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显示 31-60 共 583 条结果 关于 "A2095" 范围 论文
Jian Kang et al.
Oncotarget, 7(31), 48887-48904 (2016-07-08)
Dysregulation of RNA polymerase I (Pol I)-dependent ribosomal DNA (rDNA) transcription is a consistent feature of malignant transformation that can be targeted to treat cancer. Understanding how rDNA transcription is coupled to the availability of growth factors and nutrients will
Sevgican Demir et al.
Science advances, 8(42), eabo5555-eabo5555 (2022-10-22)
Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity represents a major goal in the treatment of patients affected by diabetes. Here, we identify transforming growth factor-β1 stimulated
Ritu Garg et al.
Cancer gene therapy (2023-08-11)
Resistance to anti-androgen therapy for metastatic prostate cancer is a major clinical problem. Sema3C promotes resistance to androgen withdrawal via its receptor, PlexinB1. Activation of PlexinB1 promotes the ligand-independent nuclear translocation of the androgen receptor (AR), which may contribute to
Jie Chen et al.
Oncology reports, 43(6), 1845-1852 (2020-04-03)
The Nemo‑like kinase (NLK), a conserved serine/threonine kinase, plays a critical role in the regulation of a variety of transcription factors, with important roles in determining cell fate. Although recent studies have demonstrated decreased expression patterns of NLK in various
Coupled protein quality control during nonsense-mediated mRNA decay.
Inglis, et al.
Journal of Cell Science, 136 (2023)
Szabolcs Pesti et al.
Cell communication and signaling : CCS, 10(1), 36-36 (2012-11-28)
Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes. Although scaffold proteins are present in all cell types, the nervous
Maria Castañeda-Bueno et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), E879-E886 (2017-01-18)
With-no-lysine kinase 4 (WNK4) regulates electrolyte homeostasis and blood pressure. WNK4 phosphorylates the kinases SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress responsive kinase), which then phosphorylate and activate the renal Na-Cl cotransporter (NCC). WNK4 levels are regulated by
Josephine Bock et al.
Cell reports, 40(6), 111175-111175 (2022-08-11)
Protein degradation is fundamentally important to ensure cell homeostasis. In the endoplasmic reticulum (ER), the ER-associated degradation (ERAD) pathway targets incorrectly folded and unassembled proteins for turnover by the cytoplasmic proteasome. Previously, we showed that the rhomboid protease RHBDL4, together
Carles Barceló et al.
Journal of cell science, 126(Pt 20), 4553-4559 (2013-08-15)
Activating mutations in the K-Ras small GTPase are extensively found in human tumors. Although these mutations induce the generation of a constitutively GTP-loaded, active form of K-Ras, phosphorylation at Ser181 within the C-terminal hypervariable region can modulate oncogenic K-Ras function
Sabira Mohammed et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4329-4347 (2020-01-24)
Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune response by production of type I interferons. Here, we report that sphingosine kinase 1 (SphK1) which produces the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), plays a critical
Yuan Fu et al.
Nature chemical biology, 14(10), 943-954 (2018-08-29)
Since the origins of DNA-based life, the enzyme ribonucleotide reductase (RNR) has spurred proliferation because of its rate-limiting role in de novo deoxynucleoside-triphosphate (dNTP) biosynthesis. Paradoxically, the large subunit, RNR-α, of this obligatory two-component complex in mammals plays a context-specific
Christoph J Burckhardt et al.
Developmental cell, 56(8), 1164-1181 (2021-03-25)
Cells probe their surrounding matrix for attachment sites via integrins that are internalized by endocytosis. We find that SH3BP4 regulates integrin surface expression in a signaling-dependent manner via clathrin-coated pits (CCPs). Dephosphorylated SH3BP4 at S246 is efficiently recruited to CCPs
Ronghua Zhang et al.
Journal of virology, 89(22), 11383-11395 (2015-09-05)
An accessory gene between the S and E gene loci is contained in all coronaviruses (CoVs), and its function has been studied in some coronaviruses. This gene locus in human coronavirus OC43 (HCoV-OC43) encodes the ns12.9 accessory protein; however, its
Shan Tang et al.
Nature, 602(7898), 701-707 (2022-02-18)
Hydrolase enzymes, including proteases, are encoded by 2-3% of the genes in the human genome and 14% of these enzymes are active drug targets1. However, the activities and substrate specificities of many proteases-especially those embedded in membranes-and other hydrolases remain
Wanze Chen et al.
Nature communications, 10(1), 1809-1809 (2019-04-20)
Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other
Maurizio Gianni et al.
