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Terry S Elton et al.
Gene, 532(1), 1-12 (2012-12-19)
MicroRNAs (miRNAs), a family of small nonprotein-coding RNAs, play a critical role in posttranscriptional gene regulation by acting as adaptors for the miRNA-induced silencing complex to inhibit gene expression by targeting mRNAs for translational repression and/or cleavage. miR-155-5p and miR-155-3p
Yao Xiong et al.
Life sciences, 106(1-2), 19-24 (2014-05-02)
The aim of the study was to identify expressions of Notch-1, microRNA-21 (miR-21), and phosphatase and tensin homolog (PTEN) in colorectal cancer (CRC), and to explore their relationship with clinical stages and metastatic status of CRC. 102 CRC patients were
Jeongmin Lee et al.
Cancers, 11(4) (2019-04-10)
Fine needle aspiration cytology (FNAC) and washout thyroglobulin (Tg) measurements are the standard for evaluating a metastatic lymph node (LN) in thyroid cancer. However, patients rarely benefit from these procedures due to false results. This study aims to identify a
Stefan Holdenrieder et al.
Lung cancer (Amsterdam, Netherlands), 63(1), 128-135 (2008-06-24)
The increasing panel of systemic therapies enables the individual management of cancer patients, even in advanced stages. However, diagnostic tools indicating early the efficacy of therapy are still needed. In prospectively collected sera of 161 patients with recurrent non-small cell
Takeshi Hanagiri et al.
Lung cancer (Amsterdam, Netherlands), 74(1), 112-117 (2011-03-15)
This study investigated the preoperative serum levels of CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer. This study evaluated 341 patients who had undergone a complete resection for stage I NSCLC between
S Knapp et al.
Proteins, 23(4), 595-597 (1995-12-01)
The thermostable amylopullulanase from Pyrococcus woesei was crystallized. Crystals, suitable for a crystallographic analysis up to a size of 0.6 mm in their longest dimension, have been obtained by the vapor diffusion method in a solution containing polyethyleneglycol 4000 (PEG
Erica Fan Clayton et al.
Annals of diagnostic pathology, 17(2), 192-197 (2012-12-12)
This study aimed to identify an immunohistochemical panel to aid in the differential diagnosis for tumors with clear cell morphology. Twenty-five clear cell renal cell carcinomas (CCRCCs), 19 clear cell ovarian carcinoma (CCOCs), 20 cases of adrenal cortical carcinomas(ACCs), and
Yasumasa Ogawa et al.
Environmental monitoring and assessment, 186(10), 6757-6770 (2014-07-10)
Fourteen different alkaline coal fly ashes (CFAs) were used for the experiment, in which each sample was mixed with water to be 28.6% of water content (wt/wt) and aged for 1-4 weeks at 10-30 °C. This simple treatment is advantageous
Mei Wang et al.
Journal of agricultural and food chemistry, 62(50), 12103-12111 (2014-11-11)
A high-resolution gas chromatography/mass spectrometry (GC/MS) with selected ion monitor method focusing on the characterization and quantitative analysis of ginkgolic acids (GAs) in Ginkgo biloba L. plant materials, extracts, and commercial products was developed and validated. The method involved sample
Pranav Pandya et al.
Fetal diagnosis and therapy, 31(2), 87-93 (2012-01-31)
To investigate whether measurement of maternal serum placental growth factor (PLGF) can improve the performance of first-trimester combined screening for trisomy-21 by fetal nuchal translucency (NT) thickness and serum free β-human chorionic gonadotropin (β-hCG) and PAPP-A. In singleton pregnancies attending
Harold J Burstein et al.
Investigational new drugs, 25(2), 161-164 (2006-09-14)
Rebeccamycin analog (NSC 655649) is a synthetic antibiotic cytotoxic agent thought to inhibit topoisomerase function. We sought to determine the response rate to rebeccamycin analog among patients with refractory advanced breast cancer using two different treatment schedules. Eligible patients had
O Orellana-Díaz et al.
International journal of dermatology, 27(4), 243-245 (1988-05-01)
Ninety-five cases of chancroid were studied during a 6-month period in a dermatologic service in San Salvador; 88 (92.6%) were men and 7 (7.4%) were women, with a ratio of 12.5:1. The minimum age was 13 years and the maximum
Nobuo Hoshi et al.
Medical molecular morphology, 42(2), 110-117 (2009-06-19)
Although a critical role of the endothelin (ET) system in differentiation of neural crest cells has been reported, implication of the ET system in human neuroblastic tumors has not been fully elucidated. We immunohistochemically examined for localization of ET-1, ET-3
Tsukasa Kitahashi et al.
Cancer science, 99(2), 241-245 (2008-02-15)
Epidermal growth factor receptor (EGFR) gene alterations have been found in human lung cancers. However, there is no information on the factors inducing EGFR mutations. In rodents, K-ras mutations are frequently found in many lung carcinogenesis models, but hitherto, Egfr
Ayalew Tefferi et al.
Blood, 103(9), 3547-3548 (2004-01-01)
Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). To validate as well as expand upon this novel observation, we conducted a prospective study
Mari Strengell et al.
