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Yang Han et al.
Drug delivery, 27(1), 502-518 (2020-04-02)
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on
Huamei He et al.
Journal of controlled release : official journal of the Controlled Release Society, 323, 387-397 (2020-04-25)
Chemotherapy is an important modality available for cancer treatment. However, the present chemotherapy is still far from being satisfactory mainly owing to the severe side effects of the chemotherapeutic agents and drug resistance of cancer cells. Thus, reversing drug resistance
Chung-Yin Lin et al.
Journal of controlled release : official journal of the Controlled Release Society, 321, 519-528 (2020-03-01)
Ultrasound-targeted microbubble destruction (UTMD) in conjunction with neurotrophic factors (NFs) gene delivery has the potential to facilitate the penetration of therapeutic genes into the brain for neuroprotective therapy against neurodegenerative diseases. We previously presented a gene delivery system that conjugates
Olga B Garbuzenko et al.
Theranostics, 9(26), 8362-8376 (2019-11-23)
Non-Small Cell Lung Carcinoma (NSCLC), is the most common type of lung cancer (more than 80% of all cases). Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC
Milda Naciute et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 152, 183-192 (2020-05-08)
The aim of this study was to develop an oral vaccine that could be used to treat colorectal cancer. Oral vaccines are technically challenging to develop due to the harsh gastric environment but have numerous benefits including high patient acceptability
Impact of hapten presentation on antibody binding at lipid membrane interfaces
Jung H, et al.
Biophysical Journal, 94(8), 3094-3103 (2008)
I Osorio-Querejeta et al.
Pharmaceutics, 12(2) (2020-02-27)
Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by
Milan Gautam et al.
Expert opinion on drug delivery, 17(3), 423-434 (2020-02-08)
Background: Phytosterols significantly reduce the risk of cancer by directly inhibiting tumor growth, inducing apoptosis, and inhibiting tumor metastasis. Stigmasterol (STS), a phytosterol, exhibits anticancer effects against various cancers, including breast cancer. Chemotherapeutics, including doxorubicin (DOX), might act synergistically with
Stabilization and immobilization of aquaporin reconstituted lipid vesicles for water purification
Sun G, et al.
Colloids and Surfaces. B, Biointerfaces, 102, 466-471 (2013)
Claudia Caviglia et al.
Analytical and bioanalytical chemistry (2020-05-27)
Evaluation and understanding the effect of drug delivery in in vitro systems is fundamental in drug discovery. We present an assay based on real-time electrical impedance spectroscopy (EIS) measurements that can be used to follow the internalisation and cytotoxic effect
Man Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 321, 23-35 (2020-02-09)
Immunotherapy has exhibited great potential in cancer treatment. However, for immunosuppressive tumors such as pancreatic cancer, immunotherapy is far from satisfactory. PI3K-γ and colony stimulating factor-1/colony stimulating factor-1 receptor (CSF-1/CSF-1R) pathways are involved in the infiltration and polarization of immunosuppressive
Rathapon Asasutjarit et al.
International journal of pharmaceutics, 577, 119084-119084 (2020-01-29)
Ganciclovir (GCV) is an antiviral drug approved for treatment of cytomegalovirus (CMV) retinitis. It can be delivered to the eye via systemic administrations. However, local delivery of GCV that targets the retina is considered as an alternative to increase efficacy
Anujan Ramesh et al.
Biomaterials, 227, 119559-119559 (2019-11-02)
Among the numerous immune interactions, or lack-thereof, that occur during cancer progression, tumor-associated macrophages (TAMs) - cancer cell interactions have been shown to play an important role in modulating the tumor-microenvironment to an immune suppressive mode, promoting accelerated tumor growth
Venugopal Vangala et al.
Molecular pharmaceutics, 17(6), 1859-1874 (2020-04-29)
Glioblastoma multiforme (GBM) is one of the most aggressive tumors with a median survival of only 15 months. Effective therapeutics need to overcome the formidable challenge of crossing the blood-brain barrier (BBB). Receptors and transporters overexpressed on BCECs are being
Ruben V Huis In 't Veld et al.
