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Iu Z Gendon et al.
Voprosy virusologii, 58(1), 11-17 (2013-06-22)
Cold-adapted (CA) strains A/Krasnodar/35 and B/Victoria/63 were isolated using passages of A/Krasnodar/101/59 and B/Victoria/2/87 wild type strains at low temperatures. The resulting CA strains possessed TS and CA phenotypes and had a reduced ability to reproduce in mouse lungs and
J Geradts et al.
The American journal of pathology, 149(1), 15-20 (1996-07-01)
The product of the CDKN2/MTS1 gene, p16(INK4A) (16), inhibits phosphorylation of the retinoblastoma protein, pRB, and thus acts as a negative cell cycle regulator. It is inactivated in a wide range of human malignancies, including breast cancer. Using an immunohistochemical
K Y Jang et al.
Analytical and quantitative cytology and histology, 23(6), 400-404 (2002-01-05)
To estimate the utility of thyroid transcription factor-1 (TTF-1) and the combined cytokeratin 7 (CK7) and 20 (CK20) immunoprofile as a marker for identifying the primary site of metastatic adenocarcinoma in effusions of the serous cavity. Formalin-fixed, paraffin-embedded cell block
Aurélie Hanin et al.
Neurobiology of disease, 154, 105346-105346 (2021-03-29)
The understanding of the excitotoxic processes associated with a severe status epilepticus (SE) is of major importance. Changes of brain cholesterol homeostasis is an emerging candidate for excitotoxicity. We conducted an overall analysis of the cholesterol homeostasis both (i) in
S Schach et al.
European journal of biochemistry, 232(2), 536-544 (1995-09-01)
The enzymes catalysing the first two steps of quinoline and 3-methylquinoline degradation by Comamonas testosteroni 63 were investigated. Quinoline 2-oxidoreductase, which catalyses the hydroxylation of (3-methyl-)quinoline to (3-methyl-)2-oxo-1,2-dihydroquinoline, was purified to apparent homogeneity. The native enzyme, with a molecular mass
J Reiterová et al.
Folia biologica, 53(4), 134-137 (2007-08-21)
ADPKD is the most common hereditary renal disease. IGAN is a mesangial proliferative glomerulonephritis characterized by diffuse mesangial deposition of immunoglobulin A. ET-1 has been suggested to be a major disease-promoting factor in renal diseases. The vasoconstrictor effect of ET-1
Laurence M M Crombag et al.
The European respiratory journal, 53(2) (2018-12-24)
Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging
Faraj Hijaz et al.
Journal of food science, 72(5), C253-C257 (2007-11-13)
The indophenol method, ammonia ion selective electrode (ISE), Reflectoquant(R) test strips, and salicylate methods were evaluated to determine those that can be used for in-plant rapid testing of meat contaminated by ammonia refrigerant leaks. Ground eye of round beef samples
Stenio Fernando Pimentel Duarte et al.
American journal of human biology : the official journal of the Human Biology Council, 18(4), 448-453 (2006-06-22)
Several genes play a major role in obese phenotypes, and studies suggest that genetic variations among individuals, as well as their lifestyles, may bring about different body compositions. Among these genes, LEP, which codifies leptin, and the LEPR gene encoding
Takao Niino et al.
Cryo letters, 28(3), 197-206 (2007-09-28)
An optimal protocol for the cryopreservation of in vitro-grown mat rush (igusa) buds by vitrification has been successfully developed. Established multiple stemmed cultures, which were induced in liquid MS medium containing 8.9 microM BA by roller culture, were cut into
Jing Chen et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3363-3367 (2014-01-16)
The study aimed to develop the assay of chrysosplenetin (CHR), a metabolic inhibitor of artemisinin by UPLC-MS/MS in rat plasma and investigate the pharmacokinetics parameters of CHR. The plasma samples were precipitated by acetonitrile to remove the proteins. Separation was
T J Seng et al.
Oncogene, 26(6), 934-944 (2006-07-25)
Identification of tumor suppressor genes (TSG) silenced by methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic tumor markers for early cancer detection. Both nasopharyngeal carcinoma (NPC) and esophageal carcinoma are major tumors in Southern China and Southeast Asia. Through
Wattana Sukeepaisarnjaroen et al.
World journal of gastroenterology, 21(28), 8660-8669 (2015-08-01)
To examined the efficacy and safety of treatment with boceprevir, PEGylated-interferon and ribavirin (PR) in hepatitis C virus genotype 1 (HCVGT1) PR treatment-failures in Asia. The Boceprevir Named-Patient Program provided boceprevir to HCVGT1 PR treatment-failures. Participating physicians were invited to
Sarah Egert et al.
European journal of nutrition, 52(1), 281-288 (2012-03-01)
To investigate the influence of dietary proteins (casein, soy protein) and skimmed milk on the plasma kinetics of green tea (GT) catechins. In a randomized cross-over design with one-week intervals, 24 healthy normal-weight women consumed a test drink containing 1.75
Kamel Ait-Tahar et al.
