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显示 31-60 共 81 条结果 关于 "88-60-8" 范围 论文
Mahesh Thirunavukkarasu et al.
Antioxidants & redox signaling, 10(8), 1475-1484 (2008-04-15)
beta-Catenin, the downstream target of glycogen synthase kinase-3beta (GSK-3beta), plays a vital role in ischemic preconditioning (IP)-mediated cardioprotection. In the present study, we investigated the mechanism of IP-mediated cardioprotection through suppression of beta-catenin expression by intramyocardial injection of adeno-sh-RNA against
Sridevi Devaraj et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(7), 1359-1363 (2005-04-30)
In addition to being a cardiovascular risk marker, recent studies support a role for CRP in atherothrombosis. Several investigators have reported that CRP binds to Fcgamma receptors on leukocytes. The aim of the study is to determine the processing of
Soni Savai Pullamsetti et al.
Thrombosis and haemostasis, 95(4), 720-727 (2006-04-08)
Treatment of hemodynamic instability in septic shock often demands the administration of vasopressor agents, although these may have deleterious effects on microcirculatory homeostasis. Inhibition of nitric oxide synthase (NOS) has been suggested as an alternative therapeutic approach, as NO formation
Marta Futema et al.
Clinical chemistry, 61(1), 231-238 (2014-11-22)
Familial hypercholesterolemia (FH) is an autosomal-dominant disorder caused by mutations in 1 of 3 genes. In the 60% of patients who are mutation negative, we have recently shown that the clinical phenotype can be associated with an accumulation of common
Kosuke Miyai et al.
Cancer science, 101(9), 1970-1976 (2010-07-09)
Little is known about the pathologic significance of epidermal growth factor receptor (EGFR) expression in malignant testicular germ cell tumors (TGCTs) in adults. From the primary tumor sites of a cohort of 110 TGCT cases, we obtained 209 histologically distinct
Justin C Y Wu et al.
Journal of neurogastroenterology and motility, 26(1), 85-95 (2019-10-10)
Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and
Yvonne H Tak et al.
Journal of chromatography. A, 1267, 138-143 (2012-09-11)
In this study, in-line frit-free solid-phase extraction (SPE) has been studied for the preconcentration of analytes prior to analysis by capillary electrophoresis-mass spectrometry (CE-MS). The mixed-mode sorbent Oasis HLB was selected for the trapping of compounds of different polarity. Using
Young Hak Kim et al.
Cancer chemotherapy and pharmacology, 71(6), 1445-1451 (2013-03-28)
Single-agent chemotherapy with third-generation non-platinum agents, such as docetaxel, vinorelbine, is a standard therapeutic option for elderly patients with non-small-cell lung cancer (NSCLC). Subset analysis of a previous phase III study comparing pemetrexed with docetaxel in the second-line setting showed
Young-Chul Yoo et al.
PloS one, 10(8), e0135412-e0135412 (2015-09-01)
This study aimed to determine whether continuous deep neuromuscular blockade (NMB) improves the surgical conditions and facilitates robotic-assisted laparoscopic radical prostatectomy (RALRP) under low intra-abdominal pressure (IAP) to attenuate the increase in intraocular pressure (IOP) during CO2 pneumoperitoneum in the
Khosrow Mehrany et al.
Journal of the American Academy of Dermatology, 51(2), 205-211 (2004-07-29)
An increased frequency of hereditary hemochromatosis gene mutations occurs in patients with porphyria cutanea tarda. Polymerase chain reaction analysis of peripheral blood for hemochromatosis gene (HFE) mutations is available for clinical use. Early detection and treatment of hereditary hemochromatosis limit
Kristine L P Garcia et al.
Behavioural brain research, 274, 10-18 (2014-08-08)
Few studies investigate factors that influence acquisition in nicotine self-administration (NSA), such as food training and training dose. Most have utilized peak doses along nicotine's dose-response curve (15 and 30μg/kg) that establish NSA in the majority of animals. To investigate
I Perković et al.
European journal of medicinal chemistry, 51, 227-238 (2012-03-13)
The novel 1-acyl-4-cycloalkyl/arylsemicarbazides (5a-y) and 1-acyl-5-benzyloxy/hydroxycarbamoylcarbazides (8a-f) derived from the nonsteroidal anti-inflammatory drugs ibuprofen, fenoprofen and reduced ketoprofen were prepared, fully chemically characterized and evaluated for their cytostatic, antiviral and antioxidant activities. Compounds 5 and 8 consist of a region
Masashi Mizokami et al.
The Lancet. Infectious diseases, 15(6), 645-653 (2015-04-13)
Compared with other countries, patients with chronic hepatitis C infection in Japan tend to be older, have more advanced liver disease, and are more likely to have been previously treated for hepatitis C. We aimed to assess the efficacy and
B J Eigl et al.
Investigational new drugs, 33(4), 969-976 (2015-05-20)
SB939 is a potent oral inhibitor of class 1, 2, and 4 histone deacetylases (HDACs). These three HDAC classes are highly expressed in castration resistant prostate cancer (CRPC) and associated with poor clinical outcomes. We designed a phase II study
Jill Ophoff et al.
Endocrinology, 150(8), 3558-3566 (2009-03-07)
Muscle frailty is considered a major cause of disability in the elderly and chronically ill. However, the exact role of androgen receptor (AR) signaling in muscle remains unclear. Therefore, a postmitotic myocyte-specific AR knockout (mARKO) mouse model was created and
D Gareth Evans et al.
