94-34-8

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Improving the detection of fungi in eosinophilic mucin: seeing what we could not see before.

Canting Guo et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 147(5), 943-949 (2012-06-13)

To investigate the improvement in histologic detection of fungi with Gomori methenamine silver (GMS) stain by trypsin predigestion in the mucus of patients with chronic rhinosinusitis (CRS). Prospective, single group, descriptive analysis. Multi-institutional. Thirty-four sinus specimens from 12 surgical patients

Differential immunodiagnosis between cystic hydatid disease and other cross-reactive pathologies.

D Poretti et al.

The American journal of tropical medicine and hygiene, 60(2), 193-198 (1999-03-11)

We assessed an Echinococcus granulosus hydatid fluid antigen-ELISA (EgHF-ELISA) as a serologic prescreening test for E. granulosus infections, supplemented by more specific confirmatory tests, including arc-5 immunoprecipitation and antigen B subunit 8-kD immunoblotting. The diagnostic sensitivity of the EgHF-ELISA was

The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis.

Earn H Gan et al.

Clinical endocrinology, 75(2), 165-168 (2011-04-28)

Genome-wide association studies have discovered various susceptibility alleles that are shared among different autoimmune conditions, implicating several biochemical pathways in the pathogenesis of autoimmunity. A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor

Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases.

Y Qian et al.

Molecular and cellular biochemistry, 181(1-2), 49-61 (1998-04-30)

Rat Atp7a occupied a single open reading frame (274502) which coded for a protein of 1492 residues. Rat Atp7a was 98% and 95% identical to published sequences for the mouse and Chinese hamster, respectively, and 94% homologous to human ATP7A.

Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1- yl)purines as potential prodrugs of penciclovir.

D K Kim et al.

Bioorganic & medicinal chemistry, 7(8), 1715-1725 (1999-09-11)

A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines (9-12) were synthesized as potential prodrugs of penciclovir. Treatment of 6-deoxypenciclovir with trimethyl orthoacetate or triethyl orthopropionate (1.2 equiv) in DMF in the presence of p-TsOH.H2O (0.1 equiv) followed by quenching

Dengue virus infections among Haitian and expatriate non-governmental organization workers--Léogane and Port-au-Prince, Haiti, 2012.

Stephanie J Salyer et al.

PLoS neglected tropical diseases, 8(10), e3269-e3269 (2014-10-31)

In October 2012, the Haitian Ministry of Health and the US CDC were notified of 25 recent dengue cases, confirmed by rapid diagnostic tests (RDTs), among non-governmental organization (NGO) workers. We conducted a serosurvey among NGO workers in Léogane and

Characterization of Staphylococcus epidermidis strains isolated from industrial cleanrooms under regular routine disinfection.

U Ribič et al.

Journal of applied microbiology, 122(5), 1186-1196 (2017-02-24)

The purpose of this study was the genotypic and phenotypic characterization of 57 strains of Staphylococcus epidermidis isolated from cleanroom environments, based on their biofilm formation and antimicrobial resistance profiles. Biofilm formation was investigated using real-time PCR (icaA, aap, bhp

Genetic analysis of chromosome 11p13 and the PAX6 gene in a series of 125 cases referred with aniridia.

David O Robinson et al.

American journal of medical genetics. Part A, 146A(5), 558-569 (2008-02-05)

A series of 125 patients referred primarily with aniridia classified as either sporadic (74), familial (24), or in association with WAGR syndrome (14) or other malformations (13) was analysed for mutations, initially by karyotyping and targeted FISH analysis of chromosome

Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer.

Shiva S Forootan et al.

Human pathology, 38(9), 1321-1329 (2007-06-30)

The levels of Id-1 (inhibitor of DNA binding or inhibitor of cell differentiation) expression in a series of prostate cell lines and in an archival set of prostate tissues were examined. Western blot analysis showed that the level of Id-1

Serum arylesterase and paraoxonase activity in patients with chronic hepatitis.

Suleyman Sirri Kilic et al.

