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Liliana Stalinska et al.
Histology and histopathology, 24(3), 299-308 (2009-01-09)
Aggressive fibromatosis (desmoid tumor) is a mesenchymal lesion originating from fascial, aponeurotic and muscular connective tissue. It rarely becomes histologically malignant. In this study we analyzed the cell cycle regulation proteins: pRb, p16, and proliferating antigens: Ki-67, PCNA, MCM5 with
Guillaume Gauchotte et al.
Virchows Archiv : an international journal of pathology, 462(6), 619-632 (2013-05-04)
Retinoid receptors (RRs) play a key role in cell proliferation and differentiation. We characterized the expression of RA receptors and retinoid X receptors (RARs and RXRs) in a series of 111 thyroid tumors and investigated the mechanisms responsible for their
Farhad Mehrkhani et al.
Journal of neuroimaging : official journal of the American Society of Neuroimaging, 28(5), 524-529 (2018-05-12)
Imaging may identify patients with very large infarcts who are unlikely to benefit from intra-arterial therapy. Although computed tomography (CT) is widely used, it suffers from poor sensitivity. We sought to evaluate whether combined evaluation of noncontrast CT (NCCT) and
Y Ohmori et al.
Biochemical and biophysical research communications, 168(3), 1261-1267 (1990-05-16)
Recently, we have isolated and characterized a set of cDNA clones which encode lipopolysaccharide-inducible proteins in murine peritoneal macrophages. Here, we report the sequence and identification of one of these cDNAs previously termed C7. Nucleotide sequence analysis revealed an open
Amir Reza Jalilian et al.
Nuclear medicine review. Central & Eastern Europe, 11(1), 1-4 (2009-01-29)
Tl-201 has potential in the preparation of radiolabelled compounds similar to its homologues, like In-111 and radiogallium. In this paper, recently prepared [(201)Tl](III) vancomycin complex ([(201)Tl](III)VAN) has been evaluated for its biological properties. [(201)Tl](III)VAN was prepared according to the optimized
Monika Sparber-Sauer et al.
Pediatric blood & cancer, 65(12), e27405-e27405 (2018-08-21)
Patients with metastatic alveolar soft-part sarcoma (ASPS) are known to have a very poor prognosis. Little is known about best treatment of primary metastatic disease (MD) or relapsed metastatic disease (rMD). Patients with localized disease (LD), primary MD, and metastatic
Thorsten Jentzsch et al.
Anticancer research, 34(12), 6961-6972 (2014-12-17)
Reliable prognostic factors for the outcome of patients with osteosarcoma (OS) remain elusive. We analyzed the relationship between immunohistochemical expression of deoxyribonucleic acid (DNA) mismatch repair (MMR) proteins, MutS protein homolog 2 (MSH2) and MSH6 using a tissue microarray (TMA)
Hiroshi Miyamoto et al.
Human pathology, 43(11), 2033-2040 (2012-05-23)
Although GATA binding protein 3, a zinc finger transcription factor and an estrogen receptor-regulated gene, has recently been suggested as a marker for urothelium, prognostic significance of GATA binding protein 3 expression in bladder tumor remains unclear. We immunohistochemically stained
Sofia Lagerholm et al.
Bone, 47(6), 1039-1047 (2010-08-12)
The F344 rat carries alleles contributing to bone fragility while the GK rat spontaneously develops type-2 diabetes. These characteristics make F344×GK crosses well suited for the identification of genes related to bone size and allow for future investigation on the
Aneesa Noormohamed et al.
Foodborne pathogens and disease, 9(7), 617-624 (2012-05-02)
Campylobacter species are one of the leading causes of foodborne disease in the United States. Campylobacter jejuni and Campylobacter coli are the two main species that are of concern to human health, and they cause approximately 95% of human infections.
S C Guru et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 10(6), 592-596 (1999-05-26)
The mouse homolog of the human MEN1 gene, which is defective in a dominant familial cancer syndrome, multiple endocrine neoplasia type 1 (MEN1), has been identified and characterized. The mouse Men1 transcript contains an open reading frame encoding a protein
Akira Ishikawa et al.
Human pathology, 35(12), 1505-1514 (2004-12-25)
Intraductal papillary neoplasm of the liver (IPNL) is a precursor lesion of intrahepatic cholangiocarcinoma (ICC) arising in hepatolithiasis. In this study, 98 foci of IPNL identified in 39 surgically resected hepatolithiatic livers were investigated for expression of p16INK4a, cyclin D1
Ariane Söling et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(1), 249-258 (2005-01-27)
The identification of new molecular markers in astrocytic tumors may help to understand the biology of these tumors in more detail. Informative tumor markers may represent prognostic factors for response to therapy and outcome as well as potential targets for
Raju K Pillai et al.
The American journal of surgical pathology, 37(3), 323-332 (2013-01-26)
Double-hit (DH) lymphomas with MYC and either BCL2 (DH-BCL2/MYC) or BCL6 (DH-BCL6/MYC) rearrangements are considered very aggressive, many of which are now included in the category B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt
B J Kudchodkar et al.
The Journal of nutrition, 130(10), 2427-2433 (2000-10-04)
We examined the effects of dietary fats with specific fatty acid compositions, on serum paraoxonase (PON1) activity in rats. Male adult Sprague-Dawley rats were divided randomly into four dietary groups. One group received the control diet [AIN 93M with soybean
Inhibition of TGFBIp expression by lithium: implications for TGFBI-linked corneal dystrophy therapy.
