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Venkata K Yellepeddi et al.
Anticancer research, 32(9), 3651-3658 (2012-09-21)
Cisplatin-resistance is one of the major challenges in the treatment of epithelial ovarian cancer. Small-molecule chemosensitizers provide a therapeutically feasible approach to overcome cisplatin resistance in ovarian cancer. However, proper selection of chemosensitizer is of prime importance owing to phenotypic
Efficient and reusable amine-functionalized polyacrylonitrile fiber catalysts for Knoevenagel condensation in water.
Li G
Green Chemistry, 14(8), 2234-2242 (2012)
Peter J Baker et al.
Macromolecular bioscience, 14(11), 1619-1626 (2014-08-27)
We report the encapsulation of three different proteases in bioinspired silica. Silica particles were formed under mild reaction conditions using cationic amine-rich ethyleneamines as initiators, which resulted in aggregations of nanoscale spheres. Following encapsulation, the proteases were characterized for their
Marc Cerrada-Gimenez et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(12), 2242-2249 (2011-09-01)
Triethylenetetramine (TETA) is an efficient copper chelator that has versatile clinical potential. We have recently shown that spermidine/spermine-N(1)-acetyltransferase (SSAT1), the key polyamine catabolic enzyme, acetylates TETA in vitro. Here, we studied the metabolism of TETA in three different mouse lines:
Shigehiro Kagaya et al.
Talanta, 147, 342-350 (2015-11-26)
The effect of the molecular weight of polyethyleneimine (PEI), defined as a compound having two or more ethyleneamine units, and of its carboxymethylation rate (CM/N), represented by the ratio of ion-exchange capacity to the amount of N on the resin
Hsiang-Ju Hsiao et al.
The American journal of emergency medicine, 31(1), 272-272 (2012-08-11)
Children with both headache and hypertension present a relatively rare condition with a broad range of differential diagnoses in pediatric emergency medicine. Some possible diagnoses are potentially life-threatening conditions and merit aggressive evaluation management. We report a case of a
A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper.
B Sarkar et al.
Proceedings of the Royal Society of Medicine, 70 Suppl 3, 13-18 (1977-01-01)
Güneş Süheyla Kürkçüoğlu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 94, 110-118 (2012-04-21)
The cyano bridged complex of triethylenetetramine was characterized by FT-IR, Raman spectroscopy and X-ray single crystal diffraction analysis. The molecular geometry and vibrational frequencies of the complex in the ground state have been calculated by using B3LYP density functional method
Garth J S Cooper
Drugs, 71(10), 1281-1320 (2011-07-21)
This article reviews recent evidence, much of which has been generated by my group's research programme, which has identified for the first time a previously unknown copper-overload state that is central to the pathogenesis of diabetic organ damage. This state
Bomi Kim et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 20(4), 606-608 (2013-01-01)
Trientine (triethylenetetramine dihydrochloride) is a copper-chelating agent used to treat patients with Wilson's disease (WD). It has been considered safe, rarely causing neurological deterioration during initial treatment. We describe a patient diagnosed with WD who became neurologically disabled after treatment
Siqing Fu et al.
Molecular cancer therapeutics, 11(6), 1221-1225 (2012-04-12)
Low levels of human copper transporter 1 (hCtr1) mRNA are associated with a shorter progression-free survival after platinum-based therapy. Pretreatment with a copper-lowering agent such as trientine enhanced hCtr1-mediated platinum uptake. Therefore, we conducted a pilot study (NCT01178112) of carboplatin
Triethylenetetramine (TETA)-assisted synthesis, dynamic growth mechanism, and photoluminescence properties of radial single-crystalline ZnS nanowire bundles.
Liu J
Journal of Crystal Growth, 311(5), 1423-1429 (2009)
Jonathan H Brumbach et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(1), 111-119 (2012-01-31)
The clinical success of non-viral gene delivery reagents is hampered by their inefficient cellular transgene delivery, which is largely influenced by carrier properties that are currently undefined and misunderstood. In an attempt to further define and understand the requirements for
Arun A Yadav et al.
Journal of inorganic biochemistry, 126, 1-6 (2013-05-28)
The bis(thiohydrazide) amide elesclomol has extremely potent antiproliferative activity and is currently in clinical trials as an anticancer agent. Elesclomol strongly binds copper and may be exerting its cell growth inhibitory effects by generating copper-mediated oxidative stress. Nickel(II) and platinum(II)
Lisa Logie et al.
Diabetes, 61(6), 1423-1433 (2012-04-12)
In recent decades, the antihyperglycemic biguanide metformin has been used extensively in the treatment of type 2 diabetes, despite continuing uncertainty over its direct target. In this article, using two independent approaches, we demonstrate that cellular actions of metformin are
Masaru Harada et al.
