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Rajan Lamichhane et al.
Structure (London, England : 1993), 28(3), 371-377 (2020-01-25)
G-protein-coupled receptors (GPCRs) mediate a wide range of human physiological functions by transducing extracellular ligand binding events into intracellular responses. GPCRs can activate parallel, independent signaling pathways mediated by G proteins or β-arrestins. Whereas "balanced" agonists activate both pathways equally
Max Piffoux et al.
ACS nano, 12(7), 6830-6842 (2018-07-06)
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery. However, efficient and reproducible loading of EVs with therapeutic or imaging agents
Lucrecia Alberdi et al.
Journal of cell science, 133(9) (2020-05-16)
Salmonella enterica is an intracellular bacterial pathogen. The formation of its replication niche, which is composed of a vacuole associated with a network of membrane tubules, depends on the secretion of a set of bacterial effector proteins whose activities deeply
Véronique Yvette Ntsogo Enguéné et al.
Frontiers in microbiology, 6, 541-541 (2015-06-18)
Efflux pumps are membrane transporters that actively extrude various substrates, leading to multidrug resistance (MDR). In this study, we have designed a new test that allows investigating the assembly of the MexA-MexB-OprM efflux pump from the Gram negative bacteria Pseudomonas
Chaohong Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3237-3246 (2012-03-06)
B cells encounter both soluble Ag (sAg) and membrane-associated Ag (mAg) in the secondary lymphoid tissue, yet how the physical form of Ag modulates B cell activation remains unclear. This study compares actin reorganization and its role in BCR signalosome
Hideyo Takatsuki et al.
Nanotechnology, 22(24), 245101-245101 (2011-04-22)
The potential of using actin bundles for the transport of liposomes and single cells across myosin-coated surfaces is investigated. Compared to that observed with filamentous actin, the liposome transport using actin bundles was more linear in nature and able to
Florian Schlosser et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1661), 20140028-20140028 (2014-12-24)
Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. To test quantitatively forces generated by cells not attached to a substrate, we used a dual optical trap to
Serapion Pyrpassopoulos et al.
Biophysical journal, 118(1), 243-253 (2019-12-31)
Kinesin motors and their associated microtubule tracks are essential for long-distance transport of cellular cargos. Intracellular activity and proper recruitment of kinesins is regulated by biochemical signaling, cargo adaptors, microtubule-associated proteins, and mechanical forces. In this study, we found that
Eric S Fried et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 3028-3039 (2017-02-16)
The popularization of studies in membrane protein lipid phase coexistence has prompted the development of new techniques to construct and study biomimetic systems with cholesterol-rich lipid microdomains. Here, microsphere-supported biomembranes with integrated α-helical peptides, referred to as proteolipobeads (PLBs), were
Yanqi Yu et al.
ACS nano (2018-11-14)
Understanding the binding of nanoparticles to receptors on biomembranes is critical to the development and screening of therapeutic materials. A prevailing understanding is that multivalent ligand-receptor binding leads to slower and confined translational motion of nanoparticles. In contrast, we report
Michael Estl et al.
International journal of molecular sciences, 21(7) (2020-04-08)
Cytotoxic T lymphocytes (CTL) are key players of the adaptive immune system that target tumors and infected cells. A central step to that is the formation of a cell-cell contact zone between the CTL and its target called an immune
Maria J Sarmento et al.
Langmuir : the ACS journal of surfaces and colloids, 33(43), 12463-12477 (2017-09-30)
Although the evidence for the presence of functionally important nanosized phosphorylated phosphoinositide (PIP)-rich domains within cellular membranes has accumulated, very limited information is available regarding the structural determinants for compartmentalization of these phospholipids. Here, we used a combination of fluorescence
Mingming Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(25), 7509-7518 (2018-06-01)
This article reports a high-yield procedure for preparing microsized (giant) Janus liposomes via gel-assisted lipid swelling and clustering behavior of these liposomes directed by biotin-avidin affinity binding. Confocal fluorescence microscopy reveals in detail that these new lipid colloidal particles display
Chaohong Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 187(1), 230-239 (2011-05-31)
The activation of the BCR, which initiates B cell activation, is triggered by Ag-induced self-aggregation and clustering of receptors at the cell surface. Although Ag-induced actin reorganization is known to be involved in BCR clustering in response to membrane-associated Ag
Federico Amadei et al.
Langmuir : the ACS journal of surfaces and colloids, 34(46), 14046-14057 (2018-10-26)
Albeit many studies demonstrated that the accumulation of phospholipids in the intestinal mucosal surfaces is essential for the protection of colon epithelia against pathogenic bacteria, the mechanism of interactions between phospholipids and the surface protein mucin is not well understood.
Orrin Shindell et al.
Langmuir : the ACS journal of surfaces and colloids, 34(15), 4673-4680 (2018-01-25)
Artificial lipid membranes incorporating proteins have frequently been used as models for the dynamic organization of biological structures in living cells as well as in the development of biology-inspired technologies. We report here on the experimental demonstration and characterization of
Maria Tsemperouli et al.
Langmuir : the ACS journal of surfaces and colloids, 35(26), 8748-8757 (2019-06-28)
Horizontal black lipid membranes (BLMs) enable optical microscopy to be combined with the electrophysiological measurements for studying ion channels, peptide pores, and ionophores. However, a careful literature review reveals that simultaneous fluorescence and electrical recordings in horizontal BLMs have been
David K Y Zhang et al.
Nature protocols, 15(3), 773-798 (2020-01-15)
Synthetic antigen-presenting cells (APCs) are used to mediate scalable ex vivo T-cell expansion for adoptive cell therapy. Recently, we developed APC-mimetic scaffolds (APC-ms), which present signals to T cells in a physiological manner to mediate rapid and controlled T-cell expansion.
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