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Jihong Bai et al.
Nature structural & molecular biology, 11(1), 36-44 (2004-01-14)
Synaptotagmin-1 (syt), the putative Ca2+ sensor for exocytosis, is anchored to the membrane of secretory organelles. Its cytoplasmic domain is composed of two Ca2+-sensing modules, C2A and C2B. Syt binds phosphatidylinositol 4,5-bisphosphate (PIP2), a plasma membrane lipid with an essential
Eric S Fried et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 3028-3039 (2017-02-16)
The popularization of studies in membrane protein lipid phase coexistence has prompted the development of new techniques to construct and study biomimetic systems with cholesterol-rich lipid microdomains. Here, microsphere-supported biomembranes with integrated α-helical peptides, referred to as proteolipobeads (PLBs), were
Krishnendu Pal et al.
NPJ precision oncology, 3, 31-31 (2019-12-17)
Clear cell renal cell carcinoma (ccRCC) is known for its highly vascular phenotype which is associated with elevated expression of vascular endothelial growth factor A (VEGF), also known as vascular permeability factor (VPF). Accordingly, VEGF has been an attractive target
Eric H Hill et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13252-13262 (2018-10-24)
Lipid vesicles are important biological assemblies, which are critical to biological transport processes, and vesicles prepared in the lab are a workhorse for studies of drug delivery, protein unfolding, biomolecular interactions, compartmentalized chemistry, and stimuli-responsive sensing. The current method of
Stephen A Pearson et al.
Metallomics : integrated biometal science, 12(6), 902-915 (2020-04-28)
Iron-sulfur cluster proteins play key roles in a multitude of physiological processes; including gene expression, nitrogen and oxygen sensing, electron transfer, and DNA repair. Biosynthesis of iron-sulfur clusters occurs in mitochondria on iron-sulfur cluster scaffold proteins in the form of
J Huang et al.
The journal of physical chemistry. B, 124(24), 4949-4959 (2020-05-22)
The energy penalty for bilayer phase domain interfaces, line tension, is an important quantity for describing the phase domain size transition from the nanometer scale to the micrometer scale and larger. We connected pairwise lipid interaction energies in ternary lipid
John E Gadbery et al.
Biochemistry, 57(36), 5370-5378 (2018-08-21)
Although the interfacial membrane protein cholesterol oxidase is structurally and kinetically well-characterized, its orientation in and mode of interaction with cholesterol-containing membranes have not been established. Cholesterol oxidase can alter the structure of the cell membrane in pathogenic bacteria and
Yi-Chih Lin et al.
Nature communications, 11(1), 230-230 (2020-01-15)
Annexins are abundant cytoplasmic proteins, which bind to membranes that expose negatively charged phospholipids in a Ca2+-dependent manner. During cell injuries, the entry of extracellular Ca2+ activates the annexin membrane-binding ability, subsequently initiating membrane repair processes. However, the mechanistic action of
Jürgen Kreiter et al.
Biomolecules, 10(5) (2020-05-06)
Several mitochondrial proteins, such as adenine nucleotide translocase (ANT), aspartate/glutamate carrier, dicarboxylate carrier, and uncoupling proteins 2 and 3, are suggested to have dual transport functions. While the transport of charge (protons and anions) is characterized by an alteration in
Naomi Benne et al.
Advanced healthcare materials, 9(10), e2000043-e2000043 (2020-04-25)
Atherosclerosis is characterized by the retention of lipids in foam cells in the arterial intima. The liver X receptor (LXR) agonist GW3965 is a promising therapeutic compound, since it induces reverse cholesterol transport in foam cells. However, hepatic LXR activation
Role of the biomolecular interactions in the structure and tribological properties of synovial fluid
Mirea D, et al.
Tribology International, 59(5), 302-311 (2013)
Alicia A Nugent et al.
Neuron, 105(5), 837-854 (2020-01-07)
Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms and cell sorting with RNA
Julia Skalska et al.
Nanoscale, 11(48), 23366-23381 (2019-12-04)
One of the most important causes of failure in tumour treatment is the development of resistance to therapy. Cancer cells can develop the ability to lose sensitivity to anti-neoplastic drugs during reciprocal crosstalk between cells and their interaction with the
Oleksandr Kolyvushko et al.
Pathogens (Basel, Switzerland), 9(5) (2020-05-14)
Exposure of phosphatidylserine (PS) in the outer leaflet of the plasma membrane is induced by infection with several members of the Alphaherpesvirinae subfamily. There is evidence that PS is used by the equine herpesvirus type 1 (EHV-1) during entry, but
Takuhiro Otosu et al.
