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关键词:'A2754'
显示 1-30 共 97 条结果 关于 "A2754" 范围 论文
Un Seng Chio et al.
Cell reports, 26(1), 37-44 (2019-01-04)
Molecular chaperones play key roles in maintaining cellular proteostasis. In addition to preventing client aggregation, chaperones often relay substrates within a network while preventing off-pathway chaperones from accessing the substrate. Here we show that a conserved lid motif lining the
Shaojie Ding et al.
Human reproduction (Oxford, England), 35(5), 1130-1144 (2020-04-19)
Does P2X ligand-gated ion channel 3 (P2X3) play a role in endometriosis pain? Upregulation of P2X3 in dorsal root ganglia (DRG) tissues via the activating transcription factor 3 (ATF3)/activator protein (AP)-1 pathway contributed to endometriosis-associated hyperalgesia, which could be attenuated
D T Gruszka et al.
Science advances, 6(38) (2020-09-20)
During replication, nucleosomes are disrupted ahead of the replication fork, followed by their reassembly on daughter strands from the pool of recycled parental and new histones. However, because no previous studies have managed to capture the moment that replication forks
P2 receptors and platelet function.
Hechler B, Gachet C.
Purinergic Signaling, 7(3), 239-303 (2011)
Ryosuke Nakata et al.
Scientific reports, 7(1), 17170-17170 (2017-12-08)
Given the rising incidence of non-alcoholic fatty liver disease (NAFLD) in both adults and children, the development of a non-invasive diagnostic method for assessing disease progression to non-alcoholic steatohepatitis (NASH) has become an important research goal. Currently available non-invasive imaging
Miguel Angel Becerril-García et al.
Frontiers in immunology, 11, 744-744 (2020-05-13)
Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules
Rachel Lopez et al.
Function (Oxford, England), 1(2), zqaa018-zqaa018 (2020-10-20)
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynthesize its entire ATP pool several times per minute.
Diane Moujalled et al.
Cell death & disease, 12(1), 133-133 (2021-01-30)
Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream regulator, RIPK3 kinase, impacted thrombosis
Marten Szibor et al.
Biochimica et biophysica acta. Bioenergetics, 1861(2), 148137-148137 (2019-12-12)
Electron transfer from all respiratory chain dehydrogenases of the electron transport chain (ETC) converges at the level of the quinone (Q) pool. The Q redox state is thus a function of electron input (reduction) and output (oxidation) and closely reflects
Yuan Qin et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 663-675 (2020-01-10)
Mitochondrial fusion and fission are essential for heart function. Abrogating mitochondrial dynamism leads to cardiomyopathy. Excessive mitochondrial fragmentation is involved in most heart diseases, thus enhancing mitochondrial fusion will be a potential therapeutic strategy. To understand the effects of promoting
Jonathan J Chen et al.
Computational biology and chemistry, 78, 317-329 (2019-01-10)
Glycolysis with PK-M2 occurs typically in anaerobic conditions and atypically in aerobic conditions, which is known as the Warburg effect. The Warburg effect is found in many oncogenic situations and is believed to provide energy and biomass for oncogenesis to
Richard C Jin et al.
Circulation, 123(18), 1963-1973 (2011-04-27)
Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke
Marta Pabis et al.
The EMBO journal, 39(19), e105087-e105087 (2020-09-10)
The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin-related modifier 1 (Urm1) pathway is responsible for the synthesis of 2-thiolated wobble uridine (U34 ). During the key
Torahiko L Higashi et al.
eLife, 10 (2021-07-27)
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational changes that
Yumiko Kurokawa et al.
Cell reports, 33(6), 108357-108357 (2020-11-12)
Cohesin, a critical mediator of genome organization including sister chromatid cohesion, is a ring-shaped multi-subunit ATPase that topologically embraces DNA. Its loading and function on chromosomes require the Scc2-Scc4 loader. Using biochemical reconstitution, we show here that the ability of
Tamara Heermann et al.
Nature methods, 18(10), 1239-1246 (2021-10-06)
In spite of their great importance in biology, methods providing access to spontaneous molecular interactions with and on biological membranes have been sparse. The recent advent of mass photometry to quantify mass distributions of unlabeled biomolecules landing on surfaces raised
Luana de Almeida-Pereira et al.
