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Mark Kriegsmann et al.
Diagnostic pathology, 10, 132-132 (2015-07-30)
According to current clinical guidelines mutational analysis for KRAS and NRAS is recommended prior to EGFR-directed therapy of colorectal cancer (CRC) in the metastatic setting. Therefore, reliable, fast, sensitive and cost-effective methods for routine tissue based molecular diagnostics are required
Valérie Pelletier et al.
Human mutation, 28(1), 81-91 (2006-09-14)
X-linked forms of retinitis pigmentosa (RP) (XLRP) account for 10 to 20% of families with RP and are mainly accounted for by mutations in the RP2 or RP GTPase regulator (RPGR) genes. We report the screening of these genes in
Chuanlong Guo et al.
Experimental and therapeutic medicine, 17(5), 3848-3858 (2019-04-17)
The novel bromophenol derivative, 3-(3-bromo-5-methoxy-4-(3-(piperidin-1-yl)propoxy)benzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-93), was synthesized in the CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences (Qingdao, China). Experimental studies have demonstrated that it could induce apoptosis and autophagy in human A549
Toni L Jones et al.
Anesthesia and analgesia, 105(6), 1650-1656 (2007-11-29)
Spinally administered non-N-methyl-D-aspartate (NMDA), but not NMDA, receptor antagonists block primary (1 degree) and secondary (2 degrees) mechanical hyperalgesia and spontaneous pain after plantar incision. Hyperalgesia after thermal stimulation is also mediated by non-NMDA, but not NMDA, receptors. Although previous
Noriaki Naeshiro et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 44(7), 740-749 (2013-06-12)
To evaluate the clinical outcomes of percutaneous transvenous embolization (PTE) for portosystemic shunt (PSS) associated with encephalopathy Fourteen patients with portosystemic encephalopathy (PSE) were enrolled in this retrospective cohort study. We evaluated technical success, clinical success, complication and outcomes. In
G Li et al.
Cancer research, 55(10), 2070-2074 (1995-05-15)
Mutations of the p53 gene have been implicated in the pathogenesis of cutaneous squamous cell carcinoma (SCC). To examine the role of p53 in skin carcinogenesis, we observed the development of skin cancers in p53 transgenic mice which carry multiple
Fabien Praz et al.
JACC. Cardiovascular interventions, 12(14), 1356-1365 (2019-05-28)
The aim of this study was to investigate the technical success and efficacy of mitral valve edge-to-edge repair using extended clip arms. A new iteration of the MitraClip system, the MitraClip XTR, was introduced in 2018 with the aim of
P Petignat et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16(4), 1679-1684 (2006-08-04)
Matrix metalloproteinases (MMPs) are group of enzymes thought to play an important role in trophoblastic and tumor invasion. The aim of our study was to investigate the trophoblastic expression of MMPs and p53 in normal trophoblast and hydatidiform moles (HM).
J Mayer et al.
Journal of biotechnology, 145(4), 387-393 (2009-12-29)
A continuous enzymatic process for the production of the prebiotic disaccharide lactulose through transgalactosylation was developed using free and immobilized beta-glycosidase from Pyrococcus furiosus. The hyperthermostable beta-glycosidase (CelB) was immobilized onto an anion-exchange resin (Amberlite IRA-93) or onto Eupergit C
Wanlong Ma et al.
PloS one, 5(8), e12165-e12165 (2010-08-24)
The JAK2 V617F mutation in exon 14 is the most common mutation in chronic myeloproliferative neoplasms (MPNs); deletion of the entire exon 14 is rarely detected. In our previous study of >10,000 samples from patients with suspected MPNs tested for
A Lwegaba et al.
The West Indian medical journal, 57(1), 63-65 (2008-01-01)
Longitudinal data from a case series indicated that clearance rates (95% CIs) of anogenital warts (AGW) by silver nitrate (n = 14) and podophyllin (n = 34) were 93% (79.35, 100) and 14.7% (3, 27) respectively; and RR, 6.31 (95%
Kentaro Inamura et al.
The American journal of surgical pathology, 29(5), 660-665 (2005-04-16)
Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles of 7 PAEDs in comparison with 14 metastatic colorectal carcinomas
Anne E Diebold et al.
Surgery, 152(6), 1172-1176 (2012-10-30)
Recent European investigations have shown that persistently elevated (>50 pg/mL) plasma neurokinin A levels are associated with poor short-term survival in patients with midgut neuroendocrine neoplasms. We hypothesized that American patients with persistently elevated plasma neurokinin A levels (>50 pg/mL)
J Marcinkeviciene et al.
FEBS letters, 318(1), 23-26 (1993-02-22)
Steady-state kinetic analysis was performed on the reaction between D-fructose and ferricyanide with the quinohemoprotein fructose dehydrogenase from Gluconobacter species. The D-fructose oxidation dependence on the ferricyanide concentration resulted in a series of parallel reciprocal plots, and the reaction was
Gema Núñez-López et al.
Enzyme and microbial technology, 122, 19-25 (2019-01-15)
Fructosylation can significantly improve the solubility, stability and bioactivity of phenolic compounds, increasing their health benefits. Levansucrase from Gluconacetobacter diazotrophicus (LsdA, EC 2.4.1.10) was found to transfer the fructosyl unit of sucrose to different classes of phenolic compounds. Among the
Raul Chavez-Valdez et al.
