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关键词:'92-92-2'
显示 1-30 共 2388 条结果 关于 "92-92-2" 范围 论文
Sabrina Blumer et al.
Cells, 10(11) (2021-11-28)
Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 (miR17-92), and Erk1/2 mitogen-activated protein kinase. This study assessed the role of miR17-92 in IPF-fibroblast
Tianji Chen et al.
Journal of the American Heart Association, 5(12) (2016-12-07)
Previously we found that smooth muscle cell (SMC)-specific knockout of miR-17~92 attenuates hypoxia-induced pulmonary hypertension. However, the mechanism underlying miR-17~92-mediated pulmonary artery SMC (PASMC) proliferation remains unclear. We sought to investigate whether miR-17~92 regulates hypoxia-inducible factor (HIF) activity and PASMC
Ece Canan Sayitoglu et al.
Frontiers in immunology, 11, 40-40 (2020-02-23)
Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments fail to increase overall survival. Natural Killer (NK) cells exert anti-tumor activity upon detection of a complex array
Kyriakos V Konstantinidis et al.
Experimental hematology, 33(2), 159-164 (2005-01-29)
Anti-tumor effects mediated by adoptively transferred natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2). IL-2 is considered to be a survival factor for NK cells and an enhancer of their cytotoxic potential. However, systemic administration of
Christian Barbato et al.
Cells, 11(6) (2022-03-26)
RNA-binding proteins (RBPs) play important roles in modulating miRNA-mediated mRNA target repression. Argonaute2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) that plays a central role in silencing mechanisms via small non-coding RNA molecules known as siRNAs
Hemoglobin J Cape Town-alpha-2 92 arginine replaced by glutamine beta-2.
M C Botha et al.
Nature, 212(5064), 792-795 (1966-11-19)
Meng Guo et al.
Frontiers in oncology, 11, 632540-632540 (2021-05-04)
Adoptive natural killer (NK) cell transfer has been demonstrated to be a promising immunotherapy approach against malignancies, but requires the administration of sufficient activated cells for treatment effectiveness. However, the paucity of clinical-grade to support the for large-scale cell expansion
Massimo Torlontano et al.
The Journal of clinical endocrinology and metabolism, 93(3), 910-913 (2007-12-13)
Type 2 deiodinase (D2) converts T4 in T3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of TSH secretion. A common variant of the gene, threonine (Thr) 92 alanine
T Hurskainen et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 44(12), 1379-1388 (1996-12-01)
Cytotrophoblasts of early placenta invade the decidual membrane, gestational endometrium, and spiral arteries during early pregnancy. Unlike tumor invasion, this physiological invasion is well controlled, although its molecular mechanisms are largely unknown. We have previously shown that cytotrophoblasts synthesize significant
H Wajcman et al.
Annals of hematology, 68(2), 73-76 (1994-02-01)
Hb Cemenelum [alpha 92 (FG4) Arg-->Trp] carries a structural modification at the same position as Hb Chesapeake, a very high oxygen affinity variant. Hb Cemenelum was found in a French diabetic patient with no abnormal hematological features. The purified abnormal
Li Yan Khor et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(12), 3585-3590 (2007-06-19)
Bcl-2 is antiapoptotic, and its overexpression has been associated with resistance to androgen deprivation and poor outcome in some patients treated with radiotherapy. Bax is proapoptotic, regulating Bcl-2 through heterodimer formation. In a prior study, Bcl-2 and Bax were not
P Reponen et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 202(4), 388-396 (1995-04-01)
Expression of 72 kDa and 92 kDa type IV collagenases and the metalloproteinase inhibitors TIMPs 1, 2, and 3 was studied by in situ hybridization in implanting mouse embryos of days 5.5 to 7.5. The 92 kDa type IV collagenase
Matthew Reid MacPherson et al.
Molecular biology of the cell, 21(2), 244-253 (2009-11-20)
Snail1 is a major factor for epithelial-mesenchymal transition (EMT), an important event in tumor metastasis and in other pathologies. Snail1 is tightly regulated at transcriptional and posttranscriptional levels. Control of Snail1 protein stability and nuclear export by GSK3beta phosphorylation is
Matthew Reid MacPherson et al.
Molecular biology of the cell, 21(2), 244-253 (2009-11-20)
Snail1 is a major factor for epithelial-mesenchymal transition (EMT), an important event in tumor metastasis and in other pathologies. Snail1 is tightly regulated at transcriptional and posttranscriptional levels. Control of Snail1 protein stability and nuclear export by GSK3beta phosphorylation is
A Balas et al.
International journal of immunogenetics, 38(5), 435-436 (2011-06-17)
Sequencing-based typing of HLA-DRB1 gene, allowed us to characterize three new alleles. DRB1*03:55 shows one nucleotide change regarding DRB1*03:01:01G, resulting in an amino acid replacement at position 80 R > I. DRB1*11:46:02 presents one synonymous nucleotide change at codon 34
Yoshihiro Motomiya et al.
