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Alexander J Adami et al.
Pediatric research, 84(3), 426-434 (2018-07-04)
Early-life exposure to antibiotics (ABX) has been linked to increases in asthma severity and prevalence in both children and laboratory animals. We explored the immunologic mechanisms behind this association using a mouse model of house dust mite (HDM)-induced asthma and
Single allergen-induced oral tolerance inhibits airway inflammation in conjugated allergen immunized mice.
Chien-Hui Chien et al.
The Journal of allergy and clinical immunology, 136(4), 1110-1113 (2015-05-31)
E Sudo et al.
American journal of respiratory cell and molecular biology, 22(3), 373-379 (2000-03-01)
We compared the action of methacholine (MCh) and uridine 5'-triphosphate (UTP) with and without pretreatment with the chloride channel blocker 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) on the transepithelial potential difference (PD), the mucus collection rate (MCR), and tracheal mucus rheology using anesthetized C57BL/6
J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Emília da Silva Gonçalves et al.
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 34(3), 271-280 (2016-03-19)
to assess the prevalence, spirometry findings and risk factors for asthma in schoolchildren who were very low birth weight infants with and without bronchopulmonary dysplasia. Observational and cross-sectional study. The parents and/or tutors answered the International Study of Asthma and
Elizabeth A Townsend et al.
American journal of physiology. Lung cellular and molecular physiology, 305(5), L396-L403 (2013-07-23)
Asthma is a disease of the airways with symptoms including exaggerated airway narrowing and airway inflammation. Early asthma therapies used methylxanthines to relieve symptoms, in part, by inhibiting cyclic nucleotide phosphodiesterases (PDEs), the enzyme responsible for degrading cAMP. The classification
Yen-Ting Lai et al.
Journal of biomedical science, 27(1), 52-52 (2020-04-17)
Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause abnormal enlargement of alveoli and lead to bronchopulmonary dysplasia (BPD)-associated emphysema.
Cheng-Jang Wu et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 50(4), 327-333 (2013-01-25)
Asthma is a chronic respiratory disorder characterized by airway hyperreactivity, eosinophilic infiltration, high titer of allergen-specific IgE, and overproduction of T helper 2 (Th2) cytokines. Antigen combined with an appropriate adjuvant and administrated through the proper route can elicit suitable
Natsuko Taniguchi et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(5), 376-381 (2013-10-16)
Clara cell secretory protein (CC16) is expressed primarily in the respiratory tract and is a potent anti-inflammatory agent that protects the airway from inflammation. The associations of the A38G polymorphism in this gene with asymptomatic airway hyper-responsiveness (AHR), which is
Tobias Bopp et al.
Journal of immunology (Baltimore, Md. : 1950), 182(7), 4017-4024 (2009-03-21)
Naturally occurring regulatory T cells (nTreg cells) are crucial for the maintenance of peripheral tolerance. We have previously shown that a key mechanism of their suppressive action is based on a contact-dependent transfer of cAMP from nTreg cells to responder
Kaharu Sumino et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(4), 354-360 (2014-02-11)
The methacholine challenge test quantifies airway hyper-responsiveness, which is measured by the provocative concentration of methacholine causing a 20% decrease in forced expiration volume in 1 second (PC20). The dose-response effect of inhaled corticosteroids (ICS) on PC20 has been inconsistent
Huihui You et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 272-281 (2014-06-24)
Di-(2-ethylhexyl) phthalate, as the most commonly used plasticizer, is considered to be related to the asthma prevalence. There are studies affirming that the DEHP has an adjuvant effect in the pathogenesis of allergy asthma. Oxidative stress is one possible pathway
Roby Greenwald et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 50(6), 619-622 (2013-04-06)
The dual actions of S-nitrosoglutathione reductase comprise reduction of S-nitrosoglutathione, a potent endogenous airway smooth muscle relaxant that is depleted in asthmatics, and detoxification of formaldehyde to formate. Airway formate production is increased in children with asthma, suggesting increased activity
Louisa J Mathias et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5914-5924 (2013-11-20)
Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy. However, the majority of MSCs administered i.v. encounter a pulmonary impasse and soon disappear from the lungs, raising the question of how they
Dapeng Gong et al.
Journal of immunology (Baltimore, Md. : 1950), 191(9), 4514-4520 (2013-09-24)
Abr deactivates Ras-related C3 botulinum toxin substrate (Rac), a master molecular switch that positively regulates many immune cell functions, by converting it to its GDP-bound conformation. In this article, we report that, in the absence of Abr function, cockroach allergen
Fabien Sauvet et al.
