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Primavera Alvarado et al.
Journal of microbiological methods, 175, 105981-105981 (2020-06-15)
The diagnosis of histoplasmosis depends on various approaches: direct clinical examination, fungus isolation from cultures of clinical samples, histopathological evaluation, and serological testing. In serodiagnostic assays, the Histoplasma capsulatum H and M antigenic glycoproteins have been extensively used. However, both
A J Friedman et al.
The Journal of clinical endocrinology and metabolism, 76(6), 1439-1445 (1993-06-01)
Treatment of women with myomas with GnRH agonists (GnRH-a) for 3-6 months will result in profound hypoestrogenism, a significant but temporary reduction in uterine volume, and menstrual suppression. Long-term (i.e. > 6 months) treatment with a GnRH-a is not recommended
Norio Sakai et al.
The Journal of organic chemistry, 68(2), 483-488 (2003-01-18)
The copper(II) triflate- and hafnium(IV) triflate-catalyzed aminomethylation of indole (2) with an N-silyl-N,O-acetal 1 containing a trichloromethyl group provides the primary amine derivative (3a) in modest yield. When 1 equiv of trimethylchlorosilane (TMSCl) was added to the reaction mixture, the
M A González-Moles et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(7), 507-513 (2014-09-04)
The aim of this study was to study the loss of asymmetrical proliferation in oral tumorigenesis. Samples: 92 oral squamous cell carcinomas (OSCC) with associated non-tumor epithelia (NTE). NTE and tumor were classified as distant from or close to the
Chowdhury F Miah et al.
Surgery, 156(6), 1491-1496 (2014-12-03)
The American Thyroid Association recommends lymph node mapping (LNM) ultrasonography 6-12 months after thyroidectomy for patients with papillary thyroid cancer (PTC). The yield of LNM over thyroglobulin (TG) screening is not well defined. We sought to investigate this relationship. Post
Jamie W Joseph et al.
The Journal of biological chemistry, 282(43), 31592-31600 (2007-09-08)
It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a signal for glucose-stimulated insulin secretion (GSIS). Key enzymes involved in synthesis of fatty acids from glucose include ATP-citrate lyase (CL) and fatty acid synthase (FAS). An
Ioana N Milos et al.
Endocrine-related cancer, 15(4), 1035-1041 (2008-09-17)
RET testing in multiple endocrine neoplasia type 2 for molecular diagnosis is the paradigm for the practice of clinical cancer genetics. However, precise data for distinct mutation-based risk profiles are not available. Here, we survey the clinical profile for one
Regis P Kowalski et al.
Cornea, 32(6), 830-834 (2012-11-08)
Cefazolin/tobramycin, cefuroxime/gentamicin, and moxifloxacin were compared using bacterial keratitis isolates to determine whether empiric therapy constituted optimal antibacterial treatment. Based on percent incidence of corneal infection, 27 Staphylococcus aureus, 16 Pseudomonas aeruginosa, 10 Serratia marcescens, 4 Moraxella lacunata, 3 Haemophilus
Konstantinos J Dabos et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(5), 707-711 (2011-04-05)
Little is known about the metabolism of acetoacetate and β-hydroxybutyrate in patients with cirrhosis and encephalopathy. We investigated the fate of ketone bodies in these conditions. We studied 18 cirrhotic patients with encephalopathy and 17 cirrhotics without. At the time
Yang Xiang et al.
Journal of immunology (Baltimore, Md. : 1950), 176(5), 3196-3204 (2006-02-24)
Autoimmunity to chondrocyte-producing proteins has been reported in patients with osteoarthritis (OA) as well as in those with rheumatoid arthritis (RA). To answer whether or not OA-specific autoimmunity exist, we performed screening of chondrocyte-producing autoantigens by two-dimensional electrophoresis and Western
Danielle M P Cronin et al.
American journal of clinical pathology, 137(3), 367-376 (2012-02-18)
Myeloid leukemia cutis (LC) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) are morphologically indistinguishable malignancies that frequently manifest in the skin. Separating myeloperoxidase-negative LC from BPDCN may be particularly challenging. We identified a panel of immunohistochemical stains to distinguish myeloid
K Miyasaka et al.
Molecular carcinogenesis, 13(1), 37-43 (1995-05-01)
Genetic changes, in particular the loss of heterozygosity (LOH) and the presence of c-Ha-ras codon 61 point mutations, were investigated in diethylnitrosamine-induced hepatocellular carcinomas (HCCs) in C3H/MSM F1 mice. (MSM are wild mice.) LOH analysis of 48 primary tumors with
K Sayama et al.
Laboratory animals, 28(1), 44-49 (1994-01-01)
Mammary tumours developed in 110 (95.7%) of 115 DDD/1-Mtv-2/Mtv-2 (DDD/1-Mtv-2) and 24 (47.1%) of 51 DDD/1fDDD/1-Mtv-2 (DDD/1fMtv-2) force-bred female mice during a one-year period. The mean tumour age +/- SE was 220 +/- 7 and 269 +/- 7 days, respectively.
Marjolein J Peters et al.
Annals of the rheumatic diseases, 72(3), 427-436 (2012-09-08)
Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP.
