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N J Bureau et al.
AJNR. American journal of neuroradiology, 35(8), 1467-1474 (2014-05-31)
Transforaminal corticosteroid injections can be performed in the management of cervical radiculopathy but carry the risk of catastrophic complications. This study compares the efficacy of transforaminal and facet corticosteroid injections at 4 weeks' follow-up. We randomly assigned 56 subjects to
A Xanthopoulos et al.
International journal of cardiology, 230, 248-254 (2017-01-08)
The use of many acute heart failure (AHF) risk scores is cumbersome. We therefore developed a simple AHF risk score (AHFRS) for early risk stratification. The study consisted of a prospective derivation cohort (PDC; N=104; age, 77[21] years; LVEF (%)
V De Stefano et al.
Journal of thrombosis and haemostasis : JTH, 5(4), 708-714 (2007-02-01)
Thrombosis of splanchnic or cerebral veins is a typical manifestation of polycythemia vera (PV) or essential thrombocythemia (ET). The recently identified Janus kinase 2 (JAK2) V617F somatic mutation is closely related to chronic myeloproliferative disorders (CMD). To assess the incidence
Fabrizio Sgolastra et al.
Journal of periodontology, 83(10), 1257-1269 (2012-01-10)
The combination of Amoxicillin and metronidazole (AMX/MET) as an adjunctive treatment to scaling root planing (SRP) has been proposed for the treatment of chronic periodontitis; however, its effectiveness and clinical safety remain to be defined. The purpose of the present
Shaji K Kumar et al.
The Lancet. Oncology, 15(13), 1503-1512 (2014-12-03)
The combination of bortezomib, lenalidomide, and dexamethasone is a highly effective therapy for newly diagnosed multiple myeloma. Ixazomib is an investigational, oral, proteasome inhibitor with promising anti-myeloma effects and low rates of peripheral neuropathy. In a phase 1/2 trial we
Susanne Lund Kristensen et al.
Fertility and sterility, 97(3), 779-785 (2012-01-17)
To investigate the association between serum antimüllerian hormone (AMH) and other reproductive parameters in young women. Cross-sectional study. University hospital. Population-based cohort of 256 women: 180 were users and 76 were nonusers of hormonal contraceptives. None. Antral follicles, androgens, age
Payal Kapur et al.
The Lancet. Oncology, 14(2), 159-167 (2013-01-22)
Clear-cell renal-cell carcinomas display divergent clinical behaviours. However, the molecular genetic events driving these behaviours are unknown. We discovered that BAP1 is mutated in about 15% of clear-cell renal-cell carcinoma, and that BAP1 and PBRM1 mutations are largely mutually exclusive.
B Gottstein et al.
International journal for parasitology, 28(4), 679-691 (1998-05-29)
Neospora caninum has gained considerable attention through its role in the aetiology of bovine abortion. Due to its close phylogenetic relationship with Toxoplasma gondii, respective unequivocal differential diagnosis deserves special consideration. In order to evaluate the diagnostic performance of molecular
Isabelle Schaub et al.
European journal of anaesthesiology, 29(6), 286-294 (2012-04-11)
Droperidol is widely used for the prevention of postoperative nausea and vomiting (PONV) in European countries. It is unclear how efficacious low-dose droperidol is in the prevention of PONV. To test the efficacy of low-dose droperidol in the prevention of
Suk-Kyun Yang et al.
The American journal of gastroenterology, 103(6), 1437-1442 (2008-04-22)
A recent genomewide association study from a Japanese population identified tumor necrosis factor superfamily member 15 (TNFSF15) as an inflammatory bowel disease gene. Previous studies have shown that expression of TNFSF15 was upregulated in macrophages and lymphocytes of the intestinal
Jinwei Du et al.
Journal of virological methods, 287, 114009-114009 (2020-11-06)
Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. The aim of this study was to evaluate the performances of a newly
Guillaume Paré et al.
Circulation, 127(13), 1404-1412 (2013-03-08)
Fixed-dose unmonitored treatment with dabigatran etexilate is effective and has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared with warfarin. We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of
Nicola J Sunter et al.
Blood, 119(1), 196-205 (2011-11-16)
Up to 15% of acute promyelocytic leukemia (APL) patients fail to achieve or maintain remission. We investigated a common G > A polymorphism at position -1377 (rs2234767) in the core promoter of the CD95 cell death receptor gene in 708
M W Peck et al.
Applied and environmental microbiology, 61(5), 1780-1785 (1995-05-01)
Spores of five type B, five type E, and two type F strains of nonproteolytic Clostridium botulinum were inoculated into tubes of an anaerobic meat medium plus lysozyme to give approximately 10(6) spores per tube. Sets of tubes were then
Xu-ling Cai et al.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 30(9), 942-945 (2010-03-03)
To evaluate the interaction between environmental factors, HBV/HCV infections and DNA repair gene XPC exon 8 Ala499Val, exon 15 Lys939Gln on related risks to primary hepatocellular carcinoma (PHC). A 1:1 matched case-control study was conducted in Shunde city, Guangdong province.
Adam S Fleisher et al.