Molecular neurobiology, 54(7), 5142-5155 (2016-08-26)
Previous studies demonstrated that exogenous ATP is able to regulate proliferation of retinal progenitor cells (RPCs) in vitro possibly via P2Y
Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation.
Guimei Yu et al.
iScience, 24(11), 103310-103310 (2021-11-13)
VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an understudied state of VCP. The structure revealed an
Kaushar Jahan et al.
Scientific reports, 10(1), 11603-11603 (2020-07-16)
Bone fracture repair is a multifaceted, coordinated physiological process that requires new bone formation and resorption, eventually returning the fractured bone to its original state. Currently, a variety of different approaches are pursued to accelerate the repair of defective bones
Xiao Wei et al.
Cell reports, 32(13), 108207-108207 (2020-10-01)
Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a primary cause of end-stage renal failure. Clinical studies indicate that metabolic surgery improves DN; however, the mechanism remains unclear. Here, we report that Roux-en-Y Gastric Bypass (RYGB) surgery
I S Kucherenko et al.
Talanta, 144, 604-611 (2015-10-11)
Creatine kinase (CK: adenosine-5-triphosphate-creatine phosphotransferase) is an important enzyme of muscle cells; the presence of a large amount of the enzyme in blood serum is a biomarker of muscular injuries, such as acute myocardial infarction. This work describes a bi-enzyme
Estela Santos-Alves et al.
Mitochondrion, 47, 103-113 (2019-06-07)
Doxorubicin (DOX), a widely used and efficient antineoplastic agent, is mainly limited by cardiotoxicity, although other tissues including liver are also affected. The effects of exercise to cope with DOX side-effects has already been studied in the heart and brain
Magdalena L Bochenek et al.
Circulation research, 126(2), 162-181 (2019-11-22)
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by defective thrombus resolution, pulmonary artery obstruction, and vasculopathy. TGFβ (transforming growth factor-β) signaling mutations have been implicated in pulmonary arterial hypertension, whereas the role of TGFβ in the pathophysiology of CTEPH is
Kaushar Jahan et al.
Carbohydrate polymers, 203, 60-70 (2018-10-16)
Biomineralization of soft scaffolds is a new venture in bone tissue engineering. This work aimed to develop a new injectable and in-situ gelling soft scaffold with chitosan and apatites through a rapid purine-crosslinking reaction. The scaffolds were fabricated by mixing
Eduardo Balsa et al.
Molecular cell, 74(5), 877-890 (2019-04-27)
Endoplasmic reticulum (ER) stress and unfolded protein response are energetically challenging under nutrient stress conditions. However, the regulatory mechanisms that control the energetic demand under nutrient and ER stress are largely unknown. Here we show that ER stress and glucose
Caroline Honaiser Lescano et al.
Food & function, 12(2), 802-814 (2021-01-05)
Alibertia edulis leaf extract is commonly used in folk medicine, with rutin caffeic and vanillic acids being its major compounds. The Alibertia edulis leaf extract was investigated for its pharmacological effects via platelet aggregation, calcium mobilization, cyclic nucleotides levels, vasodilator-stimulated
Erik Voets et al.
Journal for immunotherapy of cancer, 7(1), 340-340 (2019-12-06)
Accumulating preclinical data indicate that targeting the SIRPα/CD47 axis alone or in combination with existing targeted therapies or immune checkpoint inhibitors enhances tumor rejection. Although several CD47-targeting agents are currently in phase I clinical trials and demonstrate activity in combination
Yanyu Zhang et al.
Cancer research, 80(16), 3345-3358 (2020-06-27)
Platelet-derived growth factor B (PDGFB) plays a crucial role in recruitment of PDGF receptor β-positive pericytes to blood vessels. The endothelium is an essential source of PDGFB in this process. Platelets constitute a major reservoir of PDGFB and are continuously
George K E Umanah et al.
Cell reports, 33(5), 108329-108329 (2020-11-05)
The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization of AMPARs from the synaptic membrane. Here, we show that
Junhui Jeong et al.
Hearing research, 386, 107860-107860 (2019-12-24)
Purinergic receptors protect the cochlea during high-intensity stimulation by providing a parallel shunt pathway through non-sensory neighboring epithelial cells for cation absorption. So far, there is no direct functional evidence for the presence and type/subunit of purinergic receptors in the
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