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Liang Yin et al.
Molecular medicine reports, 5(2), 457-461 (2011-11-05)
p53 and PTEN are the two most frequently mutated tumor suppressors in human cancer. However, literature on the effect of the joint inactivation of tumor-suppressor genes in soft tissue sarcoma (STS) is lacking. The purpose of this study was to
Nadeem Hussain et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4(1), 73-80 (2006-01-25)
Hermansky-Pudlak syndrome (HPS), a rare autosomal recessive disorder characterized by oculocutaneous albinism and platelet dysfunction, results from mutations in 1 of at least 7 different genes. Some patients develop a fatal pulmonary fibrosis and others a disabling colitis. This study
B Z Yuan et al.
Cancer research, 58(10), 2196-2199 (1998-05-30)
The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here the isolation of the full-length cDNA and chromosomal localization of a new gene frequently deleted in liver cancer (DLC-1) that
Dau-Ming Niu et al.
The Journal of clinical endocrinology and metabolism, 87(9), 4208-4212 (2002-09-06)
The mutation of the thyroid peroxidase (TPO) gene that causes the total iodide organification defect (TIOD) is a common and severe condition leading to dyshormonogenesis of the thyroid gland in Caucasians. However, the role of TIOD in Chinese patients with
Mirte M Streppel et al.
Human pathology, 43(10), 1755-1763 (2012-05-01)
Mucin 16 (cancer antigen 125) is a cell surface glycoprotein that plays a role in promoting cancer cell growth in ovarian cancer. The aims of this study were to examine mucin 16 expression in a large number of digestive tract
Yan-Li Yang et al.
Chinese medical journal, 125(3), 450-454 (2012-04-12)
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies in China and epidermal growth factor receptor (EGFR) is widely distributed in human epithelial cell membrane. The aim of this study was to investigate the protein overexpression and
Matthew J Delmonico et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 62(2), 206-212 (2007-03-07)
The alpha-actinin-3 (ACTN3) R577X polymorphism has been associated with muscle power performance in cross-sectional studies. We examined baseline knee extensor concentric peak power (PP) and PP change with approximately 10 weeks of unilateral knee extensor strength training (ST) using air-powered
J P Baak et al.
The American journal of surgical pathology, 25(7), 930-935 (2001-06-23)
Prospective multicenter evaluation of the WHO classification and the morphometric D-score to predict endometrial hyperplasia cancer progression. In 132 endometrial hyperplasias WHO classification was performed by two experienced gynecologic pathologists. The D-score was assessed blindly by technicians in a routine
Yeontaek Lee et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(15), e2100231-e2100231 (2021-06-05)
Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration
Gal Frenkel et al.
The Journal of clinical pediatric dentistry, 37(2), 137-141 (2012-01-01)
To compare the long-term clinical and radiographic outcomes of pulpotomies in primary molars performed with white or gray Mineral Trioxide Aggregate (MTA) in combination with ferric sulfate (FS), when one package of MTA is used for multiple treatments. Sixty eight
A Lahti et al.
Journal of the American Academy of Dermatology, 13(4), 585-589 (1985-10-01)
The decrease in the swelling capacity and the length of the refractory period after nonimmunologic contact urticaria produced by one application of six human nonimmunologic contact urticaria agents was studied with the use of the guinea pig ear test. On
Manish M Subramaniam et al.
The American journal of gastroenterology, 104(2), 426-436 (2009-01-29)
We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis. RUNX3 protein expression was analyzed immunohistochemically in 50 sporadic colorectal polyps comprising 19 hyperplastic polyps (HPs), 14 traditional serrated adenomas (TSAs)
Laia Vilà et al.
PloS one, 7(12), e51118-e51118 (2012-12-12)
Although metabolic syndrome (MS) and systemic lupus erythematosus (SLE) are often associated, a common link has not been identified. Using the BWF1 mouse, which develops MS and SLE, we sought a molecular connection to explain the prevalence of these two
Ferdinando Maggioni et al.
The journal of headache and pain, 6(4), 322-324 (2005-12-20)
We conducted a study on 367 patients (86% female, 14% male; mean age 37+/-15 years) suffering from migraine with and without aura and chronic tension-type headache to evaluate the incidence of weight gain, an undesirable side effect observed during prophylactic
K Gill et al.
Psychopharmacology, 150(4), 412-421 (2000-08-25)
Quantitative trait loci (QTLs) for initial sensitivity to alcohol have been identified in a number of mouse strains (e.g. BXD); however, confirmation is required. The present paper aimed to characterize the C57BL/6J, A/J, and AXB/BXA recombinant inbred (RI) strains of
B Velan et al.
The Journal of biological chemistry, 260(9), 5498-5504 (1985-05-10)
The bovine genome contains a gene family of interferon-alpha s (bIFN-alpha) that consists of at least five distinct members. Four of the bIFN-alpha genes isolated show a high degree of homology (97% in the nucleotide sequence and 93% in amino
Diana M Padgett et al.
