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Pieter Sonneveld et al.
Blood, 125(3), 449-456 (2014-11-16)
This multicenter phase 2 study of the European Myeloma Network investigated the combination of carfilzomib, thalidomide, and dexamethasone (KTd) as induction/consolidation therapy for transplant-eligible patients with previously untreated multiple myeloma (N = 91). During KTd induction therapy, patients received 4
Naoyuki Takemura et al.
The Journal of veterinary medical science, 71(7), 925-929 (2009-08-05)
The diagnostic significance of the plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) was evaluated in 72 dogs with mitral valve insufficiency and 36 control dogs. In the controls, the plasma NT-proBNP concentration was 163.9 +/- 114.7 (SD) pmol/l. The
Cameron C Grant et al.
Pediatrics, 133(1), e143-e153 (2013-12-18)
To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥ 20 ng/mL during infancy. A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from
Anna Stiekema et al.
Cancer cytopathology, 125(3), 197-204 (2017-02-16)
An accurate diagnosis of cancer of Müllerian origin is required before the initiation of treatment. An overlap in clinical presentation and cytological, histological, or imaging studies with other nongynecological tumors does occur. Therefore, immunocytochemistry markers are used to determine tumor
Tsutomu Tamai et al.
Journal of gastroenterology and hepatology, 33(5), 1115-1122 (2017-10-11)
We confirmed the clinical utility of a three-dimensional navigation system during transarterial chemoembolization. We evaluated 128 tumors in 91 patients enrolled between May 2015 and August 2016. We evaluated the accuracy of the three-dimensional navigation imaging system for all tumors.
A Takahashi et al.
Cancer research, 54(15), 4233-4237 (1994-08-01)
The presence of mRNAs for vascular endothelial growth factor (VEGF) and a VEGF-related protein, placenta growth factor (PIGF) was examined in 29 cases of renal cell carcinoma tissues and adjacent normal kidney tissues and in 4 human renal cell carcinoma
Astrid Baalbergen et al.
International journal of cancer, 121(1), 106-110 (2007-03-14)
We investigated the significance of prognostic markers-estrogen receptor, progesterone receptor, p53, MIB-1 and bcl-2 - in adenocarcinoma of the uterine cervix. In 101 patients with primary cervical adenocarcinoma, treated from 1989 to 2000, we evaluated clinical parameters in relation to
P M Cury et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(2), 107-112 (2000-03-04)
Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adenocarcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and
W N Frankel et al.
Genes, brain, and behavior, 8(5), 568-576 (2009-07-25)
In a chemical mutagenesis screen we identified Szt2 (seizure threshold 2) as a gene that confers low seizure threshold to mice and may also enhance epileptogenesis. The semidominant phenotype was mapped to Chromosome 4 and narrowed further to a critical
Ivana Cvetanovic et al.
American journal of therapeutics, 14(1), 25-29 (2007-02-17)
This study was design to compare the diuretic and natriuretic effects of the 2 parenteral formulations of metolazone and the combination of these 2 formulations of metolazone with the parenteral administration of furosemide. Metolazone is an anthracrene acid derivate and
Li Zang et al.
Zhonghua yi xue za zhi, 91(20), 1408-1412 (2011-07-16)
To explore the effect of LRP (leukemia related protein) 16 on insulin resistance in C2-C12 cells and explore its molecular mechanism. Lipidosome transfection and lentivirus mediated siRNA (small interfering RNA) technology were used to establish LRP 16 overexpression and underexpression
Hye-Lim Noh et al.
American journal of physiology. Endocrinology and metabolism, 291(4), E755-E760 (2006-05-11)
The most energy-requiring organ in the body, the cardiac muscle, relies primarily on lipoprotein-derived fatty acids. Prenatal loss of cardiac lipoprotein lipase (LPL) leads to hypertriglyceridemia, but no cardiac dysfunction, in young mice. Cardiac specific loss of LPL in 8-wk-old
M M M Abd-Elnaeim et al.
Reproduction in domestic animals = Zuchthygiene, 44(2), 312-319 (2008-11-11)
The functions of placental oestrogens during equine pregnancy are still unclear. Yet, they may act predominantly as local regulators of growth and differentiation in the microplacentomes. Thus, expression patterns of oestrogen receptors (ERs) alpha and beta were investigated in the
Kotaro Yamakado
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 18(8), 887-891 (2002-10-09)
The study goal was to examine the targeting accuracy of subacromial injection to the shoulder and the influence of the location of the injected structure. A prospective nonrandomized study. Fifty-three patients (56 shoulders; 34 women and 19 men; mean age
Julian M Stewart et al.
American journal of physiology. Heart and circulatory physiology, 294(1), H466-H473 (2007-11-13)
Low-flow postural tachycardia syndrome (POTS) is associated with increased plasma angiotensin II (ANG II) and reduced neuronal nitric oxide (NO), which decreases NO-dependent vasodilation. We tested whether the ANG II type 1 receptor (AT(1)R) antagonist losartan would improve NO-dependent vasodilation
Tsuyoshi Imai et al.
