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显示 1-30 共 87 条结果 关于 "88-73-3" 范围 论文
Minjing Zou et al.
Thyroid : official journal of the American Thyroid Association, 24(8), 1256-1266 (2014-05-07)
RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We
Valerio Napolioni et al.
Cytokine, 56(2), 481-488 (2011-08-26)
Aging is a complex phenotype with multiple determinants but a strong genetic component significantly impacts on survival to extreme ages. The dysregulation of immune responses occurring with increasing age is believed to contribute to human morbidity and mortality. Conversely, some
Jean-Sylvain Hermida et al.
The American journal of cardiology, 106(12), 1758-1762 (2010-12-04)
The familial prevalence of Brugada syndrome (BrS) in a consecutive series of patients was prospectively determined. BrS is genetically determined with autosomal dominant transmission. The familial prevalence of the BrS is unknown. A detailed pedigree of each family of patients
R Z Zhang et al.
The Biochemical journal, 291 ( Pt 3), 787-792 (1993-05-01)
cDNA clones encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI have been isolated by screening cDNA libraries with the corresponding human probes. The composite cDNAs for the alpha 1, alpha 2, and alpha 3
Maurice W J de Ronde et al.
Nederlands tijdschrift voor geneeskunde, 157(26), A6037-A6037 (2013-07-10)
In this article, we present 3 women aged 73, 85 and 88 years who developed metoclopramide-induced parkinsonism. Shortly after starting metoclopramide, bradykinesia and rigidity developed in all 3 patients; tremor and postural instability in 2 of them. We discontinued the
Noboru Hanaoka et al.
Gastrointestinal endoscopy, 82(6), 1002-1008 (2015-08-04)
Although endoscopic submucosal dissection (ESD) has been applied for superficial pharyngeal cancer, no prospective trials have been reported. To investigate the efficacy and safety of ESD for superficial pharyngeal cancer, we conducted a prospective phase II trial. Fifty-four patients with
Abdelhamid Liacini et al.
Matrix biology : journal of the International Society for Matrix Biology, 21(3), 251-262 (2002-05-16)
Interleukin-1 (IL-1), the main cytokine instigator of cartilage degeneration in arthritis, induces matrix metalloproteinase-3 (MMP-3) and MMP-13 RNA and protein in chondrocytes. The molecular mechanisms of this induction were investigated with specific inhibitors of mitogen-activated protein kinase (MAPK) signaling pathways
Joseph M Amann et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(2), 169-178 (2009-12-26)
Serum proteomics and mutations in the epidermal growth factor receptor (EGFR) and KRAS have been associated with benefit after therapy with EGFR-targeted therapies in non-small cell lung cancer, but all three have not been evaluated in any one study. Pretreatment
Wen-Qiao Wang et al.
Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen), 67(2), 307-314 (2003-04-19)
In vitro, isolates resistant to metalaxyl (M) and oxadixyl (O) of Phytophthora infestans were 11.2% of 62 isolates from potato and tomato in Hebei Province, mean resistance factor was 15,022 fold and 24,733 fold, respectively, no isolates resistant either to
P J Tatnell et al.
Biochimica et biophysica acta, 1398(1), 57-66 (1998-05-29)
A 15.6 kb genomic clone encompassing the mouse procathepsin E gene was isolated and mapped. Sequencing revealed that the gene consists of nine exons followed by a polyadenylation signal at the 3'-end. The 5'-flanking region appears to be a TATA-less
Kikuo Isoda et al.
Circulation research, 91(1), 77-82 (2002-07-13)
Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several integrins and it has been found at the site of atherosclerotic lesions. However, the role of OPN expression in vivo is still poorly understood. To investigate
Guy Bertrand Djigoué et al.
Molecules (Basel, Switzerland), 18(1), 914-933 (2013-01-25)
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the
Shanshan Chen et al.
Bioelectrochemistry (Amsterdam, Netherlands), 121, 151-159 (2018-02-18)
Microbial electrosynthesis systems (MES) are promising devices in which microbes obtain electrons from electrodes to produce extracellular multicarbon compounds. This study investigates whether improvement in cell permeability can enhance electrosynthesis performance of Gram-positive Moorella thermoautotrophica in MES. Results showed that
P Huang et al.
Molecular pharmacology, 39(4), 449-455 (1991-04-01)
The action of 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) on RNA metabolism was evaluated both in whole cells and in cell-free systems. F-ara-A was converted to its 5'-triphosphate, F-ara-ATP, in cells and then incorporated into RNA as well as DNA. F-ara-A inhibited RNA synthesis
Robert C Barber et al.
Shock (Augusta, Ga.), 30(6), 705-713 (2008-05-08)
Signaling through toll-like receptor 4 (TLR4) plays an obligate role in burn-related myocardial dysfunction. We hypothesized that signaling through CD14, a cellular receptor for endotoxin that lacks a transmembrane domain but is coupled to TLR4, also plays a role in
Narendra Kumar Sharma et al.
Journal of proteomics, 79, 277-298 (2013-01-15)
Hypoxia is one of the major stressors at high altitude. Exposure to hypobaric hypoxia induces several adverse consequences to the structural and functional integrity of brain. In an attempt to understand the proteome modulation, we used 2-DE coupled with MALDI-TOF/TOF
Y Puspitasari et al.