International journal of cardiology, 190, 246-255 (2015-05-02)
Sleep loss may induce endothelial dysfunction, a key factor in cardiovascular risk. We examined the endothelial function during one week of sleep restriction and a recovery period (from 3-to-13 days) in healthy subjects, and its link to autonomic, inflammatory and/or
Rifat A Chaudry et al.
Thorax, 69(6), 580-585 (2014-02-14)
Asthma and airway hyper-responsiveness are reportedly more common in children with sickle cell disease (SCD). To determine airway responsiveness, airway inflammation and clinical features of asthma in SCD. A prospective, single-centre study of 50 SCD children without overt pulmonary vascular
Johannes Schulze et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 24(1), 19-27 (2013-01-22)
In allergic asthma, the diagnosis of house dust mite (HDM) allergy is mainly based on the patient's history, allergy testing by the skin prick test (SPT) or the levels of allergen-specific IgE. We retrospectively analysed data from 350 bronchial provocations
Wei Wang et al.
Immunity, 51(6), 1102-1118 (2019-11-24)
Young children are more susceptible to developing allergic asthma than adults. As neural innervation of the peripheral tissue continues to develop after birth, neurons may modulate tissue inflammation in an age-related manner. Here we showed that sympathetic nerves underwent a
Ivonne Bernardo Wicher et al.
Jornal de pediatria, 86(5), 384-390 (2010-08-26)
To investigate the medium-term benefits of a swimming program in schoolchildren and adolescents with moderate persistent atopic asthma (MPAA). A randomized, prospective study of children and adolescents (age 7-18 years) with MPAA was carried out at the Hospital de Clínicas
François Daubeuf et al.
Respiratory research, 16, 77-77 (2015-06-27)
Potential involvement of the CCR10/CCL28 axis was recently reported in murine models of allergic asthma. If confirmed, blockade of the CCR10 receptor would represent an alternative to current asthma therapies. We evaluated the effect of a novel Protein Epitope Mimetic
C Gontijo-Amaral et al.
European journal of clinical nutrition, 61(1), 54-60 (2006-06-22)
To investigate the long-term effect of oral magnesium supplementation on clinical symptoms, bronchial reactivity, lung function and allergen-induced skin responses in children and adolescents with moderate persistent asthma. A double-blind randomized parallel placebo-controlled study. The patients were recruited from the
Luis Prieto et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(1), 26-33 (2014-07-16)
Abstract Objective: No information is available on the effect of cigarette smoke on bronchoconstrictor-induced air trapping in asthma. The aim of this study was to evaluate the additional influence of smoking on methacholine- and adenosine 5'-monophosphate (AMP)-induced air trapping in
Rayan Khaddaj-Mallat et al.
Pflugers Archiv : European journal of physiology, 467(7), 1591-1605 (2014-08-13)
This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated guinea pig tracheal rings. Tension measurements performed on native
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Mashima R, Arimura S, Kajikawa S, Oda H, et al.
Genes Cells (2012)
Monique Badier et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 50(6), 573-578 (2013-04-12)
Asymptomatic airway hyper-responsiveness (AHR) represents a risk of further accelerated decline in lung function, and of asthma. Due to the fact that rare and contradictory results exist concerning the impact of obesity on BHR, we re-assessed the prevalence of bronchial
Bo Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3583-3593 (2015-03-18)
Type-2 innate lymphoid cells (ILC2s) and the acquired CD4(+) Th2 and Th17 cells contribute to the pathogenesis of experimental asthma; however, their roles in Ag-driven exacerbation of chronic murine allergic airway diseases remain elusive. In this study, we report that
A Cheraghvandi et al.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 19(4), 369-372 (2013-07-26)
While airways reactivity is among the characteristics of asthma, it is not considered a sufficient condition diagnostically and the methacholine challenge is a non-specific diagnostic aid in cases of chronic cough and reactive airways disease. The aim of this cross-sectional
Asger Sverrild et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 286-289 (2013-09-24)
Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only
Arvind Manoharan et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 161-164 (2013-04-04)
We previously reported that the β(2)-adrenergic receptor (ADRB2) polymorphism had no effect on bronchial hyperresponsiveness (BHR) to methacholine in asthmatic patients. We have now replicated this analysis in a different and larger cohort of patients. To assess the effect of
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