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Jie Gao et al.
PloS one, 9(7), e101206-e101206 (2014-07-02)
The optineurin gene, OPTN, is one of the causative genes of primary open-angle glaucoma. Although oligomerization of optineurin in cultured cells was previously observed by gel filtration analysis and blue native gel electrophoresis (BNE), little is known about the characteristics
Shuai Chen et al.
Histochemistry and cell biology, 144(5), 509-515 (2015-08-01)
Cultivation of oviduct epithelial cells on porous filters fosters in vivo-like morphology and functionality. However, due to the optical properties of the filter materials and the cells' columnar shape, cell quality is hard to assess via light microscopy. In this
Anyonya R Guntur et al.
Endocrinology, 155(5), 1589-1595 (2014-01-21)
Osteoblastogenesis is the process by which mesenchymal stem cells differentiate into osteoblasts that synthesize collagen and mineralize matrix. The pace and magnitude of this process are determined by multiple genetic and environmental factors. Two inbred strains of mice, C3H/HeJ and
Vanessa Cardeñosa et al.
Molecules (Basel, Switzerland), 20(5), 8287-8302 (2015-05-12)
Five sweet orange (Citrus sinensis Osbeck) varieties cultivated in Huelva (Spain) and picked at two seasons during two consecutive years, were characterized for their antioxidant activity (free radicals scavenging activity, reducing power and lipid peroxidation inhibition) and vitamin content (vitamin
Alireza Valanezhad et al.
Journal of materials science. Materials in medicine, 26(7), 212-212 (2015-07-17)
Hydroxyapatite (HAp) coating was formed on zinc phosphate (Ti-Zn-PO4) coated Ti plates by hydrothermal treatment in CaCl2 solution at 200 °C for 12 h. Uniform surface coverage of the fabricated HAp coating was obtained by this method. SEM-EDX analysis of the adhesion
Katherine Czysz et al.
PloS one, 10(2), e0117689-e0117689 (2015-02-07)
Definitive endoderm (DE) is one of the three germ layers which during in vivo vertebrate development gives rise to a variety of organs including liver, lungs, thyroid and pancreas; consequently efficient in vitro initiation of stem cell differentiation to DE
Jaime H Gibbs et al.
Journal of organometallic chemistry, 798(Pt 1), 209-213 (2015-12-22)
A series of four BODIPYs containing one or two
Takayuki Umezawa et al.
Dental materials journal, 34(5), 713-718 (2015-10-07)
To confirm similarity of hard tissue compatibility between titanium and zirconium, calcification of MC3T3-E1 cells on titanium and zirconium was evaluated in this study. Mirror-polished titanium (Ti) and zirconium (Zr) disks and zirconium-sputter deposited titanium (Zr/Ti) were employed in this
Clara Cena et al.
Bioorganic & medicinal chemistry, 16(9), 5199-5206 (2008-03-25)
In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a-f) or 2-OH group (7a-c) of ascorbic acid (ASA). Log Ps and pK(a)s of these products were experimentally evaluated. All
Young-Whan Choi et al.
Journal of natural products, 69(3), 356-359 (2006-03-28)
Phytochemical investigation of the fruits of Schisandra chinensis led to the isolation of 13 lignans including schisandrene (13), a new lignan based on a dibenzocyclooctadiene backbone with an exocyclic double bond. Its structure and absolute configuration were established using NMR
Qingyou Meng et al.
Journal of cellular biochemistry, 116(8), 1613-1623 (2015-02-06)
Deep vein thrombosis (DVT) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of miR-126 on EPCs function and venous thrombus resolution. We demonstrated that overexpression
Yi-Xian Zhang et al.
BMC neuroscience, 16, 56-56 (2015-09-08)
The transplantation of bone marrow stromal cells (MSCs) has proved to ameliorate ischemic brain injury in animals, but most transplanted MSCs undergo apoptosis in the ischemic penumbra, greatly compromising the therapeutic value of this treatment. Meanwhile, cell apoptosis can be
Eleni Pontiki et al.
European journal of medicinal chemistry, 46(1), 191-200 (2010-11-26)
A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3,5-ditert-butyl-4-hydroxyphenyl substituents have been designed, synthesized and tested as potential dual lipoxygenase/cyclooxygenase-1 (LOX/COX-1) inhibitors and as antioxidant and anti-inflammatory agents. Some compounds have shown moderate
M Sato et al.
Oral diseases, 21(1), e86-e97 (2014-03-13)
Mesiodentes are usually found in the central position of the upper or lower jaw as supernumerary teeth. Here, we obtained 10 mesiodentes and three permanent teeth (PT) and separated the dental pulp (DP) from these into crown and root portions.
Rebecca Josowitz et al.
