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Di Sun et al.
Science advances, 7(32) (2021-08-06)
Posttranscriptional gene silencing (PTGS) is a regulatory mechanism to suppress undesired transcripts. Here, we identified Flowering locus VE (FVE), a well-known epigenetic component, as a new player in cytoplasmic PTGS. Loss-of-function fve mutations substantially reduced the accumulation of transgene-derived small
Shubhi Pandey et al.
Molecular cell, 81(22), 4605-4621 (2021-09-29)
G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors (7TMRs), typically interact with two distinct signal-transducers, i.e., G proteins and β-arrestins (βarrs). Interestingly, there are some non-canonical 7TMRs that lack G protein coupling but interact with βarrs, although an understanding
Yongliang Zhang et al.
Nature communications, 10(1), 3252-3252 (2019-07-22)
Nucleotide-binding leucine-rich repeat (NLR) immune receptors play a critical role in defence against pathogens in plants and animals. However, we know very little about NLR-interacting proteins and the mechanisms that regulate NLR levels. Here, we used proximity labeling (PL) to
Maria Wiezlak et al.
Journal of cell science, 125(Pt 23), 5860-5872 (2012-09-15)
The Phactr family of PP1-binding proteins is implicated in human diseases including Parkinson's, cancer and myocardial infarction. Each Phactr protein contains four G-actin binding RPEL motifs, including an N-terminal motif, abutting a basic element, and a C-terminal triple RPEL repeat
Zhigang Yi et al.
Journal of virology, 90(21), 9953-9966 (2016-08-26)
Like almost all of the positive-strand RNA viruses, hepatitis C virus (HCV) induces host intracellular membrane modification to form the membrane-bound viral replication complex (RC), within which viral replicases amplify the viral RNA genome. Despite accumulated information about how HCV
Jamie L Courtland et al.
eLife, 10 (2021-03-23)
Mutation of the Wiskott-Aldrich syndrome protein and SCAR homology (WASH) complex subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this association is unknown. We identify the neuronal WASH complex proteome, revealing a network of endosomal
Kentaro Ohkuni et al.
G3 (Bethesda, Md.), 8(4), 1215-1223 (2018-02-13)
Stringent regulation of cellular levels of evolutionarily conserved centromeric histone H3 variant (CENP-A in humans, CID in flies, Cse4 in yeast) prevents its mislocalization to non-centromeric chromatin. Overexpression and mislocalization of CENP-A has been observed in cancers and leads to
Nan Su et al.
The Journal of biological chemistry, 283(50), 35106-35117 (2008-10-23)
C/EBP homology protein (CHOP), a stress-induced transcription factor, is involved in transcriptional regulation, cell cycle, and apoptosis. The present studies identified CHOP as an interacting partner of activating transcription factor (ATF) 4 in a yeast two-hybrid screen and confirmed their
Anna K Lee et al.
Molecular cell, 79(4), 645-659 (2020-07-22)
Stress granules (SGs) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SGs act as a protective mechanism to cope with acute stress, but persistent SGs have cytotoxic effects that are associated with several
Daniela Salat et al.
PloS one, 10(6), e0130288-e0130288 (2015-06-13)
The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types. The helix-loop-helix (HLH) domain as well as the Orange domain, mediate homo- and heterodimerization of these transcription factors. Although distinct interaction partners
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
Mohsen Sarikhani et al.
eLife, 7 (2018-03-06)
Glycogen synthase kinase 3 (GSK3) is a critical regulator of diverse cellular functions involved in the maintenance of structure and function. Enzymatic activity of GSK3 is inhibited by N-terminal serine phosphorylation. However, alternate post-translational mechanism(s) responsible for GSK3 inactivation are
J Marsolier et al.
Nature, 520(7547), 378-382 (2015-01-28)
Infectious agents develop intricate mechanisms to interact with host cell pathways and hijack their genetic and epigenetic machinery to change host cell phenotypic states. Among the Apicomplexa phylum of obligate intracellular parasites, which cause veterinary and human diseases, Theileria is
Yi Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(5) (2022-01-28)
Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of signaling across different cellular compartments. However, how nonenzymatic PTMs-despite their direct relevance to covalent drug development-impinge on cross-compartment signaling remains inaccessible as current target-identification (target-ID) technologies offer limited spatiotemporal resolution, and
Annemieke A Michels et al.
