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Renée L Crisp et al.
Pediatric blood & cancer, 59(7), 1299-1301 (2012-04-11)
We studied 31 children with hemolytic anemia, or with positive family history for hereditary spherocytosis (HS), to assess the reliability of capillary blood samples for the diagnosis. HS was diagnosed in 20 patients. Cryohemolysis (CH) was positive in 94% and
Hidefumi Inaba et al.
Endocrinology, 154(6), 2234-2243 (2013-04-18)
Development of Graves' disease is related to HLA-DR3. The extracellular domain (ECD) of human TSH receptor (hTSH-R) is a crucial antigen in Graves' disease. hTSH-R peptide 37 (amino acids 78-94) is an important immunogenic peptide in DR3 transgenic mice immunized
Rachid Souktani et al.
Fundamental & clinical pharmacology, 17(5), 555-561 (2004-01-06)
Apoptosis is a significant contributor to myocardial cell death during ischemia-reperfusion and swelling-activated chloride channels (I(Cl,swell)) contribute to apoptosis. However, the relationship between I(Cl,swell) ischemia-reperfusion and apoptosis remains unknown. To further investigate this, New Zealand rabbits underwent a 20-min coronary
Eva-Katrin Bentz et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(7), 705-709 (2007-11-15)
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100 male-to-female (MtF) transsexuals, 47 female-to-male (FtM) transsexuals, and 1670 controls, the authors assess allele and genotype frequencies of the steroid 5-alpha
Tasneem Asghar et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 20(2), 59-63 (2005-04-13)
Endometriosis is a complex trait, which means that multiple susceptibility genes interact with one another and the environment to produce the phenotype. One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays
Tanya Simuni et al.
Movement disorders : official journal of the Movement Disorder Society, 25(16), 2863-2866 (2010-09-08)
Recent data suggests that isradipine, a dihydropyridine calcium channel blocker, is neuroprotective in preclinical models of parkinsonism. Isradipine has not been systematically studied in patients with Parkinson's disease (PD). The aim of this study was to evaluate safety and tolerability
Jie Liu et al.
Annals of clinical and laboratory science, 33(4), 429-434 (2003-10-31)
Recent studies have shown that a single nucleotide polymorphism of A/G substitution in the androgen response element-1 (ARE-1) of the promoter for the prostate-specific antigen gene is a biomarker of prostate cancer. Portugese men with prostate cancer have a high
Daniela V Barreto et al.
Nephron. Clinical practice, 117(4), c363-c372 (2010-11-13)
To assess (a) plasma osteopontin (pOPN) in a cohort of chronic kidney disease (CKD) patients; (b) the relationship between pOPN and aortic calcification and stiffness, and (c) the association between pOPN and the overall and cardiovascular mortality risk. pOPN, the
M C Yagmurdur et al.
International surgery, 93(3), 163-168 (2008-10-03)
The study group was derived from the archive materials of 55 invasive ductal breast cancer (IDC) patients who had undergone breast-preserving surgery (partial mastectomy/ axillary dissection). All patients included in the study had clinically T(1)-2, N0-M0 invasive ductal carcinoma. Genomic
Sophie Liabeuf et al.
Atherosclerosis, 215(1), 116-124 (2010-12-25)
Tenascin-C (TN-C) is an adhesion-modulating extracellular matrix glycoprotein which is overexpressed in various organs under disease conditions (infection and inflammation). In patients with heart disease, plasma TN-C levels have been shown to be predictive of cardiac remodeling. Chronic kidney disease
Masaya Tanno et al.
Journal of molecular and cellular cardiology, 35(12), 1523-1527 (2003-12-05)
Brief exposure to tumor necrosis factor (TNF) is known to trigger subsequent cardioprotection. TNF activates multiple downstream signaling cascades including p38-MAPK, a kinase known to initiate ischemic preconditioning. However, it is not known whether this kinase is similarly involved in
Joann M Moulds et al.
Transfusion, 55(6 Pt 2), 1418-1422 (2014-12-17)
The r'(s) haplotype is found in 5% to 15% of individuals of African descent. Persons with this haplotype have a partial C antigen and weakened e and can produce anti-C or other "e-like" alloantibodies. Thus, for these chronically transfused patients
Matthias Griese et al.
American journal of respiratory and critical care medicine, 170(9), 1000-1005 (2004-07-24)
Cystic fibrosis (CF) lung disease is primarily a disease of the small airways. We hypothesized that even in patients with normal lung function, a reduced surfactant function would be present and favor small airway obstruction. Bronchoalveolar lavages from 76 patients
Dong Hyun Sinn et al.
Hepato-gastroenterology, 56(91-92), 672-676 (2009-07-23)
A panel of five markers (two mononuclotide markers and three dinucleotide markers; the so-called Bethesda markers) has been proposed to define MSI status. However reducing these 5 markers into one or two markers have been suggested to be sufficient for
Nick Bishop et al.
Lancet (London, England), 382(9902), 1424-1432 (2013-08-10)
Children with osteogenesis imperfecta are often treated with intravenous bisphosphonates. We aimed to assess the safety and efficacy of risedronate, an orally administered third-generation bisphosphonate, in children with the disease. In this multicentre, randomised, parallel, double-blind, placebo-controlled trial, children aged
Takeo Abumiya et al.
