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R S Puranam et al.
Somatic cell and molecular genetics, 19(6), 581-588 (1993-11-01)
We isolated a human glutamate receptor subunit 7 (GluR-7) cosmid after high stringency screening of a human genomic placental library using a rat GluR-7 cDNA as a probe. A 614-bp fragment of the GluR-7 cosmid was sequenced, and an exon
C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy.
Pablo Olmos et al.
Diabetes research and clinical practice, 74(2), 175-182 (2006-05-17)
To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy. DNAs of 96 control subjects and 53 long-standing (duration 17.9+/-5.4 years) type-2
Sylvie Di Filippo et al.
Human immunology, 66(2), 133-139 (2005-02-08)
Late renal dysfunction may affect long-term outcome of nonrenal transplant recipients. We hypothesized that transforming growth factor beta1 (TGFbeta1) might play a role in the fibrogenic mechanisms leading to renal dysfunction. The aim was to determine whether TGFbeta1 gene polymorphisms
Yaqing Zhang et al.
Journal of experimental & clinical cancer research : CR, 28, 111-111 (2009-08-12)
APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression profile for further understanding of its
Bharat Rekhi et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 126(1), 45-55 (2017-12-22)
Clear cell carcinoma (CCC) of the ovary is an uncommon, but an aggressive epithelial ovarian cancer (EOC), which has overlapping histopathologic features with other ovarian tumours. Lately, Napsin A has been identified as its useful diagnostic immunohistochemical (IHC) marker. Fifty-eight
R Jensen et al.
Journal of neurochemistry, 45(3), 700-705 (1985-09-01)
Two major components of human brain S100 fraction were purified by HPLC and an amino acid sequence was elucidated for the S100 beta component. Human S100 proteins showed absorption spectra and amino acid compositions similar to S100 alpha and S100
Anna Tamburrino et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(13), 3532-3540 (2012-07-04)
Understanding the molecular pathogenesis of medullary thyroid carcinoma (MTC) is prerequisite to the design of targeted therapies for patients with advanced disease. We studied by immunohistochemistry the phosphorylation status of proteins of the RAS/MEK/ERK and PI3K/AKT/mTOR pathways in 53 MTC
Gerard J Oakley et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(8), 1407-1412 (2011-05-19)
The clinical significance of epidermal growth factor receptor (EGFR) mutant allele specific imbalance (MASI) in lung adenocarcinomas is unknown. EGFR MASI was characterized by sequencing electropherograms (SEs) and EGFR fluorescence in situ hybridization (FISH) in 96 prospectively tested lung adenocarcinoma
Tony Antoniou et al.
Antiviral therapy, 19(6), 607-611 (2014-02-13)
We sought to determine the pharmacokinetic disposition of raltegravir in the blood and seminal plasma of HIV-infected men. We conducted a pharmacokinetic study using a staggered sampling approach. A total of 16 HIV-infected men receiving raltegravir-based therapy were recruited into
I Azaiez et al.
Toxicon : official journal of the International Society on Toxinology, 63, 137-146 (2013-01-02)
Fumonisins (FBs) are bioactive compounds produced by several strains of Fusarium spp. which contain a polyketide structure similar to sphinganine. These mycotoxins contain a free amino group that could work as an electron donor and react with the electrophile carbon
A A Rivera et al.
Gene, 133(2), 261-266 (1993-11-15)
A cDNA encoding phosphoglucomutase (PGM) has been isolated from a rat liver cDNA library following screening with a polymerase chain reaction product. The cDNA was found to contain a 53-base-pair (bp) 5' untranslated region (5' UTR), a single start codon
Inès Friha et al.
Journal of environmental management, 160, 184-192 (2015-06-26)
The performance of a pilot-scale membrane bioreactor (MBR) system for the treatment of textile wastewater was investigated. The MBR was continuously operated for 7 months. Very high treatment efficiencies were achieved (color, 100%; chemical oxygen demand (COD), 98%; biochemical oxygen
Jorge E Cortes et al.
The Lancet. Haematology, 3(12), e581-e591 (2016-11-29)
Optimal management of patients with chronic myeloid leukaemia in chronic phase with suboptimal cytogenetic response remains undetermined. This study aimed to investigate the safety and efficacy of switching to nilotinib vs imatinib dose escalation for patients with suboptimal cytogenetic response
Farhad Ravandi et al.
Cancer, 118(10), 2665-2673 (2011-10-25)
IDH1 and IDH2 gene mutations are novel, recurring molecular aberrations among patients with normal karyotype acute myeloid leukemia (AML). Among 358 patients with AML treated on 4 protocols using high-dose ara-C plus idarubicin induction, pretreatment samples were available for 170
T K Newman et al.