Mathieu Boulin et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 43(11), 905-911 (2011-08-02)
There is no consensus about the most effective method for transarterial chemoembolisation of hepatocellular carcinoma. The aim of this phase II trial was to compare the efficacy and toxicity of lipiodol transarterial chemoembolisation with amiodarone in association with pirarubicin or
Florent Malard et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(6), 1059-1067 (2015-02-25)
This retrospective report compared the 4-year outcomes of allogeneic stem cell transplantation (allo-SCT) in 651 adult patients with acute myeloid leukemia receiving a reduced-intensity (RIC) or nonmyeloablative conditioning (NMA) regimen according to the type of unrelated donors. These were either
Adnan Ayhanci et al.
Drug and chemical toxicology, 32(4), 424-428 (2009-10-02)
Cyclophosphamide (CP) is a widely used antineoplastic drug that causes toxicity in the normal cell due to its metabolites. The major drawback of this drug is an undesirable myelosuppression. Selenium (Se) is a potent nutritional antioxidant that carries out biological
L B Jardim et al.
Journal of neurology, 248(10), 870-876 (2001-11-08)
The autosomal dominant spinocerebellar ataxias (SCAs) are a clinical and genetically heterogeneous group of debilitating, neurodegenerative diseases, related to fourteen different loci - SCAs 1, 2, 4, 5, 6, 7, 8, 10, 11,12,13 and 14, Machado-Joseph disease (MJD/SCA 3), and
Gerhard Binder et al.
Clinical endocrinology, 82(1), 100-105 (2014-09-11)
The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in
Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro.
Alexandra Yvon et al.
Anesthesiology, 99(1), 27-33 (2003-06-27)
The authors examined the role of adenosine triphosphate-sensitive potassium channels and adenosine A(1) receptors in sevoflurane-induced preconditioning on isolated human myocardium. The authors recorded isometric contraction of human right atrial trabeculae suspended in oxygenated Tyrode's solution (34 degrees C; stimulation
J S McPhee et al.
Experimental physiology, 96(7), 699-707 (2011-05-17)
Skeletal muscles improve their oxidative fatty acid and glucose metabolism following endurance training, but the magnitude of response varies considerably from person to person. In 20 untrained young women we examined interindividual variability in training responses of metabolic enzymes following
Hyun-Chang Lim et al.
Journal of periodontal & implant science, 45(2), 46-55 (2015-05-02)
This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. BCP blocks with three distinct ratios of hydroxyapatite
Florence Joly et al.
BJU international, 115(1), 65-73 (2013-11-05)
To evaluate the overall benefits of non-taxane chemotherapies in a non-selected population including unfit patients presenting with symptoms and pain. This randomized phase II study reports data from 92 patients (52% >70 years old; 40% with a performance score of
Megha Suri et al.
Pediatric research, 76(4), 370-377 (2014-07-06)
Endogenous glucagon-like peptide-2 (GLP-2) levels and intestinal adaptation are reduced in distal-intestinal resection animal models of short bowel syndrome (SBS) that lack remnant ileum. We hypothesized that exogenous GLP-2 would improve intestinal adaptation in a distal-intestinal resection neonatal piglet model
The site of intestinal disappearance of DL-methionine and methionine hydroxy analog differs in pigs.
J A Jendza et al.
Journal of animal science, 89(5), 1385-1391 (2011-01-11)
A study was conducted with pigs to determine the sites of and the influence of dietary wheat middlings (WM) as a fiber source on the absorption of dl-Met (DLM) and dl-2-hydroxy-4-methylthio butanoic acid (HMTBA). Twelve 25-kg barrows were used in
Jaime Onofre et al.
Reproductive biomedicine online, 37(1), 6-17 (2018-05-20)
From a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions? We studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular
Kohei Nakata et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(3), 460-468 (2009-01-13)
Subclassification of intraductal papillary mucinous neoplasms of the pancreas (IPMNs), based on morphological features and immunohistochemical profiles, has been proposed. Intestinal-type IPMNs frequently show moderate to severe dysplasia. Regenerating islet-derived family, member 4 (REG4) is associated with the adenoma-carcinoma sequence
D G Gascoyne et al.
The Journal of organic chemistry, 66(9), 3041-3048 (2001-04-28)
2,3-Dihydro-3-(4'-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol, 1, is a chiral bisphenol useful for preparation of polymers. Previous screening of commercial hydrolases identified lipase from Chromobacterium viscosum (CVL) as a highly regio- and enantioselective catalyst for hydrolysis of diesters of 1. The regioselectivity was > or
Emmanuelle Berthelot et al.
European journal of clinical investigation, 44(10), 982-988 (2014-09-05)
Coupled arterial and left ventricular properties are poorly documented in acute heart failure. The aim of this prospective noninvasive study was to document early changes in ventricular-arterial coupling in patients with acutely decompensated HF (ADHF). We studied 19 patients hospitalized
Tiffany E Choe et al.
PloS one, 9(11), e113011-e113011 (2014-11-14)
To determine the relationship between longitudinal in vivo measurements of retinal nerve fiber layer thickness (RNFLT) and retinal ganglion cell (RGC) density after unilateral optic nerve transection (ONT). Nineteen adult Brown-Norway rats were studied; N = 10 ONT plus RGC label, N = 3
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