PloS one, 9(7), e101316-e101316 (2014-07-11)
The use of human stem cell-derived cardiomyocytes to study atrial biology and disease has been restricted by the lack of a reliable method for stem cell-derived atrial cell labeling and purification. The goal of this study was to generate an
Koji Y Arai et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 701-711 (2014-09-17)
Epidermal-dermal interaction plays important roles in physiological events such as wound healing. In this study, we examined a double paracrine mechanism between keratinocytes and fibroblasts through interleukin-1 (IL-1) and an IL-1-induced inflammatory mediator prostaglandin E₂ (PGE₂) using the skin equivalent.
Akif Güneş et al.
The journal of international advanced otology, 11(1), 48-52 (2015-08-01)
In the present study, tympanic membranes (TM) harvested from myringotomized rats were analyzed histopathologically to compare the systemic and local effects of ascorbic acid on the development of myringosclerosis. Forty male Wistar-Albino rats weighing between 350-400 g were included in
C Li et al.
Journal of dental research, 94(3), 455-463 (2015-01-15)
Recent studies have demonstrated that erythropoietin (EPO) has extensive nonhematopoietic biological functions. However, little is known about how EPO regulates bone formation, although several studies suggested that EPO can affect bone homeostasis. In this study, we investigated the effects of
Mário Mil-Homens et al.
The Science of the total environment, 540, 231-240 (2015-07-27)
Twenty century time-resolved variability of riverine deposits of polychlorobiphenyls (PCBs), DDTs, hexachlorocyclohexanes (HCHs) and hexachlorobenzene (HCB) was studied in three (210)Pb dated sediment cores collected in a depositional shelf area adjacent to the Tagus estuary (the Tagus Prodelta). The geographic
Werner E G Müller et al.
Chembiochem : a European journal of chemical biology, 16(9), 1323-1332 (2015-04-15)
Studies indicate that mammalian bone formation is initiated at calcium carbonate bioseeds, a process that is driven enzymatically by carbonic anhydrase (CA). We show that amorphous calcium carbonate (ACC) and bicarbonate (HCO3 (-) ) cause induction of expression of the
Minseok Seo et al.
Lab on a chip, 15(17), 3581-3590 (2015-07-30)
Perfluorocarbon (PFC) nanodroplet agents are exciting new biomaterials that can be remotely vapourized by ultrasound or light to change into micron-scale gas bubbles in situ. After PFC nanodroplet vapourization, the micron-scale gas bubble can interact strongly with ultrasound radiation, such
Marc C Ford et al.
Nature communications, 6, 8073-8073 (2015-08-26)
Action potential timing is fundamental to information processing; however, its determinants are not fully understood. Here we report unexpected structural specializations in the Ranvier nodes and internodes of auditory brainstem axons involved in sound localization. Myelination properties deviated significantly from
Qing Tong et al.
Journal of pharmaceutical and biomedical analysis, 114, 455-461 (2015-07-03)
Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang has long been used as a traditional Chinese medicinal herb among the indigenous people in the Yangtze River region of China. Dihydromyricetin (DMY) is the most abundant (approximately 30%) and bioactive constituent in A. grossedentata
Clémentine Bosch-Bouju et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 15836-15850 (2014-11-28)
Motor thalamus (Mthal) is a key node in the corticobasal ganglia (BG) loop that controls complex, cognitive aspects of movement. In Parkinson's disease (PD), profound alterations in neuronal activity occur in BG nuclei and cortex. Because Mthal is located between
Francisca Alcayaga-Miranda et al.
Stem cell research & therapy, 6, 32-32 (2015-04-19)
Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over other sources for the isolation of MSCs, including ease of access and repeated sampling in a
Jie Yu et al.
Theranostics, 5(9), 931-945 (2015-07-15)
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted
Afrouz Yousefi et al.
International journal of pharmaceutics, 472(1-2), 175-184 (2014-06-21)
Angiogenesis is one of the hallmarks of cancer which renders it an attractive target for therapy of malignancies. Tumor growth suppression can be achieved by inhibiting angiogenesis since it would deprive tumor cells of oxygen and vital nutrients. Activation of
Ji-Kan Ryu et al.
The journal of sexual medicine, 11(2), 411-423 (2013-11-21)
Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of
Amel Dudakovic et al.
Journal of cellular physiology, 230(1), 52-62 (2014-06-10)
Human adipose-derived mesenchymal stromal cells (AMSCs) grown in platelet lysate are promising agents for therapeutic tissue regeneration. Here, we investigated whether manipulation of epigenetic events by the clinically relevant histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alters differentiation of AMSCs.
Esther Campos-Giménez et al.
Journal of AOAC International, 96(5), 1065-1067 (2013-11-29)
During the AOAC Annual Meeting held in Las Vegas, NV from September 30 to October 3, 2012, the Stakeholder Panel on Infant Formula and Adult Nutritionals convened to review single-laboratory validation data submitted for the method, Vitamin C in Adult/Pediatric
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