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National Toxicology Program technical report series, (574)(574), 1-167 (2013-03-23)
The current main commercial use of pyrogallol is the production of pharmaceuticals and pesticides. In analytical chemistry, pyrogallol is used as a complexing agent, reducing agent, and, in alkaline solution, as an indicator of gaseous oxygen. Pyrogallol was nominated for
L Garrigue-Antar et al.
The Journal of biological chemistry, 276(28), 26237-26242 (2001-04-03)
Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage occurs between a specific alanine or glycine residue (depending
J-B Delhorme et al.
The British journal of surgery, 105(6), 668-676 (2018-02-08)
The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic
Maurizio Mandalà et al.
Regulatory peptides, 124(1-3), 73-80 (2004-11-17)
Chromogranin A (CgA), an acidic granule protein of the regulated secretory pathway in the diffuse neuroendocrine system, is postulated to serve as a prohormone for regulatory peptides. Betagranin (rCgA(1-128)), the first N-terminal cleavage product of rat CgA, is 87% homologous
Eira Kelo et al.
Glycobiology, 15(1), 79-85 (2004-09-03)
Aspartylglycosaminuria (AGU) is caused by deficient enzymatic activity of glycosylasparaginase (GA). The disease is characterized by accumulation of aspartylglucosamine (GlcNAc-Asn) and other glycoasparagines in tissues and body fluids of AGU patients and in an AGU mouse model. In the current
Hengwei Zhang et al.
Oncology letters, 14(3), 3734-3740 (2017-09-21)
Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell
Yong-Fen Qi et al.
Peptides, 26(7), 1257-1263 (2005-06-14)
Adrenomedullin (ADM) is a potent vasodilatory peptide. It regulates blood pressure by increasing cyclic adenosine monophosphate (cAMP) and guanosine-3',5'-monophosphate (cGMP). We sought to investigate the effect of ADM on heme oxygenase-1 (HO-1) gene expression and cGMP formation in cultured rat
Ze-Hua Wang et al.
Asian Pacific journal of cancer prevention : APJCP, 12(8), 1973-1977 (2012-02-02)
Human arrest defective 1 protein (ARD1), as a N-terminal acetyltransferase, has been reported to play a crucial role in tumorigenesis, but the results are somewhat controversial. To explore the clinical and pathological significance of ARD1 in breast tumorigenesis, we analyzed
A C Haglund et al.
Thrombosis research, 98(2), 147-156 (2000-03-14)
Fibrinogen was purified by protamine-agarose chromatography from plasma from three patients after their submission to hospital due to acute myocardial infarction. The total amount of phosphate bound to fibrinogen and the concentration of fibrinogen was determined in samples withdrawn immediately
Y Ohnishi et al.
Journal of virology, 68(6), 4075-4079 (1994-06-01)
Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease
D Moya et al.
Journal of animal science, 93(7), 3623-3638 (2016-01-05)
Two groups of cattle were used to develop (model data set: 384 heifers, 228 ± 22.7 kg BW, monitored over a 225-d feeding period) and to validate (naïve data set: 384 heifers, 322 ± 34.7 kg BW, monitored over a
Heide Muckenfuss et al.
Nucleic acids research, 35(11), 3784-3796 (2007-05-23)
APOBEC3G (A3G), a member of the recently discovered family of human cytidine deaminases, is expressed in peripheral blood lymphocytes and has been shown to be active against HIV-1 and other retroviruses. To gain new insights into the transcriptional regulation of
Carina Domingues et al.
Journal of biotechnology, 164(3), 433-440 (2012-08-21)
Biodiesel production from high acidity industrial by-products was studied using heterogeneous acid catalysts. These by-products contain 26-39% of free fatty acids, 45-66% of fatty acids methyl esters and 0.6-1.1% of water and are consequently inadequate for direct basic catalyzed transesterification.
Qiujin Shen et al.
The Lancet. Oncology, 13(8), 817-826 (2012-06-29)
Hepatocellular carcinoma (HCC) is prevalent worldwide and improvements in timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf-1 (DKK1) in serum could improve diagnostic accuracy for HCC. We analysed data for patients with HCC, chronic hepatitis B
Gajraj Singh Kushwaha et al.
Biochimica et biophysica acta, 1824(4), 679-691 (2012-03-01)
The ribosome inactivating proteins (RIPs) of type 1 are plant toxins that eliminate adenine base selectively from the single stranded loop of rRNA. We report six crystal structures, type 1 RIP from Momordica balsamina (A), three in complexed states with
Cameron C Grant et al.
Pediatrics, 133(1), e143-e153 (2013-12-18)
To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥ 20 ng/mL during infancy. A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from
K Hirota et al.