Journal of leukocyte biology, 79(6), 1279-1285 (2006-03-23)
Dendritic cells (DCs) play an important role in innate and adaptive immune responses. In addition to their phagocytic activity, DCs present foreign antigens to naïve T cells and regulate the development of adaptive immune responses. Upon contact with DCs, activated
Ana Friães et al.
Molecular genetics and metabolism, 88(1), 58-65 (2006-01-24)
More than 90% of congenital adrenal hyperplasia (CAH) cases are caused by 21-hydroxylase deficiency. In this study, the CYP21 gene was genotyped in 56 Portuguese unrelated patients with clinical symptoms of 21-hydroxylase deficiency, in a total of 112 independent alleles.
K R Williams et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 9(10), 3631-3637 (1989-10-01)
ARPP-21 (cAMP-regulated phosphoprotein, Mr = 21,000 as determined by SDS-PAGE) is a major cytosolic substrate for cAMP-stimulated protein phosphorylation in dopamine-innervated regions of the rat CNS. It has recently been purified to homogeneity from bovine caudate nucleus and characterized (Hemmings
Si Eun Lee et al.
Obstetrics and gynecology, 109(3), 634-640 (2007-03-03)
To compare the accuracy of an immunoassay to measure levels of placental alpha-microglobulin-1 in cervicovaginal secretions with that of conventional clinical assessment for the diagnosis of rupture of membranes. A prospective observational study was performed in consecutive patients with signs
Rupa S Appa et al.
Thrombosis and haemostasis, 104(2), 243-251 (2010-05-29)
Clearance mechanisms for recombinant activated human FVII (rFVIIa; NovoSeven), a heterogeneously glycosylated protein, have yet to be fully elucidated, but may involve the liver. The effects of the gamma-carboxy glutamic acid (Gla) domain and the sialic acid content of the
Christine Sato et al.
Movement disorders : official journal of the Movement Disorder Society, 20(3), 367-370 (2004-11-02)
Parkinson's disease (PD) is a common progressive neurodegenerative disorder characterized clinically by a combination of motor symptoms. Identifying novel PD genetic risk factors is important for understanding its pathogenesis. A recent study suggested that up to 21% of subjects with
Kristen E Bower et al.
Oncogene, 23(54), 8805-8814 (2004-10-07)
p21SNFT (21 kDa small nuclear factor isolated from T cells) is a human basic leucine zipper transcription factor that can repress AP-1-mediated transcription. We show here that overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by
B P Korge et al.
The Journal of investigative dermatology, 99(6), 697-702 (1992-12-01)
Two size variants of the type II human keratin 1 protein chain, termed 1a and 1b, have been described previously. Using amplification of genomic DNA by the polymerase chain reaction and sequence analysis we show here that the difference between
Quail Das et al.
Poultry science, 100(2), 517-526 (2021-02-02)
With the pressure to reduce antibiotics use in poultry production, cost-effective alternative products need to be developed to enhance the bird's immunity. The present study evaluated the efficacy of cranberry fruit by-products to modulate immunity in broiler chickens. Broiler Cobb
Michelle Hernandez et al.
The Journal of infectious diseases, 198(12), 1862-1869 (2008-11-07)
Signaling defects in the Toll-like receptor (TLR) pathway, such as interleukin-1 receptor-associated kinase 4 deficiency, highlight the prominence of TLR signaling in the defense against bacterial disease. Because myeloid differentiation primary response gene 88 (MyD88) can transduce signals from almost
Pedram Argani et al.
The American journal of surgical pathology, 34(9), 1295-1303 (2010-08-04)
Xp11 translocation renal cell carcinoma (RCC) harbor various TFE3 gene fusions, and are known to underexpress epithelial immunohistochemical (IHC) markers such as cytokeratin and EMA relative to usual adult type RCC; however, their profile in reference to other IHC markers
Monica Else et al.
Leukemia & lymphoma, 52 Suppl 2, 75-78 (2011-04-21)
The purine analogs pentostatin and cladribine are effective treatments for hairy cell leukemia (HCL). However, alternative treatments are needed for patients with recurrent disease. We reviewed retrospectively data from 18 patients who were retreated with either pentostatin (n = 12) or cladribine
Katharina Schmölzer et al.
Bioresource technology, 108, 216-223 (2012-01-28)
We report herein on bioprocess development guided by the hydrophobicities of substrate and product. Bioreductions of o-chloroacetophenone are severely limited by instability of the catalyst in the presence of aromatic substrate and (S)-1-(2-chlorophenyl)ethanol. In situ substrate supply and product removal
Masaaki Kawahara et al.
Anticancer research, 33(10), 4631-4637 (2013-10-15)
Assessment of the efficacy of docetaxel plus carboplatin vs. paclitaxel plus carboplatin in Japanese patients with advanced non-small cell lung cancer (NSCLC). Chemotherapy-naïve patients were randomly assigned at a ratio of 2 to 1 to receive six cycles of either
H Sun et al.
American journal of clinical pathology, 115(1), 32-38 (2001-02-24)
To determine the potential role of PTEN in the process of endometrial carcinogenesis, we examined a series of endometrial carcinoma and hyperplasia of the uterine corpus for the presence of a PTEN mutation. The entire coding region of the gene
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