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Guo-Yang Zhao et al.
Biological trace element research, 150(1-3), 487-495 (2012-10-12)
Bone metabolism has a close relationship with iron homeostasis. To examine the effects of iron excess and iron deficiency on the biological activities of osteoblast in vitro, human osteoblast cells (hFOB1.19) were incubated in a medium supplemented with 0-200 μmol/L ferric
Jaya P Gnana-Prakasam et al.
Investigative ophthalmology & visual science, 52(6), 3751-3758 (2011-03-02)
GPR91, a succinate receptor, is expressed in retinal ganglion cells and induces vascular endothelial growth factor (VEGF) expression. RPE also expresses VEGF, but whether this cell expresses GPR91 is not known. Excessive iron is also proangiogenic, and hemochromatosis is associated
Jirapas Sripetchwandee et al.
Life sciences, 92(4-5), 298-304 (2013-01-22)
Although iron overload induces oxidative stress and brain mitochondrial dysfunction, and is associated with neurodegenerative diseases, brain mitochondrial iron uptake has not been investigated. We determined the role of mitochondrial calcium uniporter (MCU) in brain mitochondria as a major route
Gabriela A Salvador et al.
Neurotoxicology, 32(1), 75-82 (2010-12-07)
Excessive neuronal iron has been proposed to contribute to the pathology of several neurodegenerative diseases including Alzheimer's and Parkinson's diseases. This work characterized human neuroblastoma IMR-32 cells exposure to ferric ammonium citrate (FAC) as a model of neuronal iron overload
Donald J Messner et al.
Digestive diseases and sciences, 58(7), 1899-1908 (2013-04-06)
Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma. To identify potential role(s) of iron in NAFLD, we measured its effects on pathways of oxidative stress and insulin
Dola Das et al.
PloS one, 5(7), e11420-e11420 (2010-07-14)
Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear. Using cell models of familial prion disorders, we demonstrate that
Yupeng Feng et al.
Journal of biomedicine & biotechnology, 2012, 434878-434878 (2012-04-27)
An emerging MRI reporter, ferritin heavy chain (FTH1), is recently applied to enhance the contrast and increase the sensitivity of MRI in the monitoring of solid tumors. However, FTH1-overexpression-related cytotoxicity is required to be explored. By using the Tet-Off system
Satoru Morita et al.
Japanese journal of radiology, 27(10), 423-429 (2009-12-26)
To compare three-dimensional segmented true fast imaging with steady-state precession magnetic resonance cholangiopancreatography (3D-trueFISP-MRCP) to conventional MRCP sequences with an oral negative contrast agent for diagnosing juxtapapillary diverticulum. A total of 42 patients with (n = 21) and without (n
Fabia Febbraro et al.
Neuroreport, 23(9), 576-580 (2012-05-15)
Several studies have suggested an interaction between α-synuclein protein and iron in Parkinson's disease. The presence of iron together with α-synuclein in Lewy bodies, the increase of iron in the substantia nigra and the correlation between polymorphism of the several
Anja Hausmann et al.
FEBS letters, 585(4), 687-692 (2011-02-02)
Iron regulatory protein 2 (IRP2) is a critical switch for cellular and systemic iron homeostasis. In iron-deficient or hypoxic cells, IRP2 binds to mRNAs containing iron responsive elements (IREs) and regulates their expression. Iron promotes proteasomal degradation of IRP2 via
Peng Jia et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(11), 1843-1852 (2012-05-10)
Iron overload is widely regarded as a risk factor for osteoporosis. It has been demonstrated that iron can inhibit osteoblast differentiation. However, the effects of iron on osteoclast differentiation and bone resorption remain controversial. In this study, we found that
Claudio A Álvarez et al.
Developmental and comparative immunology, 41(1), 77-81 (2013-04-23)
Hepcidin is a small, cationic peptide which displays antimicrobial activities and iron regulatory function. Originally identified in mammals, this peptide is also present in fish. Hepcidin mRNA is predominantly expressed in liver and is regulated by iron and pathogen infection.
C Salis et al.
Neurochemistry international, 61(5), 798-806 (2012-07-11)
The differentiation of myelin-forming Schwann cells (SC) is completed with the appearance of myelin proteins MBP and P(0) and a concomitant downregulation of markers GFAP and p75NTR, which are expressed by immature and adult non-myelin-forming SC. We have previously demonstrated
Peng Jia et al.
Zhonghua yi xue za zhi, 92(31), 2214-2218 (2012-11-20)
To explore the effects of ferric ion on the differentiation from both RAW264.7 and bone marrow macrophages to osteoclast in vitro and bone resorption in vivo. In the presence of 50 ng/ml receptor activator of nuclear factor kappa-B ligand (RANKL)
Yulia Pollak et al.
