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显示 1-18 共 18 条结果 关于 "89-05-4" 范围 论文
Bharti Balhara et al.
Endocrinology, 156(6), 2039-2048 (2015-03-27)
Donohue syndrome (DS) is characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced
E Wesley Ely et al.
Critical care medicine, 35(1), 112-117 (2006-11-30)
To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium. Prospective, observational cohort study. A 541-bed, community-based teaching hospital. Fifty-three mechanically ventilated intensive care unit patients. None. All patients were managed with standardized
Gregor Theilmeier et al.
Blood, 99(12), 4486-4493 (2002-05-31)
Platelets are thought to play a causal role during atherogenesis. Platelet-endothelial interactions in vivo and their molecular mechanisms under shear are, however, incompletely characterized. Here, an in vivo platelet homing assay was used in hypercholesterolemic rabbits to track platelet adhesion
Vijayalakshmi Ananthanarayanan et al.
American journal of clinical pathology, 142(1), 82-87 (2014-06-14)
To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions. Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n = 17), and "suspicious for mesothelioma" (n
Shujun Sun et al.
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 20(24), 1116-1119 (2007-03-16)
To study the expression of eukaryotic initiation factor4E (eIF4E)and matrix metalloproteinase-9 (MMP-9) in supraglottic, hypopharyngeal carcinoma, different distance surgical margins and lymphatic metastasis; to study the relationship of two molecular markers. Expression of elF4E and MMP-9 in carcinoma and different
Demidmaa Tuvdendorj et al.
Surgery, 149(5), 645-653 (2011-02-22)
We recently showed that mechanisms of protein turnover in skeletal muscle are unresponsive to amino acid (AA) infusion in severely burned pediatric patients at 6 months postinjury. In the current study, we evaluated whether oxandrolone treatment affects mechanisms of protein
Leah Winer et al.
JAMA neurology, 70(2), 201-207 (2012-11-14)
Therapies designed to decrease the level of SOD1 are currently in a clinical trial for patients with superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis (ALS). To determine whether the SOD1 protein in cerebral spinal fluid (CSF) may be a pharmacodynamic
Elias Jabbour et al.
Blood, 117(13), 3641-3647 (2010-12-16)
Hematopoietic stem cell transplantation (HSCT) is effective therapy for patients with chronic myelogenous leukemia (CML) but is now mostly indicated for patients who develop resistance to tyrosine kinase inhibitors (TKIs), which can be associated with point mutations in BCR-ABL1. We
Tyler M Bauman et al.
Human pathology, 46(11), 1744-1751 (2015-09-08)
Single Ig IL-1-related receptor (SIGIRR) is a negative regulator of toll-like receptor 4 and IL-1-mediated activation of nuclear factor κ-light-chain enhancer of activated B cells. The purpose of this study was to qualitatively and quantitatively determine SIGIRR protein expression in
Norbert W Guldner et al.
The Journal of thoracic and cardiovascular surgery, 143(5), 1152-1159 (2011-12-14)
An IgG and granulocyte-activating immune response with secondary dystrophic calcification might be the reason glutaraldehyde (GA)-fixed xenograft valves fail, especially in young patients, who are more immunocompetent than the elderly. Titanium nanocoating on GA-fixed bovine pericardium was tested for its
Corbin Jacobs et al.
International journal of radiation oncology, biology, physics, 89(4), 729-735 (2014-05-29)
This pilot study investigates the role of DOC-2/DAB2 Interacting Protein (DAB2IP) and enhancer of zeste homolog 2 (EZH2) as prognostic biomarkers in high-risk prostate cancer patients receiving definitive radiation therapy. Immunohistochemistry was performed and scored by an expert genitourinary pathologist.
Zhenwen Chen et al.
European journal of clinical investigation, 42(3), 310-320 (2011-09-02)
Topoisomerase IIα (topo IIα) protein expression has prognostic significance in many cancers. However, it is still unclear whether topo IIα protein expression and gene alterations play roles as prognostic factors in diffuse large B-cell lymphoma (DLBCL). We selected 102 patients
Manish Mani Subramaniam et al.
Archives of pathology & laboratory medicine, 135(8), 1001-1009 (2011-08-04)
Synovial sarcomas are mesenchymal tumors with epithelial nature and comprise biphasic and monophasic fibrous subtypes. However, factors determining epithelial or spindle cell differentiation are still unexplored. Aberrant epithelial-mesenchymal transition has been implicated in the pathogenesis of diverse human malignancies. To
Elin Chorell et al.
The British journal of nutrition, 110(1), 116-126 (2012-12-12)
The gut microbiome interacts with the host in the metabolic response to diet, and early microbial aberrancies may be linked to the development of obesity and metabolic disorders later in life. Probiotics have been proposed to affect metabolic programming and
Sally N Adebamowo et al.
International journal of stroke : official journal of the International Stroke Society, 10(7), 1093-1100 (2015-06-06)
Intakes of magnesium, potassium, and calcium have been inversely associated with the incidence of hypertension, a known risk factor for stroke. However, only a few studies have examined intakes of these cations in relation to risk of stroke. The aim
M A Pericak-Vance et al.
JAMA, 278(15), 1237-1241 (1997-10-23)
Four genetic loci have been identified as contributing to Alzheimer disease (AD), including the amyloid precursor protein gene, the presenilin 1 gene, the presenilin 2 gene, and the apolipoprotein E gene, but do not account for all the genetic risk
Stephanie M Cohen et al.
American journal of surgery, 204(6), 895-900 (2012-12-13)
Sorafenib (SO), a multikinase-targeted inhibitor in clinical trials for papillary and anaplastic cancers, shows limited efficacy with moderate toxicity. Withaferin A (WA), a natural withanolide, shows potent preclinical anticancer activity in thyroid cancers through multiple cytotoxic mechanisms including heat-shock protein
Katharina Fleischhauer et al.
The Lancet. Oncology, 13(4), 366-374 (2012-02-22)
The risks after unrelated-donor haemopoietic-cell transplantation with matched HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 alleles between donor and recipient (10/10 matched) can be decreased by selection of unrelated donors who also match for HLA-DPB1; however, such donors are difficult to find.
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