Microbial pathogenesis, 131, 170-174 (2019-04-13)
Pasteurella multocida B:2 is a Gram-negative organism causing haemorrhagic septicaemia (HS) in buffaloes. It causes severe pulmonary infection, leading to infiltration of numerous macrophages and neutrophils. Despite the inflammatory response, buffaloes succumb to HS. This study aims to evaluate the
Virginie Lattard et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(2), 119-128 (2002-01-17)
The expression of flavin-containing monooxygenases (FMOs) in dog liver microsomes was suggested by a high methimazole S-oxidase activity. When the reaction was catalyzed by dog liver microsomes, apparent V(max) and K(m) values were 6.3 nmol/min/mg and 14 microM, respectively. This
Hwei-Ming Peng et al.
The Journal of biological chemistry, 289(49), 33838-33849 (2014-10-16)
Two acidic residues, Glu-48 and Glu-49, of cytochrome b5 (b5) are essential for stimulating the 17,20-lyase activity of cytochrome P450c17 (CYP17A1). Substitution of Ala, Gly, Cys, or Gln for these two glutamic acid residues abrogated all capacity to stimulate 17,20-lyase
G A Pankey
Clinical pharmacokinetics, 16 Suppl 1, 46-51 (1989-01-01)
Enoxacin achieves a high penetration into skin tissue and blister fluid, reaching a maximum serum concentration (Cmax) of 3.7 mg/L at a time to reach maximum concentration (tmax) of 1.9 hours and a blister-fluid Cmax of 2.9 mg/L at a
Javier Zarranz-Ventura et al.
American journal of ophthalmology, 158(6), 1136-1145 (2014-09-15)
To identify clinical outcomes and treatment patterns of intravitreal dexamethasone implant (Ozurdex; Allergan, Inc) in noninfectious uveitis in the clinical setting. Multicenter retrospective cohort study. Eighty-two eyes (63 patients) receiving 142 implant injections over 35 months were included. Treatment indication
A J Ouellette et al.
Infection and immunity, 62(11), 5040-5047 (1994-11-01)
Cryptdins are antimicrobial peptides of the defensin family that are produced by intestinal Paneth cells. mRNAs encoding 17 cryptdin isoforms have been characterized from a cDNA library generated from a single jejunal crypt. Six cryptdin cDNAs correspond to known peptides
Chenguang Sui et al.
Oncology reports, 22(6), 1391-1396 (2009-11-04)
Pancreatic cancer is generally refractory to most chemotherapeutic agents. We investigated whether hSSTR2 expression and octreotide treatment reverse multidrug resistance of human pancreatic cancer cells. We used pancreatic cancer cells that were transfected by using a lentivirus expression system, which
Yong-Hyun Kim et al.
Analytica chimica acta, 712, 162-167 (2011-12-20)
Whole air sampling using containers such as flexible bags or rigid canisters is commonly used to collect samples of volatile organic compounds (VOC) in air. The objective of this study was to compare the stability of polyester aluminum (PEA) and
Sarat Chandarlapaty et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(24), 6784-6791 (2012-10-25)
HER2-amplified breast cancer is sometimes clinically insensitive to HER2-targeted treatment with trastuzumab. Laboratory models of resistance have causally implicated changes in HER2 expression and activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway. We conducted a prospective tissue acquisition study to determine
Katia Borgia Barbosa Pagnano et al.
Clinical lymphoma, myeloma & leukemia, 17(11), 728-733 (2017-08-22)
The prognostic significance of breakpoint cluster region gene-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL1) transcripts in chronic myeloid leukemia (CML) is still controversial. All consecutive CML patients in chronic phase treated with imatinib in a single center were analyzed
Khalid Touzani et al.
The European journal of neuroscience, 30(2), 289-298 (2009-07-21)
This study examined the role of dopamine within the amygdala (AMY) in flavor preference learning induced by post-oral glucose. In Experiment 1, rats were trained with a flavor [conditioned stimulus (CS+)] paired with intragastric (IG) infusions of 8% glucose and
Shishir K Maithel et al.
Annals of surgical oncology, 18(9), 2699-2705 (2011-03-02)
Increased tumor expression of excision repair cross-complementing gene-1 (ERCC1) is associated with decreased survival in patients with various cancers. Its effect in pancreatic adenocarcinoma (PAC) is not defined. Ninety-five patients were selected from a prospective database of all patients (nxa0=xa0220)
Amanda M Fretts et al.
The British journal of nutrition, 112(7), 1206-1213 (2014-08-28)
Previous studies have suggested that long-chain n-3 fatty acids derived from seafood are associated with a lower risk of mortality, CHD and stroke. Whether α-linolenic acid (ALA, 18 : 3n-3), a plant-derived long-chain essential n-3 fatty acid, is associated with a lower
O L van der Hel et al.
European journal of cancer (Oxford, England : 1990), 118, 97-104 (2019-07-22)
About 5% of ovarian tumours have a non-epithelial histology, including germ cell tumours (GCTs), sex cord-stromal tumours (SCSTs) and sarcomas. Because these non-epithelial ovarian tumours are rare and population-based studies are scarce, the aim of this population-based study is to
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