Neuroscience letters, 223(3), 169-172 (1997-02-28)
Radioligand binding studies using the L-type voltage sensitive Ca2+ channel (VSCC) antagonist (+)-[3H]PN200-110 revealed the following rank order channel density in rat brain and cultured neuronal cell homogenates: striatum > or = cerebrocortex > > cerebellum = brainstem > SH-SY5Y
Yoshiaki Kawano et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 24(4), 330-334 (2005-09-22)
Receptor-binding antigen expressed on a human uterine adenocarcinoma cell line, SiSo (RCAS1), has been reported to be a prognostic factor of various malignant tumors, and it has also been proven to induce apoptosis of lymphoid cells. However, its normal distribution
Victoria Valls et al.
Clinical rheumatology, 34(1), 29-34 (2014-01-28)
Tuberculosis reactivation is a serious threat in patients treated with anti-tumour necrosis factor therapy. A 6-month regimen with isoniazid is considered as the standard of care, but patient adherence is a major shortcoming. We carried out an open-label, single-arm intervention
Hannah M Schneider et al.
Plant, cell & environment, 40(8), 1392-1408 (2017-02-07)
The functional implications of root cortical senescence (RCS) are poorly understood. We tested the hypotheses that RCS in barley (1) reduces the respiration and nutrient content of root tissue; (2) decreases radial water and nutrient transport; and (3) is accompanied
Theodore Chiras et al.
In vivo (Athens, Greece), 23(1), 177-181 (2009-04-17)
Human platelets carry membrane glycoproteins that control platelet aggregation and activation. A number of clinical studies have suggested that certain polymorphisms of genes encoding these proteins increase the risk for cardiovascular disease. The frequency of gene polymorphisms for the four
P Carmeliet et al.
The Journal of clinical investigation, 92(6), 2756-2760 (1993-12-01)
The effects of plasminogen activator inhibitor-1 (PAI-1) gene inactivation on hemostasis, thrombosis and thrombolysis were studied in homozygous PAI-1-deficient (PAI-1-/-) mice, generated by homologous recombination in D3 embryonic stem cells. Diluted (10-fold) whole blood clots from PAI-1-/- and from PAI-1
Haimei Yang et al.
Mikrochimica acta, 185(11), 512-512 (2018-10-22)
A fluorescent array based on the use of saccharide-functionalized multicolored quantum dots (s-QDs) and of 4-mercaptophenylboronic acid-functionalized MoS2 nanosheets (PBA-MoS2) was constructed for multiple identification and quantitation of lectins and bacteria. In this array, the fluorescence of the s-QDs is quenched by
Ryan R Reeves et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 85(1), 13-22 (2014-04-23)
To characterize the prevalence of thrombus burden, collateral vessels to the infarct-related artery, epicardial coronary artery flow, and myocardial perfusion in patients with angiographically confirmed definite stent thrombosis (ST), and to define their relationship with associated treatments and outcomes. Angiographic
Christina Yoon et al.
Journal of acquired immune deficiency syndromes (1999), 65(5), 551-556 (2013-12-19)
Symptom-based tuberculosis screening identifies less than one-third of eligible HIV-infected patients as candidates for isoniazid preventive therapy (IPT). We evaluated whether testing for C-reactive protein (CRP) improves patient selection for IPT. We measured CRP levels (normal <10 mg/L) using a
Julia Araya et al.
Obesity (Silver Spring, Md.), 18(7), 1460-1463 (2009-10-31)
Steatosis in obese nonalcoholic fatty liver disease (NAFLD) patients is a clinicopathological condition associated with depletion of n-3 polyunsaturated fatty acids (PUFA), a feature that may be related to PUFA desaturation. Liver Delta-6 and Delta-5 desaturase (Delta-6D and Delta-5D) activities
Juliana Maria Saez et al.
Ecotoxicology and environmental safety, 144, 351-359 (2017-06-26)
Lindane is an organochlorine pesticide which persists in the environment and can cause serious health problems due to its chlorinated and hydrophobic nature. Microemulsions are isotropic and macroscopically homogeneous systems with high solubilization capacity of hydrophilic and hydrophobic compounds. The
Zeen Tong et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(1), 43-53 (2017-12-06)
1. The absorption, distribution, metabolism, and excretion of CC-223 were studied following a single oral dose of [14C]CC-223 to rats (3 mg/kg; 90 μCi/kg), dogs (1.5 mg/kg; 10 μCi/kg), and healthy volunteers (20 mg; 200 nCi). 2. CC-223-derived radioactivity was widely distributed in
Raveena Ramphal et al.
American journal of clinical pathology, 126(3), 349-364 (2006-08-02)
We describe the clinical features, outcome, pathology, cytogenetics, and molecular aspects of 13 pediatric papillary renal cell carcinomas during a 19-year period. Seven cases (54%) had translocations involving Xp11.2 (TFE3). They were identified by cytogenetic, molecular, and/or immunohistochemical analyses. All
Ankie M Harmsze et al.
European heart journal, 31(24), 3046-3053 (2010-09-14)
despite treatment with clopidogrel on top of aspirin, stent thrombosis (ST) still occurs being the most serious complication after percutaneous coronary interventions (PCIs). In this study, we aimed to determine the effect of variations in genes involved in the absorption
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