Internal medicine (Tokyo, Japan), 50(14), 1461-1464 (2011-07-16)
A 37-year-old man was diagnosed with Wilson disease at the age of 14. His first manifestations were neurological. He was treated with trientine for more than 10 years and suffered from anemia and liver dysfunction. Wilson disease is a genetic
Jun Lu
Molecular cancer therapeutics, 9(9), 2458-2467 (2010-07-28)
Triethylenetetramine (TETA), a Cu(II)-selective chelator, is commonly used for the treatment of Wilson's disease. Recently, it has been shown that TETA can be used in the treatment of cancer because it possesses telomerase inhibiting and anti-angiogenesis properties. Although TETA has
Fabrizio Carta et al.
Journal of medicinal chemistry, 53(15), 5511-5522 (2010-07-02)
Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, phenols, and coumarins. Polyamines such as spermine, spermidine, and many synthetic congeners are described to constitute a novel class of CA inhibitors (CAIs), interacting with the different CA isozymes with efficiency
A copper for your thoughts.
Robert A Coates
Journal of insurance medicine (New York, N.Y.), 43(2), 112-115 (2012-08-11)
Lars Roll et al.
Frontiers in cellular neuroscience, 14, 102-102 (2020-06-09)
The mammalian central nervous system (CNS) is characterized by a severely limited regeneration capacity. Comparison with lower species like amphibians, which are able to restore even complex tissues after damage, indicates the presence of an inhibitory environment that restricts the
Mario Arciello et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 24(2), 269-278 (2010-12-09)
The role of copper in the toxicity of mutant copper-dependent enzyme superoxide dismutase (SOD1) found in patients affected with the familial form of amyotrophic lateral sclerosis (fALS) is widely debated. Here we report that treatment of human neuroblastoma cells SH-SY5Y
Rupert Purchase
Science progress, 96(Pt 1), 19-32 (2013-06-07)
Wilson's disease is a rare autosomal recessive disease characterised by the deposition of copper in the brain, liver; cornea, and other organs. The overload of copper inevitably leads to progressive liver and neurological dysfunction. Copper overload in patients with Wilson's
Hisao Hayashi et al.
Medical molecular morphology, 45(2), 105-109 (2012-06-22)
This is the first report describing the liver structures of a Japanese patient with idiopathic copper toxicosis, which should be differentiated from hepatolenticular degeneration of Wilson disease. An 11-year-old Japanese boy presented with ascites associated with biochemical liver damage. Involvement
Walter Christopher Wilfong et al.
ChemSusChem, 8(12), 2041-2045 (2015-05-28)
Rapid testing of hydrophilic and hydrophobic basic immobilized amine sorbents (BIAS) for CO2 capture stability under practical conditions was achieved by direct contact of the sorbents with flowing liquid water. Losses in both CO2 capture capacity and amine content of
Petra Sucha et al.
Neurochemical research, 45(1), 68-82 (2019-10-31)
Hapln4 is a link protein which stabilizes the binding between lecticans and hyaluronan in perineuronal nets (PNNs) in specific brain regions, including the medial nucleus of the trapezoid body (MNTB). The aim of this study was: (1) to reveal possible
Wilson's disease--treatment of psychiatric manifestations in pregnancy.
Anne M Rich et al.
Psychosomatics, 53(2), 175-177 (2012-03-20)
Margherita Sini et al.
European journal of gastroenterology & hepatology, 25(1), 111-117 (2012-09-27)
Wilson's disease (WD) is a rare inborn disease related to copper storage, leading to liver cirrhosis and neuropsychological deterioration. The aim of this study was to determine the clinical presentation and long-term outcome, and to examine the progression of hepatic
Pushpjeet Kanwar et al.
The Medical clinics of North America, 98(1), 87-102 (2013-11-26)
Hereditary hemochromatosis and Wilson disease are autosomal recessive storage disorders of iron and copper overload, respectively. These metals are involved in multiple redox reactions, and their abnormal accumulation can cause significant injury in the liver and other organs. Over the
Kevin Jooß et al.
Analytical and bioanalytical chemistry, 409(26), 6057-6067 (2017-08-13)
Capillary zone electrophoresis (CZE) is a powerful tool that is progressively being applied for the separation of monoclonal antibody (mAb) charge variants. Mass spectrometry (MS) is the desired detection method concerning identification of mAb variants. In biopharmaceutical applications, there exist
Charles O'Doherty et al.
Biochemical and biophysical research communications, 524(4), 847-852 (2020-02-13)
Homeostasis of metal micronutrients such as copper is tightly regulated to ensure deficiency does not occur while restricting damage resulting from excess accumulation. Using LC-MS the effect on the proteome of intestinal Caco-2 cells of exposure to the chelator triethylenetetramine (TETA)
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