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显示 1-30 共 37 条结果 关于 "A28651" 范围 论文
Stephanie Schaefer-Ramadan et al.
Biochemistry, 52(46), 8323-8332 (2013-10-24)
Augmenter of liver regeneration is a member of the ERV family of small flavin-dependent sulfhydryl oxidases that contain a redox-active CxxC disulfide bond in redox communication with the isoalloxazine ring of bound FAD. These enzymes catalyze the oxidation of thiol
Lorena Valle et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(6), 1051-1061 (2012-03-22)
The singlet and triplet excited states properties of lumiflavin (LF), riboflavin (RF), flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) in reversed micelles (RM) of sodium docusate (AOT) in n-hexane solutions were evaluated as a function of the water to
Dorota Prukała et al.
Rapid communications in mass spectrometry : RCM, 23(5), 619-628 (2009-01-24)
The fragmentation pathways in electron ionization (EI) mass spectra of a series of new N(5)-oxides of alloxazines and iso-alloxazine are presented, and compared with those of substituted alloxazines and iso-alloxazine. The EI mass spectra of these compounds showed characteristic fragmentation
Tae-Kyung Lee et al.
Journal of cardiovascular pharmacology, 53(2), 167-172 (2009-02-04)
Previous reports have suggested that the posterior hypothalamic adenosine A2 receptors may play a role in central cardiovascular regulation. In this study, we examined the influence of posterior hypothalamic adenosine A2B receptors on the regulation of blood pressure and heart
Limor Radoszkowicz et al.
Physical chemistry chemical physics : PCCP, 13(25), 12058-12066 (2011-06-01)
Time-resolved fluorescence decay of flavin adenine dinucleotide (FAD) was studied at room temperature in water and water-methanol mixtures by a fluorescence upconversion technique. The observations were focused on the most initial decay phase (200 ps), before the residual fluorescence assumes
Amanda B Witte et al.
Biomacromolecules, 13(2), 507-516 (2011-12-24)
The present study describes the biophysical characterization of generation-five poly(amidoamine) (PAMAM) dendrimers conjugated with riboflavin (RF) as a cancer-targeting platform. Two new series of dendrimers were designed, each presenting the riboflavin ligand attached at a different site (isoalloxazine at N-3
Achuthan C Raghavamenon et al.
Toxicology mechanisms and methods, 19(8), 498-502 (2009-10-13)
A fluorometric, reversed-phase high-performance liquid chromatography (RP-HPLC) method that allows quantitation of low levels of alloxan has been described. The method involved derivatization of alloxan with 500-200,000-fold excess of 1, 2-phenylenediamine (PD) in 0.1 M acetate buffer, pH 4.5 for
Burki Rajendar et al.
Organic & biomolecular chemistry, 8(21), 4949-4959 (2010-09-08)
Using the DNA duplex containing an AP site (5'-TCC AGX GCA AC-3'/3'-AGG TCN CGT TG-5', X = AP site, N = A, T, C, or G), we have found that 2-amino-4-hydroxypteridine (pterin) selectively binds to guanine (G), and that the
Zachary C Berwick et al.
Microcirculation (New York, N.Y. : 1994), 17(8), 600-607 (2010-11-04)
This study was designed to elucidate the contribution of adenosine A(2A) and A(2B) receptors to coronary reactive hyperemia and downstream K(+) channels involved. Coronary blood flow was measured in open-chest anesthetized dogs. Adenosine dose-dependently increased coronary flow from 0.72 ±
Viktor Mojr et al.
Organic & biomolecular chemistry, 9(21), 7318-7326 (2011-09-01)
Four structurally different alloxazine-cyclodextrin conjugates were prepared and tested as catalysts for the enantioselective oxidation of prochiral sulfides to sulfoxides by hydrogen peroxide in aqueous solutions. The alloxazinium unit was appended to the primary face of α- and β-cyclodextrins via
Haoran Yu et al.
Virology, 521, 1-19 (2018-06-05)
Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate
Fei Bei et al.
Gene, 524(2), 396-400 (2013-04-17)
Isovaleric acidemia (IVA) is a rare inherited metabolic disease caused by a deficiency in isovaleryl-CoA dehydrogenase (IVD). Newborn screening with tandem mass spectrometry leads to early identification of individuals with risk of IVA. The family specific mutations are useful for
Dovenia S Ponnoth et al.
American journal of physiology. Heart and circulatory physiology, 297(5), H1655-H1660 (2009-09-15)
Adenosine mediates vascular responses through four receptor subtypes: A(1), A(2A), A(2B), and A(3). The role of A(2A) receptors in aortic vascular tone was investigated using A(2A) adenosine receptor (AR) knockout (A(2A)KO) and corresponding wild-type (A(2A)WT) mice. Isolated aortic rings from
Benjamin Rieff et al.
Photochemistry and photobiology, 87(3), 511-523 (2010-12-01)
The photophysics and photochemistry of flavin dyes determine the functional dynamics of a series of blue light photoreceptors that include the so-called BLUF (blue light sensors using flavin) domains. To enable molecular dynamics (MD) simulation studies of such signaling processes
Tzong-Yuan Lin et al.
The Journal of biological chemistry, 287(45), 38338-38346 (2012-09-21)
The three-component toluene dioxygenase system consists of an FAD-containing reductase, a Rieske-type [2Fe-2S] ferredoxin, and a Rieske-type dioxygenase. The task of the FAD-containing reductase is to shuttle electrons from NADH to the ferredoxin, a reaction the enzyme has to catalyze
Allen M Orville et al.
