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Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat.
S D Vinay et al.
Bulletin of environmental contamination and toxicology, 49(1), 78-84 (1992-07-01)
S M Naqvi et al.
Neuroreport, 2(1), 61-63 (1991-01-01)
The present study was undertaken to evaluate the neurotoxic effects of the organophosphate, phosphamidon, on glutathione-S-transferase (GST) activity and concentration of sulphhydryl groups, and to study the possible protection against these effects by the simultaneous administration of the antioxidant, acetylhomocysteine
Iris Bertani et al.
Applied and environmental microbiology, 70(9), 5493-5502 (2004-09-04)
Quorum sensing is a cell population-density dependent regulatory system which in gram-negative bacteria often involves the production and detection of N-acyl homoserine lactones (AHLs). Some Pseudomonas putida strains have been reported to produce AHLs, and one quorum-sensing locus has been
N Emonet et al.
Journal of photochemistry and photobiology. B, Biology, 40(1), 84-90 (1997-08-01)
The sensitivity of human dermal fibroblasts to UVA radiation has been linked to a decrease in intracellular glutathione (GSH) levels. GSH (gamma-glutamyl-cysteinyl-glycine) is a radical scavenger and a cofactor for protective enzymes such as selenium-dependent GSH peroxidases. In this study
Comparison of monothiols and vitamin therapy administered alone or in combinations during methylmercury poisoning.
C Bapu et al.
Bulletin of environmental contamination and toxicology, 52(2), 182-189 (1994-02-01)
G Papaccio et al.
Histochemistry, 101(3), 215-221 (1994-03-01)
A decrease in superoxide dismutase (SOD), the first cellular defence against free radicals, occurs at about the same time as the activation of macrophages within the islets of low-dose streptozocin (LDS)-treated mice. Furthermore, a decrease in the total islet capillary
P P Sood et al.
Cellular and molecular biology (Noisy-le-Grand, France), 39(2), 213-219 (1993-03-01)
The extent of mercury mobilisation was recorded from various tissues (brain, spinal cord, liver and kidney) of male mice administered with a daily dose of methylmercury chloride (1 mg/kg) for seven days. For this purpose 10 groups of animals were
G Papaccio
Diabetes research and clinical practice, 13(1-2), 95-102 (1991-08-01)
We used acetyl-homocysteine-thiolactone (citiolone) as an enhancer of superoxide dismutase (SOD), a free radical scavenger, in order to assay any possible prevention of the insulitis and subsequent B cell damage caused by streptozotocin (STZ) when given in multiple low doses.
J Kruuv et al.
Cryobiology, 30(3), 313-321 (1993-06-01)
The Arrhenius plot of inactivation (killing) rates of V-79 Chinese hamster cells exposed to hypothermia contains a break at about 8 degrees C, which corresponds to the minimum inactivation rate, implying that there are distinct hypothermic damage mechanisms above (Range
S D Vinay et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 9(4), 351-359 (1989-07-01)
Acid and alkaline phosphatase changes in various parts of the central nervous system (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata, and spinal cord) were analyzed during methylmercury chloride (MMC) treatment with a dose of 5 mg/kg/day body weight. The drug
Feng Qian
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 29(4), 254-257 (2011-10-07)
To conjugate Plasmodium falciparum Pfs25 to recombinant Pseudomonas aeruginosa Exo-Protein A (rEPA) and test the effect of conjugation using different chemical linkers. The Pfs25 was thiolated by NAHT (DL-N-acetylhomocysteine thiolactone), whereas the carrier protein rEPA was modified by Sulfo-EMCS, EMCH
C Bapu et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 17(1), 75-80 (1998-03-07)
The aim of our investigation was to examine the efficacy of monothiols and vitamins in the restoration of ion-dependent ATPases in mice intoxicated with methylmercury chloride (MMC). A daily dose of glutathione (GSH), N-acetyl-DL-homocysteine thiolactone (NAHT), vitamin B complex, or
G Papaccio et al.
Journal of cellular biochemistry, 71(4), 479-490 (1998-11-25)
This study showed that citiolone (CIT), a free radical scavenger, significantly increased superoxide dismutase (P < 0.001 vs. untreated NOD, NMMA-treated, and silica-treated animals), catalase (P < 0.01 vs. untreated NOD), and glutathione peroxidase (P < 0.001 vs. untreated NOD
R W Powers et al.
Endocrinology, 137(7), 3101-3110 (1996-07-01)
The activity of nitric oxide (NO) has been implicated as an important mediator in ovarian function, including the regulation of the blood-follicle barrier and ovulation. Both clinical and experimental diabetes have been found to impair endothelial-dependent vascular activity through the
Fixed drug eruption due to citiolone.
P G Delgado et al.
Contact dermatitis, 33(5), 352-352 (1995-11-01)
W Sumoski et al.
Diabetologia, 32(11), 792-796 (1989-11-01)
A possible role for oxygen free radicals in mediating the cytotoxic effects of cytokines in islets was sought by the use of agents that scavenge free radicals. Rat islet cell monolayer cultures were incubated for 6 days with t-butylhydroperoxide, alloxan
[Serum sickness type reaction to citiolone].
M Luque Sánchez et al.
Atencion primaria, 16(5), 295-296 (1995-09-30)
S M Naqvi et al.
Indian journal of experimental biology, 30(9), 850-852 (1992-09-01)
Phosphamidon intoxication (2 mg/kg body wt./day for 7 days) inhibited SOD activity, but enhanced the lipid peroxidation in various CNS regions. Administration of cithiolone (8 mg/kg body wt./day, ip for 7 days), however, elevated SOD activity and depleted lipid peroxidation.
I Flechner et al.
Diabetes research (Edinburgh, Scotland), 13(2), 67-73 (1990-02-01)
The possible value of radical scavengers in the prevention of beta cell destruction was studied in two animal models of type I diabetes. Eight compounds were tested alone or in combinations. In the low-dose streptozotocin model treatment started 24 hr
P P Sood et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 14(2), 101-105 (1995-01-01)
Male albino mice were intoxicated with a daily dose of 1 mg/kg of methylmercury chloride (MMC) for 7 days, and were treated thereafter with glutathione, N-acetyl-DL-homocysteine thiolactone, vitamin B complex, and vitamin E, either alone or in combinations, for the
S D Vinay et al.
Pharmacology & toxicology, 69(1), 71-74 (1991-07-01)
Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride (MMC), N-acetyl-DL-homocysteine thiolactone (NAHT) and glutathione (GSH) treatment. Male albino rats were
U J Eriksson et al.
Diabetologia, 34(5), 325-331 (1991-05-01)
This study addresses the possibility that the teratogenic effects of a diabetic pregnancy are associated with increased embryonic activities of free oxygen radicals. Rat embryos were cultured in 50 mmol/l glucose for 48 h and subsequently showed pronounced growth retardation
L A Borg et al.
Endocrinology, 130(5), 2851-2857 (1992-05-01)
The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human recombinant IL-1 beta (rIL-1 beta) on the activities of superoxide
Differential effects of methylmercury, thiols, and vitamins on galactosidases of nervous and non-nervous tissues.
K Vijayalakshmi et al.
Bulletin of environmental contamination and toxicology, 49(1), 71-77 (1992-07-01)
M de Barrio et al.
Journal of investigational allergology & clinical immunology, 7(3), 193-194 (1997-05-01)
Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on
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