World journal of gastroenterology, 11(46), 7351-7354 (2006-01-27)

To investigate the relationship between serum paraoxonase (PON1), AST, ALT, GGT, and arylesterase (AE) activity alterations and the degree of liver damage in patients with chronic hepatitis. We studied 34 chronic hepatitis patients and 32 control subjects, aged between 35

Duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: short-chain fatty acid and lactate absorption, saliva production, and blood metabolites.

T Schwaiger et al.

Journal of animal science, 91(12), 5743-5753 (2013-10-26)

This study was conducted to determine if the duration of time that beef cattle are fed a high-grain diet affects short-chain fatty acid (SCFA) absorption, saliva production, and blood metabolites before, during, and following an induced bout of ruminal acidosis.

Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms.

P A Bejarano et al.

Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 189-194 (2000-09-12)

Thyroid transcription factor-1 (TTF-1), a member of the NKx2 family of homeodomain transcription factors, is a mediator of thyroid-specific transcription of the thyroglobulin (TG) gene. The combined immunohistochemical profile of TTF-1, TG, cytokeratin 7 (CK7), and cytokeratin 20 (CK20) in

HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.

Junkichi Takemoto et al.

Human pathology, 85, 162-167 (2018-11-24)

The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; 3 ganglioneuroblastomas

High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.

Stefan Aretz et al.

Human mutation, 26(6), 513-519 (2005-11-16)

Germline mutations in the STK11 gene have been identified in 10-70% of patients with Peutz-Jeghers syndrome (PJS), an autosomal-dominant hamartomatous polyposis syndrome. A second locus was assumed in a large proportion of PJS patients. To date, STK11 alterations comprise mainly

Final results of a randomized phase III trial comparing cyclophosphamide, epirubicin, and fluorouracil with a dose-intensified epirubicin and cyclophosphamide + filgrastim as neoadjuvant treatment in locally advanced breast cancer: an EORTC-NCIC-SAKK multicenter study.

P Therasse et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(5), 843-850 (2003-03-01)

To compare the efficacy of a standard anthracycline-based regimen to a dose-intensified anthracycline regimen in locally advanced breast cancer. Locally advanced breast cancer patients were randomly assigned onto a study comparing cyclophosphamide (C; 75 mg/m(2) orally days 1 to 14)

Autoimmunity predominates in a large South African cohort with Addison's disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201.

Ian Ross et al.

Clinical endocrinology, 73(3), 291-298 (2010-05-12)

We sought to determine whether autoimmunity is the predominant cause of Addison's disease in South Africa and whether human leucocyte antigen (HLA) DQ association exists. We compiled a national registry of patients from primary care, referral centres and private practices.

In vivo efficacy of humanized exposures of Ceftazidime-Avibactam in comparison with Ceftazidime against contemporary Enterobacteriaceae isolates.

Shawn H MacVane et al.

Antimicrobial agents and chemotherapy, 58(11), 6913-6919 (2014-09-17)

Ceftazidime-avibactam is a β-lactam β-lactamase inhibitor combination under investigation for the treatment of serious Gram-negative infections. When combined with avibactam, a novel non-β-lactam β-lactamase inhibitor, ceftazidime has activity against isolates that produce Ambler class A, class C, and some class

Polymorphisms in cytokine genes do not predict progression to end-stage heart failure in children.

Steven A Webber et al.

Cardiology in the young, 12(5), 461-464 (2005-03-19)

A number of cytokines have been implicated in the pathophysiology of congestive heart failure. Genetic polymorphisms of several cytokine genes are known to result in altered gene expression, enabling us to characterize patients as "high" or "low" producers of specific

Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway.

Rakshya Gorkhali et al.

Scientific reports, 11(1), 20576-20576 (2021-10-20)

G-protein-coupled receptors (GPCRs) are a target for over 34% of current drugs. The calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca2+) homeostasis that is critical for many physiological, calciotropical, and noncalciotropical outcomes in multiple organs. However, the

Cardiovascular manifestations in men and women carrying a FBN1 mutation.

Delphine Détaint et al.

European heart journal, 31(18), 2223-2229 (2010-08-17)

In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery

Enzyme assay and clinical assessment in subjects with a Chinese hotspot late-onset Fabry mutation (IVS4 + 919G→A).

