrane biogenesis but not photosynthetic electron transport in Arabidopsis chloroplasts. In plants and cyanobacteria, anionic phosphatidylglycerol (PG) is the only major phospholipid in thylakoid membranes

Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.

Peter Reinink et al.

The Journal of experimental medicine, 216(4), 757-771 (2019-02-26)

Salmonella species are among the world's most prevalent pathogens. Because the cell wall interfaces with the host, we designed a lipidomics approach to reveal pathogen-specific cell wall compounds. Among the molecules differentially expressed between Salmonella Paratyphi and S. Typhi, we

Human autoreactive T cells recognize CD1b and phospholipids.

Ildiko Van Rhijn et al.

Proceedings of the National Academy of Sciences of the United States of America, 113(2), 380-385 (2015-12-02)

In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans. Here we report the development of polyvalent complexes of CD1b proteins and

Charge and aggregation pattern govern the interaction of plasticins with LPS monolayers mimicking the external leaflet of the outer membrane of Gram-negative bacteria.

J P Michel et al.

Biochimica et biophysica acta, 1848(11 Pt A), 2967-2979 (2015-09-08)

Bacterial resistance to antibiotics has become today a major public health issue. In the development of new anti-infectious therapies, antimicrobial peptides appear as promising candidates. However, their mechanisms of action against bacterial membranes are still poorly understood. We describe for

Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins.

Joury S van 't Klooster et al.

eLife, 9 (2020-04-18)

Yeast tolerates a low pH and high solvent concentrations. The permeability of the plasma membrane (PM) for small molecules is low and lateral diffusion of proteins is slow. These findings suggest a high degree of lipid order, which raises the

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.

Adam Shahine et al.

Nature communications, 10(1), 56-56 (2019-01-06)

CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and

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