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Hayato Nishida et al.
Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)
Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight
Larissa Nelson et al.
Cartilage, 5(4), 203-214 (2015-06-13)
Osteoarthritis (OA) is a debilitating disease affecting more than 4 million people in the United Kingdom. Despite its prevalence, there is no successful cell-based therapy currently used to treat patients whose cartilage is deemed irrecoverable. The present study aimed to
Pratima Tripathi et al.
Indian journal of biochemistry & biophysics, 50(2), 99-104 (2013-06-01)
Increased production of oxygen free radicals and decreased oxidant capacity occur in coronary artery diseases (CAD) This pro-oxidant shift in intracellular redox state may induce cell death by either direct cell membrane damage by lipic peroxidation or apoptosis through activation
Henriette Jülke et al.
Cell transplantation, 24(6), 1111-1125 (2013-12-18)
The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep
Yalin Wu et al.
Journal of natural products, 71(2), 241-245 (2008-01-12)
The structure of an antiradical arabinoglucogalactan ( 1) from Panax notoginseng roots was determined. This polymeric carbohydrate was obtained through successive phosphate buffer (pH 7.0) extraction after cold-water pretreatment and purification by ion-exchange and gel-filtration chromatography. Monosaccharide analysis, permethylation analysis
Fiona Allum et al.
Nature communications, 6, 7211-7211 (2015-05-30)
Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for
Yi-Chun Kuo et al.
PloS one, 6(7), e22382-e22382 (2011-08-06)
Surface plasmon resonance (SPR) biosensors have been recognized as a useful tool and widely used for real-time dynamic analysis of molecular binding affinity because of its high sensitivity to the change of the refractive index of tested objects. The conventional
Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.
A Maqbool et al.
eLife, 4 (2015-08-26)
Plants have evolved intracellular immune receptors to detect pathogen proteins known as effectors. How these immune receptors detect effectors remains poorly understood. Here we describe the structural basis for direct recognition of AVR-Pik, an effector from the rice blast pathogen
Hannah E Da Silva et al.
Journal of the Academy of Nutrition and Dietetics, 114(8), 1181-1194 (2014-03-19)
Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD). Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations. This was a cross-sectional study. Seventy-four patients
Basavaraj Girennavar et al.
Bioorganic & medicinal chemistry, 15(11), 3684-3691 (2007-04-03)
Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against
Ilkka Alahuhta et al.
Experimental cell research, 336(1), 130-140 (2015-06-27)
The turnover of extracellular matrix liberates various cryptic molecules with novel biological activities. Endostatin is an endogenous angiogenesis inhibitor that is derived from the non-collagenous domain of collagen XVIII. Although there are a large number of studies on its anti-tumor
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Xia Xiang et al.
Talanta, 141, 182-187 (2015-05-13)
We have developed a label-free fluorescence sensor for caffeic acid (CA) by the use of CdTe:Zn(2+) quantum dots (CdTe:Zn(2+) QDs) as an output signal. The principle of sensor is based on the fluorescence quenching and binding properties of Fe(2+) toward
Mei-Lin Yang et al.
Journal of natural products, 74(9), 1996-2000 (2011-08-19)
In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has
Judit Bartalis et al.
Bioorganic & medicinal chemistry, 19(8), 2757-2766 (2011-04-05)
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten
Kathryn Futrega et al.
Biomaterials, 62, 1-12 (2015-05-27)
Microwell platforms are frequently described for the efficient and uniform manufacture of 3-dimensional (3D) multicellular microtissues. Multiple partial or complete medium exchanges can displace microtissues from discrete microwells, and this can result in either the loss of microtissues from culture
Jae Hyeon Kim et al.
Oncology reports, 34(1), 221-226 (2015-05-23)
Ligularia fischeri (LF) has been used as an edible herb and traditional medicine for the treatment of inflammatory and infectious diseases. In the present study, we report the effects and molecular mechanism of the ethanolic extract of LF on cell
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose
Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with
Q Liu et al.