Physical chemistry chemical physics : PCCP, 22(3), 1242-1249 (2019-12-19)
A supported lipid bilayer (SLB) is now an indispensable tool to analyze the dynamical properties of biomembranes. However, the effect of a solid support on the leaflet-specific lipid dynamics in a SLB remains elusive, which hampers the further application of
Mitchell DiPasquale et al.
Biochimica et biophysica acta. Biomembranes, 1862(8), 183189-183189 (2020-01-19)
The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now
Yun-Chieh Sung et al.
Nature nanotechnology, 14(12), 1160-1169 (2019-11-20)
Abnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to normalize tumour vasculature. However, a NO-delivery system with a prolonged half-life
Oscar Saavedra V et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 5709-5716 (2020-05-20)
Elastic properties of biological membranes are involved in a large number of membrane functionalities and activities. Conventionally characterized in terms of Young's modulus, bending stiffness and stretching modulus, membrane mechanics can be assessed at high lateral resolution by means of
Rashik Ahmed et al.
Chemical science, 10(24), 6072-6082 (2019-07-31)
Soluble amyloid beta assemblies (Aβ n
Kuan-Wei Huang et al.
Science advances, 6(3), eaax5032-eaax5032 (2020-01-31)
While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer immunotherapy. Here, we report a combinatorial immunotherapy approach that uses a highly efficient and
Heun Jin Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19253-19257 (2008-12-03)
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture detailed 3-dimensional conformations of membranes in cellular
Thomas Berry et al.
Langmuir : the ACS journal of surfaces and colloids, 34(38), 11586-11592 (2018-08-19)
Melimine and its derivatives are synthetic chimeric antimicrobial agents based on protamine and melittin. The binding of solubilized melimine and its derivative, with a cysteine on N-terminus, (cys-melimine) on tethered bilayer lipid membranes (tBLMs) was examined using ac electrical impedance
Peter J Chung et al.
Langmuir : the ACS journal of surfaces and colloids, 34(43), 13000-13005 (2018-10-12)
Spherical nanoparticle-supported lipid bilayers (SSLBs) combine precision nanoparticle engineering with biocompatible interfaces for various applications, ranging from drug delivery platforms to structural probes for membrane proteins. Although the bulk, spontaneous assembly of vesicles and larger silica nanoparticles (>100 nm) robustly
Tun Naw Sut et al.
Langmuir : the ACS journal of surfaces and colloids, 36(18), 5021-5029 (2020-04-21)
Supported lipid bilayers (SLBs) are versatile cell membrane-mimicking biointerfaces for various applications such as biosensors and drug delivery systems, and there is broad interest in developing simple, cost-effective methods to achieve SLB fabrication. One promising approach involves the deposition of
Jayesh A Kulkarni et al.
Nanoscale, 11(45), 21733-21739 (2019-11-13)
Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells (hepatocytes) following intravenous (i.v.) administration. These LNP-siRNA systems consist of four lipid components
Hilal Yılmaz et al.
Protein expression and purification, 173, 105664-105664 (2020-05-08)
In this study, effect of affinity tags, Histidine (His) and Glutathione-S-Transferase (GST), on the activity of halophilic aquaporin was analyzed. The gene coding for H. elongata aquaporin was cloned into pET28a vector and expressed in E. coli BL21 successfully. Stopped
Madhabi Lata Shuma et al.
Biochemistry, 59(18), 1780-1790 (2020-04-15)
The entry of cell-penetrating peptides (CPPs) into live cells and lipid vesicles has been monitored using probe (e.g., fluorescent dye)-labeled CPPs. However, probe labeling may alter the interaction of CPPs with membranes. We have developed a new method to detect
Mohammad Abu Sayem Karal et al.
Chemistry and physics of lipids, 230, 104916-104916 (2020-05-15)
The interaction of anionic magnetite nanoparticles (MNPs) of size 18 nm with negatively charged giant unilamellar vesicles (GUVs) formed from a mixture of neutral dioleoylphosphatidylcholine (DOPC) and negatively charged dioleoylphosphatidylglycerol (DOPG) lipids has been investigated. It has been obtained that
Peter J Beltramo et al.
Langmuir : the ACS journal of surfaces and colloids, 34(20), 5880-5888 (2018-05-02)
Capacitance measurements provide unique insights into the thickness, compressibility, and composition of large-area membrane bilayers and are used here in addition to demonstrate the successful incorporation of model ion channels. The simultaneous ability to control the bilayer size, manipulate tension
Tess A Stanly et al.
The Journal of biological chemistry, 295(15), 5036-5050 (2020-02-09)
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to its ligand hyaluronan in the leukocyte surface glycocalyx. To bind hyaluronan efficiently, LYVE-1 must undergo surface clustering, a
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