Arteriosclerosis, thrombosis, and vascular biology, 22(6), 907-913 (2002-06-18)
Fluid shear stress is 1 of the major factors that control gene expression in vascular endothelial cells. We investigated the role of shear stress in the regulation of the expression of fetal liver kinase-1/kinase domain region (Flk-1/KDR), a vascular endothelial
L G Carr et al.
The Journal of biological chemistry, 265(3), 1658-1664 (1990-01-25)
The human alcohol dehydrogenase gene ADH2 is expressed at high levels in the liver. At least five different complexes between nuclear proteins from mouse liver or rat hepatoma cells and the proximal promoter region extending from nucleotides -188 to +31
L Banci et al.
European journal of biochemistry, 249(1), 270-279 (1997-11-18)
The solution structure of the major form of the reduced soluble fragment of rat microsomal cytochrome b5 has been solved through 1H-NMR spectroscopy. The protein contains 98 amino acids. Proton assignment was available for residues 1-94, except 90 [Guiles, R.
Rimple Bhatia et al.
Journal of basic microbiology, 52(5), 504-512 (2011-12-07)
This work evaluates the antifungal activity of two essential oil components against 28 clinical isolates (17 sensitive, 11 resistant) and 3 standard laboratory strains of Candida. Growth of the organisms was significantly effected in both solid and liquid media at
Punit Sharma et al.
Clinical nuclear medicine, 40(7), e351-e356 (2015-03-19)
The aim of this study was to evaluate the role of ⁶⁸Ga DOTANOC PET/CT imaging in patients with multiple endocrine neoplasia (MEN) syndromes. Data of 33 patients (age, 33.5 [13.8] years; male 14/female 19) with MEN syndromes (MEN 1, 9;
C E Grue et al.
Environmental research, 35(2), 454-465 (1984-12-01)
The 24-hr median lethal dose (LD50) of dicrotophos (3-hydroxy-N,N-dimethyl-cis-crotonamide dimethyl phosphate) for free-living 5-day-old nestling European starlings (Sturnus vulgaris, LD50 = 4.92 mg/kg body wt) was about one-half that obtained for free-living 15-day-old nestlings (9.59 mg/kg) and captive adult males
Miguel M Fernandes-Silva et al.
JACC. Heart failure, 5(3), 157-165 (2016-12-27)
The aim of this study was to evaluate racial differences in arterial elastance (Ea), which reflects the arterial afterload faced by the left ventricle, and its associations with cardiac structure and function. The hypothesis under study was that the left
Brett R Blackwell et al.
Environmental science & technology, 49(14), 8796-8803 (2015-06-23)
Studies of steroid growth promoters from beef cattle feedyards have previously focused on effluent or surface runoff as the primary route of transport from animal feeding operations. There is potential for steroid transport via fugitive airborne particulate matter (PM) from
Toshiyuki Shiogai et al.
Acta neurochirurgica. Supplement, 118, 229-233 (2013-07-24)
We have improved a transducer holder for transcranial color duplex sonography (TCDS) monitoring via both the temporal and foraminal windows (TW/FW). The objective is to clarify the clinical usefulness of and identify problems with TCDS monitoring in the evaluation of
Atef Hanna et al.
Diagnostic cytopathology, 38(4), 264-269 (2010-02-11)
The diagnosis of malignant mesothelioma in serosal effusions continues to be a major challenge because some of its cytomorphological features closely resemble adenocarcinomas. Immunohistochemistry is a valuable tool in the differentiation of epithelioid mesothelioma from metastatic adenocarcinomas. However, no single
Gerson Dierley Keppeke et al.
Journal of genetics and genomics = Yi chuan xue bao, 42(6), 287-299 (2015-07-15)
Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5'-monophosphate dehydrogenase 2 (IMPDH2). We aim to explore the
Jaeeun Yoo et al.
Archives of pathology & laboratory medicine, 143(8), 999-1005 (2019-02-15)
Infectious gastroenteritis is caused by various pathogens, including bacteria, viruses, and parasites. To compare the performance of Seegene Allplex Gastrointestinal (24 targets: 13 bacteria, 5 viruses, and 6 parasites in 4 panels), Luminex xTAG Gastrointestinal Pathogen Panel (15 targets: 9
M Bryer-Ash et al.
Regulatory peptides, 51(2), 101-109 (1994-05-05)
Feedback regulation of glucose-dependent insulinotropic polypeptide (GIP) was studied in a conscious rat model. Male Wistar rats were preconditioned to partial restraint, the tail artery and vein were cannulated under local anesthesia. All animals received 1 g/kg oral glucose by
Maria Gabriella Scordo et al.
Pharmacological research, 53(2), 162-165 (2005-12-13)
Allelic variation at the CYP2D6 gene has been suggested to be associated with CNS disorders, including Parkinson's disease and Lewy body dementia. In order to elucidate whether a relationship exists between CYP2D6 polymorphism and the risk of developing Alzheimer's disease
Pierre Nahon et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 3(3), 292-298 (2005-03-15)
A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import. However, the role of this dimorphism in the susceptibility of alcoholic patients to develop
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