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Monique Badier et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 50(6), 573-578 (2013-04-12)
Asymptomatic airway hyper-responsiveness (AHR) represents a risk of further accelerated decline in lung function, and of asthma. Due to the fact that rare and contradictory results exist concerning the impact of obesity on BHR, we re-assessed the prevalence of bronchial
Bo Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3583-3593 (2015-03-18)
Type-2 innate lymphoid cells (ILC2s) and the acquired CD4(+) Th2 and Th17 cells contribute to the pathogenesis of experimental asthma; however, their roles in Ag-driven exacerbation of chronic murine allergic airway diseases remain elusive. In this study, we report that
Rayan Khaddaj-Mallat et al.
Pflugers Archiv : European journal of physiology, 467(7), 1591-1605 (2014-08-13)
This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated guinea pig tracheal rings. Tension measurements performed on native
Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis.
Pei-Chi Chen et al.
The Journal of allergy and clinical immunology, 140(4), 1146-1149 (2017-04-17)
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Mashima R, Arimura S, Kajikawa S, Oda H, et al.
Genes Cells (2012)
David M Guimond et al.
PloS one, 8(5), e63645-e63645 (2013-05-15)
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires the interaction of
Ahmed Lazrak et al.
American journal of physiology. Lung cellular and molecular physiology, 318(3), L459-L471 (2020-01-09)
We investigated the mechanisms involved in the development of airway hyperresponsiveness (AHR) following exposure of mice to halogens. Male mice (C57BL/6; 20-25 g) exposed to either bromine (Br2) or Cl2 (600 or 400 ppm, respectively, for 30 min) developed AHR
Asger Sverrild et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 286-289 (2013-09-24)
Mast cells are involved in a number of diseases, including inflammatory diseases such as asthma. Tryptase is a known marker of mast cell burden and activity. However, little is known about the genetic influence on serum tryptase variation. Also, only
Matheus Silverio Mattos et al.
Frontiers in immunology, 11, 566953-566953 (2020-10-31)
Increased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD. Chronic neutrophilic inflammation is usually corticosteroid insensitive and may be relevant
Daniel O Amakye et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(3), 182-184 (2013-08-31)
A positive response to indirect airway challenges (eg, mannitol) that cause release of mast cell mediators causes refractoriness to a repeat exposure to the same or different indirect stimulus that lasts for at least several hours. Allergen challenge causes increased
Christopher M Evans et al.
Nature communications, 6, 6281-6281 (2015-02-18)
In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle-relaxing treatments are often temporary or ineffective. Overproduction of the mucin MUC5AC is an additional disease feature that, while strongly
Methap Yurt et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L859-L867 (2014-10-12)
Whereas epidemiological data strongly link vitamin D (VD) deficiency to childhood asthma, the underlying molecular mechanisms remain unknown. Although VD is known to stimulate alveolar epithelial-mesenchymal interactions, promoting perinatal lung maturation, whether VD supplementation during this period protects against childhood
S J Wilson et al.
Journal of toxicology and environmental health. Part A, 76(3), 176-191 (2013-01-30)
This study detailed the sequence of recurring inflammatory events associated with episodic allergen exposures of mice resulting in airway hyperreactivity, sustained inflammation, goblet-cell hyperplasia, and fibrogenesis that characterize a lung with chronic asthma. Ovalbumin (OVA)-sensitized female BALB/c mice were exposed
Arvind Manoharan et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 161-164 (2013-04-04)
We previously reported that the β(2)-adrenergic receptor (ADRB2) polymorphism had no effect on bronchial hyperresponsiveness (BHR) to methacholine in asthmatic patients. We have now replicated this analysis in a different and larger cohort of patients. To assess the effect of
Hai Lee Chung et al.
Pediatric pulmonology, 50(9), 841-847 (2014-07-22)
Airway remodeling is known to be a consequence of repeated injury and thought to be involved in early stage of asthma. We aimed to investigate the mediators associated with airway remodeling in recurrent early wheezers. Thirty-three infants, aged 2 years
Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
Justin Stocks et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(8), 886-890 (2014-05-07)
Bronchial hyper-responsiveness in a military population has been evaluated by direct and indirect challenge methods. We hypothesized that negative methacholine challenge testing (MCT) was not sufficient to exclude significant bronchial hyper-responsiveness in a symptomatic military population with exertional dyspnea. The
Ahmed Lazrak et al.
American journal of physiology. Lung cellular and molecular physiology, 308(9), L891-L903 (2015-03-10)
Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts with epithelial lining fluid, forming by-products that damage hyaluronan, a constituent of the extracellular matrix, causing the release of
Megan Osbourn et al.
Immunity, 47(4), 739-751 (2017-10-19)
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway.
Mohammad Hossein Boskabady et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 200-208 (2013-04-12)
The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to
C Barnig et al.
Journal of investigational allergology & clinical immunology, 23(4), 267-274 (2013-08-24)
Conflicting results have been reported in studies of predictive factors for airway responsiveness to allergens during bronchial challenges. The aim of this study was to assess determinants of airway responsiveness to 3 different allergens during standardized bronchial challenges. Data were
Michelle L North et al.
American journal of respiratory cell and molecular biology, 48(6), 694-702 (2013-03-09)
Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes. The product of arginase activity, L-ornithine, can be metabolized into polyamines by ornithine decarboxylase. We tested the hypothesis that
Michael J Segel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(6), 429-432 (2013-05-28)
The methacholine challenge test (MCT) is a test of bronchial hyperreactivity used as an aid in the diagnosis of asthma. MCT results are reported as the provocation concentration at which the forced expiratory volume in 1 second (FEV1) decreases 20%
Lynda S Ostedgaard et al.
eLife, 9 (2020-10-08)
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which have lungs like humans
Alexander J Adami et al.
Pediatric research, 84(3), 426-434 (2018-07-04)
Early-life exposure to antibiotics (ABX) has been linked to increases in asthma severity and prevalence in both children and laboratory animals. We explored the immunologic mechanisms behind this association using a mouse model of house dust mite (HDM)-induced asthma and
Single allergen-induced oral tolerance inhibits airway inflammation in conjugated allergen immunized mice.
Chien-Hui Chien et al.
The Journal of allergy and clinical immunology, 136(4), 1110-1113 (2015-05-31)
Emília da Silva Gonçalves et al.
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 34(3), 271-280 (2016-03-19)
to assess the prevalence, spirometry findings and risk factors for asthma in schoolchildren who were very low birth weight infants with and without bronchopulmonary dysplasia. Observational and cross-sectional study. The parents and/or tutors answered the International Study of Asthma and
Natsuko Taniguchi et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(5), 376-381 (2013-10-16)
Clara cell secretory protein (CC16) is expressed primarily in the respiratory tract and is a potent anti-inflammatory agent that protects the airway from inflammation. The associations of the A38G polymorphism in this gene with asymptomatic airway hyper-responsiveness (AHR), which is
Johannes Schulze et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 24(1), 19-27 (2013-01-22)
In allergic asthma, the diagnosis of house dust mite (HDM) allergy is mainly based on the patient's history, allergy testing by the skin prick test (SPT) or the levels of allergen-specific IgE. We retrospectively analysed data from 350 bronchial provocations
Huihui You et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 272-281 (2014-06-24)
Di-(2-ethylhexyl) phthalate, as the most commonly used plasticizer, is considered to be related to the asthma prevalence. There are studies affirming that the DEHP has an adjuvant effect in the pathogenesis of allergy asthma. Oxidative stress is one possible pathway
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