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J L Parker-Cote et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 118-120 (2014-01-15)
CONTEXT. Antivenom is expensive and not always available, so alternative treatments are being investigated. OBJECTIVE. The efficacy of trypsin or rosmarinic acid (RA) in treating Micrurus fulvius in a murine model is determined. MATERIALS AND METHODS. randomized controlled blinded study.
Paul P Geurink et al.
Journal of medicinal chemistry, 56(3), 1262-1275 (2013-01-17)
Proteasomes degrade the majority of proteins in mammalian cells by a concerted action of three distinct pairs of active sites. The chymotrypsin-like sites are targets of antimyeloma agents bortezomib and carfilzomib. Inhibitors of the trypsin-like site sensitize multiple myeloma cells
Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.
Aimee M Two et al.
The Journal of investigative dermatology, 134(4), 1143-1145 (2013-11-12)
Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein.
Hao-Ching Wang et al.
Nucleic acids research, 41(9), 5127-5138 (2013-03-28)
DNA mimic proteins are unique factors that control the DNA-binding activity of target proteins by directly occupying their DNA-binding sites. To date, only a few DNA mimic proteins have been reported and their functions analyzed. Here, we present evidence that
Lenka Gahurova et al.
Epigenetics & chromatin, 10, 25-25 (2017-05-17)
Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. Molecular and functional studies have
Peng Geng et al.
Biochemical and biophysical research communications, 445(1), 64-70 (2014-02-05)
A novel fibrin(ogen)olytic protease from Antheraea pernyi (important economically insect), named cocoonase, was isolated by a combination of ion-exchange chromatography and gel filtration. Furthermore, the characterization of cocoonase was investigated using fibrin(ogen)olytic, thrombolysis, and hemorrhagic assays. The NH2-terminal sequence (IVGGY
Sevil Ozcan et al.
Journal of medicinal chemistry, 56(10), 3783-3805 (2013-04-04)
Screening of the 50000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC50 = 0.60 μM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like
R Chalghoumi et al.
Poultry science, 87(1), 32-40 (2007-12-15)
The present study was an attempt to raise hen egg yolk Ig (IgY) simultaneously directed against Salmonella Enteritidis (SE) and Salmonella Typhimurium (ST) in the same egg yolk. The immunopotentiating effect of 2 different adjuvants -- Freund's adjuvants (FA) and
M F Domínguez et al.
Experimental parasitology, 138, 25-29 (2014-01-29)
Cestodes show a remarkable proliferative capability that sustains the constant growth and differentiation of proglottids essential for their lifestyle. It is believed that a separate population of undifferentiated stem cells (the so-called germinative cells) are the only cells capable of
Different methods of detaching adherent cells significantly affect the detection of TRAIL receptors.
Bo Zhang et al.
Tumori, 98(6), 800-803 (2013-02-08)
As a powerful technique allowing analysis of large numbers of cells, fluorescence-activated cell sorting (FACS) is used more and more widely. For FACS analysis, adherent cells are usually detached by trypsinization, followed by centrifugation and resuspension. However, trypsinization can cut
Eric W Klee et al.
American journal of clinical pathology, 141(4), 527-533 (2014-03-13)
Harmonization of prostate-specific antigen (PSA) immunoassays is important for good patient care. The specificity of the antibodies used to detect circulating PSA could cause differences in the PSA measurements. We used mass spectrometry (MS) to quantitate the concentration of five
Janina Boyken et al.
Neuron, 78(2), 285-297 (2013-04-30)
Neurotransmission involves calcium-triggered fusion of docked synaptic vesicles at specialized presynaptic release sites. While many of the participating proteins have been identified, the molecular composition of these sites has not been characterized comprehensively. Here, we report a procedure to biochemically
Aatur D Singhi et al.
The American journal of surgical pathology, 38(3), 346-353 (2014-02-15)
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred to as serine protease 1 (PRSS1). Other than inheritance, PRSS1
Takehiro K Sato et al.
Nature chemical biology, 9(6), 383-389 (2013-04-09)
Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC) and forms a 250-Å transmembrane β-barrel pore in the cell membrane. Each PFO monomer has two sets of three short α-helices
S K Sossou et al.
Environmental technology, 35(5-8), 674-680 (2014-03-22)
This study aimed to compare the inactivation rate and the mechanisms of pathogenic bacteria in three matrixes (sawdust, rice husk and charcoal) during the composting process. The inactivation rate was evaluated with Escherichia coli strain and the damaged parts and/or
Nucleotide sequence of the human pancreatic trypsinogen III cDNA.
