Alec I McKenzie et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(3), R503-R511 (2020-01-30)
Toll-like receptor 4 (TLR4) is a proposed mediator of ceramide accumulation, muscle atrophy, and insulin resistance in skeletal muscle. It is currently unknown whether pharmacological inhibition of TLR4, using the TLR4-specific inhibitor TAK-242 during muscle disuse, is able to prevent