Kidney international, 67(1), 314-320 (2004-12-22)
In 1997, Stoppini et al reported that monoclonal antibody specific to the C-terminal 92-99 of beta(2)-microglobulin (beta(2)m) had been capable of inhibiting fibrillogenesis of beta(2)m in vitro. Meanwhile, recent studies have indicated that an acidifying procedure can unfold conformation of
W H Yu et al.
Life sciences, 55(2), 93-102 (1994-01-01)
Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active
Vit Pospisil et al.
The EMBO journal, 30(21), 4450-4464 (2011-09-08)
The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel mechanism of the regulation of miR-17-92 cluster. Using transgenic PU.1(-/-) myeloid
Duaa Dakhlallah et al.
American journal of respiratory and critical care medicine, 187(4), 397-405 (2013-01-12)
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a high mortality rate. In organ repair and remodeling, epigenetic events are important. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and can target epigenetic molecules important in DNA methylation.
I I Senin et al.
Biochemistry. Biokhimiia, 76(3), 332-338 (2011-05-17)
Antibodies AB(60-72) and AB(80-92) against two immune-dominant epitopes of photoreceptor Ca(2+)-binding protein recoverin, 60-DPKAYAQHVFRSF-72 and 80-LDFKEYVIALHMT-92, which can be exposed in a Ca(2+)-dependent manner, were obtained. The presence of AB(60-72) or AB(80-92) results in a slight increase in Ca(2+)-affinity of
R W Thompson et al.
The Journal of clinical investigation, 96(1), 318-326 (1995-07-01)
Abdominal aortic aneurysms (AAA) are characterized by disruption and degradation of the elastic media, yet the elastolytic proteinases involved and their cellular sources are undefined. We examined if 92-kD gelatinase, an elastolytic matrix metalloproteinase, participates in the pathobiology of AAA.
Jason K Molitoris et al.
Molecular endocrinology (Baltimore, Md.), 25(3), 409-420 (2011-01-18)
Synthetic glucocorticoids were one of the first effective treatments for lymphoid malignancies because of their ability to induce apoptosis and are still used in combination with other chemotherapeutic agents. Up-regulation of Bim, a proapoptotic member of the B-cell lymphoma-2 family
Kotaro Sasaki et al.
Journal of translational medicine, 8, 17-17 (2010-02-20)
Type-1 T cells are critical for effective anti-tumor immune responses. The recently discovered microRNAs (miRs) are a large family of small regulatory RNAs that control diverse aspects of cell function, including immune regulation. We identified miRs differentially regulated between type-1
Gisella Vetere et al.
Hippocampus, 24(12), 1458-1465 (2014-07-06)
Post-transcriptional gene regulation mediated by microRNAs (miRNAs) is implicated in memory formation; however, the function of miR-92 in this regulation is uncharacterized. The present study shows that training mice in contextual fear conditioning produces a transient increase in miR-92 levels
Kostyantyn Krysan et al.
Molecular cancer research : MCR, 12(5), 765-774 (2014-01-29)
Aberrant expression of microRNAs (miRNA) with oncogenic capacities (oncomiRs) has been described for several different malignancies. The first identified oncomiR, miR-17-92, is frequently overexpressed in a variety of cancers and its targets include the tumor suppressor PTEN. The transcription factor
Moutushy Mitra Kandalam et al.
Molecular vision, 18, 2279-2287 (2012-09-13)
Several miRNAs have been reported as candidate oncogenes and tumor suppressors, which are involved in the pathways specifically altered during tumorigenesis or metastasis. The miR 17-92 cluster located in 13q31 locus might contribute to retinoblastoma (RB) oncogenesis as 13q31 is
Mi H Park et al.
Immunology, 135(1), 63-72 (2011-11-03)
Studies have demonstrated that the anti-tumour effect of natural killer (NK) cells is successful for patients with several cancers. Although interleukin-32 (IL-32) is endogenously expressed in NK cells, cytolytic function of NK cells against cancer cells has not been fully
David H Winslow et al.
Sleep, 35(11), 1529-1539 (2012-11-02)
To evaluate safety and efficacy of phentermine 15 mg plus extended-release topiramate 92 mg for treatment of moderate to severe obstructive sleep apnea (OSA) in obese adults. This phase 2, randomized, double-blind, placebo-controlled study included 2-week screening and 28-week treatment
Arif A Khan et al.
Blood, 121(22), 4473-4483 (2013-04-19)
The precise microRNAs and their target cellular processes involved in generation of durable T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as CD8 T cells differentiate from naïve to effector and memory states, with short-lived effectors
Holger Budde et al.
Development (Cambridge, England), 137(13), 2127-2132 (2010-05-28)
The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play an important role in this process by regulating crucial developmental genes. Microarray profiling
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