90-04-0

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Pharmacokinetic interactions of OBE001 and betamethasone in healthy female volunteers.

O Pohl et al.

Journal of clinical pharmacy and therapeutics, 40(3), 328-332 (2015-04-23)

To treat preterm labour, antenatal corticosteroids and tocolytics are often co-administered. OBE001 is an orally active oxytocin receptor antagonist under development for preterm labour treatment. Co-administration of OBE001 and betamethasone to determine pharmacokinetic interactions was studied during an open-label, randomized

Four polymorphisms of the CAPN 10 gene and their relationship to polycystic ovary syndrome susceptibility: a meta-analysis.

Miaoling Huang et al.

Clinical endocrinology, 76(3), 431-438 (2011-09-13)

To investigate the association between CAPN 10 gene polymorphism and polycystic ovary syndrome (PCOS) susceptibility. Meta-analysis of published case-control studies of four single nucleotide polymorphisms (SNPs) in CAPN 10 and PCOS susceptibility. Women with PCOS. Odds ratios (ORs) and 95%

Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial.

Timo Mäkikallio et al.

Lancet (London, England), 388(10061), 2743-2752 (2016-11-05)

Coronary artery bypass grafting (CABG) is the standard treatment for revascularisation in patients with left main coronary artery disease, but use of percutaneous coronary intervention (PCI) for this indication is increasing. We aimed to compare PCI and CABG for treatment

Anthracyclines during induction therapy in acute myeloid leukaemia: a systematic review and meta-analysis.

Oliver Teuffel et al.

British journal of haematology, 161(2), 192-203 (2013-02-13)

This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in

Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy.

Ananth Shankar et al.

British journal of haematology, 165(4), 534-544 (2014-04-24)

The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]

A comparison between intensive and conventional cabergoline treatment of newly diagnosed patients with macroprolactinoma.

Ashu Rastogi et al.

Clinical endocrinology, 79(3), 409-415 (2013-01-26)

Intensive treatment with cabergoline may lead to earlier reduction in prolactin and tumour volume in comparison to conventional schedule. To compare the efficacy and safety of two different dosing schedules of cabergoline in patients with macroprolactinoma. Prospective, randomized trial in

Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel-arm, open-label study.

Gian Luca Forni et al.

British journal of haematology, 158(2), 274-282 (2012-05-11)

Neridronate is a third generation bisphosphonate with established efficacy in metabolic bone disease. In this randomized, open-label study, 118 adults with β-thalassaemia and bone mineral density (BMD) Z scores ≤-2·0 were randomized 1:1-500 mg calcium with 400 international unis (iu)

A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1.

E C Engle et al.

American journal of human genetics, 60(5), 1150-1157 (1997-05-01)

Hereditary isolated congenital ptosis is an autosomal dominant disorder with incomplete penetrance characterized by a variable degree of unilateral or bilateral drooping of the upper eyelids. We report linkage of this disorder in a large family to markers on chromosome

Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome.

Bunyong Phakdeekitcharoen et al.

Clinical endocrinology, 74(2), 152-159 (2010-11-04)

In Conn's syndrome, hypokalaemia normally results from renal potassium loss because of the effect of excess aldosterone on Na(+) -K(+) -ATPase in principal cells. Little is known about the effect of aldosterone on cellular potassium redistribution in skeletal muscle. Our

Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor-hematopoietic cell transplantation.

S Giebel et al.

Transplantation proceedings, 38(1), 287-291 (2006-03-01)

In a previous study we demonstrated that incompatibility regarding ligands for inhibitory killer immunoglobulin-like receptors (KIRs) is associated with a survival advantage following unrelated donor-hematopoietic cell transplantation (URD-HCT). The goal of the present analysis was to evaluate whether genotype of

Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease.

B Ziedén et al.

Arteriosclerosis, thrombosis, and vascular biology, 19(4), 967-971 (1999-04-09)

The mortality in coronary heart disease among 50- to 54-year-old men is 4 times higher in Lithuania than in Sweden. It was recently suggested that traditional risk factors could not explain this mortality difference. LDL of Lithuanian men showed, however

Basal and meal-stimulated ghrelin, PYY, CCK levels and satiety in lean women with polycystic ovary syndrome: effect of low-dose oral contraceptive.

Gulcan Arusoglu et al.

The Journal of clinical endocrinology and metabolism, 98(11), 4475-4482 (2013-09-05)

Ghrelin is an orexigenic peptide that stimulates food intake, whereas peptide YY (PYY) and cholecystokinin (CCK) are anorexigenic gut hormones. Patients with polycystic ovary syndrome (PCOS) appear to have alterations in appetite regulation. We aimed to determine whether fasting or

Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger.

Denise Baratti-Mayer et al.

The Lancet. Global health, 1(2), e87-e96 (2014-08-12)

Noma is a poorly studied disease that leads to severe facial tissue destruction in children in developing countries, but the cause remains unknown. We aimed to identify the epidemiological and microbiological risk factors associated with noma disease. We did a

Surgical ablation of atrial fibrillation concomitant to coronary-artery bypass grafting provides cost-effective mortality reduction.

J Scott Rankin et al.

The Journal of thoracic and cardiovascular surgery, 160(3), 675-686 (2019-10-16)

Data on the longitudinal impact of surgical ablation (SA) for atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG) remain limited. This study examined 2-year risk-adjusted mortality and total hospital costs in Medicare beneficiaries with AF requiring CABG

Effectiveness of Parasagittal Interlaminar Epidural Local Anesthetic with or without Steroid in Chronic Lumbosacral Pain: A Randomized, Double-Blind Clinical Trial.

Babita Ghai et al.

Pain physician, 18(3), 237-248 (2015-05-23)

Epidural injections (EI) are the most commonly performed minimally invasive intervention to manage chronic low back pain (CLBP) with lumbosacral radicular pain (LRP). Local anesthetic (LA) and/or steroids are frequently used injectates for EI and are reported with variable effectiveness.

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