Biochemistry, 48(4), 720-728 (2009-01-13)
Flavin C4a-OO(H) and C4a-OH adducts are critical intermediates proposed in many flavoenzyme reaction mechanisms, but they are rarely detected even by rapid transient kinetics methods. We observe a trapped flavin C4a-OH or C4a-OO(H) adduct by single-crystal spectroscopic methods and in
Sammeta V Raju et al.
PloS one, 7(3), e32112-e32112 (2012-03-24)
Alcohol abuse is associated with increased lung infections. Molecular understanding of the underlying mechanisms is not complete. Airway epithelial ion transport regulates the homeostasis of airway surface liquid, essential for airway mucosal immunity and lung host defense. Here, air-liquid interface
Alexander Barthel et al.
Archiv der Pharmazie, 342(8), 445-452 (2009-07-01)
The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins
Shuxia Chen et al.
PloS one, 8(11), e79730-e79730 (2013-11-16)
Two phenolic compound parameters (total phenolic and flavonoid contents) and 5 antioxidant parameters (DPPH [2, 2-diphenyl-1-picrylhydrazyl] radical scavenging activity, HRSC (hydroxyl radical scavenging capacity), FRAP (ferric ion reducing antioxidant power), CUPRAC (cupric ion reducing antioxidant capacity), and MCA (metal chelating
Jesús I Martínez et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 218, 153-162 (2012-03-27)
A complete study of Anabaena flavodoxin in the neutral semiquinone state by means of the EPR pulse technique HYSCORE is here presented. The results provide new information about the hyperfine interactions of the unpaired electronic spin and the nuclei in
Sarah Raffelberg et al.
Biological chemistry, 394(11), 1517-1528 (2013-07-06)
Flavin-binding light, oxygen, and voltage (LOV) domains are UVA/blue-light-sensing protein units that form a reversible flavin mononucleotide-cysteine adduct upon light induction. In their dark-adapted state, LOV domains exhibit the typical spectral features of fully oxidized riboflavin derivatives. A survey on
Katalin Módis et al.
International journal of molecular medicine, 31(2), 437-446 (2012-12-13)
Liver ischemia represents a common clinical problem. In the present study, using an in vitro model of hepatic ischemia-reperfusion injury, we evaluated the potential cytoprotective effect of the purine metabolites, such as adenosine and inosine, and studied the mode of
Naris Thengchaisri et al.
Microvascular research, 77(3), 356-363 (2009-03-28)
We previously demonstrated a vascular network response initiated by elevated tissue concentrations of adenosine that is distinct from the dilation caused when adenosine is applied directly to the arteriole. The purpose of this study was to elucidate the potential mechanism(s)
Stefan Weber et al.
Photochemistry and photobiology, 87(3), 574-583 (2011-01-05)
Blue-light sensitive photoreceptory BLUF domains are flavoproteins, which regulate various, mostly stress-related processes in bacteria and eukaryotes. The photoreactivity of the flavin adenine dinucleotide (FAD) cofactor in three BLUF domains from Rhodobacter sphaeroides, Synechocystis sp. PCC 6803 and Escherichia coli
Fabian Offensperger et al.
Cell chemical biology, 27(12), 1510-1520 (2020-09-24)
Genetic aberrations of the UBE3A gene encoding the E3 ubiquitin ligase E6AP underlie the development of Angelman syndrome (AS). Approximately 10% of AS individuals harbor UBE3A genes with point mutations, frequently resulting in the expression of full-length E6AP variants with
Olayinka O Ogunro et al.
Nano letters, 9(3), 1034-1038 (2009-02-25)
We have studied the structural and electronic stability of a helical ribbon of flavin mononucleotide wrapping around single-walled carbon nanotubes using first-principles density-functional calculations. The helical ribbon is formed through hydrogen bonding between adjacent uracil moieties of the isoalloxazine ring
Junlong Dang et al.
Journal of autoimmunity, 113, 102491-102491 (2020-06-23)
Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE). Mesenchymal stem cells (MSCs) have emerged as a novel therapy to address the dysregulation in autoimmune diseases but also have limitations. Human gingiva derived MSCs (GMSCs) are
Determination of mutated genes in the presence of wild-type DNA by using molecular beacons as probe.
Yonghua Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 174, 286-290 (2016-12-14)
Low-abundance mutations in the presence of wild-type DNA can be determined using molecular beacon (MB) as probe. A MB is generally used as DNA probe because it can distinguish single-base mismatched target DNA from fully matched target DNA. However, the
Hideaki Takahashi et al.
The Journal of chemical physics, 129(20), 205103-205103 (2008-12-03)
The isoalloxazine ring (flavin ring) is a part of the coenzyme flavin adenine dinucleotide and acts as an active site in the oxidation of a substrate. We have computed the free energy change Deltamicro(red) associated with one-electron reduction of the
Isaias Lans et al.
Biochimica et biophysica acta, 1817(12), 2118-2127 (2012-09-18)
The chemical versatility of flavin cofactors within the flavoprotein environment allows them to play main roles in the bioenergetics of all type of organisms, particularly in energy transformation processes such as photosynthesis or oxidative phosphorylation. Despite the large diversity of
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