Seung-Il Choi et al.
Investigative ophthalmology & visual science, 52(6), 3293-3300 (2011-02-12)
PURPOSE. The purpose of this study was to investigate the effects and molecular mechanisms of lithium on inhibition of TGFBIp expression as a potential therapy for TGFBI-linked corneal dystrophy. METHODS. Primary culture corneal fibroblasts were isolated from the corneas of
Micha Tobias Maeder et al.
Wiener klinische Wochenschrift, 120(21-22), 672-678 (2009-01-01)
In patients with clinically stable chronic heart failure, circulating B-type natriuretic peptide (BNP) levels may exhibit considerable variation over a period of a few days. The aim of this study was to evaluate the clinical impact of this phenomenon. In
Nicole A van der Linde et al.
Journal of hypertension, 21(2), 345-351 (2003-02-06)
Experimental evidence suggests that in conditions associated with an activated renin-angiotensin system, unopposed activity of angiotensin II underlies the marked renal vasoconstrictor response to nitric oxide synthase inhibition. In the present study, we investigated whether this holds true in hypertensive
Nancy M Joseph et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(3), 315-326 (2012-10-09)
Recent work has demonstrated that nearly all diffuse gliomas display nuclear immunoreactivity for the bHLH transcription factor OLIG2, and the R132H mutant isocitrate dehydrogenase 1 (IDH1) protein is expressed in the majority of diffuse gliomas other than primary glioblastoma. However
Sandra Faias et al.
Digestive diseases and sciences, 65(7), 2071-2078 (2019-11-11)
CEA in pancreatic cystic fluid (PCF) is standard for mucinous cysts diagnosis. Glucose is an alternative, but its accuracy remains poorly described. To evaluate PCF glucose using a glucometer and compare its accuracy with CEA for mucinous cysts diagnosis. In
So Young Park et al.
The British journal of nutrition, 109(2), 210-222 (2012-06-22)
Maslinic acid is found in various natural sources, most notably in pomace olive oil, and exerts pro-apoptotic activities in various cancer cells in vitro. In the present study, DU145 human prostate cancer cells were cultured with 0-25 μm-maslinic acid to
James Church et al.
Diseases of the colon and rectum, 56(1), 120-125 (2012-12-12)
Coating of the cecum with sticky bile causes a problem with inspection of the mucosa during colonoscopy. This study aimed to see whether 4 mg of loperamide taken after colonoscopy preparation would delay the passage of bile and improve the
Suleyman Sirri Kilic et al.
World journal of gastroenterology, 11(46), 7351-7354 (2006-01-27)
To investigate the relationship between serum paraoxonase (PON1), AST, ALT, GGT, and arylesterase (AE) activity alterations and the degree of liver damage in patients with chronic hepatitis. We studied 34 chronic hepatitis patients and 32 control subjects, aged between 35
L N Nejsum et al.
American journal of physiology. Renal physiology, 280(4), F715-F726 (2001-03-16)
Diabetes mellitus (DM) is associated with osmotic diuresis and natriuresis. At day 15, rats with DM induced by streptozotocin (n = 13) had severe hyperglycemia (27.1 +/- 0.4 vs. 4.7 +/- 0.1 mM in controls) and had a fivefold increase
Shereen Nizari et al.
Cell death & disease, 7(12), e2514-e2514 (2016-12-09)
The amyloid beta (Aβ) pathway is strongly implicated in neurodegenerative conditions such as Alzheimer's disease and more recently, glaucoma. Here, we identify the α2 adrenergic receptor agonists (α2ARA) used to lower intraocular pressure can prevent retinal ganglion cell (RGC) death
Ajay Vora et al.
The Lancet. Oncology, 15(8), 809-818 (2014-06-14)
No randomised study has shown whether stratification of treatment by minimal residual disease (MRD) response improves outcome in children and young people with acute lymphoblastic leukaemia (ALL). We assessed whether children and young people with clinical standard and intermediate-risk ALL
T Klatte et al.
British journal of cancer, 95(9), 1167-1173 (2006-10-13)
We conducted a non-randomised controlled phase II trial to investigate the role of preoperative administration of interleukin-2 (IL-2) in patients with renal cell carcinoma undergoing tumour nephrectomy. A total of 120 consecutive patients were allocated alternately to the two study
Johan Stender et al.
Lancet (London, England), 384(9942), 514-522 (2014-04-22)
Bedside clinical examinations can have high rates of misdiagnosis of unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The diagnostic and prognostic usefulness of neuroimaging-based approaches has not been established in a clinical setting. We did a validation study
Anu Suomalainen et al.
The Lancet. Neurology, 10(9), 806-818 (2011-08-09)
Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders because of the lack of sensitive biomarkers in serum. Fibroblast growth factor 21 (FGF-21) is a growth factor with regulatory roles in lipid metabolism and the starvation response, and
S Tucek
The Journal of physiology, 322, 53-69 (1982-01-01)
1. The synthesis of acetylcholine (ACh) has been measured in homogenates of the sciatic nerve, normal and denervated extensor digitorum longus (e.d.l.) muscles, and central (innervated) and peripheral (non-innervated) parts of the diaphragm of the rat. The synthesis proceeded under
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