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A A Jerkins et al.
The Journal of biological chemistry, 270(3), 1416-1421 (1995-01-20)
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the acylation of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate, a committed step in triacylglycerol and phospholipid biosynthesis. We have previously reported the cDNA cloning and transcriptional regulation of the murine mitochondrial GPAT (mGPAT). We now report
A M Zeiher et al.
Lancet (London, England), 344(8934), 1405-1406 (1994-11-19)
Acute coronary syndromes are accompanied by exaggerated vasoconstriction. Since thrombin induces production of the potent vasoconstrictor endothelin-1, we used immunohistochemistry on coronary atherosclerotic specimens from 30 consecutive patients. Endothelin-1-like immunoreactivity was present in 5 of 9 (55%) lesions from patients
K Ben Rhouma et al.
Archives of physiology and biochemistry, 105(2), 216-224 (1997-04-01)
The thymolytic action of dexamethasone (DEXA) and aldosterone (ALDO) has been studied in vitro and in vivo. In vitro, in the presence of DEXA, the number of apoptotic cells increased with time. After 6 hours of incubation, 55 and 86%
Ana I Seixas et al.
Behavioral and brain functions : BBF, 7, 19-19 (2011-06-07)
The fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansions of 55-200 CGG repeats in the 5'UTR of the FMR1 gene. These FMR1 premutation expansions have relatively high frequency in the general population. To estimate the
Martin J Gallagher et al.
The Journal of biological chemistry, 280(45), 37995-38004 (2005-08-27)
A GABA(A) receptor alpha1 subunit epilepsy mutation (alpha1(A322D)) introduces a negatively charged aspartate residue into the hydrophobic M3 transmembrane domain of the alpha1 subunit. We reported previously that heterologous expression of alpha1(A322D)beta2gamma2 receptors in mammalian cells resulted in reduced total
J S Sevall
Biochemistry, 27(14), 5038-5044 (1988-07-12)
Interaction of rat liver histone H1 fraction with the 5'-end of the rat serum albumin gene was localized within a 346 base pair (bp) restriction fragment. Sequence analysis of the fragment showed the fragment was 72 mol % adenosine-thymidine, which
S Tomatsu et al.
Gene, 80(2), 353-361 (1989-08-15)
The organization and the complete nucleotide (nt) sequence of the b5R gene encoding human NADH-cytochrome b5 reductase (b5R; EC 1.6.2.2) have been determined by a combination of restriction mapping and nt sequence analysis of overlapping genomic DNA clones. The entire
Z Suo et al.
Histopathology, 23(1), 45-54 (1993-07-01)
The expression of cytokeratins (CK) 1, 4, 5/6, 8, 13, 18, 19 and 20 and involucrin in 42 cases of squamous cell carcinomas from various locations was examined. The tumours expressed CK5/6 in 55%, CK8 in 76%, CK13 in 43%
Janak Koirala et al.
Diagnostic microbiology and infectious disease, 97(1), 114999-114999 (2020-02-16)
We reviewed susceptibility of 840 A. baumannii complex isolates at two academic medical centers and explored their mechanism of carbapenem resistance. Carbapenem resistance rates among A. baumannii increased from <5% before 2005 to 55% in 2011 and declined thereafter. We
Dieter Hoelzer et al.
Blood, 124(26), 3870-3879 (2014-11-02)
This largest prospective multicenter trial for adult patients with Burkitt lymphoma/leukemia aimed to prove the efficacy and feasibility of short-intensive chemotherapy combined with the anti-CD20 antibody rituximab. From 2002 to 2011, 363 patients 16 to 85 years old were recruited
D J Smith et al.
Journal of agricultural and food chemistry, 62(48), 11756-11766 (2014-11-20)
The distribution and chemical fate of (36)Cl-ClO2 gas subsequent to fumigation of tomatoes or cantaloupe was investigated as were major factors that affect the formation of chloroxyanion byproducts. Approximately 22% of the generated (36)Cl-ClO2 was present on fumigated tomatoes after
Angela Lluque et al.
International journal of medical microbiology : IJMM, 305(4-5), 480-490 (2015-05-23)
The study was aimed to describe the serotype, mechanisms of antimicrobial resistance, and virulence determinants in Shigella spp. isolated from Peruvian children. Eighty three Shigella spp. were serogrouped and serotyped being established the antibiotic susceptibility. The presence of 12 virulence
A Thabaut et al.
Pathologie-biologie, 42(5), 369-374 (1994-05-01)
The antibacterial activities of pefloxacin (PEF), ofloxacin (OFL), ciprofloxacin (CIP) were measured by agar diffusion (5 micrograms strength disks) against 6370 non duplicate clinical isolates collected in November 1991 in 40 hospitals from various areas in France. The MICs of
Karl Sörelius et al.
Circulation, 130(24), 2136-2142 (2014-11-08)
Mycotic aortic aneurysm (MAA) is a rare and life-threatening disease. The aim of this European multicenter collaboration was to study the durability of endovascular aortic repair (EVAR) of MAA, by assessing late infection-related complications and long-term survival. All EVAR treated
Hélène Blons et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(8), 2594-2599 (2004-04-23)
Treatment of head and neck cancer often associates different therapeutic modalities, including surgery, radiotherapy, and chemotherapy. In an attempt to optimize therapeutics, the identification of molecular markers linked to response to chemotherapy remains important. Recently, the involvement of metalloproteinases in
P M Cury et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(2), 107-112 (2000-03-04)
Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adenocarcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and
Dongyu Shen et al.
