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关键词:'96-33-3'
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Theodore R Johnson et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 45-59 (2014-07-19)
1. Crizotinib (XALKORI®), an oral inhibitor of anaplastic lymphoma kinase (ALK) and mesenchymal-epithelial transition factor kinase (c-Met), is currently approved for the treatment of patients with non-small cell lung cancer that is ALK-positive. 2. The metabolism, excretion and pharmacokinetics of
David Neal Franz et al.
The Lancet. Oncology, 15(13), 1513-1520 (2014-12-03)
In the EXIST-1 trial, initiated on Aug 10, 2009, more than 35% of patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex had at least 50% reduction in SEGA volume after 9·6 months of treatment with everolimus.
Nagham R El Saidy et al.
Environmental monitoring and assessment, 192(12), 779-779 (2020-11-25)
The remediation of wastewater (WW) is a promising solution for limited water sources. This study aimed to evaluate rice straw (RS) and zeolite (Z) as bioadsorbents for the removal of pollutants, including heavy metals (HMs) (cadmium [Cd], nickel [Ni], and
Stefano Christian Londero et al.
Acta oncologica (Stockholm, Sweden), 47(3), 451-457 (2007-10-02)
Papillary microcarcinomas (PMC) of the thyroid gland are defined according to The WHO Committee as papillary carcinomas measuring 10 mm or less in diameter. A large proportion of these tumours are found coincidentally in the treatment of symptomatic goitre and
H Okumura et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 121(3), 253-257 (2001-03-27)
Persistent dry cough is well known as the most common side-effect of angiotensin-converting enzyme (ACE) inhibitors. We examined the relationship between a cough and ACE gene polymorphism, plasma bradykinin (BK), substance P (SP) and ACE inhibitor concentrations in patients with
Jens R Wendland et al.
Experimental brain research, 153(1), 1-6 (2003-09-05)
The neuropeptide galanin is known to have an antinociceptive effect under neuropathic conditions. After axotomy, galanin is upregulated in sensory neurons, presumably in the capsaicin-sensitive ones. Here, the sensitivity to capsaicin and the expression of galanin were simultaneously examined by
M Yao et al.
Letters in applied microbiology, 61(4), 374-380 (2015-07-24)
Human bikunin is a glycoprotein that exhibits trypsin inhibitory activity against serine proteases, and is effective in clinic. However, limited productivity and high price of human bikunin retard its further application. In this study, a high-yield, low-cost process of recombinant
Luigi Rigacci et al.
Cancer, 97(1), 97-104 (2002-12-20)
Patients with aggressive non-Hodgkin lymphoma (NHL) require intensive and extensive therapy, which seems impracticable in elderly patients due to hematologic and extrahematologic toxicity. Consequent dose reduction and therapy attenuation can reduce treatment-related toxicity but also decreases therapeutic efficacy. Thus, age
Valerie Toteu Djomte et al.
Chemosphere, 241, 124972-124972 (2019-10-15)
Effects of chemical uptake onto polar organic chemical integrative samplers (POCIS) exposed to total suspended solid (TSS) sediment concentrations of 0 and 3600 ppm were investigated for 12 pesticides at constant concentration, temperature, and flow velocity. The effects of sediment exposure
Antonio López-López et al.
Foods (Basel, Switzerland), 9(3) (2020-03-07)
For the first time, the bioaccessibility of the mineral nutrients in ripe table olives and their contributions to the recommended daily intake (RDI), according to digestion methods (Miller's vs. Crews' protocols), digestion type (standard vs. modified, standard plus a post-digest
Maysaa Nemer et al.
Occupational and environmental medicine, 72(6), 428-434 (2015-02-06)
Little is known about the working conditions and airway inflammation in hairdressers in Palestine. We aimed to investigate if hairdressers in Palestine have a higher level of airway inflammation as compared to a control group. We also assessed the hairdressers'
Wolfgang Bogner et al.
Radiology, 274(1), 74-84 (2014-10-24)
To evaluate the image quality, robustness, and diagnostic performance of submillimeter in-plane resolution diffusion-weighted ( DW diffusion-weighted ) magnetic resonance (MR) imaging at 7 T in the assessment of breast tumors. Institutional review board approval and written informed consent of
Rogelio Barreto et al.
Hepatology (Baltimore, Md.), 59(4), 1505-1513 (2013-09-17)
Type-1 hepatorenal syndrome (HRS) is a common complication of bacterial infections in cirrhosis, but its natural history remains undefined. To assess the outcome of kidney function and survival of patients with type-1 HRS associated with infections, 70 patients diagnosed during
Ying-Xue Ding et al.
Developmental medicine and child neurology, 52(11), 1028-1032 (2010-08-21)
Adrenocorticotropic hormone (ACTH) has been used as the major therapy for infantile spasms since 1958 because it effectively suppresses seizures; it also normalizes the electroencephalogram in the short-term treatment of infantile spasms. G protein-regulated inducer of neurite outgrowth 1 (GRIN1
Sueli M Oba-Shinjo et al.
