861324

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[Not Available].

F PASCUCCI et al.

Rivista critica di clinica medica, 45(6-9), 484-493 (1945-11-30)

Internucleosomal DNA cleavage and neuronal cell survival/death.

A Batistatou et al.

The Journal of cell biology, 122(3), 523-532 (1993-08-01)

Serum-free PC12 cell cultures have been used to study the mechanisms of neuronal death after neurotrophic factor deprivation. We previously reported that PC12 cells undergo "apoptotic" internucleosomal DNA cleavage after withdrawal of trophic support. Here, we have used a sensitive

Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship.

S L de Castro et al.

Microbios, 78(315), 83-90 (1994-01-01)

The activity of 45 compounds against bloodstream forms of Trypanosoma cruzi was investigated. The aim was to consider new agents which might subsequently be assayed for chemoprophylaxis in donated blood. In a preliminary screening the drugs were assayed (50 to

Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells.

M Abend et al.

International journal of radiation biology, 75(12), 1567-1578 (2000-01-06)

To investigate the mechanism of micronucleus formation in irradiated L929 cells. Radiation-induced micronuclei (MN) of L929 cells isolated at 48 and 72 h after irradiation were processed for detection of DNA-laddering and higher-order chromatin fragments using conventional gel electrophoresis and

Heparin potentiation of collagen-induced platelet aggregation is related to the GPIIb/GPIIIa receptor and not to the GPIb receptor, as tested by whole blood aggregometry.

J Chen et al.

Thrombosis research, 66(2-3), 111-120 (1992-05-01)

To determine whether heparin potentiation of platelet aggregation is related to platelet GP IIb/IIIa and GP Ib receptors, four series of experiments were performed on blood from normal volunteers. In the first experiment pretreatment with the monoclonal antibody 7E3 (MAb

Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells.

Roberta Foresti et al.

The Journal of pharmacology and experimental therapeutics, 312(2), 686-693 (2004-11-13)

The induction of heme oxygenase-1 (HO-1) is widely recognized as an effective cellular strategy to counteract a variety of stressful events. We have shown that curcumin and caffeic acid phenethyl ester, two naturally occurring phytochemicals that possess antioxidant, anti-inflammatory, and

Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

J Balzarini et al.

Biochemical and biophysical research communications, 136(1), 64-71 (1986-04-14)

Aurintricarboxylic acid, an anionic triphenylmethane dye, and Evans Blue, an anionic compound structurally related to suramin, are, like suramin itself, inhibitors of human T-cell lymphotropic virus type III (HTLV-III)/-lymphadenopathy-associated virus (LAV) in vitro. These compounds may be targeted, at least

[Not Available].

A DESAUX et al.

Annales de dermatologie et de syphiligraphie, 6(9), 504-504 (1946-09-01)

Ligand polarizability contributes to tau fibril binding affinity.

Jordan R Jensen et al.

Bioorganic & medicinal chemistry, 19(17), 5147-5154 (2011-08-02)

Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggregates have been reported from high-throughput screens, but the affinity driving features common

Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF.

Meyer C, et al.

Methods, S1046-2023 (2016)

[Not Available].

M MERINO SIMON et al.

Galicia-clinica, 18(12), 741-743 (1946-12-01)

Comparative bacteriostatic assays with rosaniline and its phenolic analog (rosolic acid).

E FISCHER et al.

Journal of bacteriology, 53(4), 381-388 (1947-04-01)

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening.

Anthony N Gerber et al.

Proceedings of the National Academy of Sciences of the United States of America, 106(12), 4929-4934 (2009-03-04)

Glucocorticoids are widely used to suppress inflammation and treat various immune-mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the therapeutic response, whereas others cause debilitating side effects. To discover selective modulators of the GR response, we developed a high-throughput, multiplexed

Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.

H Nar et al.

Journal of molecular biology, 221(3), 765-772 (1991-10-05)

The X-ray crystal structure of recombinant wild-type azurin from Pseudomonas aeruginosa was determined by difference Fourier techniques using phases derived from the structure of the mutant His35Leu. Two data sets were collected from a single crystal of oxidized azurin soaked

Biological evaluation, chelation, and molecular modeling studies of novel metal-chelating inhibitors of NF-kappaB-DNA binding: structure activity relationships.

Rakesh K Sharma et al.

Journal of medicinal chemistry, 49(12), 3595-3601 (2006-06-09)

Previously, we have reported that aurintricarboxylic acid (ATA) is one of the most potent inhibitors of the DNA binding of transcription factor NF-kappaB. We now report the NF-kappaB-DNA binding inhibitory activity of ATA analogues. An electrophoretic mobility shift assay has

Evaluation of standard and modified M-FC, MacConkey, and Teepol media for membrane filtration counting of fecal coliforms in water.

W O Grabow et al.

Applied and environmental microbiology, 42(2), 192-199 (1981-08-01)

MacConkey agar, standard M-FC agar, M-FC agar without rosolic acid, M-FC agar with a resuscitation top layer, Teepol agar, and pads saturated with Teepol broth, were evaluated as growth media for membrane filtration counting of fecal coliform bacteria in water.

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