Oncotarget, 8(23), 37041-37060 (2016-07-16)
Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) is the first example of targeted therapy. In fact, the oncogenic fusion-protein (PML-RAR) typical of this leukemia contains the retinoid-nuclear-receptor RARα. PML-RAR is responsible for the differentiation block of
Jingjing Lin et al.
Molecular cell, 80(4), 607-620 (2020-10-29)
Aberrant mitophagy has been implicated in a broad spectrum of disorders. PINK1, Parkin, and ubiquitin have pivotal roles in priming mitophagy. However, the entire regulatory landscape and the precise control mechanisms of mitophagy remain to be elucidated. Here, we uncover
Shuji Matsuda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(35), 8668-8676 (2008-08-30)
Genetic alterations of amyloid beta-peptide (Abeta) production caused by mutations in the Abeta precursor protein (APP) cause familial Alzheimer's disease (AD). Mutations in BRI2, a gene of undefined function, are linked to familial British and Danish dementias, which are pathologically
Wenjuan Li et al.
FEBS letters, 594(14), 2294-2302 (2020-05-16)
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a central protein in necroptosis with great potential as a target for treating necroptosis-associated diseases, such as Crohn's disease. However, blockade of RIPK3 kinase activity leads to unexpected RIPK3-initiated apoptosis. Herein, we found that
Clive P Morgan et al.
Frontiers in cellular neuroscience, 12, 41-41 (2018-03-09)
Hair cells of the inner ear transduce mechanical stimuli like sound or head movements into electrical signals, which are propagated to the central nervous system. The hair-cell mechanotransduction channel remains unidentified. We tested whether three transient receptor channel (TRP) family
Ronit Nir et al.
PLoS genetics, 8(3), e1002632-e1002632 (2012-04-06)
Drosophila melanogaster Held Out Wings (HOW) is a conserved RNA-binding protein (RBP) belonging to the STAR family, whose closest mammalian ortholog Quaking (QKI) has been implicated in embryonic development and nervous system myelination. The HOW RBP modulates a variety of
Fengwu Zhang et al.
The Journal of biological chemistry, 297(4), 101109-101109 (2021-08-24)
The stability of a protein is regulated by a balance between its ubiquitylation and deubiquitylation. S-phase kinase-associated protein 2 (SKP2) is an oncogenic F-box protein that recognizes tumor suppressor substrates for targeted ubiquitylation by the E3 ligase SKP1-Cullin1-F-box and degradation
Prashant K Mishra et al.
PLoS genetics, 7(9), e1002303-e1002303 (2011-10-08)
The kinetochore (centromeric DNA and associated proteins) is a key determinant for high fidelity chromosome transmission. Evolutionarily conserved Scm3p is an essential component of centromeric chromatin and is required for assembly and function of kinetochores in humans, fission yeast, and
Juan Liu et al.
Nature metabolism, 4(12), 1830-1846 (2022-12-20)
The glycolytic enzyme lactate dehydrogenase A (LDHA) is frequently overexpressed in cancer, which promotes glycolysis and cancer. The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogenic mechanism of LDHA;
Sumanprava Giri et al.
eLife, 4 (2015-04-30)
Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs). The pre-replication complex protein, origin recognition complex-associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells. Its role in heterochromatin organization
Rainer D Will et al.
Circulation research, 107(10), 1253-1264 (2010-09-18)
The M-band represents a transverse structure in the center of the sarcomeric A-band and provides an anchor for the myosin-containing thick filaments. In contrast to other sarcomeric structures, eg, the Z-disc, only few M-band-specific proteins have been identified to date
Pablo Sánchez-Martín et al.
Journal of cell science, 136(3) (2023-01-17)
Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of the cell. The fusion of autophagosomes with the lytic compartment
Yunting Jian et al.
Journal of experimental & clinical cancer research : CR, 40(1), 56-56 (2021-02-06)
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high proliferative activity. TNBC tumors exhibit elevated MYC expression and altered expression of MYC regulatory genes, which are associated with tumor progression and poor prognosis; however, the
Shouta Kitano et al.
Journal of central nervous system disease, 7, 15-26 (2015-06-25)
Expanded GGGGCC hexanucleotide repeats located in the noncoding region of the chromosome 9 open reading frame 72 (C9orf72) gene represent the most common genetic abnormality for familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Formation of nuclear
Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.
Chen YC, Umanah GK, Dephoure N, et al.
The Embo Journal, 33(14), 1548-1564 (2014)
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