Journal of food science and technology, 56(7), 3239-3253 (2019-07-06)
To improve and confirm the dual functions of flavor and antioxidant potential of porcine bone marrow extract (PBME). Response surface methodology and Box-Behnken design was employed to optimize the conditions for enzymatic hydrolysis of PBME. The optimal hydrolysis conditions were:
H R Denny et al.
The Journal of small animal practice, 59(6), 350-356 (2018-03-27)
To determine the long-term results and complications associated with the Helica® cementless hip endoprosthesis system. Retrospective study of 55 consecutive Helica total hip replacements performed between January 2010 and February 2015. A total of 55 total hip replacements were performed
Gerwin Heller et al.
Breast cancer research and treatment, 103(3), 283-291 (2007-01-30)
TSLC1 and DAL-1 are tumor suppressor genes involved in cell adhesion. In this study, we examined the expression and methylation pattern of these genes in breast cancer cell lines and primary breast carcinomas. TSLC1 expression was lost in 5 of
Chad Tang et al.
Scientific reports, 8(1), 1922-1922 (2018-02-02)
With increasing use of immunotherapy agents, pretreatment strategies for identifying responders and non-responders is useful for appropriate treatment assignment. We hypothesize that the local immune micro-environment of NSCLC is associated with patient outcomes and that these local immune features exhibit
Fiona V Cresswell et al.
The Lancet. Infectious diseases, 20(3), 308-317 (2020-01-12)
Tuberculous meningitis accounts for 1-5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis diagnosis. In this prospective validation study, we tested the cerebrospinal fluid
K A Al-Hussein et al.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, 30(2), 115-119 (2003-03-22)
The human leukocyte antigen (HLA) class II DQB1*0201/0202-DRB1*04 genotype has been identified as predisposing to type 1 diabetes [insulin-dependent diabetes mellitus (IDDM)] in the Saudi Arabian population (P = 0.0002; odds ratio = 0.67; 95% confidence interval = 0.009-0.381). In
Niels P Riksen et al.
European heart journal, 28(9), 1085-1091 (2007-03-23)
In patients with coronary artery disease, the 34C > T variant of the adenosine mono-phosphate deaminase gene (AMPD1), encoding a dysfunctional protein, predicts improved survival. We hypothesized that in subjects with this variant allele, ischaemia-induced intracellular adenosine formation is increased
David Schrama et al.
The Journal of investigative dermatology, 131(6), 1280-1290 (2011-03-11)
Genetic variants in DNA repair enzymes contribute to the susceptibility to cutaneous melanoma; consequently, we analyzed whether common nonsynonymous single-nucleotide polymorphisms in DNA repair enzyme genes might also influence the course of disease. To this end, we determined eight polymorphisms
Kirsi Gröndahl-Yli-Hannuksela et al.
The Journal of infectious diseases, 205(8), 1214-1219 (2012-03-03)
Toll-like receptors play an important role in the regulation of adaptive immunity. This study aimed to investigate whether Toll-like receptor 4 (TLR4) polymorphisms influence the production and persistence of antibodies after acellular pertussis booster vaccination during adolescence. Seventy-five subjects received
Stephanie Cheung et al.
PloS one, 14(3), e0214275-e0214275 (2019-03-22)
Evaluation of reproductive quality of spermatozoa by standard semen analysis is often inadequate to predict ART outcome. Men may be prone to meiotic error and have higher proportion of spermatozoa with fragmented chromatin, capable of affecting the conceptus' health. In
Andreas Jantke et al.
The journal of obstetrics and gynaecology research, 38(10), 1254-1259 (2012-05-09)
The aim of this study was to compare self-reported questionnaire-based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence. In a cross-sectional study, questionnaires and hormone analyses (anti-Müllerian hormone [AMH], follicle-stimulating
Mu-Min Shao et al.
Histopathology, 59(2), 264-273 (2011-09-03)
Epidermal growth factor receptor (EGFR) is frequently expressed in basal-like breast cancer (BLBC). The aim of this study was to evaluate their correlation as detected by immunohistochemistry (IHC) or fluorescence in-situ hybridization (FISH). IHC for oestrogen receptor (ER), progesterone receptor
Mireia Margeli et al.
PloS one, 5(3), e9499-e9499 (2010-03-09)
A fraction of sporadic breast cancers has low BRCA1 expression. BRCA1 mutation carriers are more likely to achieve a pathological complete response with DNA-damage-based chemotherapy compared to non-mutation carriers. Furthermore, sporadic ovarian cancer patients with low levels of BRCA1 mRNA
Alberto F Maffey et al.
Archivos argentinos de pediatria, 106(4), 302-309 (2008-09-04)
Respiratory viruses are associated with respiratory exacerbations, more frequently Respiratory Syncytial Virus in infants and Rhinovirus in children. To evaluate the prevalence and epidemiological features of newer and traditional respiratory viruses in infants and young children with recurrent wheeze. Cross
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