Scandinavian journal of rheumatology, 44(3), 182-191 (2014-12-03)
Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a
Michiel Croes et al.
PloS one, 10(7), e0132781-e0132781 (2015-07-16)
Several inflammatory processes underlie excessive bone formation, including chronic inflammation of the spine, acute infections, or periarticular ossifications after trauma. This suggests that local factors in these conditions have osteogenic properties. Mesenchymal stem cells (MSCs) and their differentiated progeny contribute
Martin Spickenreither et al.
Bioorganic & medicinal chemistry letters, 16(20), 5313-5316 (2006-08-16)
Previously, we identified ascorbic acid 6-O-hexadecanoate as an up to 1500 times more potent inhibitor of bacterial and bovine hyaluronidases than the parent compound, vitamin C, and determined a crystal structure of hyaluronidase from Streptococcus pneumoniae in complex with the
Wei-Ming Chai et al.
Journal of agricultural and food chemistry, 63(33), 7381-7387 (2015-08-11)
Proanthocyanidins were purified from avocado (Persea americana) fruit, and their structures were analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and high-performance liquid chromatography-electrospray ionization-QTRAP mass spectrometry (HPLC-ESI-QTRAP MS) techniques. The results obtained from mass spectrometry (MS) analysis demonstrated
Marylhi Mora et al.
Investigacion clinica, 54(2), 161-170 (2013-08-21)
In the present study we compared the effects of minocycline and ascorbic acid in the life span, motor activity and lipid peroxidation of Drosophila melanogaster, in an effort to find a substance capable of providing protection against oxidative stress in
Hemant Mittal et al.
International journal of biological macromolecules, 79, 8-20 (2015-05-03)
Biodegradable hydrogels of gum ghatti (Gg) with a co-polymer mixture of acrylamide (AAm) and methacrylic acid (MAA) (termed as Gg-cl-P(AAm-co-MAA)) were synthesised by microwave-assisted free radical graft co-polymerisation technique. The hydrogel polymer was characterized by FTIR, SEM, and Brunauer-Emmett-Teller techniques.
Dongfeng Wei et al.
Carbohydrate polymers, 125, 161-168 (2015-04-11)
Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease, invokes oxidative damage to neurons and eventually leads to neuronal death. Selenylation modification of polysaccharide obtained from Radix hedysari (RHP) was studied to access antioxidant activities and neuroprotective effects against oxidative stress
Feng Shi et al.
Bioorganic & medicinal chemistry letters, 19(19), 5565-5568 (2009-09-05)
The green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives was achieved in water via microwave-assisted three-component reactions of malononitrile, aromatic aldehydes and 2-mercaptoacetic acid with molar ratios of 2:1:1.5 and 2:2.2:1, respectively. These compounds were subject to the experiments of antioxidant activity
Lean-Teik Ng et al.
Bioorganic & medicinal chemistry, 17(13), 4360-4366 (2009-06-02)
Deoxybenzoins (DOBs) are one-pot synthetic precursors of isoflavones with feature analogous to those beneficial polyphenols such as resveratrol (stilbene) and phloretin (dihydrochalcone). In this study, seventeen polyphenolic DOBs were synthesized and evaluated by various antioxidant assays and tyrosinase inhibitory effect
Kanagalakshmi Ambothi et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 72-78 (2015-05-20)
The aim of this study was to evaluate the photochemopreventive effects of ferulic acid (FA) against chronic ultraviolet-B (290-320 nm) induced oxidative stress, inflammation and angiogenesis in the skin of Swiss albino mice. Chronic UVB exposure (180 mJ/cm(2) for 30 weeks;
[Recent advance in the study of ascorbic acid in photosynthe-sizing organisms].
Takahiro Ishikawa
Seikagaku. The Journal of Japanese Biochemical Society, 83(9), 838-841 (2011-11-25)
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