The American journal of surgical pathology, 32(1), 123-127 (2007-12-29)
Immunohistochemistry using a broad panel of markers is an invaluable tool for diagnosing sarcomatoid mesothelioma. Membranous podoplanin staining has been proposed as a specific and sensitive marker to distinguish epithelioid mesothelioma from adenocarcinoma. We found that cytoplasmic podoplanin staining was
Cuizhen Li et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20(12), 1263-1268 (2007-09-22)
Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is a newly identified oncofetal mRNA-binding protein that is involved in embryogenesis and carcinogenesis of some malignant neoplasms. To investigate the diagnostic and clinicopathologic significance of this protein in endometrial carcinomas, we evaluated
J Sadeghinezhad et al.
Anatomia, histologia, embryologia, 42(3), 201-212 (2012-09-05)
Most investigations related to the characterisation of the enteric nervous system (ENS) are pivoted on the intestine of small rodents, but few studies are available on the ENS of wild or 'unconventional' rodents. Anti-PGP 9.5 and anti-Hu antibodies were utilised
Andrea Veronesi et al.
BMC cancer, 5, 70-70 (2005-07-06)
The clinical and pathological characteristics and the clinical course of patients with breast cancer and BRCA 1-2 mutation are poorly known. From 1997, patients with breast cancer and a family history of breast or ovarian cancer were offered BRCA testing.
Avik Chakraborty et al.
Endocrine pathology, 23(2), 83-93 (2011-11-23)
B-Raf (BRAF) is the strongest activator in the downstream of MAP kinase signaling. The somatic point mutation of BRAF gene (V600E) is the most common and specific event in papillary thyroid carcinoma (PTC). However, its prevalence is variable among different
Jeffrey E Rubnitz et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(13), 2186-2191 (2008-05-01)
To prospectively determine the prognostic significance of the TEL-AML1 fusion in children with acute lymphoblastic leukemia (ALL). TEL gene status was determined for 926 patients with B-precursor ALL enrolled on the Pediatric Oncology Group ALinC 16 trials and patients were
Paulo Castro-Chaves et al.
European journal of pharmacology, 544(1-3), 91-96 (2006-07-18)
We analyzed the influence of endothelin-1 and endocardial endothelium on the myocardial effects of angiotensin-II. Angiotensin-II (10(-9)-10(-5) M) was tested in rabbit right papillary muscles in absence (Protocol-A) or presence of PD-145065 (10(-7) M; Protocol-B), BQ-123 (10(-7) M; Protocol-C) or
Jessica A Pollard et al.
Blood, 115(12), 2372-2379 (2010-01-09)
KIT receptor tyrosine kinase mutations are implicated as a prognostic factor in adults with core binding factor (CBF) acute myeloid leukemia (AML). However, their prevalence and prognostic significance in pediatric CBF AML is not well established. We performed KIT mutational
Tomoyuki Moriya et al.
Surgery, 155(4), 711-718 (2014-02-11)
Parenteral nutrition (PN) is indispensable for meeting the caloric and substrate needs of patients who cannot receive adequate amounts of enteral nutrition. However, PN decreases hepatic mononuclear cell (MNC) numbers and impairs their functions. We examined the effects of various
A Thabaut et al.
Pathologie-biologie, 42(5), 369-374 (1994-05-01)
The antibacterial activities of pefloxacin (PEF), ofloxacin (OFL), ciprofloxacin (CIP) were measured by agar diffusion (5 micrograms strength disks) against 6370 non duplicate clinical isolates collected in November 1991 in 40 hospitals from various areas in France. The MICs of
Nobuo Hoshi et al.
Medical molecular morphology, 42(2), 110-117 (2009-06-19)
Although a critical role of the endothelin (ET) system in differentiation of neural crest cells has been reported, implication of the ET system in human neuroblastic tumors has not been fully elucidated. We immunohistochemically examined for localization of ET-1, ET-3
Elisabetta Munzone et al.
Clinical breast cancer, 10(5), 392-397 (2010-10-06)
HER2/neu status of tumor cells at metastatic sites in patients with advanced disease may differ from that of the primary tumor. Assessing the presence of target antigens on circulating tumor cells (CTCs) might affect treatment choice. From June 2007 to
F McGarry et al.
Rheumatology (Oxford, England), 40(12), 1359-1364 (2001-12-26)
Genetic factors that predispose individuals to ankylosing spondylitis (AS) are not fully understood, but are unlikely to be restricted to HLA-B27. Proinflammatory cytokines are implicated in the development of sacroiliitis. We have examined the allele frequencies of three polymorphic sites
Akiko Kusume et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 76(4), 155-162 (2009-07-03)
High mobility groupbox-1 (HMGB1) is a multifunctional cytokine secreted by cancer cells, which accelerates cell growth, invasion and angiogenesis in cancer, and induces apoptosis in macrophages. Thioglycolate-stimulated mouse peritoneal macrophages were induced to differentiate into dendritic cells by co-treatment with
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