Journal of applied physiology (Bethesda, Md. : 1985), 112(10), 1762-1772 (2012-03-17)
Synaptic activity can modify expression of neurotrophins, which influence the development of neuronal circuits. In the newborn rat, early hyperoxia silences the synaptic activity and input from the carotid body, impairing the development and function of chemoreceptors. The purpose of
Akihiko Yoshida et al.
The American journal of surgical pathology, 36(7), 993-999 (2012-03-27)
Ewing sarcoma is a high-grade round cell sarcoma that affects bones and soft tissues in children and young adults. Its diagnosis can be challenging, and the differential diagnoses include a wide variety of small round cell tumors. CD99 and FLI-1
Tatyana Milman et al.
American journal of ophthalmology, 205, 115-131 (2019-05-13)
To evaluate the clinical and pathologic characteristics of conjunctival myxoid lesions, with specific focus on PRKAR1A studies, in order to distinguish neoplastic conjunctival myxoma from other myxoid conjunctival lesions. A retrospective, interventional, multicenter study of all patients with conjunctival myxoma
Manish Mani Subramaniam et al.
Archives of pathology & laboratory medicine, 135(8), 1001-1009 (2011-08-04)
Synovial sarcomas are mesenchymal tumors with epithelial nature and comprise biphasic and monophasic fibrous subtypes. However, factors determining epithelial or spindle cell differentiation are still unexplored. Aberrant epithelial-mesenchymal transition has been implicated in the pathogenesis of diverse human malignancies. To
W H Griest et al.
Journal of chromatography, 600(2), 273-277 (1992-05-29)
Chemical warfare agent simulants are efficiently recovered from 2-ppm spikes in 1 g of Rocky Mountain Arsenal Standard Soil using methanol-carbon dioxide (5:95) at 300 atm for 2 min at 60 degrees C. Recoveries (n = 3) were 79 +/-
Carlos Henrique Miranda et al.
Atherosclerosis, 247, 184-188 (2016-03-02)
Endothelial glycocalyx (EG) is sugar-based cell-bound surface molecules linked to transmembrane proteins observed on the endothelial surface of the vessels. Damage to this structure causes an increase in platelet and leucocyte adhesion and shear stress in the vessel. We hypothesized
Sang Gyune Kim et al.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 48(4), 269-276 (2006-10-25)
p53 is known to play a central role in sensing and signaling for the growth arrest and apoptosis in cells with DNA damage. Mutation of p53 is a frequent event in esophageal squamous cell carcinoma (ESCC). p16 protein binds to
M F Gurish et al.
The Journal of biological chemistry, 268(15), 11372-11379 (1993-05-25)
Mouse mast cells differentially express at least four chymases (mouse mast cell protease (mMCP) 1, mMCP-2, mMCP-4, and mMCP-5), a tryptase (mMCP-6), and an exopeptidase (mouse mast cell carboxypeptidase A (mMC-CPA)). The previously uncharacterized 2.5-kilobase mMCP-2 gene was isolated and
Wei-ying Jiang et al.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 22(6), 607-611 (2005-12-07)
Of denaturing high performance liquid chromatography (DHPLC), a technique platform was developed for screening G6PD deficient variants. When applied to screen and identify the G6PD deficient variants from 124 patients who come from 11 nations in China, the DHPLC was
Jana Held et al.
The Lancet. Infectious diseases, 15(12), 1409-1419 (2015-09-08)
Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to assess different doses of ferroquine in combination with artesunate against uncomplicated
Tadashi Terada
Applied immunohistochemistry & molecular morphology : AIMM, 19(5), 450-453 (2011-03-16)
Protein expression and gene mutational status of KIT and PDGFRA were investigated in formalin-fixed, paraffin-embedded specimens of 14 ipsilateral testicular seminomas. The analysis was performed by ordinary immunohistochemistry and polymerase chain reaction-direct sequencing methods. The genetic analysis was performed in
Kyoichi Kaira et al.
Cancer science, 99(12), 2380-2386 (2008-11-21)
The significance of L-type amino acid transporter (LAT) 1 expression remains unclear in the metastatic process of human neoplasms, whereas experimental studies have demonstrated that LAT1 is associated with the metastatic process of cancer cells. We compared the immunohistochemical expression
Essel Dulaimi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(12 Pt 1), 3972-3979 (2004-06-26)
Promoter hypermethylation is an important mechanism of inactivation of tumor suppressor genes in cancer cells. Kidney tumors are heterogeneous in their histology, genetics, and clinical behavior. To gain insight into the role of epigenetic silencing of tumor suppressor and cancer
Alexis V Nathanail et al.
Analytical and bioanalytical chemistry, 407(16), 4745-4755 (2015-05-04)
A reliable and sensitive liquid chromatography-tandem mass spectrometric method was developed for the simultaneous quantitative determination in cereals of the Fusarium mycotoxins HT-2 toxin, T-2 toxin, deoxynivalenol, nivalenol and zearalenone, as well as the modified metabolites 3-acetyl-deoxynivalenol, α-zearalenol, β-zearalenol, deoxynivalenol-3-glucoside
C Kafarnik et al.
Veterinary pathology, 46(3), 464-473 (2009-01-30)
The morphology of a duplication phenomenon of the canine Descemet's membrane (DM) is described in relation to signalment, history, and ocular disease status. Sixty-six canine eyes from the Comparative Ocular Pathology Laboratory of Wisconsin archives between 2000 and 2007 were
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