A268

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Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists.

Christopher S Rex et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(25), 5956-5966 (2005-06-25)

Memory loss in humans begins early in adult life and progresses thereafter. It is not known whether these losses reflect the failure of cellular processes that encode memory or disturbances in events that retrieve it. Here, we report that impairments

Adenosine receptors in health and disease.

Stefania Gessi et al.

Advances in pharmacology (San Diego, Calif.), 61, 41-75 (2011-05-19)

The adenosine receptors A(1), A(2A), A(2B), and A(3) are important and ubiquitous mediators of cellular signaling, which play vital roles in protecting tissues and organs from damage. In particular, adenosine triggers tissue protection and repair by different receptor-mediated mechanisms, including

Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and basal ganglia.

S A Rivkees et al.

Brain research, 677(2), 193-203 (1995-04-24)

Polyclonal antisera were generated against two identical regions of rat and human A1 adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western blotting showed that the antisera recognized a single protein in brain of the expected size for A1 receptors. Immunohistochemistry

Immunological identification of A1 adenosine receptors in brain cortex.

F Ciruela et al.

Journal of neuroscience research, 42(6), 818-828 (1995-12-15)

The A1 adenosine receptor from pig brain cortex has been identified by means of two antipeptide antibodies against two domains of the receptor molecule: PC/10 antiserum was raised against a part of the third intracellular loop, and PC/20 antiserum was

Dual Effect of Adenosine A1 Receptor Activation on Renal O2 Consumption.

Victor Babich et al.

Journal of cellular physiology, 230(12), 3093-3104 (2015-05-27)

The high requirement of O2 in the renal proximal tubule stems from a high rate of Na(+) transport. Adenosine A1 receptor (A1R) activation regulates Na(+) transport in this nephron segment. Thus, the effect of the acute activation and the mechanisms

Development of an antiserum to rat-brain A1 adenosine receptor: application for immunological and structural comparison of A1 adenosine receptors from various tissues and species.

Nakata, H.

Biochimica et Biophysica Acta, 117, 93-93 (1993)

Immunohistochemical localization of adenosine A1 receptors in human brain regions.

M Schindler et al.

Neuroscience letters, 297(3), 211-215 (2001-01-04)

Adenosine exerts its physiological actions by binding to G-protein coupled receptors, four of which have been identified and cloned to date (A1, A2a, A2b and A3). Here we report the development of anti-human adenosine A1, receptor anti-peptide polyclonal antibodies and

Differential expression of adenosine A1 and A2A receptors after upper cervical (C2) spinal cord hemisection in adult rats.

Theodor Petrov et al.

The journal of spinal cord medicine, 30(4), 331-337 (2007-09-15)

In an animal model of spinal cord injury, a latent respiratory motor pathway can be pharmacologically activated via adenosine receptors to restore respiratory function after cervical (C2) spinal cord hemisection that paralyzes the hemidiaphragm ipsilateral to injury. Although spinal phrenic

Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury

Schneyvays V et al

American Journal of Physiology. Heart and Circulatory Physiology, 288, H2792-H2792 (2004)

Adenosine receptor distribution in Rhesus monkey ocular tissue.

Krista M Beach et al.

Experimental eye research, 174, 40-50 (2018-05-25)

Adenosine receptor (ADOR) antagonists, such as 7-methylxanthine (7-MX), have been shown to slow myopia progression in humans and animal models. Adenosine receptors are found throughout the body, and regulate the release of neurotransmitters such as dopamine and glutamate. However, the

Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action.

Sonia Muñoz-López et al.

Frontiers in endocrinology, 13, 1007801-1007801 (2022-11-22)

Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy. The mode of action of resveratrol is still poorly understood, but

Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis.

Jae-Wan Huh et al.

Bioconjugate chemistry, 16(3), 710-716 (2005-05-19)

We have identified a UDP-glucose-binding site within human UDP-glucose dehydrogenase (hUGDH) by photoaffinity labeling with a specific probe, [(32)P]5N(3)UDP-glucose, and cassette mutagenesis using a synthetic hUGDH gene. Photolabel-containing peptides were generated by photolysis followed by tryptic digestion and isolated using

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