94-02-0

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[Studies of the relationship of HLA polymorphisms and the infection of H. pylori in the population of Linqu in Shandong Province].

Zhao-Hui Li et al.

Yi chuan = Hereditas, 26(2), 143-146 (2005-01-25)

In order to analyze the relationship of HLA polymorphisms and the infection of H. pylori in the population of Linqu County in Shandong Province, polymerase chain reaction with sequence-specific primers(PCR-SSP) was used to determine the alleles of HLA type I

Agonist-induced platelet reactivity correlates with bleeding in haemato-oncological patients.

B Batman et al.

Vox sanguinis, 112(8), 773-779 (2017-09-30)

Prophylactic platelet transfusions are administered to prevent bleeding in haemato-oncological patients. However, bleeding still occurs, despite these transfusions. This practice is costly and not without risk. Better predictors of bleeding are needed, and flow cytometric evaluation of platelet function might

Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial.

Olivier Varenne et al.

Lancet (London, England), 391(10115), 41-50 (2017-11-06)

Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration

Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial.

Raymond Hang Wun Li et al.

Lancet (London, England), 402(10405), 851-858 (2023-08-20)

Levonorgestrel, a standard drug for emergency contraception (EC), is not effective if administered post-ovulation. A cyclo-oxygenase inhibitor could contribute synergistic effects. We investigated whether a single 40 mg oral dose of piroxicam as co-treatment with levonorgestrel improved emergency contraceptive efficacy.

Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.

Annemiek Broyl et al.

The Lancet. Oncology, 11(11), 1057-1065 (2010-09-25)

Bortezomib-induced peripheral neuropathy is a dose-limiting toxicity in patients with multiple myeloma, often requiring adjustment of treatment and affecting quality of life. We investigated the molecular profiles of early-onset (within one treatment cycle) versus late-onset (after two or three treatment

Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial.

Tom P Freeman et al.

The lancet. Psychiatry, 7(10), 865-874 (2020-08-01)

Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe. Therefore, we aimed to identify efficacious doses and

A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.

Josep M Llovet et al.

Gastroenterology, 131(6), 1758-1767 (2006-11-08)

Small liver nodules approximately 2 cm are difficult to characterize by radiologic or pathologic examination. Our aim was to identify a molecular signature to diagnose early hepatocellular carcinoma (HCC). The transcriptional profiles of 55 candidate genes were assessed by quantitative

Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

Andrea Morelli et al.

JAMA, 310(16), 1683-1691 (2013-10-11)

β-Blocker therapy may control heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects. To

Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials.

Huib A M Kerstjens et al.

The Lancet. Respiratory medicine, 3(5), 367-376 (2015-02-16)

In patients with severe asthma, tiotropium improves lung function and exacerbation risk when added to high-dose inhaled corticosteroids plus long-acting β2 agonists. We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic

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