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Maryam Ghafari et al.
Brain structure & function, 220(4), 2209-2221 (2014-05-09)
Reduced daily intake of magnesium (Mg(2+)) is suggested to contribute to depression. Indeed, preclinical studies show dietary magnesium restriction (MgR) elicits enhanced depression-like behaviour establishing a causal relationship. Amongst other mechanisms, Mg(2+) gates the activity of N-methyl-D-asparte (NMDA) receptors; however
Hisataka Taguchi et al.
Journal of bioscience and bioengineering, 114(6), 586-588 (2012-08-08)
We synthesized N-(4-nitrophenyl)-6-aminohexanamide (AHpNA) and used it as a substrate in a kinetic study of 6-aminohexanoate-hydrolase (NylB), a nylon oligomer-hydrolyzing enzyme. NylBs derived from Arthrobacter sp. KI72 and Pseudomonas sp. NK87 hydrolyzed AHpNA as well as a 6-aminohexanoic acid dimer
Lingyan Ma et al.
Gut microbes, 12(1), 1-19 (2020-11-06)
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction. However, the mechanism of spermidine on
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Ana G Antun et al.
Cancer, 119(21), 3784-3787 (2013-08-08)
Despite prophylactic platelet transfusions, bleeding remains a significant problem in thrombocytopenic patients. The antifibrinolytic agent epsilon aminocaproic acid (EACA) was administered to 44 chronically (median duration, 273 days) and severely (platelet count, 8 × 10(9)/L; range, 1 × 10(9)/L-19 ×
Xinhua Cao et al.
Physical chemistry chemical physics : PCCP, 17(48), 32297-32303 (2015-11-20)
A two-component light-harvesting organogel containing a naphthalimide-based gelator (1) as a donor and a phosphorescent Ir(III) complex [Ir(bt)2(acac)] (bt = 2-phenylbenzothiazole and acac = acetylacetone) (Ir) as an acceptor was used to produce white-light-emitting organogels. The addition of complex Ir
Moamen Bydoun et al.
Molecular oncology, 12(11), 1895-1916 (2018-07-17)
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome
Seung Yon Han et al.
The Journal of pharmacy and pharmacology, 64(10), 1452-1460 (2012-09-05)
Anti-ulcer drugs are frequently used in patients with acute renal failure (ARF). Zinc acexamate is ionized to zinc and ε-acetamidocaproic acid and free EACA exerts a potent therapeutic effect in treating gastric or duodenal ulcers with few side effects. Thus
Are antifibrinolytic agents effective in the treatment of aneurysmal subarachnoid hemorrhage?
Travis R Eastin et al.
Annals of emergency medicine, 64(6), 658-659 (2014-06-24)
Sergio Guerrero-Castillo et al.
The EMBO journal, 40(21), e108648-e108648 (2021-09-21)
So-called ρ0 cells lack mitochondrial DNA and are therefore incapable of aerobic ATP synthesis. How cells adapt to survive ablation of oxidative phosphorylation remains poorly understood. Complexome profiling analysis of ρ0 cells covered 1,002 mitochondrial proteins and revealed changes in
Jaruwan Siritapetawee et al.
Plant physiology and biochemistry : PPB, 92, 30-38 (2015-04-23)
A dimeric protease designated as EuP-82 was purified from Euphorbia cf. lactea latex. Since its proteolytic activity was inhibited by a serine protease specific inhibitor (PMSF), EuP-82 was classified as a serine protease. N-glycan deglycosylation tests revealed that EuP-82 was
Allergic contact dermatitis due to epsilon-aminocaproic acid: a case report and mini-review of the published work.
Yuriko Yamamoto et al.
The Journal of dermatology, 40(4), 301-303 (2013-02-13)
M Heimrich et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(5), 846-860 (2012-02-15)
Cyclic oligomers are the major substances migrating from polyamide (PA) food contact materials. However, no commercial standards are available for the quantification of these substances. For the first time the quantification of cyclic oligomers was carried out by HPLC coupled
Rachael J Borg et al.
PloS one, 10(7), e0131216-e0131216 (2015-07-02)
Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein misfolding event that orchestrates the plasmin-dependent proteolytic degradation of necrotic cells. As impaired clearance of dead cells by
Moitza Principe et al.
Oncotarget, 6(13), 11098-11113 (2015-04-11)
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness and resistance to treatment. We have previously demonstrated that most PDAC patients have circulating antibodies against the glycolytic enzyme alpha-enolase (ENO1), which correlates with a better
María D Valls et al.
Frontiers in pharmacology, 12, 654104-654104 (2021-05-15)
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the fibrinolytic system. In order to
Nicholas Mavrogiannis et al.