Blood, 115(16), 3314-3319 (2010-02-27)
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) constitutes an ideal model disease to study tumor-specific immune responses. All the tumor cells express oncogenic ALK resulting from a chromosomal translocation involved in lymphomagenesis. Although antibodies and T-cell responses to
Kinga I Stanczak-Mrozek et al.
The Journal of antimicrobial chemotherapy, 70(8), 2191-2198 (2015-05-10)
MRSA is a major antimicrobial resistance (AMR) pathogen. The reservoir of infecting isolates is colonization, which is the site of evolutionary selection. The aim was to identify if AMRs in colonizing MRSA populations diversified and potential mechanisms of resistance gene
Ankur R Sangoi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(5), 660-667 (2009-03-10)
On the basis of recent clinical studies, some urologic oncologists do not offer bladder-sparing therapy for patients diagnosed with micropapillary carcinoma of the urinary bladder, even in the setting superficially invasive disease. Unfortunately, the distinction of invasive micropapillary carcinoma from
Laiju Kuzhuppillymyal-Prabhakarankutty et al.
World journal of microbiology & biotechnology, 36(3), 47-47 (2020-03-08)
Beauveria bassiana (Bals.) Vuillemin (B. bassiana) is an entomopathogenic fungus that establishes endophytic symbiosis with plants. In the present study, the effects of B. bassiana strains colonization in growing Zea mays L. (Z. mays), crop production, and drought tolerance were evaluated.
Sylvestre Le Moulec et al.
Bulletin du cancer, 100(12), 30-37 (2013-12-10)
The combination of paclitaxel and bevacizumab was EMA-approved as first-line therapy in metastatic breast cancer. Moreover, in vitro studies showed a potential antiangiogenic synergistic effect of paclitaxel and bevacizumab. Between November 2008 and March 2010, this case series study included
Sunil Kumar et al.
Journal of gastroenterology and hepatology, 27(12), 1825-1830 (2012-09-20)
Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms. A total of 150 IBS
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic
Masaki Maeda et al.
Arzneimittel-Forschung, 61(12), 734-741 (2012-01-28)
Certain kinds of peptide antibiotics are suggested to have immunomodulatory effects; however, few studies have been carried out systemically to evaluate the antiproliferative effects of peptide antibiotics in human lymphoid cells. The suppressive efficacies of nine peptide antibiotics and seven
Nga Bien-Ly et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(10), 4236-4241 (2011-03-04)
Apolipoprotein (apo) E4 is the major known genetic risk factor for Alzheimer's disease (AD). We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage in neurons, yielding neurotoxic C-terminal-truncated fragments. To study the effect of these
N Koyanagi et al.
Cancer research, 54(7), 1702-1706 (1994-04-01)
The search for compounds active against solid tumors has led us to the discovery of a novel sulfonamide, E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4- methoxybenzenesulfonamide), which inhibits tubulin polymerization. When administered orally, E7010 showed good antitumor activity against various rodent tumors and human tumor
Elizabeth G Raymond et al.
Contraception, 87(1), 26-37 (2012-08-18)
The dose of mifepristone approved by most government agencies for medical abortion is 600 mg. Our aim was to summarize extant data on the effectiveness and safety of regimens using the widely recommended lower mifepristone dose, 200 mg, followed by
Juan A Araya et al.
Journal of Alzheimer's disease : JAD, 42(1), 143-155 (2014-05-16)
Alzheimer's disease (AD) is a progressive and neurodegenerative disorder and one of the current therapies involves strengthening the cholinergic tone in central synapses. Neuroprotective properties for nicotine have been described in AD, through its actions on nicotinic receptors and the
Guillermo Ruiz-Irastorza et al.
Autoimmunity reviews, 13(2), 206-214 (2013-11-06)
To assess the effectiveness and safety of a protocol using medium doses of prednisone to treat lupus nephritis. Patients receiving the 'Cruces-protocol cohort' (CPC) were paired 1:2 with patients from the 'historic cohort' (HC). The CPC received medium doses of
Teela Jones et al.
Veterinary anaesthesia and analgesia, 46(3), 315-324 (2019-03-09)
To evaluate effects of anesthesia induced with alfaxalone and maintained with alfaxalone, dexmedetomidine and remifentanil infusions in foals. Prospective, experimental study. A group of six healthy foals [median (range) 11 (8-33) days] undergoing abdominal surgery. Intravenous (IV) dexmedetomidine (3-7μgkg-1) provided
Mika Asai-Coakwell et al.
Investigative ophthalmology & visual science, 47(11), 4905-4909 (2006-10-27)
Axenfeld-Rieger malformations of the anterior segment are clinically heterogeneous, and up to 50% of cases are attributable to PITX2 or FOXC1 mutation. In view of PITX2's contribution to corneal development and the altered CCT in some FOXC1-related cases, this study
A Santoro et al.
Arzneimittel-Forschung, 50(9), 786-794 (2000-10-29)
The pharmacokinetic characteristics and the bioavailability of glyceryl trinitrate (GTN, CAS 55-63-0) and of its main metabolities 1,2-glyceryl dinitrate (1,2-GDN, CAS 621-65-8) and 1,3-glyceryl dinitrate (1,3-GDN, CAS 623-87-0) during a single 24-h application of three strengths of a newly developed
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