Physiologia plantarum, 136(2), 139-149 (2009-05-21)
The L-ascorbate (AsA) content and the expression of six L-galactose pathway-related genes were analyzed in peach flesh during fruit development. Fluctuation of AsA during peach fruit development was divided into four phases based on the overall total AsA (T-AsA) content
S J Wall et al.
Molecular pharmacology, 40(5), 783-789 (1991-11-01)
A synthetic oligopeptide (QCDKRKRRKQQYQQRQSV) corresponding to a carboxyl-terminal sequence of the rat m3 receptor (amino acids 561-578) was coupled to carrier proteins and used to generate a polyclonal antiserum. This serum selectively immunoprecipitates at least 90% of the m3 receptors
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
S Futagami et al.
Digestion, 86(2), 114-121 (2012-08-01)
In this crossover study, we investigated whether nizatidine, a H(2)-receptor antagonist, can alleviate clinical symptoms and gastric emptying in patients with Rome III-based functional dyspepsia (FD) with or without impaired gastric emptying. We enrolled 30 patients presenting with FD symptoms
Lisa M Sullivan et al.
The American journal of surgical pathology, 36(1), 73-80 (2011-10-13)
Claudins are tight junction proteins with claudin-6 (CLDN6) expression mostly restricted to embryonic and fetal life. Previously reported gene expression microarray analysis showed an increased level of CLDN6 in atypical teratoid rhabdoid tumors (AT/RT) compared with other central nervous system
E Willems et al.
Naunyn-Schmiedeberg's archives of pharmacology, 358(2), 212-219 (1998-09-28)
It has been suggested that opening of cephalic arteriovenous anastomoses may be involved in the headache phase of migraine. Indeed, a number of acutely acting anti-migraine drugs, including the ergot alkaloids and sumatriptan, constrict porcine carotid arteriovenous anastomoses. In this
Yiannis Athanasiou et al.
Clinical journal of the American Society of Nephrology : CJASN, 6(6), 1436-1446 (2011-05-14)
Complement factor H and related proteins (CFHR) are key regulators of the alternative complement pathway, where loss of function mutations lead to a glomerulopathy with isolated mesangial C3 deposits without immunoglobulins. Gale et al. (12) reported on 26 patients with
T Rowlison et al.
Reproduction in domestic animals = Zuchthygiene, 52 Suppl 2, 193-196 (2016-11-04)
The sperm centrosome is an essential organelle with a key role in organizing the sperm aster for proper syngamy and formation of the first mitotic spindle. The sperm cell acquires the functional capability during epididymal transit by incorporation of key
Jinho Kim et al.
Biochimica et biophysica acta, 1802(7-8), 673-681 (2010-05-13)
A major goal of current clinical research in Huntington's disease (HD) has been to identify preclinical and manifest disease biomarkers, as these may improve both diagnosis and the power for therapeutic trials. Although the underlying biochemical alterations and the mechanisms
Peter Schiellerup et al.
The Journal of rheumatology, 35(3), 480-487 (2008-01-19)
We conducted a case-case comparison study to estimate the attack-rate of reactive joint pain (JPrea) following intestinal infections, and evaluated whether the susceptibility and severity of joint symptoms was associated with the tissue-type HLA-B27. Consecutive patients with positive fecal culture
S Terris et al.
The American journal of cardiology, 58(7), 596-600 (1986-09-15)
The hemodynamic effects of CI-914, a phosphodiesterase inhibitor, were studied in 12 patients with left ventricular (LV) dysfunction who were undergoing diagnostic cardiac catheterization. CI-914 was infused intravenously at a rate of 0.8 to 7.0 micrograms/kg/min for 30 to 60
Olof Rask et al.
Thrombosis research, 125(1), 19-24 (2009-03-24)
This investigation aimed to evaluate thrombotic risk factors in children, with special reference to autoantibodies against prothrombin and protein S. We studied 57 consecutive Swedish children and adolescents referred with a radiologically confirmed acute thrombotic event. Clinical data were collected
H Lee et al.
Genome research, 10(10), 1561-1567 (2000-10-24)
For those searching for human disease-causing genes, information on the position of genes with respect to genetic markers is essential. The physical map composed of ESTs and genetic markers provides the positional information of these markers as well as the
Eric C Stecker et al.
Heart rhythm, 3(6), 697-700 (2006-05-30)
Most sudden cardiac arrests occur in patients who have associated significant coronary artery disease (CAD), but current methods of risk stratification are inadequate. The purpose of this study was to evaluate whether allelic variation of SCN5A could determine risk of
Wan Beom Park et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 51(1), 101-106 (2010-05-28)
High prevalence of severe atazanavir-associated hyperbilirubinemia in Asians with low prevalence of the UDP-glucuronosyltransferase (UGT)1A1*28 polymorphism suggests the importance of genetic factors other than UGT1A1*28 for atazanavir-associated hyperbilirubinemia in these populations. Serum bilirubin levels were measured in 129 Korean human
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