BMC cancer, 8, 155-155 (2008-06-03)
The identification of a BRCA1 or BRCA2 mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who test positive for the family mutation. We reviewed 385
D Uren et al.
The Journal of clinical investigation, 105(5), 663-671 (2000-03-11)
Complete ablation of nonmuscle myosin heavy chain II-B (NMHC-B) in mice resulted in cardiac and brain defects that were lethal during embryonic development or on the day of birth. In this paper, we report on the generation of mice with
Chrishan S Samuel et al.
Endocrinology, 145(9), 4125-4133 (2004-05-25)
Cardiac fibrosis is a key component of heart disease and involves the proliferation and differentiation of matrix-producing fibroblasts. The effects of an antifibrotic peptide hormone, relaxin, in inhibiting this process were investigated. We used rat atrial and ventricular fibroblasts, which
Fengchen Bi et al.
Experimental and therapeutic medicine, 21(3), 204-204 (2021-02-13)
The chaperone protein heat shock protein 60 (HSP60) is considered a tumor promoter in several types of primary human tumors, where it orchestrates a broad range of survival programs. Curcumin (CCM) is well-established to exhibit several anticancer properties with an
Teresa Jackowska et al.
Medycyna wieku rozwojowego, 12(2 Pt 2), 705-712 (2009-05-08)
the basis of urinary tract infection (UTI) diagnosis in children is based on positive results of microbiological tests. The selection of an antimicrobial drug for empirical treatment and prophylaxis of UTI is determined by the susceptibility of bacterial strains isolated
U Sahin et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(10), 3916-3922 (2000-10-29)
Cancer-testis (CT) genes are expressed in a variety of human cancers but not in normal tissues, except for testis tissue, and represent promising targets for immunotherapeutic and gene therapeutic approaches. Because little is known about their composite expression in human
Naphtali Savion et al.
PloS one, 13(3), e0194780-e0194780 (2018-03-27)
S-allylmercapto-N-acetylcysteine (ASSNAC) was shown in our previous study to activate Nrf2-mediated processes and increase glutathione level and resistance to oxidative stress in cultured endothelial cells. In this study, we explored the antioxidant protective effect of ASSNAC in Caenorhabditis elegans (C.
B Gerling et al.
Journal of hepatology, 25(1), 79-84 (1996-07-01)
The aminoterminal procollagen type-III-peptide, which can be released during collagen type III deposition, has been suggested as a serum marker of fibrogenesis in patients with chronic liver disease. However, longitudinal studies correlating procollagen type-III-peptide concentrations in serum with the evolution
Laura Ormesher et al.
Hypertension (Dallas, Tex. : 1979), 76(6), 1828-1837 (2020-10-06)
Hypertensive disease in pregnancy is associated with future cardiovascular disease and, therefore, provides an opportunity to identify women who could benefit from targeted interventions aimed at reducing cardiovascular morbidity. This study focused on the highest-risk group, women with preterm preeclampsia
Mauren M de Freitas et al.
Experimental gerontology, 132, 110835-110835 (2020-01-19)
The aim of this study was to establish the prevalence of sarcopenia and associated factors in elderly patients with type 2 diabetes mellitus (DM) according to 2010 (EWGSOP1) and 2018 (EWGSOP2) European consensus. Cross-sectional study. Elderly outpatients ≥60 years with type
BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds.
Sonali Pal-Ghosh et al.
Experimental eye research, 87(5), 478-486 (2008-09-24)
Genetically engineered mice are usually produced on a mixed genetic background and can be derived from several mouse strains including 129SvJ, C57BL6, and BALB/c. To determine whether differences in recurrent corneal epithelial erosions (RCEEs), corneal epithelial stem cell deficiency (CESCD)
Jie Wang et al.
World journal of gastroenterology, 21(27), 8314-8325 (2015-07-29)
To characterize high-mobility group protein 1-toll-like receptor 4 (HMGB1-TLR4) and downstream signaling pathways in intestinal ischemia/reperfusion (I/R) injury. Forty specific-pathogen-free male C57BL/6 mice were randomly divided into five groups (n = 8 per group): sham, control, anti-HMGB1, anti-myeloid differentiation gene
S K Urwyler et al.
Letters in applied microbiology, 62(2), 130-137 (2015-11-20)
Fast microbial identification is becoming increasingly necessary in industry to improve microbial control and reduce biocide consumption. We compared the performances of two systems based on MALDI-TOF MS (VITEK MS and BIOTYPER) and two based on biochemical testing (BIOLOG, VITEK
Nils T Vethe et al.
Therapeutic drug monitoring, 41(5), 607-614 (2019-10-05)
Therapeutic drug monitoring is standard practice for the immunosuppressant tacrolimus (Tac). Venous blood sampling at outpatient clinics is time-consuming and impractical with regard to obtaining trough concentrations on clinical visit days. Home-based blood sampling may be patient friendly and pave
Binaifer Bedford et al.
Journal of food protection, 80(4), 692-702 (2017-03-18)
Undeclared allergens in chocolate products have been responsible for numerous allergen-related recalls in the United States. A survey was conducted to determine the prevalence of undeclared milk and peanut in 88 and 78 dark chocolate bars, respectively. Concentrations of milk
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