James M Phang et al.
Frontiers in bioscience (Landmark edition), 17, 1835-1845 (2011-12-29)
Proline plays a special role in cancer metabolism. Proline oxidase (POX), a.k.a. proline dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the tumor suppressor. Ectopic expression of POX under control of tet-off promoter initiated mitochondrial