Molecular and cellular biology, 30(15), 3749-3757 (2010-06-03)
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets have been identified. RNA polymerase (pol) III produces a number of essential RNA molecules involved in protein synthesis, RNA maturation, and other processes. Its
Jianping Guo et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(18), e2004303-e2004303 (2021-07-20)
Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3-kinase (PI3K)-protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to facilitate
TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner.
Liu, et al.
Cancers, 15 (2023)
ChihFeng Tien et al.
PloS one, 13(1), e0191372-e0191372 (2018-01-18)
HIV-1 protease autoprocessing is responsible for liberation of free mature protease (PR) from the Gag-Pol polyprotein precursor. A cell-based model system was previously developed to examine the autoprocessing mechanism of fusion precursors carrying the p6*-PR miniprecursor sandwiched between various proteins
Jae-Hoon Jung et al.
Nature, 585(7824), 256-260 (2020-08-28)
Temperature controls plant growth and development, and climate change has already altered the phenology of wild plants and crops1. However, the mechanisms by which plants sense temperature are not well understood. The evening complex is a major signalling hub and
Jennifer C McGarvey et al.
The Journal of biological chemistry, 291(21), 10986-11002 (2016-03-25)
The G protein-coupled parathyroid hormone receptor (PTHR) regulates mineral-ion homeostasis and bone remodeling. Upon parathyroid hormone (PTH) stimulation, the PTHR internalizes into early endosomes and subsequently traffics to the retromer complex, a sorting platform on early endosomes that promotes recycling
Tao Shi et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Reversible cysteine oxidation plays an essential role in redox signaling by reversibly altering protein structure and function. Cysteine oxidation may lead to intra- and intermolecular disulfide formation, and the latter can drastically stabilize protein-protein interactions in a more oxidizing milieu.
Nikita M Shepelev et al.
Scientific reports, 10(1), 11109-11109 (2020-07-08)
Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and
Andriana Margariti et al.
Circulation research, 106(7), 1202-1211 (2010-03-13)
Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism.
Jianping Guo et al.
Nature cell biology, 21(2), 226-237 (2019-01-30)
Aberrant activation of AKT disturbs the proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand the upstream signalling pathways governing AKT activation. Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its
Laia Simó-Riudalbas et al.
Nature communications, 13(1), 4913-4913 (2022-08-21)
The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we find that expression of the
Eri Miyagi et al.
Journal of virology, 88(9), 4839-4852 (2014-02-14)
Vif is a lentiviral accessory protein that regulates viral infectivity in part by inducing proteasomal degradation of APOBEC3G (A3G). Recently, CBFβ was found to facilitate Vif-dependent degradation of A3G. However, the exact role of CBFβ remains unclear. Several studies noted
Elizabeth A White et al.
Journal of virology, 86(24), 13174-13186 (2012-09-28)
We have begun to define the human papillomavirus (HPV)-associated proteome for a subset of the more than 120 HPV types that have been identified to date. Our approach uses a mass spectrometry-based platform for the systematic identification of interactions between
Kristy J Wilson et al.
Molecular biology of the cell, 23(14), 2623-2634 (2012-05-25)
The ubiquitin proteasome system is involved in degradation of old or damaged sarcomeric proteins. Most E3 ubiquitin ligases are associated with cullins, which function as scaffolds for assembly of the protein degradation machinery. Cullin 3 uses an adaptor to link
Yang Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(7), 1949-1954 (2016-02-03)
Drought stress is an important environmental factor limiting plant productivity. In this study, we screened drought-resistant transgenic plants from 65 promoter-pyrabactin resistance 1-like (PYL) abscisic acid (ABA) receptor gene combinations and discovered that pRD29A::PYL9 transgenic lines showed dramatically increased drought
Bing Yao et al.
Molecular cell, 71(5), 848-857 (2018-08-07)
A ten-eleven translocation (TET) ortholog exists as a DNA N6-methyladenine (6mA) demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD remain unexplored. Through genome-wide 6mA and transcriptome profiling in Drosophila brains and neuronal cells, we found that
Christina James et al.
International journal of molecular sciences, 22(24) (2021-12-25)
VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane. As a component of many contact sites between the endoplasmic reticulum and other organelles, VAPB is
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