Cancer immunity, 8, 7-7 (2008-04-23)
Medulloblastoma is the most common childhood malignant tumor of the central nervous system. Treatment of medulloblastoma requires harmful therapy and nevertheless carries a poor prognosis. Due to their presence in various cancers and their limited expression in normal tissues, CT
Makoto Ishikawa et al.
World journal of gastroenterology, 12(34), 5517-5522 (2006-09-29)
To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. By immunohistochemical staining using specific antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas)
Fausto J Rodriguez et al.
Journal of neuropathology and experimental neurology, 71(9), 789-794 (2012-08-16)
Optic pathway gliomas represent a specific subtype of astrocytoma with unique clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper have been hampered by limited tissue availability. We analyzed optic nerve gliomas of 59 patients (median
Luca Gianni et al.
The Lancet. Oncology, 13(1), 25-32 (2011-12-14)
Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and
Gaurav Rao et al.
Vascular medicine (London, England), 24(3), 241-247 (2019-03-28)
Both catheter-directed thrombolysis (CDT) and ultrasound-assisted thrombolysis (USAT) are novel treatment modalities for patients presenting with acute pulmonary embolism (PE). The objective of this study was to compare clinical and quality-of-life (QOL) outcomes for patients undergoing either treatment modality. We
Niek E G Beurskens et al.
The international journal of cardiovascular imaging, 33(11), 1723-1730 (2017-06-02)
Quantification of pulmonary regurgitation (PR) is essential in the management of patients with repaired tetralogy of Fallot (TOF). We sought to evaluate the accuracy of first-line Doppler echocardiography in comparison with cardiac magnetic resonance imaging (MRI) to identify hemodynamic significant
Genevieve Schindler et al.
Acta neuropathologica, 121(3), 397-405 (2011-01-29)
Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) gene. Initially described in melanoma, colon and papillary thyroid carcinoma, these alterations have also been observed
Martyn E Caplin et al.
The New England journal of medicine, 371(3), 224-233 (2014-07-12)
Somatostatin analogues are commonly used to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects are limited. We conducted a randomized, double-blind, placebo-controlled, multinational study of the somatostatin analogue lanreotide in patients with advanced
David Gonzalez et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(16), 2223-2229 (2011-04-13)
TP53 mutations have been described in chronic lymphocytic leukemia (CLL) and have been associated with poor prognosis in retrospective studies. We aimed to address the frequency and prognostic value of TP53 abnormalities in patients with CLL in the context of
M Breidert et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 44(1), 70-74 (2011-12-30)
Serotoninergic 5-HT(4) receptors have been detected in several tissues including the heart. An autoimmune mechanism may underline the pathogenesis of heart failure. The aim of this work was to look for autoantibodies to the 5-HT(4) receptor in patients with heart
Natalie K Stilwell et al.
Diseases of aquatic organisms, 128(2), 105-116 (2018-05-08)
Ranaviruses are globally emerging pathogens negatively impacting wild and cultured fish, amphibians, and reptiles. Although conventional and diagnostic real-time PCR (qPCR) assays have been developed to detect ranaviruses, these assays often have not been tested against the known diversity of
Sakhawat Hussain Rahman et al.
Digestive diseases and sciences, 50(7), 1376-1383 (2005-07-29)
Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of
Yang Gao et al.
Molecular pharmacology, 67(1), 204-211 (2004-10-07)
We previously found that injection of a cocaine hydrolase (CocE) engineered from human butyrylcholinesterase will transiently accelerate cocaine metabolism in rats while reducing physiological and behavioral responses. To investigate more extended therapeutic effects, CocE cDNA was incorporated into a replication-incompetent
Suzanne Doyon et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 941-948 (2013-10-18)
Deaths from overdose of acetaminophen (APAP) combination medications are reported, yet the individual ingredients are not well examined as individual putative causes of death. To examine the individual contribution of APAP or other ingredient(s) to fatalities resulting from ingestion of
Yang Jilong et al.
Pathology, 39(3), 319-325 (2007-06-15)
The abnormalities of the Wnt signalling pathway in desmoid-type fibromatosis were analysed, with the purpose of exploring the mechanism of tumorigenesis and progression. The clinical and histopathological features of 96 cases were analysed. Beta-catenin, cyclin-D1, c-myc, and Ki-67 proteins were
T Byk et al.
European journal of biochemistry, 254(1), 14-24 (1998-07-04)
The search for intracellular phosphoproteins implicated in the regulation of neuronal differentiation led to the identification of Ulip1, a mammalian protein related to the Caenorhabditis elegans unc-33 gene product [Byk, T., Dobransky, T., Cifuentes-Diaz, C. & Sobel, A. (1996) J.
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