T Tani et al.
Nucleic acids research, 18(6), 1631-1631 (1990-03-25)
Zhiyu Liu et al.
Biochimica et biophysica acta, 1843(2), 299-308 (2013-11-19)
In nematode, sperm activation (or spermiogenesis), a process in which the symmetric and non-motile spermatids transform into polarized and crawling spermatozoa, is critical for sperm cells to acquire fertilizing competence. SPE-8 dependent and SPE-8 independent pathways function redundantly during sperm
Nashwa H Kamel et al.
Journal of the Egyptian Society of Parasitology, 43(1), 245-258 (2013-05-24)
This work monitored changes in some digestive enzymes (trypsin and aminopeptidase) associated with the building up of resistance in Cx. pipiens larvae to two chemical insecticides (methomyl and/or malathion) and one biological insecticide (Bacillus thuringiensis-H14 or B.t H 14). The
Vittorio Limongelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6358-6363 (2013-04-05)
A detailed description of the events ruling ligand/protein interaction and an accurate estimation of the drug affinity to its target is of great help in speeding drug discovery strategies. We have developed a metadynamics-based approach, named funnel metadynamics, that allows
Fikadu G Tafesse et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411 (2013-04-12)
Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The transport of HA to
Bernard A Fang et al.
Biochimica et biophysica acta, 1845(1), 1-19 (2013-11-26)
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses and immunity. In addition to its primary role as a
Balázs Csaba Németh et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(6), G466-G473 (2014-01-25)
Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen have been conclusively associated with autosomal dominant hereditary pancreatitis and sporadic nonalcoholic chronic pancreatitis. Most high-penetrance PRSS1 variants increase intrapancreatic trypsin activity by stimulating trypsinogen autoactivation and/or by
Kyoung-Ho Pyo et al.
Natural product communications, 8(12), 1755-1758 (2014-02-22)
The activation of macrophages by trypsin-digested silk peptides was investigated by considering CD1 lb and CD40 expression in the RAW264.7 cell, a murine macrophage. Silk protein hydrolysates were digested with trypsin, following by centrifugal purification using the Centriprep 30k concentrator.
Ying Zhang et al.
Molecular bioSystems, 9(3), 492-500 (2013-01-31)
As two of the most common and important post-translational modifications (PTMs) of proteins, glycosylation and phosphorylation play critical roles in biological processes. Because of the low abundance of phosphopeptides/glycopeptides, specific and sensitive strategies are especially indispensable for the identification of
R J Read et al.
Biochemistry, 23(26), 6570-6575 (1984-12-18)
The X-ray crystal structure of Streptomyces griseus trypsin has been solved and refined at 1.7-A resolution. The structure of this protein had been predicted in two models on the basis of its expected homology to structures of bovine trypsin and
Yuji Naito et al.
Journal of gastroenterology, 41(3), 198-208 (2006-05-16)
Reflux of the duodenal contents with gastric acid has been reported to contribute to the development of esophageal mucosal damage and inflammation. Recent studies show that pancreatic trypsin can stimulate the production of inflammatory mediators, including chemokines and prostaglandins from
Joyce Souza et al.
Experimental parasitology, 135(4), 701-707 (2013-11-05)
Trypsin and bile salts have been identified as important triggers for excystation of Echinostoma metacercariae. Although excystation in trematodes is a well-known phenomenon, some morphological developmental changes remain to be elucidated. In order to gain further insight into the in
Adam Cryar et al.
Journal of AOAC International, 96(6), 1350-1361 (2014-03-22)
Current routine food allergen quantification methods, which are based on immunochemistry, offer high sensitivity but can suffer from issues of specificity and significant variability of results. MS approaches have been developed, but currently lack metrological traceability. A feasibility study on
Treatment of proton pump inhibitor-resistant patients with gastroesophageal reflux disease.
Yoshikazu Kinoshita et al.
Journal of gastroenterology, 41(3), 286-287 (2006-05-16)
Norelle L Daly et al.
The Journal of biological chemistry, 288(50), 36141-36148 (2013-10-31)
MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity and, on the basis of its exceptional proteolytic stability, is a valuable template for the design of novel drug leads. Insights into inhibitor dynamics and interactions with biological targets
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