JAMA neurology, 72(3), 316-324 (2015-01-13)
Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1)E280A mutation carriers and noncarriers from the world's largest known autosomal dominant Alzheimer disease (AD) kindred. To characterize and compare age-associated changes in brain imaging
Nancy A Dawson et al.
Clinical genitourinary cancer, 6(2), 110-116 (2008-10-01)
Docetaxel/estramustine is a known active regimen in hormonerefractory prostate cancer (HRPC). A phase II study was conducted to assess the safety and efficacy of docetaxel/estramustine combined with exisulind, an apoptotic antineoplastic drug. Eighty men with chemotherapy-naive HRPC were enrolled in
Koichiro Yamakado et al.
International journal of clinical oncology, 19(5), 955-962 (2013-11-30)
The aim of this study was to evaluate the safety and clinical utility of radiofrequency ablation (RFA) retrospectively in non-surgical candidates with recurrent bone and soft-tissue sarcomas. Percutaneous RFA was used in 52 patients (21 female, 31 male; mean age
Letizia Straniero et al.
Neurology. Genetics, 6(6), e523-e523 (2020-11-20)
To provide a variant-specific estimate of incidence, penetrance, sex distribution, and association with dementia of the 4 most common Parkinson disease (PD)-associated GBA variants, we analyzed a large cohort of 4,923 Italian unrelated patients with primary degenerative parkinsonism (including 3,832
Boyoung Joung et al.
American heart journal, 150(6), 1213-1219 (2005-12-13)
This study was sought to investigate whether plasma N-terminal pro-brain natriuretic peptide (proBNP) can help identify patients with an elevated left ventricular end-diastolic pressure (LVEDP) or filling pressures in patients with a normal systolic function. The proBNP is a good
Alberto Alvarez-Larrán et al.
British journal of haematology, 146(5), 504-509 (2009-07-17)
Postpolycythaemic myelofibrosis (PPMF) is a known complication of polycythaemia vera (PV) but information regarding its incidence and predisposing factors is not well defined. In 116 subjects consecutively diagnosed with PV in a single institution (median age 62 years, range: 20-88)
Dominique Valteau-Couanet et al.
Pediatric blood & cancer, 61(6), 977-981 (2013-08-24)
To evaluate long-term survival of the first cohort of stage-4 neuroblastoma patients treated with the N7 induction chemotherapy, surgery of the primary tumor and high-dose chemotherapy (HDC) containing Busulfan-Melphalan (Bu-Mel) followed by autologous stem cell transplantation (ASCT). From 1998 to
Akbar Khalilpour et al.
The American journal of tropical medicine and hygiene, 91(5), 994-999 (2014-09-10)
Cystic echinococcosis (CE) caused by infection with Echinococcus granulosus is of major concern for humans in many parts of the world. Antigen B was prepared from E. granulosus hydatid fluid, and Western blots confirmed eight batches showing a band corresponding
B Yu et al.
The British journal of dermatology, 162(5), 1038-1043 (2010-03-05)
Atopic dermatitis (AD) is a chronic skin disease affecting more than 15% of children and 2% of adults. A strong connection between genetic factors and AD has been described for a long time. Histamine receptor H4 (HRH4) has been shown
Amar Akhtar Sethi et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(7), 1269-1275 (2003-06-14)
The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations. One hundred twenty-seven
Albert Font et al.
Investigational new drugs, 21(4), 435-443 (2003-10-31)
Inherited variations in drug metabolizing enzymes may influence drug efficacy. This phase II study assesses the impact of second-line weekly irinotecan (CPT-11)/docetaxel in non-small cell lung cancer (NSCLC) patients, and gauges the uridine diphosphate glucuronosyl transferase (UGT1A1) polymorphism influence in
Zhichao Jin et al.
Annals of the rheumatic diseases, 73(11), 1962-1967 (2013-07-31)
To summarise the evidence regarding the dose-response association between alcohol consumption and risk of rheumatoid arthritis (RA). Studies were identified from search of MEDLINE, Embase and Web of Science databases between 1 January 1946 and 10 April 2013, and from
Steven Attia et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(8), 2437-2443 (2008-04-17)
Docetaxel is standard of care for androgen-independent prostate cancer (AIPC). Doxercalciferol (1 alpha-hydroxyvitamin D2) had modest activity in phase I/II trials. Preclinical data support combining vitamin D analogues with docetaxel to treat AIPC. Chemotherapy-naive men with metastatic AIPC were randomized
S I Nwadioha et al.
The Nigerian postgraduate medical journal, 20(1), 9-13 (2013-05-11)
To determine the common aetiolog of acute bacterial meningitis in children and their antibiotic susceptibility pattern. A retrospective study with a review of cerebrospinal fluid culture reports of paediatric patients aged 0-15 years, suspected of acute meningitis in the Medical
Gervasio A Lamas et al.
JAMA, 309(12), 1241-1250 (2013-03-28)
Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy. To determine if an EDTA-based chelation regimen reduces cardiovascular events. Double-blind, placebo-controlled, 2 × 2 factorial randomized trial enrolling 1708
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