850715P

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Formulation and characterization of folate receptor-targeted PEGylated liposome encapsulating bioactive compounds from Kappaphycus alvarezii for cancer therapy.

Suraj Baskararaj et al.

3 Biotech, 10(3), 136-136 (2020-03-12)

This study aimed to formulate and characterize the folate receptor-targeted PEGylated liposome encapsulating bioactive compounds from Kappaphycus alvarezii to enhance the anticancer activity. Twenty valued bioactive compounds (3-hydroxy benzoicacid, gallicacid, chlorogenicacid, cinnamicacid, artemiseole, hydrazine carbothioamide, etc.,) are confirmed from methanol

Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; a potential approach for the treatment of channelopathies.

Shahenda Ramadan et al.

International journal of biological macromolecules, 153, 1080-1089 (2019-11-23)

Defects in transmembrane ion channels underlie many disorders, commonly known as channelopathies. Current therapies are mostly symptomatic and do not treat the underlying cause. Here, we demonstrate the delivery of functional ion channels in protein form into the membrane of

Promoting apical-to-basolateral unidirectional transport of nanoformulations by manipulating the nutrient-absorption pathway.

Lei Wu et al.

Journal of controlled release : official journal of the Controlled Release Society, 323, 151-160 (2020-04-12)

The epithelium is a formidable barrier to the absorption of orally delivered nano-vehicles. Here, by exploring a nutrient-absorption pathway, a self-amplified nanoplatform was developed to promote apical-to-basolateral transcytosis across the epithelium. The nanoplatform consisted of fructose-modified polyethylene glycol coated nanoparticles

Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei

Farine L, et al.

Scientific reports, 5, 16787-16787 (2015)

Phosphatidylserine Allows Observation of the Calcium-Myristoyl Switch of Recoverin and Its Preferential Binding.

Philippe Calvez et al.

Journal of the American Chemical Society (2016-10-01)

Recoverin undergoes a calcium-myristoyl switch during visual phototransduction. Indeed, calcium binding by recoverin results in the extrusion of its myristoyl group, which allows its membrane binding. However, the contribution of particular lipids and of specific amino acids of recoverin in

An Introduction to Biological Membranes: Composition, Structure and Function (2016)

In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow.

Otto K Kari et al.

Nanoscale, 12(3), 1728-1741 (2020-01-03)

Methodological constraints have limited our ability to study protein corona formation, slowing nanomedicine development and their successful translation into the clinic. We determined hard and soft corona structural properties along with the corresponding proteomic compositions on liposomes in a label-free

Metronomic doses of temozolomide enhance the efficacy of carbon nanotube CpG immunotherapy in an invasive glioma model

Ouyang M, et al.

Testing, 11(2), e0148139-e0148139 (2016)

Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells

Vance JE and Tasseva G

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831(3), 543-554 (2013)

Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy.

Yu-Qing Wang et al.

International journal of pharmaceutics, 582, 119331-119331 (2020-04-15)

The major drawbacks of the cytotoxin like DM1 are the off-target effects. Here, the targeting nanovesicles were developed by synthesizing tocopherol-SS-DM1 and conjugating a pH low insertion peptide (pHLIP) to PEGylated phospholipids, in which tocopherol-SS-DM1 improves the drug loading and

The Membranes of Cells (2016)

Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model.

Mao Ouyang et al.

PloS one, 11(2), e0148139-e0148139 (2016-02-02)

Even when treated with aggressive current therapies, most patients with glioblastoma survive less than two years. Rapid tumor growth, an invasive nature, and the blood-brain barrier, which limits the penetration of large molecules into the brain, all contribute to the

Phosphatidylethanolamine is a key regulator of membrane fluidity in eukaryotic cells

Dawaliby R, et al.

The Journal of Biological Chemistry, 291(7), 3658-3667 (2016)

Nano electrospray differential mobility analysis based size-selection of liposomes and very-low density lipoprotein particles for offline hyphenation to MALDI mass spectrometry.

Victor U Weiss et al.

Journal of pharmaceutical and biomedical analysis, 179, 112998-112998 (2019-11-30)

Gas-phase electrophoresis of single-charged analytes (nanoparticles) enables their separation according to the surface-dry particle size (Electrophoretic Mobility Diameter, EMD), which corresponds to the diameter of spherical shaped particles. Employing a nano Electrospray Differential Mobility Analyzer (nES DMA), also known as

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