Hsiang-Yu Lin et al.

Journal of inherited metabolic disease, 33(5), 619-624 (2010-09-08)

Newborn screening for Fabry disease in Taiwan Chinese has revealed a high incidence of the late-onset GLA mutation IVS4 + 919G→A (∼1 in 1,500-1,600 males). We studied 94 adults with this mutation [22 men, 72 women; mean age: men 57.8 ± 6.0 (range 42-68)

CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.

Vera Grossmann et al.

British journal of haematology, 161(5), 649-658 (2013-03-26)

Acute myeloid leukaemia (AML) with CEBPA mutations is listed as a provisional entity in the current World Health Organization classification. A difference in clinical outcome between single- (sm) and double-mutated (dm) cases has been reported, whereupon CEBPAdm cases were shown

Susceptibility to Reiter's syndrome is associated with alleles of TAP genes.

K S Barron et al.

Arthritis and rheumatism, 38(5), 684-689 (1995-05-01)

Although HLA-B27 is strongly associated with susceptibility to Reiter's syndrome (RS), recent data suggest that an additional modifying or susceptibility gene(s) acts in concert with HLA-B27 to contribute to disease pathogenesis. The recently described TAP genes (transporters associated with antigen

Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions.

Jianhui Shi et al.

Human pathology, 38(9), 1335-1344 (2007-05-22)

p16INK4a has been shown to be overexpressed in nearly all high-grade squamous intraepithelial lesions (HSILs). Other cell-cycle regulators, such as minichromosome maintenance protein 2 (MCM2), DNA topoisomerase IIalpha (TOP IIA), and ProE(X) C (a cocktail of MCM2 and TOP IIA)

[Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women].

Iván Quevedo L et al.

Revista medica de Chile, 136(4), 475-481 (2008-09-05)

Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (BMD) and bone fragility fractures. Vitamin D receptor (VDR) gene polymorphisms explain a small part of the genetic influence

Solitary (juvenile) xanthogranuloma: a comprehensive immunohistochemical study emphasizing recently developed markers of histiocytic lineage.

Rosalind F Sandell et al.

Human pathology, 46(9), 1390-1397 (2015-07-30)

Solitary (juvenile) xanthogranuloma (SXG) is an uncommon, benign lesion that usually occurs in children. The cell of origin of SXG has been the subject of debate, with hypotheses including endothelium, dermal dendrocytes, dermal indeterminate cells, and the plasmacytoid monocyte, among

Treatment of Severe Aortic Bleeding Using Hemopatch in Swine on Dual Antiplatelet Therapy.

Bernhard Baumgartner et al.

Journal of investigative surgery : the official journal of the Academy of Surgical Research, 29(6), 343-351 (2016-03-24)

The perioperative management of patients on antithrombotic therapy is currently an unresolved problem as these therapies pose a considerable risk for perioperative hemorrhagic complications. The presented studies investigated the efficacy of a new collagen technology to achieve hemostasis. A polyethylene

The effect of hypothermia on neuronal viability following cardiopulmonary bypass and circulatory arrest in newborn piglets.

Peter Pastuszko et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 35(4), 577-581 (2009-02-17)

To determine the effect of recovery with mild hypothermia after cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) on the activity of selected key proteins involved in initiation (Bax, Caspase-3) or inhibition of apoptotic injury (Bcl-2, increased ratio Bcl-2/Bax)

Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial.

Jyh-Ming Liou et al.

Lancet (London, England), 381(9862), 205-213 (2012-11-20)

Whether sequential treatment can replace triple therapy as the standard treatment for Helicobacter pylori infection is unknown. We compared the efficacy of sequential treatment for 10 days and 14 days with triple therapy for 14 days in first-line treatment. For

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel.

Emily R Adams et al.

Wellcome open research, 5, 139-139 (2021-03-23)

Background: The COVID-19 pandemic caused >1 million infections during January-March 2020. There is an urgent need for reliable antibody detection approaches to support diagnosis, vaccine development, safe release of individuals from quarantine, and population lock-down exit strategies. We set out

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