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Nurhayat Barlas et al.
Toxicology letters, 226(1), 35-42 (2014-02-04)
Chemicals that occur in vegetal food and known as phytoestrogens, because of their structures similarity to estrogen, have benefits on chronic diseases. Despite this, when they are taken at high amounts, they can cause harmful effects on endocrine system of
Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice.
Han SI, Komatsu Y, Murayama A, et al.
Hepatology, 59(5), 1791-1802 (2014)
Alberto Soriano-Maldonado et al.
European journal of nutrition, 53(8), 1645-1657 (2014-02-18)
The aim of the present study was to investigate the effects of the consumption of two cloudy apple juices with different polyphenol and vitamin C contents on antioxidant status, cardiometabolic and inflammation markers in healthy young adults. Twenty subjects, aged
Sandhya V G Nair et al.
PloS one, 9(9), e107149-e107149 (2014-09-18)
Phloridzin (phlorizin or phloretin 2'-O-glucoside) is known for blocking intestinal glucose absorption. We have investigated the anticarcinogenic effect of phloridzin and its novel derivatives using human cancer cell lines. We have synthesised novel acylated derivatives of phloridzin with six different
Mingqi Xie et al.
Nucleic acids research, 42(14), e116-e116 (2014-07-18)
Synthetic biology has significantly advanced the design of mammalian trigger-inducible transgene-control devices that are able to programme complex cellular behaviour. Fruit-based benzoate derivatives licensed as food additives, such as flavours (e.g. vanillate) and preservatives (e.g. benzoate), are a particularly attractive
Binghua Wu et al.
Nature communications, 6, 6284-6284 (2015-02-12)
Maintenance of a high glycolytic flow rate is critical for the rapid growth and virulence of malarial parasites. The parasites release two moles of lactic acid per mole of glucose as the anaerobic end product. However, the molecular identity of
Hiromi Matsugami et al.
Biomedical research (Tokyo, Japan), 35(6), 397-405 (2014-01-01)
Transplantation of cultured adipose-derived regenerative cells (ADRCs) into ischemic tissues promotes neovascularization and blood perfusion recovery. These effects are attenuated in diabetes patients. We examined the effects of hyperglycemia on the angiogenic capacity of ADRCs derived from Wistar rats both
Bioavailability of phloretin and phloridzin in rats.
Crespy V, et al.
The Journal of Nutrition, 131(12), 3227-3230 (2001)
Eun-Jung Lee et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(10), 1208-1215 (2014-06-17)
Bone-remodeling imbalance induced by increased osteoclast formation and bone resorption is known to cause skeletal diseases such as osteoporosis. The reduction of estrogen levels at menopause is one of the strongest risk factors developing postmenopausal osteoporosis. This study investigated osteoprotective
Katherine A Thompson-Witrick et al.
Journal of agricultural and food chemistry, 62(41), 10181-10191 (2014-09-18)
Polyphenols and maturity parameters were determined in 20 apple cultivars with potential for hard cider production grown in Virginia, U.S.A. Concentrations of five classes of polyphenols were significantly different across cultivar for both peel and flesh. Total polyphenol concentration ranged
Pedro Gonzalez-Menendez et al.
Endocrinology, 155(9), 3238-3250 (2014-06-17)
Cancer cells show different metabolic requirements from normal cells. In prostate cancer, particularly, glycolytic metabolism differs in androgen-responsive and nonresponsive cells. In addition, some natural compounds with antiproliferative activities are able to modify glucose entry into cells by either modulating
Ometeotl Acosta et al.
American journal of obstetrics and gynecology, 212(2), 227-227 (2014-08-19)
Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth
Samuel B Low et al.
American journal of veterinary research, 75(7), 653-657 (2014-06-25)
To evaluate the effectiveness of a topically applied gel containing essential oils (menthol and thymol) and polyphenolic antioxidants (phloretin and ferulic acid) for reducing halitosis in dogs. 20 dogs. A blinded crossover clinical trial was conducted. Dogs received a dental
M Pérez-Domínguez et al.
Neurochemical research, 39(7), 1219-1231 (2014-04-08)
Thrombin effect increasing swelling-induced glutamate efflux was examined in cultured cortical astrocytes, cerebellar granule neurons (CGN), hippocampal and cortical neurons. Hypotonic glutamate efflux (monitored by D-[(3)H]aspartate) from cortical astrocytes was increased by thrombin (5 U/mL) to reach 16% of the
Nadav Ben-Dov et al.
Biochimica et biophysica acta, 1848(3), 869-877 (2014-12-30)
Cell penetrating peptides (CPPs) have been extensively studied as vectors for cellular delivery of therapeutic molecules, yet the identity of their uptake routes remained unclear and is still under debate. In this study we provide new insights into CPP entry
Andreas Üllen et al.
Biochemical pharmacology, 93(4), 470-481 (2015-01-13)
Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential
Yong Shao et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(3), R237-R247 (2014-06-13)
Glucose is a major substrate for milk synthesis and is taken up from the blood by mammary epithelial cells (MECs) through facilitative glucose transporters (GLUTs). The expression levels of GLUT1 and GLUT8 are upregulated dramatically in the mammary gland from
Guohua An et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1357-1366 (2014-07-09)
Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity is of great
Kalathookunnel Antony Antu et al.
PloS one, 9(9), e105829-e105829 (2014-09-04)
The study is designed to find out the biochemical basis of antidiabetic property of Symplocos cochinchinensis (SC), the main ingredient of 'Nisakathakadi' an Ayurvedic decoction for diabetes. Since diabetes is a multifactorial disease, ethanolic extract of the bark (SCE) and
Bashir M Rezk et al.
Biochemical and biophysical research communications, 295(1), 9-13 (2002-06-27)
Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is
Eduardo H Moriyama et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 16(4), 495-503 (2013-12-11)
We have developed and tested a novel conjugation of the clinically used prodrug aminolevulinic acid with 2-deoxyglucosamine as a novel probe (ALA-2DG) for fluorescence imaging and photodynamic therapy. ALA-2DG was successfully synthesized, and the mechanisms of probe uptake, PpIX synthesis
Determination of sterols and diterpenoids from brown algae (Cystoseiraceae).
Piovetti L, et al.
Journal of Chromatography A, 588(1-2), 99-105 (1991)
Katheryn M Goodrich et al.
Journal of agricultural and food chemistry, 62(46), 11190-11199 (2014-10-23)
Metabolism of flavanols (catechins, procyanidins) by gut microbiota has been extensively characterized. Comparatively little is known about accumulation of flavanols and their metabolites in the colon tissues, particularly during chronic exposure to low doses. Mice were fed low doses of
Sisir Kumar Barik et al.
The Journal of nutritional biochemistry, 78, 108325-108325 (2020-01-18)
The hypoglycaemic effects of two Ribes sp. i.e., anthocyanin-rich black currants (BC) were compared to green currants (GC), which are low in anthocyanins to establish which compounds are involved in the regulation of postprandial glycaemia. We determined the effect of
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