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Alexander Jais et al.
Neuron, 106(6), 1009-1025 (2020-04-18)
Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of mice activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC). PNOCARC neurons represent a previously unrecognized GABAergic
Glial cell regulation of rhythmic behavior
Jackson FB, et al.
Methods in Enzymology, 552, 45-73 (2015)
N Singh et al.
Molecular and cellular biology, 14(1), 21-31 (1994-01-01)
A single metabolic path leading to synthesis of ether lipids is known in animal cells, the major products of which are plasmalogens. To learn whether this peroxisomal path is also responsible for the synthesis of base-resistant lipid components of glycosylphosphoinositol
Aaron P Landry et al.
Cell chemical biology, 26(11), 1515-1525 (2019-10-09)
Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H2S to glutathione persulfide with concomitant reduction of CoQ10. We report herein that the promiscuous activity of human SQR supported the conversion of CoA to CoA-SSH (CoA-persulfide), a potent inhibitor of
Qing Chen et al.
Biomaterials, 251, 120008-120008 (2020-05-11)
Active targeting modification is one of the foremost nanomedicine strategies for the efficacy improvement. Compared to the homogeneous ligandation on spherical nanocarriers, non-spherical nanomedicines usually make the ligand modification more complicated. The modified ligands always exhibit anisotropy and heterogeneity. However
J Kessi et al.
Biochemistry, 33(35), 10825-10836 (1994-09-06)
The solubilization of plasma and organelle membranes by diheptanoylphosphatidylcholine (DHPC) has been studied. This short-chain phosphatidylcholine is shown to act as a mild detergent, solubilizing effectively both kinds of membranes at DHPC concentrations of 10-20 mM (0.5-1%). The size of
Molecular characterization of neuronal cell types based on patterns of projection with Retro-TRAP
Nectow AR, et al.
Nature Protocols, 10(9), 1319-1319 (2015)
Jonathan F Tait et al.
Analytical biochemistry, 329(1), 112-119 (2004-05-12)
We developed a method for measuring the binding affinity of annexin V for phospholipid vesicles and cells at very low levels of membrane occupancy. The annexin V-117 mutant was labeled with fluorescein iodoacetamide on its single N-terminal cysteine residue; binding
Rebecca L Ouwenga et al.
Molecular autism, 6, 16-16 (2015-03-20)
Many studies have demonstrated a robust statistical overlap between genes whose transcripts are reported as Fragile X Mental Retardation Protein (Fmrp)-binding targets and genes implicated in various psychiatric disorders, including autism. However, it is not clear how to interpret this
Kamil Sebastian Rosiewicz et al.
Journal of neuroscience methods, 333, 108545-108545 (2019-12-11)
Molecular analyses of cell populations and single cells have been instrumental in the advancement of our understanding of the physiology and pathologic processes of the nervous system. However, the limitation of these methods is the dependence on a gentle, efficient
Chris Miranda et al.
Langmuir : the ACS journal of surfaces and colloids, 34(39), 11759-11771 (2018-09-11)
SP-B63-78, a lung surfactant protein fragment, and magainin 2, an antimicrobial peptide, are amphipathic peptides with the same overall charge but different biological functions. Deuterium nuclear magnetic resonance has been used to compare the interactions of these peptides with dispersions
Tun Naw Sut et al.
Langmuir : the ACS journal of surfaces and colloids, 35(47), 15063-15070 (2019-11-02)
Supported lipid bilayers (SLBs) are simplified model membrane systems that mimic the fundamental properties of biological cell membranes and allow the surface-sensitive tools to be used in numerous sensing applications. SLBs can be prepared by various methods including vesicle fusion
H Hauser
Biochimica et biophysica acta, 1508(1-2), 164-181 (2000-11-25)
The physico-chemical properties of short-chain phosphatidylcholine are reviewed to the extent that its biological activity as a mild detergent can be rationalized. Long-chain diacylphosphatidylcholines are typical membrane phospholipids that form preferentially smectic lamellar phases (bilayers) when dispersed in water. In
Profiling changes in cortical astroglial cells following chronic stress
Simard S, et al.
Neuropsychopharmacology, 43(9), 1961-1961 (2018)
E F Kot et al.
Langmuir : the ACS journal of surfaces and colloids, 34(28), 8302-8313 (2018-06-21)
Isotropic bicelles are a widely used membrane mimetic for structural studies of membrane proteins and their transmembrane domains. Simple and cheap in preparation, they contain a patch of lipid bilayer that reproduces the native environment of membrane proteins. Despite the
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