Journal of neural transmission (Vienna, Austria : 1996), 120(1), 37-48 (2012-03-27)
Iron accumulation and iron-related oxidative stress are involved in several pathological conditions and provide a rationale for the development of iron chelators as novel promising therapeutic strategies. Thus, we have recently synthesized multifunctional non-toxic, brain permeable iron chelating compounds, M30
Harsh Vardhan et al.
Cell biology international, 35(8), 793-798 (2011-03-19)
Chlamydia trachomatis is the leading cause of sexually transmitted infection worldwide, in which disease outcome is determined by the balance between pro- and anti-inflammatory host immune responses. Iron plays important roles in regulation and enhancement of various pro- and anti-inflammatory
Alejandro Miguel Figueroa-López et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 50(3), 817-824 (2019-04-13)
This study focuses on the prevalence of Listeria monocytogenes (Lm) in pork meat and on inert surfaces from slaughterhouses in Sonora, Mexico. A total of 21 Lm were obtained from 103 samples, giving a prevalence of 20.3%. The prevalence of
Ryan M Mitchell et al.
Neurobiology of aging, 32(6), 1114-1123 (2009-06-30)
HFE gene variants are relatively common genetic variants in Caucasians. The H63D HFE genetic variant has been repeatedly associated with a number of neurodegenerative diseases. We developed neuroblastoma cell lines expressing different HFE polymorphisms to explore the mechanisms behind these
T Takahara et al.
Nihon rinsho. Japanese journal of clinical medicine, 56(11), 2865-2869 (1998-12-16)
The high signal intensity from the intestinal fluid usually deteriorates the projection images of MR cholangiopancreatography (MRCP) because it superimposes on the biliary tract. FerriSeltz (Otsuka pharmaceutical, Tokushima, Japan; a ferric ammonium citrate-based positive oral contrast agent) solution in a
Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.
M Doyard et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(10), 2435-2445 (2012-01-13)
In order to understand mechanisms involved in osteoporosis observed during iron overload diseases, we analyzed the impact of iron on a human osteoblast-like cell line. Iron exposure decreases osteoblast phenotype. HHIPL-2 is an iron-modulated gene which could contribute to these
Nootchanat Mairuae et al.
Neuroscience letters, 500(1), 36-40 (2011-06-21)
Activation of microglia could be beneficial and yet simultaneously harmful depending upon nature of pathological milieu. Regardless of disease-specific etiology, iron accumulation, particularly in activated microglia, is a notable feature associated with a series of neuropathologies, including Alzheimer's diseases. Although
Satoru Morita et al.
Japanese journal of radiology, 28(2), 117-122 (2010-02-26)
The aim of this study was to compare prospectively the image quality of magnetic resonance cholangiopancreatography (MRCP) using manganese chloride tetrahydrate (Bothdel Oral Solution 10) (MCT), a new negative oral contrast agent; ferric ammonium citrate (FerriSeltz powder 20%) (FAC); and
Samuele Marro et al.
Haematologica, 95(8), 1261-1268 (2010-02-25)
Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma
Yinghui Zhang et al.
Antioxidants & redox signaling, 13(7), 999-1009 (2010-04-22)
Cytosolic ferritins sequester and store iron, consequently protecting cells against iron-mediated free radical damage. However, the mechanisms of iron exit from the ferritin cage and reutilization are largely unknown. In a previous study, we found that mitochondrial ferritin (MtFt) expression
Tomoya Ohno et al.
Journal of biochemistry, 151(1), 109-114 (2011-10-14)
There is a little information about the effects of iron overload on cartilage metabolism. In the present study, we examined the effects of excess iron on the differentiation and mineralization of cultured chondrocytes, ATDC5 cells. We used ferric ammonium citrate
Rita Polati et al.
Journal of proteomics, 76 Spec No., 10-27 (2012-07-28)
Macrophages play a critical role at the crossroad between iron metabolism and immunity, being able to store and recycle iron derived from the phagocytosis of senescent erythrocytes. The way by which macrophages manage non-heme iron at physiological concentration is still
Luca Valenti et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(3), 683-690 (2010-12-25)
Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking. The aim of this study was to evaluate the effect of
Michaela Hohnholt et al.
Neurochemical research, 35(8), 1259-1268 (2010-05-15)
The oligodendroglial cell line OLN-93 was used as model system to investigate the consequences of iron deprivation or iron excess on cell proliferation. Presence of ferric or ferrous iron chelators inhibited the proliferation of OLN-93 cells in a time and
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