Genes, brain, and behavior, 8(6), 626-630 (2009-07-01)
The mesolimbic dopamine system plays an important role in mediating a variety of behaviors and is involved in mediating the reinforcing effects of ethanol. Genes encoding dopamine receptor subtypes are thus good candidate loci for understanding the genetic etiologies of
Hiromi Kimura et al.
Circulation. Cardiovascular genetics, 5(3), 344-353 (2012-05-17)
Mutations of KCNJ2, the gene encoding the human inward rectifier potassium channel Kir2.1, cause Andersen-Tawil syndrome (ATS), a disease exhibiting ventricular arrhythmia, periodic paralysis, and dysmorphic features. However, some KCNJ2 mutation carriers lack the ATS triad and sometimes share the
Zhi Peng et al.
Molecular cancer therapeutics, 14(11), 2634-2641 (2015-09-04)
MET and its sole ligand, hepatocyte growth factor (HGF), are promising targets in gastric and gastroesophageal junction cancer. We evaluated whether MET protein expression or MET gene amplification is prognostic for overall survival (OS) in Chinese patients with advanced gastric
S J Lees et al.
Acta physiologica Scandinavica, 181(2), 239-245 (2004-06-08)
Gel electrophoresis revealed a band of molecular weight approximately 160 000 Da associated with the skeletal muscle sarcoplasmic reticulum (SR) vesicle preparations. This investigation sought to examine glycogen debranching enzyme associated with skeletal muscle SR. Sarcoplasmic reticulum samples were also
S B Bleyl et al.
European journal of human genetics : EJHG, 15(9), 950-958 (2007-06-15)
Congenital diaphragmatic hernia (CDH) is a common, life threatening birth defect. Although there is strong evidence implicating genetic factors in its pathogenesis, few causative genes have been identified, and in isolated CDH, only one de novo, nonsense mutation has been
Martin Cerny et al.
Journal of experimental botany, 62(3), 921-937 (2010-10-27)
Cytokinins are plant hormones involved in regulation of diverse developmental and physiological processes in plants whose molecular mechanisms of action are being intensely researched. However, most rapid responses to cytokinin signals at the proteomic and phosphoproteomic levels are unknown. Early
M C Gates et al.
New Zealand veterinary journal, 65(6), 285-291 (2017-07-01)
AIMS To estimate the prevalence of cats testing positive for antibodies to feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) antigens in domestic cats entering a New Zealand animal shelter, based on a commercial point-of-care ELISA, to identify risk
E Aboulmagd et al.
Applied and environmental microbiology, 67(5), 2176-2182 (2001-04-25)
Synechocystis sp. strain PCC6308 cyanophycin synthetase was purified 72-fold in three steps by anion exchange chromatography on Q Sepharose, affinity chromatography on the triazine dye matrix Procion Blue HE-RD Sepharose, and gel filtration on Superdex 200 HR from recombinant cells
Shirley H J Mei et al.
PLoS medicine, 4(9), e269-e269 (2007-09-07)
The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. ALI is characterized by disruption of the lung alveolar-capillary membrane barrier
Yannick Duguay et al.
Clinical pharmacology and therapeutics, 75(3), 223-233 (2004-03-06)
To clarify the molecular determinants of the metabolic variability of morphine, we searched for genetic polymorphisms in the gene for uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) and evaluated their functional impact in vitro and in patients with cancer receiving long-term morphine therapy.
J Glenn et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6(3), 462-468 (1988-03-01)
By radioimmunoassay we determined circulating levels of a tumor-associated antigen, CA 19-9, in 47 patients with pancreatic adenocarcinoma, to learn if serial testing was useful in predicting prognosis or in detecting disease progression. Before treatment, 42 (89%) had an abnormal
Christian Borup et al.
The American journal of gastroenterology, 115(12), 2086-2094 (2020-08-03)
The diagnosis of bile acid diarrhea is often missed because the availability of the seleno-taurohomocholic acid (SeHCAT) test is limited. We aimed to compare the biomarkers 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor 19 (FGF19) with the SeHCAT test. Patients with
C H Bangma et al.
Urology, 46(6), 779-784 (1995-12-01)
The ratio between free and total prostate-specific antigen (PSA) in serum (F/T ratio) was shown to improve the specificity of total serum PSA for the detection of prostate carcinoma in selected populations. In this study, the value of the F/T
Miao-jing Fan et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)
To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19
Jürgen Knapp et al.
Shock (Augusta, Ga.), 43(6), 576-581 (2015-02-24)
The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after
J-B Delhorme et al.
The British journal of surgery, 105(6), 668-676 (2018-02-08)
The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic
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