Journal of controlled release : official journal of the Controlled Release Society, 320, 19-31 (2020-01-04)
In cancer treatment, nanomedicines may be employed in an attempt to improve the tumor localization of antineoplastic drugs e.g. immunotherapeutic agents either through passive or active targeting, thereby potentially enhancing therapeutic effect and reducing undesired off-target effects. However, a large
Yi Zhao et al.
Nature communications, 7, 11822-11822 (2016-06-07)
Metformin, a widely implemented anti-diabetic drug, exhibits potent anticancer efficacies. Herein a polymeric construction of Metformin, PolyMetformin (PolyMet) is successfully synthesized through conjugation of linear polyethylenimine (PEI) with dicyandiamide. The delocalization of cationic charges in the biguanide groups of PolyMet
Yi Zhang et al.
Analytical chemistry, 92(5), 3990-3997 (2020-02-06)
Mercury (Hg), as a highly harmful environmental pollutant, poses severe ecological and health risks even at low concentrations. Accurate and sensitive methods for detecting Hg2+ ions in aquatic environments are highly needed. In this work, we developed a highly sensitive
Hong Ding et al.
Nanotechnology, 25(5), 055101-055101 (2014-01-11)
The blood-brain barrier (BBB) is considered as the primary impediment barrier for most drugs. Delivering therapeutic agents to the brain is still a big challenge to date. In our study, a dual mechanism, receptor mediation combined with external non-invasive magnetic
Outi Supponen et al.
The Journal of the Acoustical Society of America, 147(5), 3236-3236 (2020-06-04)
Microbubble translations driven by ultrasound-induced radiation forces can be beneficial for applications in ultrasound molecular imaging and drug delivery. Here, the effect of size range in microbubble populations on their translations is investigated experimentally and theoretically. The displacements within five
Landscape phage fusion protein-mediated targeting of nanomedicines enhances their prostate tumor cell association and cytotoxic efficiency
Jayanna PK, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 6(4), 538-546 (2010)
Xiangru Wen et al.
PloS one, 9(9), e106652-e106652 (2014-09-05)
Magnetic poly (D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) were fabricated from PLGA, L-α-phosphatidylethanolamine (DOPE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino (polyethylene glycol) (DSPE-PEG-NH2), and magnetic nanoparticles (NPs), and then conjugated to trans-activating transcriptor (TAT) peptide. The TAT-MPLs were designed to target the brain by magnetic guidance and
Elizabeth D Hood et al.
Bioconjugate chemistry, 29(11), 3626-3637 (2018-09-22)
Liposomes are a proven, versatile, and clinically viable technology platform for vascular delivery of drugs and imaging probes. Although targeted liposomes have the potential to advance these applications, complex formulations and the need for optimal affinity ligands and conjugation strategies
Vasanth S Murali et al.
Experimental biology and medicine (Maywood, N.J.), 240(9), 1147-1151 (2015-02-11)
Polyethylene glycol (PEG) and related polymers are often used in the functionalization of carbon nanomaterials in procedures that involve sonication. However, PEG is very sensitive to sonolytic degradation and PEG degradation products can be toxic to mammalian cells. Thus, it
Federico Perche et al.
Cancer biology & therapy, 13(12), 1205-1213 (2012-08-16)
To determine whether the spheroid culture can be used to evaluate drug efficacy, we have evaluated the toxicity of free or carrier-associated doxorubicin as a single drug or in combination with other antineoplastic agents using the spheroid cultures of drug-resistant
Angel Tan et al.
Materials (Basel, Switzerland), 13(4) (2020-02-28)
Both lamellar and non-lamellar configurations are naturally present in bio-membranes, and the synthetic lipid-based liquid crystalline nano-assemblies, mimicking these unique structures, (including liposomes, cubosomes and hexosomes) are applicable in the controlled delivery of bioactives. However, it remains uncertain whether these
Maria Angela Castriciano et al.
Nanomaterials (Basel, Switzerland), 10(2) (2020-01-25)
Clusters of superparamagnetic iron oxide nanoparticles (SPIONs) have been incorporated into the hydrophobic core of polyethylene glycol (PEG)-modified phospholipid micelles. Two different PEG-phospholipids have been selected to guarantee water solubility and provide an external corona, bearing neutral (SPIONs@PEG-micelles) or positively
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