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Qian Xiang et al.
Journal of clinical pharmacology, 50(6), 659-666 (2010-03-25)
Clinical studies suggest that plasma levels of risperidone and its active moiety (risperidone + 9-hydroxyrisperidone) correlate with adverse drug effects. The aim of this study is to evaluate the pharmacogenetic variability in the disposition of risperidone and the active moiety
I Del Giudice et al.
Leukemia, 20(7), 1231-1237 (2006-04-28)
B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes
Sirish I Kumar et al.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 24(5), 211-215 (2005-12-20)
Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are known to be associated with venous thromboembolism. Several studies have shown an association of these mutations with hepatic venous outflow tract obstruction (HVOTO). We studied the prevalence of these mutations
Yuling Zhu et al.
Disease markers, 2015, 543282-543282 (2015-06-13)
Differentiation among types of muscular dystrophy (MD) has remained challenging. In this retrospective study, we sought to develop a methodology for differentiation of MD types using analysis of serum enzyme profiles. The serum levels of enzymes from 232 patients, including
Pin Yue et al.
Human mutation, 20(2), 110-116 (2002-07-19)
Familial hypobetalipoproteinemia (FHBL) is a genetic disorder characterized by low levels of apoB-100 and LDL cholesterol. Truncation-producing mutations of apoB (chromosome 2) are among several potential causes of FHBL in patients. Ten new families with FHBL linked to chromosome 2
Glen Kristiansen et al.
The American journal of pathology, 161(4), 1215-1221 (2002-10-09)
CD24 is a small heavily glycosylated glycosylphosphatidylinositol-linked cell surface protein, which is expressed in hematological malignancies as well as in a large variety of solid tumors. Very recently its expression in ovarian cancer has been found on RNA level by
P M Cury et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 13(2), 107-112 (2000-03-04)
Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adenocarcinoma-associated antibodies. However, several "mesothelium-associated" antibodies have been proposed as useful in this situation, and
Meinolf Suttorp et al.
Leukemia, 32(7), 1657-1669 (2018-06-22)
A total of 156 patients (age range 1.3-18.0 years, median 13.2 years; 91 (58.3%) male) with newly diagnosed CML (N = 146 chronic phase (CML-CP), N = 3 accelerated phase (CML-AP), N = 7 blastic phase (CML-BP)) received imatinib up-front (300, 400, 500 mg/m2, respectively) within a
Seyyed Mortaza Haghgoo et al.
Clinical biochemistry, 50(6), 293-300 (2016-12-08)
A number of complex and rare mutations in epidermal growth factor receptor (EGFR) gene have been identified and the clinical implication of serum EGFR ligands has also been reported. However, the prognostic significance of these mutations and also the serum
Adoke Yeka et al.
PloS one, 8(1), e53772-e53772 (2013-01-26)
The treatment of falciparum malaria poses unique challenges in settings where malaria transmission intensity is high because recurrent infections are common. These could be new infections, recrudescences, or a combination of the two. Though several African countries continue to use
K Varani et al.
Circulation, 99(19), 2499-2502 (1999-05-20)
Caffeine acts mainly via blockade of adenosine receptors, which have been classified into A1, A2A, A2B, and A3 subtypes. We determined whether repeated caffeine administration (750 mg/d for 1 week) upregulates the human platelet A2A adenosine receptor and is accompanied
Sandra Faias et al.
Digestive diseases and sciences, 65(7), 2071-2078 (2019-11-11)
CEA in pancreatic cystic fluid (PCF) is standard for mucinous cysts diagnosis. Glucose is an alternative, but its accuracy remains poorly described. To evaluate PCF glucose using a glucometer and compare its accuracy with CEA for mucinous cysts diagnosis. In
Karine Schaal et al.
Medicine and science in sports and exercise, 47(7), 1416-1425 (2014-10-15)
Elite athletes frequently undergo periods of intensified training (IT) within their normal training program. These periods can lead athletes into functional overreaching, characterized by high perceived fatigue, impaired sleep, and performance. Because whole-body cryostimulation (WBC) has been proven to be
Janez Stupar et al.
Metabolism: clinical and experimental, 56(1), 94-104 (2006-12-13)
Longitudinal hair chromium (H-Cr) profiles in a group of patients with type 2 diabetes mellitus (n = 59; age, 62 +/- 9 years) and healthy elderly (control) subjects (n = 49; age, 59 +/- 10 years) matched by age and
Yi-Bin Chen et al.
Cancer, 121(2), 226-233 (2014-09-11)
High-dose thiotepa, busulfan, and cyclophosphamide (TBC) with autologous stem cell transplantation (ASCT) has been used in patients with central nervous system (CNS) involvement by non-Hodgkin lymphoma (NHL). Despite limited penetration into the CNS, rituximab is active in primary CNS NHL.
Helena W Rodbard et al.
The lancet. Diabetes & endocrinology, 2(1), 30-37 (2014-03-14)
We compared stepwise addition of bolus insulin with a full basal-bolus regimen in patients with type 2 diabetes inadequately controlled on basal insulin plus oral antidiabetic drugs. The FullSTEP study was a phase 4, 32-week, randomised, open-label, two-arm, parallel-group, multinational
F Barnabi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(5), R1665-R1674 (2001-10-20)
Neurotransmitters relaying ascending visceral information were examined by comparing the response of neurons in the insular cortex to vagal stimulation (0.8 Hz, 2 mA) before and after neurotransmitter antagonist injections (200 nl) in the ventroposterior parvocellular nucleus of the thalamus
Benjamin Speich et al.
The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)
Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy
Jamie N Bakkum-Gamez et al.
Gynecologic oncology, 108(1), 141-148 (2007-11-09)
Müllerian inhibiting substance type II receptor (MISIIR) is expressed by ovarian, breast, and prostate cancers [Masiakos PT, et al. Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) Type II Receptor, bind, and
Anna L Peljto et al.
JAMA, 309(21), 2232-2239 (2013-05-23)
Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF), which are based on clinical and physiological parameters, have modest value in predicting which patients will progress. In addition to the potential for improving prognostic models, identifying genetic and molecular
Narek Shaverdian et al.
The Lancet. Oncology, 18(7), 895-903 (2017-05-30)
Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. We assessed patients with advanced NSCLC treated on
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