Electrophoresis, 36(13), 1386-1395 (2014-12-20)
Traditional particle-based dielectrophoresis has been exploited to manipulate bubbles, particles, biomolecules, and cells. In this work, we investigate analytically and experimentally how to utilize Maxwell-Wagner polarization to initiate fluidic dielectrophoresis (fDEP) at electrically polarizable aqueous liquid-liquid interfaces. In fDEP, an
Liliana M Marín et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 22(3), 332-340 (2012-05-23)
To determine the frequency of delayed postoperative bleeding in retired racing Greyhounds with appendicular bone tumors undergoing limb amputations. To identify if administration of epsilon-aminocaproic acid (EACA) was effective on the prevention of postoperative bleeding. Retrospective study from December 2003
Irene Lecker et al.
The Journal of clinical investigation, 122(12), 4654-4666 (2012-11-29)
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying such seizures remain poorly understood. The antifibrinolytic drugs tranexamic acid (TXA) and ε-aminocaproic acid (EACA)
Ian Roberts et al.
The Cochrane database of systematic reviews, 12, CD004896-CD004896 (2013-02-20)
Uncontrolled bleeding is an important cause of death in trauma victims. Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may also be effective in reducing blood loss following trauma. To quantify the effects of antifibrinolytic drugs
Ya-Hsueh Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 885-886, 61-65 (2012-01-13)
A simple and rapid assay based on hydrophilic interaction liquid chromatography with tandem mass spectrometry has been first developed and validated for simultaneous determination of caprolactam (CA) and 6-aminocaproic acid (6-ANCA) in human urine using 8-aminocaprylic acid as internal standard.
Chengfei Lu et al.
Langmuir : the ACS journal of surfaces and colloids, 28(40), 14415-14423 (2012-09-11)
We report on the synthesis and characterization of a PEGylated IR786 GUMBOS (Group of Uniform Materials Based on Organic Salts). The synthesis of this material was accomplished using a three step protocol: (1) substitution of chloride on the cyclohexenyl ring
Alba Timón-Gómez et al.
STAR protocols, 1(2) (2020-10-01)
By using negatively charged Coomassie brilliant blue G-250 dye to induce a charge shift on proteins, blue native polyacrylamide gel electrophoresis (BN-PAGE) allows resolution of enzymatically active multiprotein complexes extracted from cellular or subcellular lysates while retaining their native conformation.
Andrew B Jackson et al.
Nuclear medicine and biology, 39(3), 377-387 (2012-01-10)
The present study describes the design and development of a new heterodimeric RGD-bombesin (BBN) agonist peptide ligand for dual receptor targeting of the form (64)Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH(2) in which Cu-64=a positron emitting radiometal; NO2A=1,4,7-triazacyclononane-1,4-diacetic acid; Glu=glutamic acid; 6-Ahx=6-aminohexanoic acid; RGD=the amino acid
Brian Hutton et al.
BMJ (Clinical research ed.), 345, e5798-e5798 (2012-09-13)
To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and
Mohammad Golam Sabbir
Cell communication and signaling : CCS, 18(1), 80-80 (2020-05-29)
Circulatory iron is a hazardous biometal. Therefore, iron is transported in a redox-safe state by a serum glycoprotein - transferrin (TF). Different organs acquire iron from the systemic circulation through a tightly regulated mechanism at the blood-tissue interface which involves
Takunori Nagashima et al.
Advanced biosystems, 4(11), e2000121-e2000121 (2020-10-22)
In the development process for drugs used to treat skeletal muscle, cell-based contractile force assays have been considered as a useful in vitro test. Immortalized human myogenic cells are promising as cell sources for reproducible and well-characterized in vitro models.
Ruba Khnouf et al.
The Analyst, 139(18), 4564-4571 (2014-07-17)
We have developed a microfluidic device that enhances the sensitivity of protein immunoassays by preconcentrating the protein sample using isotachophoresis (ITP). Two approaches were followed to study the sensitivity gain achieved that way. The first approach was using antibody-coated magnetic
Tulsidas G Shrivastav et al.
Journal of immunoassay & immunochemistry, 34(1), 94-108 (2013-01-18)
In steroid enzyme immunoassay (EIA), there is an increase or decrease of labeled steroid recognition by antibody due to homologous and heterologous combinations of enzyme conjugate with immunogen that affects sensitivity of the assay. We have introduced three to 18
Aditya Kapil Valiveti et al.
Chemico-biological interactions, 237, 125-132 (2015-06-14)
A series of mono pyridinium oximes linked with arenylacetamides as side chains were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by organophosphorus inhibitors (OP) such as sarin, VX and tabun. The reactivation data
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